Diffusion-weighted MRI of female pelvic tumors

- Frontmatter - Contents - List of contributors - Preface - 1 Basic physical principles of body diffusion-weighted MRI - 2 Diffusion-weighted MRI of the liver - 3 Diffusion-weighted MRI of diffuse renal disease and kidney transplant - 4 Diffusion-weighted MRI of focal renal masses - 5 Diffusion-weighted MRI of the pancreas - 6 Diffusion-weighted MRI of the prostate - 7 Breast applications of diffusion-weighted MRI - 8 Diffusion-weighted MRI of lymph nodes - 9 Diffusion-weighted MRI of female pelvic tumors - 10 Diffusion-weighted MRI of the bone marrow and the spine - 11 Diffusion-weighted MRI of soft tissue tumors - 12 Evaluation of tumor treatment response with diffusion-weighted MRI - 13 Diffusion-weighted MRI: future directions - Index - References Published online by Cambridge University Press: 10 November 2010 Edited by Book contents - Frontmatter - Contents - List of contributors - Preface - 1 Basic physical principles of body diffusion-weighted MRI - 2 Diffusion-weighted MRI of the liver - 3 Diffusion-weighted MRI of diffuse renal disease and kidney transplant - 4 Diffusion-weighted MRI of focal renal masses - 5 Diffusion-weighted MRI of the pancreas - 6 Diffusion-weighted MRI of the prostate - 7 Breast applications of diffusion-weighted MRI - 8 Diffusion-weighted MRI of lymph nodes - 9 Diffusion-weighted MRI of female pelvic tumors - 10 Diffusion-weighted MRI of the bone marrow and the spine - 11 Diffusion-weighted MRI of soft tissue tumors - 12 Evaluation of tumor treatment response with diffusion-weighted MRI - 13 Diffusion-weighted MRI: future directions - Index - References Introduction Magnetic resonance imaging (MRI) plays essential roles at every stage in the management of patients with gynecological cancer, from initial diagnosis and lesion characterization, to assessments of treatment effectiveness as well as for the determination of the activity of residual disease and the detection of recurrent active cancer. The limitations of morphological MRI assessments are well documented. For example, the detection of malignant lesions can be difficult particularly when disease burden is small or when disease is intermixed with normal or benign disease processes (e.g., detecting a small endometrial cancer in an endometrial polyp). Similarly, diagnostic accuracy of myometrial invasion by endometrial cancer is impaired particularly in patients with distortions of the endometrial cavity due to congenital abnormalities or fibroids or when there is scarring due to prior surgery. Coincident adenomyosis or a thinned/indistinct junctional zone can also impair assessments of depth of tumor invasion. Lesion characterization can be equally problematic, for example differentiating uterine sarcoma from degenerating leiomyomas or determining the nature of an adnexal mass. Detection and assessment of the activity of residual disease is also problematic for morphology-based imaging; for example, subtle serosal disease due to ovarian carcinoma is easily overlooked. Finally, determining relapsed disease in areas of therapy-induced scarring can be problematic requiring careful comparisons to be made with prior examinations (e.g., it is often difficult to differentiate tumor recurrence from post-surgical/post-radiotherapy fibrosis following pelvic surgery). - Type - Chapter - Information - Extra-Cranial Applications of Diffusion-Weighted MRI , pp. 119 - 143Publisher: Cambridge University PressPrint publication year: 2010 Body diffusion-weighted MR imaging of uterine endometrial cancer: is it helpful in the detection of cancer in nonenhanced MR imaging?Eur J Radiol 2009;70 (1): 122–7.CrossRefGoogle ScholarPubMed , , , et al. Diffusion weighted MRI in cervical cancer. Eur Radiol 2008; 18(5):1058–64.CrossRefGoogle ScholarPubMed , , , , . Detection of peritoneal dissemination in gynecological malignancy: evaluation by diffusion-weighted MR imaging. Eur Radiol 2008;18:18CrossRefGoogle ScholarPubMed , , , et al. Diffusion-weighted MR imaging of female pelvic tumors: a pictorial review. Radiographics 2009;29:759–74.CrossRefGoogle ScholarPubMed , , , et al. Role of diffusion-weighted imaging in the diagnosis of gynecological