DENTAL EXTRACTION & DENOSUMAB. EVALUATION OF PIEZOELECTRIC SURGICAL PROTOCOL FOR MRONJ PREVENTION. PRELIMINARY REPORT.

AIM: To evaluate incidence of wound healing complications and MRONJ following tooth extractions in patients treated with Denosumab (Dmab). MATERIALS AND METHODS: Atraumatic piezosurgery-aided tooth extractions in Dmab treated patients during appropriate drug holiday protocol. RESULTS: Fortyfive atraumatic tooth extractions in 15 consecutive caucasian patients were performed. High dose regimen patients / Low dose regimen patients : 1/4. Healing of surgical wounds without complications/delay was achieved in 42 extraction sites (93.3%) in 17 patients (85%) by 8 weeks evaluation.  DISCUSSION: Despite the little experience existing regarding tooth extraction in exclusive Dmab-treated patients, our preliminary data suggest that atraumatic piezosurgery-aided tooth extractions permit elimination of dental foci without significant complications or delays in Dmab therapy in most cases.