A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review

Sonal Upadhyay, Ravi Bhushan, Vivek Pandey, Anima Tripathi, Alakh N. Sahu, Anjali Rani, Amita Diwakar, Rashmi Gupta, Pawan K. Dubey
In: Research Square · 2023 · doi:10.21203/rs.3.rs-2615175/v1 · W4323310836
review OA: green CC0
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review analyzes phytochemicals like curcumin and resveratrol, finding they potentially treat uterine fibroids by modulating key pathways involved in proliferation, inflammation, angiogenesis, and fibrosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This systematic review compared phytochemicals with synthetic drugs/nanomedicines for treating uterine fibroids (leiomyoma), summarizing proposed mechanisms from available experimental evidence, focusing on botanical compounds with reported anti-fibroid efficacy. The authors report that dehydroxyelephantopin, butein, capsaicin, fisetin, kaempferol, resveratrol, silibinin, and curcumin can modulate key fibroid processes—including proliferation, inflammation, angiogenesis, and fibrosis—by regulating signaling pathways such as Smad 2/3, PI3K/AKT/mTOR, ERK1/2, and β-catenin across different experimental setups. A major caveat is that the work is a preprint that has not undergone peer review, and the conclusions are based on summarized mechanistic findings rather than a stated clinical evidence synthesis. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

Abstract Uterine fibroids (UFs) or leiomyoma is the most common gynaecological disorder affecting 70% of premenopausal women and one of the leading causes of infertility. To date, there is no specific therapy available except surgical intervention including hysterectomy or myomectomy. However, to manage UFs, lot of high cost medications are prescribed although they have serious side effects on women’s reproductive health. Recently an increasing trend has been seen on consuming dietary phytochemicals to control diverse gynaecological ailments. This review's goal is to provide a summary of the knowledge that is currently available regarding the mechanisms of action of various botanical medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (Dehydroxyelephantopin, Butein, Capsaicin, Fisetin, Kaempferol, Resveratrol, Silibinin and Curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setup through modulating various signalling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of ULM. This review provides key molecular insights for development of phytochemical based novel personalized therapy for non-surgical management of ULMs which may help to avoid hysterectomy.

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infertility

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References (93)

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europepmc
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openalex
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License: CC0 · commercial use OK