diseases. Eur Radiol 2009;19(3):745–60.CrossRefGoogle Scholar , , , et al. Diffusion-weighted MR imaging of uterine endometrial cancer. J Magn Reson Imag 2007;26:682–7.CrossRefGoogle ScholarPubMed , , et al. Three dimensional fiber architecture of the non pregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging. Anat Rec A 2006;228:84–90.CrossRefGoogle Scholar , , , et al. Ventricular myocardial architecture as visualised in postmortem swine hearts using magnetic resonance diffusion tensor imaging. Eur J Cardiothorac Surg 2005;27:468–72.CrossRefGoogle ScholarPubMed , , , et al. Quantitative analysis of three-dimensional-resolved fiber architecture in heterogeneous skeletal muscle tissue using NMR and optical imaging methods. Biophys J 2001;80:2968–75.CrossRefGoogle ScholarPubMed , , , , . The utility of diffusion-weighted MR imaging for differentiating uterine sarcomas from benign leiomyomas. Eur Radiol 2007;18:723–30.CrossRefGoogle ScholarPubMed , , , et al. Diffusion weighted MRI: correlation with tumor grade and stage in endometrial cancer and normal tissue. Cancer Imag 2006;6:158–62.Google Scholar , , , et al. Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix. EurRadiol 2005;15(1):71–8.Google ScholarPubMed , , , et al. Diffusion-weighted MRI in the body: applications and challenges in oncology. Am J Roentgenol 2007;188(6):1622–35.CrossRefGoogle Scholar , . , , , et al. Radiological staging in patients with endometrial cancer: a meta-analysis. Radiology 1999;212:711–18.CrossRefGoogle Scholar , , , et al. Endometrial cancer: magnetic resonance imaging. Abdom Imag 2005;30:626–36.CrossRefGoogle ScholarPubMed , , , , . Normal uterus and FIGO stage 1 endometiral carcinoma: dynamic gadolinium-enhanced MR imaging. Radiology 1993; 186:495–501.CrossRefGoogle Scholar , , , et al. Preoperative staging of endometrial carcinoma: diagnostic effect of T2-weighted fast spin-echo MR imaging. Radiology 1998;206:539–47.CrossRefGoogle ScholarPubMed , , , et al. Body diffusion-weighted MR imaging of uterine endometrial cancer: is it helpful in the detection of cancer in nonenhanced MR imaging?Eur J Radiol 2009;70(1):122–7.CrossRefGoogle ScholarPubMed , , , et al. Atlas of Tumor Pathology, vol 3. Washington, DC: Armed Forces Institution of Pathology; 2002, 113–51.Google Scholar , . Tumors of the uterine corpus and gestational trophoblastic disease. In: , , eds. Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results. Eur Radiol 2008;18:384–9.CrossRefGoogle ScholarPubMed , , , et al. MRI findings including gadolinium-enhanced dynamic studies of malignant, mixed, mesodermal tumors of the uterus: differentiation from endometrial carcinoma. Eur Radiol 2002;12:2737–42.Google Scholar , , , et al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics 1999;19:131–45.CrossRefGoogle ScholarPubMed , , , et al. Computing diffusion rates in T2-dark haematomas and areas of low T2 signal. Am J Neuroradiol 2001;22:112–18.Google ScholarPubMed , , , . Hypointensity on diffusion-weighted MRI of brain related to T2 shortening and susceptibility effects. Am J Roentgenol 2003;181:1705–9.CrossRefGoogle Scholar , , , et al. Differentiation between completely hyalinised uterine leiomyomas: three phase dynamic magnetic resonance imaging (MRI) vs. diffusion weighted MRI with very small b-factors. J Magn Reson Imag 2004; 20:97–104.CrossRefGoogle Scholar , , , et al. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds. Radiographics 1999;19:131–45.CrossRefGoogle ScholarPubMed , , , et al. Sarcomas of the uterus: a clinicopathologic study of 119 patients. Obstet Gynecol 1986;67:417–24.Google ScholarPubMed , , , et al. Blaustein's Pathology of the Female Genital Tract. 