Past and future episodic detail retrieval is reduced among clinically normal older adults at higher genetic risk for late-onset Alzheimer’s disease

INTRODUCTION: Remembering and imagining personal events that are rich in episodic (i.e., event-specific) detail is compromised in older adults who have mild cognitive impairment, a known risk factor for Alzheimer’s disease dementia. Less clear is whether lower episodic detail generation is associated with higher risk for Alzheimer’s disease dementia before mild clinical decline is detectable. METHODS: We compared past and future autobiographical thinking in clinically normal older adult carriers of the Alzheimer’s disease-associated apolipoprotein E e4 allele (APOE4) (n = 39) to demographically and neuropsychologically similar non-APOE4 carriers (n = 43). RESULTS: APOE4 carriers showed a robust reduction for episodic details, but not for non-episodic details when remembering past events and imagining future events. DISCUSSION: Despite normal neuropsychological functioning, past and future autobiographical thinking are commonly compromised in older APOE4 carriers. Reduced episodic detail generation, therefore, may be an early cognitive associate of higher risk for Alzheimer’s disease dementia.