Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs

Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs Xiaoyu Hu, Wen Qu, Shaohua Fu, Yanmei Li, Xin Cong, Yue Zhang, and 3 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2173093/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract The aim of this study was to investigate the absorption, distribution, excretion of Selenium-enriched peptides(SeP) in miniature Bama pigs via oral route. Two different dosage groups of SeP was designed given 0.2 and 0.02 mg selenium per kilogram body weight respectively, and one control group was set given basic diet. A single administration of SeP was finished following with 2 weeks washout period and then a 7-day repeated administration of SeP was given. The concentrations of Se in plasma, tissues, urine and feces were measured by ICP-MS/MS, the activity of Glutathione peroxidase (GSH-PX) and content of selenium protein (SelP) in plasma were determined by ELISA Kit. Toxicokinetic parameters were calculated by fitting data with metabolic dynamics model using WinNonlin (6.3) software. Selenium from SeP was absorbed to plasma to maximum concentration with hours, mostly accumulated in the liver and kidney and mostly excreted by the gastrointestinal tract than by urine. Compared with control group, GSH-PX activity in SeP groups increased significantly after single or repeated administration, but no significant change were observed in SelP content, biochemical or hematological parameters. selenium kinetics absorption distribution excretion pig GSH-PX Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2173093","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":144972959,"identity":"ade65169-fc2b-4098-91bd-0d37c44f9e75","order_by":0,"name":"Xiaoyu Hu","email":"","orcid":"","institution":"Hubei University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Xiaoyu","middleName":"","lastName":"Hu","suffix":""},{"id":144972960,"identity":"d6935d8d-ec06-4985-809c-e38c7d952d1a","order_by":1,"name":"Wen Qu","email":"","orcid":"","institution":"Hubei Provincial Centers for Disease Control and 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absorption, distribution, excretion, pig, GSH-PX ","lastPublishedDoi":"10.21203/rs.3.rs-2173093/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-2173093/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe aim of this study was to investigate the absorption, distribution, excretion of Selenium-enriched peptides(SeP) in miniature Bama pigs via oral route. Two different dosage groups of SeP was designed given 0.2 and 0.02 mg selenium per kilogram body weight respectively, and one control group was set given basic diet. A single administration of SeP was finished following with 2 weeks washout period and then a 7-day repeated administration of SeP was given. The concentrations of Se in plasma, tissues, urine and feces were measured by ICP-MS/MS, the activity of Glutathione peroxidase (GSH-PX) and content of selenium protein (SelP) in plasma were determined by ELISA Kit. Toxicokinetic parameters were calculated by fitting data with metabolic dynamics model using WinNonlin (6.3) software. Selenium from SeP was absorbed to plasma to maximum concentration with hours, mostly accumulated in the liver and kidney and mostly excreted by the gastrointestinal tract than by urine. Compared with control group, GSH-PX activity in SeP groups increased significantly after single or repeated administration, but no significant change were observed in SelP content, biochemical or hematological parameters.\u003c/p\u003e","manuscriptTitle":"Oral Absorption, Distribution and Excretion of Selenium-Enriched Peptides from Cardamine violifolia in Miniature Bama pigs","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2022-10-20 17:15:04","doi":"10.21203/rs.3.rs-2173093/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2e62ad07-c7f2-40fa-a12a-1d8c3a6ab96d","owner":[],"postedDate":"October 20th, 2022","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-02-24T18:29:21+00:00","versionOfRecord":[],"versionCreatedAt":"2022-10-20 17:15:04","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-2173093","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-2173093","identity":"rs-2173093","version":["v1"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}