5th edn. New York: Springer; 2002, 561–616.Google Scholar , . Mesenchymal tumors of the uterus. In: , ed. , , , et al. Diffusion weighted echo-planar MR imaging and ADC mapping in the differential diagnosis of ovarian cystic masses: usefulness of detecting keratinoid substancesin mature cystic teratomas. J Magn Reson Imag 2005;22:271–8.CrossRefGoogle ScholarPubMed , , , et al. Diagnostic accuracy of diffusion-weighted imaging in differentiating benign from malignant ovarian lesions. J Magn Reson Imag 2008;28:1149–56.CrossRefGoogle ScholarPubMed , , , et al. Diffusion-weighted echo planar imaging of ovarian tumors: is it useful to measure apparent diffusion coefficients?J Comput Assist Tomogr 2002;26:250–6.CrossRefGoogle ScholarPubMed , , , et al. Diffusion weighted EPI of cystic ovarian lesions: evaluation of cystic contents using apparent diffusion coefficients. J Magn Reson Imag 2000; 12:1014–19.3.0.CO;2-T>CrossRefGoogle ScholarPubMed , . Epithelial ovarian tumors: value of dynamic contrast-enhanced MR imaging and correlation with tumor angiogenesis. Radiology 2008;248 (1):148–59.CrossRefGoogle ScholarPubMed , , , et al. Prediction of deep myometrial invasion in patients with endometrial cancer: clinical utility of contrast-enhanced MR imaging: a meta-analysis and Bayesian analysis. Radiology 2000;216(2):444–9.CrossRefGoogle ScholarPubMed , , , et al. Diffusion-weighted single-shot echo-planar imaging with parallel technique in assessment of endometrial cancer. Am J Roentgenol 2008;190(2):481–8.CrossRefGoogle ScholarPubMed , , , et al. Myometrial invasion in endometrial cancer: diagnostic accuracy of diffusion-weighted 3.0-T MR imaging: initial experience. Radiology 2009;250:784–92.CrossRefGoogle ScholarPubMed , , , et al. Staging of advanced ovarian cancer: comparison of imaging modalities: report from the Radiological Diagnostic Oncology Group. Radiology 2000;215:761–7.CrossRefGoogle Scholar , , , et al. Prospective evaluation of contrast enhanced MRI in the depiction of peritoneal spread in primary or recurrent ovarian cancer. Eur Radiol 2003;13:943–9.Google ScholarPubMed , , , et al. Lymph node size in uterine cancer: a revisit. Int J Gynecol Cancer 2006;16(5):1880–4.CrossRefGoogle ScholarPubMed , , , , . Preoperative staging of cervical carcinoma: phased array coil fast spin-echo versus body coil spin-echo T2-weighted MR imaging. Am J Roentgenol 1998;171:707–11.CrossRefGoogle ScholarPubMed , , , , . Metastatic lymph nodes in patients with cervical cancer: detection with MR imaging and FDG PET. Radiology 2001; 218:776–82.CrossRefGoogle ScholarPubMed , , , et al. Diagnostic performance of nanoparticle-enhanced magnetic resonance imaging in the diagnosis of lymph node metastases in patients with endometrial and cervical cancer. J Clin Oncol 2005;23 (12):2813–21.CrossRefGoogle Scholar , , , et al. MRI for pretreatment lymph node staging in uterine cervical cancer. Am J Roentgenol 2006;187: 538–43.CrossRefGoogle ScholarPubMed , , , et al. Lymph node metastasis in patients with clinical early-stage cervical cancer: detection with integrated FDG PET/CT. Radiology 2006;238:272–9.CrossRefGoogle ScholarPubMed , , , et al. Low value of [F]-fluoro-2-deoxy-D-glucose positron emission tomography in primary staging of early-stage cervical cancer before radical hysterectomy. J Clin Oncol 2006;24:123–8.CrossRefGoogle Scholar , , , et al. Feasibility of diffusion-weighted imaging in the differentiation of metastatic from non-metastatic lymph nodes: early experience. J Magn Reson Imag 2008;28:714–19.CrossRefGoogle Scholar , , , , . Combined ultrasmall superparamagnetic particles of iron oxide-enhanced and diffusion-weighted magnetic resonance imaging reliably detect pelvic lymph node metastases in normal-sized nodes of bladder and prostate cancer patients. Eur Urol 2009;55(4):770–2.CrossRefGoogle Scholar , , , et al. Sodium and proton diffusion MRI as biomarkers for early therapeutic response in subcutaneous tumors. Magn Reson Imag 2006;24:273–8.CrossRefGoogle ScholarPubMed , , , et al. Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res 1997;3:1457–66.Google ScholarPubMed , , . , , , . Uterine fibroids: diffusion weighted MR imaging for monitoring therapy with focused ultrasound surgery-preliminary study. Radiology 2005; 236:196–203.CrossRefGoogle ScholarPubMed , , . Assessment of response of uterine fibroids and myometrium to embolisation using diffusion-weighted echoplanar MR imaging. J Comput Assist Tomogr 2005; 29:82–6.CrossRefGoogle ScholarPubMed , , , , . Accessibility compliance for the PDF of this chapter is currently unknown and may be updated in the future. - 1 - Cited by To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle. 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