Uterine Artery Embolization for the Treatment of Adenomyosis

Martin Popovic, Stephan Puchner, Dominik Berzaczy, Johannes Lämmer, RA Bucek
In: RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · vol. 182(S 01) · doi:10.1055/s-0030-1253029 · W2094104578
Systematic review / meta-analysis OA: closed CC0
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This review of 16 studies involving 314 women indicates that uterine artery embolization provides symptomatic improvement for adenomyosis, although long-term data and randomized controlled trials are needed to validate these findings.

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This review evaluates the efficacy of uterine artery embolization as a therapeutic option for adenomyosis by analyzing literature retrieved from Medline, Embase, and PubMed between 1999 and August 2009. The authors assessed data from sixteen studies involving 314 women, finding that approximately 78% of patients reported symptomatic improvements regarding bleeding, pain, and bulk-related discomfort. While the evidence is primarily classified as Level II-2 through Level III, the analysis indicates clear trends toward clinical benefit despite the lack of long-term follow-up data. This paper is centrally about adenomyosis — specifically investigating uterine artery embolization as a treatment modality for this condition.

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Abstract

Ziele: The constellation of symptoms of uterine fibroids and adenomyosis are similar. Based on positive results reported as a treatment for uterine fibroids, uterine artery embolization (UAE) has been investigated as a possible therapeutic tool to treat adenomyosis. Methode: All publications retrievable through Medline, Embase or Pubmed with keywords such as adenomyosis, uterine artery embolization, uterine fibroid embolization, adenomyosis therapy and adenomyosis treatment were included in this report. All studies written or abstracted in English were utilized. Data available from reports from 1999 through august 2009 were evaluated. Level of evidence was classified as Level I, II, or III with 3 subcategories in Level II based on the quality of evidence developed by the United States Preventive Services Task Force (USPSTF) Ergebnis: UAE was performed in and follow-up data is available from 314 affected women. The included 16 studies report on outcomes from 3 to 54 patients per study. Improvements in symptoms largely related to bleeding, pain and bulk related discomfort were reported by 245 (78%) patients. The median follow-up for the collective group is 19.6 months. The studies outlined herein mostly provide level II-2 through level III type of evidence. Some better designed trials offer level II-1 evidence as defined by the USPSTF. Schlussfolgerung: UAE as treatment for adenomyosis shows clear trends of clinical and symptomatic improvements. Long-term data are needed to verify initial results and randomized, controlled trials are essential to validate current research data.
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Subscribe to RSS DOI: 10.1055/s-0030-1253029 Uterine Artery Embolization for the Treatment of Adenomyosis Ziele: The constellation of symptoms of uterine fibroids and adenomyosis are similar. Based on positive results reported as a treatment for uterine fibroids, uterine artery embolization (UAE) has been investigated as a possible therapeutic tool to treat adenomyosis. Methode: All publications retrievable through Medline, Embase or Pubmed with keywords such as adenomyosis, uterine artery embolization, uterine fibroid embolization, adenomyosis therapy and adenomyosis treatment were included in this report. All studies written or abstracted in English were utilized. Data available from reports from 1999 through august 2009 were evaluated. Level of evidence was classified as Level I, II, or III with 3 subcategories in Level II based on the quality of evidence developed by the United States Preventive Services Task Force (USPSTF) Ergebnis: UAE was performed in and follow-up data is available from 314 affected women. The included 16 studies report on outcomes from 3 to 54 patients per study. Improvements in symptoms largely related to bleeding, pain and bulk related discomfort were reported by 245 (78%) patients. The median follow-up for the collective group is 19.6 months. The studies outlined herein mostly provide level II-2 through level III type of evidence. Some better designed trials offer level II-1 evidence as defined by the USPSTF. Schlussfolgerung: UAE as treatment for adenomyosis shows clear trends of clinical and symptomatic improvements. Long-term data are needed to verify initial results and randomized, controlled trials are essential to validate current research data. Korrespondierender Autor: Popovic M Medizinische Universität Wien, Radiodiagnostik, Kardiovaskuläre und Interventionelle Radiologie, Währinger Gürtel 18–20, 1090, Wien E-Mail: [email protected] Adenomyosis - Uterine Artery Embolization - Treatment Options

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