Study on the association between the polymorphism of progesterone receptor G886 G gene and the susceptibility to endometriosis

Objective To investigate the association of the single nucleotide polymorphism(SNP) of progesterone receptor(PR) gene exon 8 region G886G(rs500760) site with the genetic susceptibility to endometriosis( Ems) in southern Han Chinese women. Methods Peripheral blood samples of 431 patients with endometriosis(Ems group) and 499 women with non-endometriosis(control group) were collected. All cases were confirmed by operation and pathology. The fluorescent quantitative PCR-based high resolution melting( HRM) method was used to evaluate the SNP of PR G886G site among all cases. Results The A and G of PR G886G allele frequencies were 79. 1%,20. 9% in the Ems group and 79. 4%,20. 6% in the control group,respectively. The AA,AG and GG of PR G886G genotype frequencies were 61. 7%,34. 8%,3. 5% in Ems group and 61. 3%,36. 1%,2. 6% in control group respectively. There were no statistically significant differences between the two groups,both in the PR G886G alleles distribution( P = 0. 899) and genotypes distribution(P = 0. 705). Conclusion There may be no association between the SNP of PR G886G and the genetic susceptibility of Ems in southern Han Chinese women.