ABO blood group and the risk of CHB patients with decompensated cirrhosis: a case-control study

Objective: ABO blood group, a genetic marker of blood, has been shown to be associated with risk of cardiovascular disease and several malignancies. The study aimed to assess whether there was associated with hepatitis B decompensated cirrhosis. Results: After adjusting for age, hepatitis B virus (HBV)-DNA nucleic acid (HBV-DNA), blood group A was an independent risk factor for decompensated cirrhosis compared to patients with type O. Age after multivariate stratified analysis showed that the risk of decompensated cirrhosis was also significantly higher in patients with aged 55 years or older with blood group A compared to blood group O. No significant differences were found in the severity of laboratory indicators in patients with decompensated cirrhosis among different ABO blood groups. Additionally, there was no significant difference in the survival rate of decompensated cirrhosis during the 12-month observation period among different ABO blood groups. Taken together, these findings indicated that the independent risk factor of developing decompensated cirrhosis was associated with A blood group, age and HBV-DNA levels in CHB patients.