The Undervalued Role of 5-Minute HRV in Post-Acute Infection Syndromes: A Commentary

2025 · doi:10.32388/578upd
preprint OA: closed CC-BY-4.0
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Abstract

Post-Acute Infection Syndromes (PAIS), including ME/CFS and Long COVID, involve immune dysfunction and autonomic nervous system (ANS) imbalance. This commentary emphasizes the value of 5-minute ECG-derived Heart Rate Variability (HRV) as a simple, non-invasive tool to assess ANS dysfunction in PAIS. Reduced HRV reflects parasympathetic withdrawal and sympathetic dominance linked to symptoms and inflammation. Although standardization challenges exist, 5-minute HRV can aid diagnosis, monitoring, and treatment evaluation, offering important insights into PAIS mechanisms and clinical care.
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License: CC-BY-4.0