The MTL200: a surface-based, probabilistic atlas of the medial temporal lobe

2025 · doi:10.64898/2025.12.04.692420
preprint OA: closed CC-BY-4.0
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The study aimed to create the MTL200, a surface-based, probabilistic atlas defining anatomical boundaries for medial temporal lobe regions including temporopolar cortex, entorhinal cortex, perirhinal cortex, and parahippocampal cortex. Using anatomical MRI from 200 participants, the authors generated region labels from hand-drawn delineations based on gross anatomical features intended to correspond to cytoarchitectonic boundaries, addressing limitations of prior atlases that were volumetric, lacked TPC, or were derived from small samples. The key output is a tool intended to support surface-based analysis of MRI and to improve characterization of the less well-defined temporopolar cortex. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The human medial temporal lobe (MTL) includes a number of cortical regions surrounding the hippocampus implicated in long-term memory and high-level perception, including temporopolar cortex (TPC), entorhinal cortex (ERC), perirhinal cortex (PRC), and parahippocampal cortex (PHC). A critical prerequisite to studying the function of these areas is to define their anatomical boundaries. While several atlases or segmentations methods for automated boundary definition exist, they have limitations: 1) they are derived from small sample sizes; 2) most do not include TPC; and 3) they are volumetric rather than surface-based and are therefore not straightforward to use for surface-based analysis of MRI data. Here we present the MTL200: a surface-based, probabilistic atlas of MTL regions TPC, ERC, PRC, and PHC. The atlas is derived from hand drawings of regions based on gross anatomical features corresponding to cytoarchitectonic boundaries, using anatomical MRI data from 200 human participants. This work provides a valuable tool for researchers studying the anatomy and function of MTL regions, particularly the poorly characterized area TPC.
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Abstract The human medial temporal lobe (MTL) includes a number of cortical regions surrounding the hippocampus implicated in long-term memory and high-level perception, including temporopolar cortex (TPC), entorhinal cortex (ERC), perirhinal cortex (PRC), and parahippocampal cortex (PHC). A critical prerequisite to studying the function of these areas is to define their anatomical boundaries. While several atlases or segmentations methods for automated boundary definition exist, they have limitations: 1) they are derived from small sample sizes; 2) most do not include TPC; and 3) they are volumetric rather than surface-based and are therefore not straightforward to use for surface-based analysis of MRI data. Here we present the MTL200: a surface-based, probabilistic atlas of MTL regions TPC, ERC, PRC, and PHC. The atlas is derived from hand drawings of regions based on gross anatomical features corresponding to cytoarchitectonic boundaries, using anatomical MRI data from 200 human participants. This work provides a valuable tool for researchers studying the anatomy and function of MTL regions, particularly the poorly characterized area TPC. Competing Interest Statement The authors have declared no competing interest.

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License: CC-BY-4.0