Biomarkers of inflammation and cardiovascular risk in people with chronic obstructive respiratory disease

Biomarkers of inflammation and cardiovascular risk in people with chronic obstructive respiratory disease | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Biomarkers of inflammation and cardiovascular risk in people with chronic obstructive respiratory disease JUAN MANUEL ESCOBAR-MONTALVO, FERNANDO RODRÍGUEZ-ARTALEJO, IÑAKI GALÁN LABACA This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3752906/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background : Metabolic syndrome (MetS) is associated with increased frequency and severity of chronic obstructive respiratory diseases (CORD). Objectives: to examine the association of CORD with MetS, inflammatory and cardiovascular biomarkers, and its combined effect on health status and cardiovascular disease (CVD). Methods : a cross-sectional study of 11602 adults of ≥18 years participants in the Study on Nutrition and Cardiovascular Risk in Spain (ENRICA) was conducted. Biomarkers were obtained using standardized laboratory techniques. CORD was defined as a diagnosis of chronic bronchitis and/or asthma, MetS was defined according to the criteria of the International Diabetes Federation, and CVD as a diagnosis of myocardial infarction, heart failure, or stroke. The associations were evaluated using linear and logistic regression models, adjusting for potential confounding variables. Results : prevalence of MetS in subjects with and without CORD was 26.9% and 23% respectively. CORD was associated with a higher frequency of MetS in <65 years (odds ratio[OR]=1.38; 95%CI:1.07;1.77), higher levels of leptin (21.12%; 95%CI: 6.68;37.50) and fibrinogen (3.79%; 95%CI:0.19;7.52) in ≥65 years, and in whole population with higher prevalence of central obesity (OR=1.30; 95%CI:1.06;1.59) and elevated C-reactive protein levels (17.75%; 95%CI:2.67;35.04). People with CORD, with and without MetS, had a worse health status, and a higher risk of CVD when coexisting with MetS. Conclusions : CORD was associated with alterations in inflammatory and cardiovascular biomarkers, higher frequency of MetS in <65 years, poorer health status, and higher risk of CVD when coexisted with MetS. Chronic obstructive respiratory diseases metabolic syndrome cardiovascular risk biomarkers Full Text Additional Declarations Tables 1 to 5 are available in the Supplementary Files section. Supplementary Files 2.TablesMetSCORD.pdf Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3752906","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":261055333,"identity":"ab335632-894c-44c8-a61a-c655808fb93f","order_by":0,"name":"JUAN MANUEL ESCOBAR-MONTALVO","email":"","orcid":"","institution":"Autonomous University of Madrid Public Health University Center: Universidad Autonoma de Madrid Centro Universitario de Salud Publica","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"JUAN","middleName":"MANUEL","lastName":"ESCOBAR-MONTALVO","suffix":""},{"id":261055334,"identity":"16a7fcc3-911e-413a-8270-0184de2b610a","order_by":1,"name":"FERNANDO RODRÍGUEZ-ARTALEJO","email":"","orcid":"","institution":"Autonomous University of Madrid Public Health University Center: Universidad Autonoma de Madrid Centro Universitario de Salud Publica","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"FERNANDO","middleName":"","lastName":"RODRÍGUEZ-ARTALEJO","suffix":""},{"id":261055335,"identity":"b7ce1567-55bd-43b6-b4d0-4d7d87980370","order_by":2,"name":"IÑAKI GALÁN LABACA","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAvklEQVRIiWNgGAWjYBACNgYGxgMMDDY8QLrhQAKRWhiAWtJI0MIA0XKYBIfx8S9+cODnjvMy8u2HGw88YLCxJ+wwiWcGB3vP3OYxOJMIclhaYgNhLQcMDvC2AbVIgP1yOIEIW45/OPi37RyP/Aywlv9EOIy/x+Awb9sBHoYbYC0HGIlwGE/BYdm2ZKhfDJIJ+0W+//jGh2/b7Ozl248//vijwo6wwxgkEpB5BoQ1MDDwHyBG1SgYBaNgFIxoAADc50CNVeoY6AAAAABJRU5ErkJggg==","orcid":"https://orcid.org/0000-0001-8280-814X","institution":"Instituto de Salud Carlos III Centro Nacional de Epidemiología: Centro Nacional de Epidemiologia","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"IÑAKI","middleName":"GALÁN","lastName":"LABACA","suffix":""}],"badges":[],"createdAt":"2023-12-14 10:16:43","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3752906/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3752906/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":48878626,"identity":"11c3cdaa-21ac-430a-ad9c-1cb8b023e7dd","added_by":"auto","created_at":"2023-12-28 02:07:37","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":238373,"visible":true,"origin":"","legend":"","description":"","filename":"1.ManuscriptMetSCORDCoverletterPAge1wotables.