P31.03: Tumor volume as risk factor for nodal diffusion in endometrial cancer

To evaluate tumor volume as possible risk factor for nodal diffusion in patients with endometrial cancer. All consecutive patients with histological diagnosis of endometrial cancer confirmed at biopsy were enrolled and underwent transvaginal ultrasound (TVUS) with storage of 2D clips and acquisition of 3D volumes. Using VOCAL software tumor volumes were designed and related to nodal positivity at final histology (for all patients at least sentinel nodes were assessed). Myometrial infiltration (more or less 50%) was also recorded. Fourty patients with histological diagnosis of endometrial cancer were enrolled. All underwent TVUS within one week prior to surgery. Twelve patients had positive lymph nodes at final histology: all these patients had a tumor volume evaluated with VOCAL software greater than 10 cm3; in 67% (8/12) a myometrial infiltration greater than 50% was assessed, in 17% (2/12) myometrial infiltration was not assessable because of fibroids presence. Tumor volume is an easy parameter to evaluate in all patients and well reproducible, even when tumor infiltration is doubt and difficult to assess (fibroids, adenomyosis). It can be assessed during offline analysis avoiding patients' disconfort with too long ultrasound examinations. A tumor volume grater than 10 cm3 could be considered as a risk factor for nodal positivity.