Полиморфизм генов системы репарации ДНК при генитальном эндометриозе

With the help of up-to-date molecular-genetic methods the research of alleles and genotypes of polymorphous variants of genes XRCC1 (G280A, G399A, C194T) and XPD (A751C) distribution was accomplished at 200 females with genital endometriosis and 100 females without endometriosis from Tomsk and Tomsk region. At females with genital endometriosis statistically significant increase of frequency of «pathological» alleles of genes XRCC1 G280A and XPD A751C was registered. It was found that the risk of genital endometriosis is statistically associated with the presence in female genotype of TT genotype of C194T polymorphism of XRCC1 gene and CC genotype of XPD A751C gene.