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3752906/v1_covered_0a8031a4-14c5-43a9-8fbf-74c6be0ef864.pdf"},{"id":48508009,"identity":"92ad0430-3b53-48bd-963f-fee4f0009c08","added_by":"auto","created_at":"2023-12-20 04:35:30","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":298220,"visible":true,"origin":"","legend":"","description":"","filename":"2.TablesMetSCORD.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3752906/v1/845a11257cdc98668662c5ea.pdf"}],"financialInterests":"\u003cp\u003eTables 1 to 5 are available in the Supplementary Files section.\u003c/p\u003e","formattedTitle":"Biomarkers of inflammation and cardiovascular risk in people with chronic obstructive respiratory disease","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Chronic obstructive respiratory diseases, metabolic syndrome, cardiovascular risk, biomarkers","lastPublishedDoi":"10.21203/rs.3.rs-3752906/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3752906/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e: Metabolic syndrome (MetS) is associated with increased frequency and severity of chronic obstructive respiratory diseases (CORD). Objectives: to examine the association of CORD with MetS, inflammatory and cardiovascular biomarkers, and its combined effect on health status and cardiovascular disease (CVD).\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e: a cross-sectional study of 11602 adults of ≥18 years participants in the Study on Nutrition and Cardiovascular Risk in Spain (ENRICA) was conducted. Biomarkers were obtained using standardized laboratory techniques. CORD was defined as a diagnosis of chronic bronchitis and/or asthma, MetS was defined according to the criteria of the International Diabetes Federation, and CVD as a diagnosis of myocardial infarction, heart failure, or stroke. The associations were evaluated using linear and logistic regression models, adjusting for potential confounding variables.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: prevalence of MetS in subjects with and without CORD was 26.9% and 23% respectively. CORD was associated with a higher frequency of MetS in \u0026lt;65 years (odds ratio[OR]=1.38; 95%CI:1.07;1.77), higher levels of leptin (21.12%; 95%CI: 6.68;37.50) and fibrinogen (3.79%; 95%CI:0.19;7.52) in ≥65 years, and in whole population with higher prevalence of central obesity (OR=1.30; 95%CI:1.06;1.59) and elevated C-reactive protein levels (17.75%; 95%CI:2.67;35.04). People with CORD, with and without MetS, had a worse health status, and a higher risk of CVD when coexisting with MetS.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e: CORD was associated with alterations in inflammatory and cardiovascular biomarkers, higher frequency of MetS in \u0026lt;65 years, poorer health status, and higher risk of CVD when coexisted with MetS.\u003c/p\u003e","manuscriptTitle":"Biomarkers of inflammation and cardiovascular risk in people with chronic obstructive respiratory disease","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2023-12-20 04:35:25","doi":"10.21203/rs.3.rs-3752906/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"0c0cad69-18db-436f-b7c9-5d611e69e226","owner":[],"postedDate":"December 20th, 2023","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2023-12-28T01:59:24+00:00","versionOfRecord":[],"versionCreatedAt":"2023-12-20 04:35:25","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-3752906","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-3752906","identity":"rs-3752906","version":["v1"]},"buildId":"uwybb5PU2iWlRI8EIam5Y","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}