CYCLIC CHANGES IN THE CONCENTRATION OF PROSTAGLANDIN F2α IN HUMAN UTERINE FLUSHINGS

J. B. Maathuis
In: BJOG: An International Journal of Obstetrics & Gynaecology · 1978 · vol. 85(3) , pp. 207–210 · doi:10.1111/j.1471-0528.1978.tb10483.x · PMID:629900 · W1964545360
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Prostaglandin F2alpha concentration in human uterine flushings varied cyclically, peaking in the mid-secretory phase.

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Abstract

Prostaglandin F2alpha (PGF2alpha) was measured by radioimmunoassay in uterine flushings obtained from 41 women at various stages of the menstrual cycle. The concentration of PGF2alpha changed significantly during the cycle, with highest values in the mid secretory phase of the cycle (mean 9.1 ng/ml of uterine flushing, range 3.9 to 16.0 ng/ml, n = 9). The still unresolved role of intrauterine PGF2alpha is discussed in relation to luteolysis, myometrial contractility and implantation.

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