A prostaglandin analogue (ONO-802) in treatment of missed abortion, intrauterine fetal death and hydatiform mole: a dose-finding trial

N Garcea, R Dargenio, Ruggero Dargenio, V. Panetta, E Moneta, G Tancredi, Giulietta Tancredi, A Giannitelli, Aldo Giannitelli
European Journal of Obstetrics & Gynecology and Reproductive Biology · 1987 · vol. 25(1) , pp. 15–22 · doi:10.1016/0028-2243(87)90087-6 · PMID:3595971 · W2098534115
Non-randomised trial OA: bronze CC0
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A dose-finding trial in 48 patients with missed abortion, intrauterine fetal death, or hydatidiform mole found that three vaginal suppositories of the prostaglandin analogue ONO-802 expelled products of conception in 100% of cases with fewer side effects than five doses.

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Abstract

Forty-eight patients affected with missed abortion, intrauterine fetal death and hydatiform mole were treated with vaginal suppositories containing 1 mg of 16,16-dimethyl-trans-delta 2-PGE1 methyl ester (ONO-802). The patients were divided into two treatment groups. The first, Group A, was given one vaginal suppository every 3 h to a maximum of five suppositories. The product of conception was expelled in 95.8% of patients. In Group B the maximum number of suppositories was reduced to three. The product of conception was expelled in 100% of cases and the average duration of treatment was similar to that for the first group. Although side-effects were mild in both groups, they were reduced in the patients of Group B.

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MeSH descriptors

Abortifacient Agents Abortifacient Agents, Nonsteroidal Abortion, Missed Alprostadil Fetal Death Hydatidiform Mole Prostaglandins E, Synthetic Uterine Neoplasms Abortifacient Agents Abortifacient Agents, Nonsteroidal Abortifacient Agents, Nonsteroidal Abortion, Missed Administration, Intravaginal Adult Alprostadil Alprostadil Alprostadil Dose-Response Relationship, Drug Drug Evaluation Female

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References (21)

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chemicals 3
prostaglandin dimethyl ethynylboronate methyl ester

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License: CC0 · commercial use OK