循证血管发生因子PD—ECGF、VEGF及抑制因子TSP—1在子宫内膜异位症发病因素中的作用
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This study investigated the expression of angiogenesis factors PD-ECGF and VEGF alongside the inhibitor TSP-1 to elucidate their roles in the pathogenesis of endometriosis.
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Abstract
血小板衍化内皮细胞生长因子(platelet-derived endothelial cell growth factor,PD-ECGF)、血管内皮细胞生长因子(Vascular endotheliod growth factor, VEGF)的生物学功能是诱导血管生成,二者有部分的同源性[1];血小板反应素(thrombospondin-1,TSP-1)则是血管生成抑制因子.大多数肿瘤组织中PD-ECGF、VEGF高效活化,而TSP-1含量降低[2],有研究表明PD-ECGF不仅与肿瘤组织中血管增生有关,还作为炎症因子与肿瘤的生长侵袭有关;VEGF的表达增高是肿瘤增生活跃的重要标志;TSP-1则与微血管密度负相关.子宫内膜异位症(endometriosis,EM)具有类似恶性肿瘤的侵袭转移、免疫失调等特点.异位内膜的种植及浸润性生长,其发生发展与多种因素有关,动物实验发现成功移植人体子宫内膜于豚鼠腹腔,早期即可观察到间质细胞增殖及新生血管网[3],据此推测EM病因与血管发生过程有关.本研究旨在观察PD-ECGF、VEGF和TSP-1在EM的表达,循证这三个因子在EM的发病因素中的作用机制.
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
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