A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review

A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article A comparative analysis of phytochemicals vs synthetic drugs/nanomedicines in the treatment of Uterine Fibroid: A Systematic Review Sonal Upadhyay, Ravi Bhushan, Vivek Pandey, Anima Tripathi, Alakh N. Sahu, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-2615175/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Uterine fibroids (UFs) or leiomyoma is the most common gynaecological disorder affecting 70% of premenopausal women and one of the leading causes of infertility. To date, there is no specific therapy available except surgical intervention including hysterectomy or myomectomy. However, to manage UFs, lot of high cost medications are prescribed although they have serious side effects on women’s reproductive health. Recently an increasing trend has been seen on consuming dietary phytochemicals to control diverse gynaecological ailments. This review's goal is to provide a summary of the knowledge that is currently available regarding the mechanisms of action of various botanical medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (Dehydroxyelephantopin, Butein, Capsaicin, Fisetin, Kaempferol, Resveratrol, Silibinin and Curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setup through modulating various signalling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of ULM. This review provides key molecular insights for development of phytochemical based novel personalized therapy for non-surgical management of ULMs which may help to avoid hysterectomy. Uterine Leiomyoma Therapeutics Signaling Cascades Phytochemicals Figures Figure 1 Figure 2 Figure 3 Figure 4 Full Text Additional Declarations No competing interests reported. Tables 1 and 2 are available in the Supplementary Files section. Supplementary Files Table.docx Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2615175","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":179965043,"identity":"6075ba43-9631-4c51-92fe-918f44c65aa3","order_by":0,"name":"Sonal Upadhyay","email":"","orcid":"","institution":"Banaras Hindu University","correspondingAuthor":false,"prefix":"","firstName":"Sonal","middleName":"","lastName":"Upadhyay","suffix":""},{"id":179965044,"identity":"7e3e1679-5e19-4b45-8db8-148248764e09","order_by":1,"name":"Ravi Bhushan","email":"","orcid":"","institution":"Banaras Hindu University","correspondingAuthor":false,"prefix":"","firstName":"Ravi","middleName":"","lastName":"Bhushan","suffix":""},{"id":179965045,"identity":"d547a0dd-8553-4403-a1f5-b4ad4830a15c","order_by":2,"name":"Vivek Pandey","email":"","orcid":"","institution":"Banaras Hindu University","correspondingAuthor":false,"prefix":"","firstName":"Vivek","middleName":"","lastName":"Pandey","suffix":""},{"id":179965046,"identity":"97719f46-89fb-4181-980a-ba204d6c3ee7","order_by":3,"name":"Anima Tripathi","email":"","orcid":"","institution":"MMV, Banaras Hindu University","correspondingAuthor":false,"prefix":"","firstName":"Anima","middleName":"","lastName":"Tripathi","suffix":""},{"id":179965049,"identity":"d56c487e-7303-4854-933b-f685612f2c40","order_by":4,"name":"Alakh N. 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To date, there is no specific therapy available except surgical intervention including hysterectomy or myomectomy. However, to manage UFs, lot of high cost medications are prescribed although they have serious side effects on women’s reproductive health. Recently an increasing trend has been seen on consuming dietary phytochemicals to control diverse gynaecological ailments. This review's goal is to provide a summary of the knowledge that is currently available regarding the mechanisms of action of various botanical medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (Dehydroxyelephantopin, Butein, Capsaicin, Fisetin, Kaempferol, Resveratrol, Silibinin and Curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setup through modulating various signalling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of ULM. 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