WITHDRAWN: Transarterial Chemoembolization, Immunotherapy and Lenvatinib for Intrahepatic Cholangiocarcinoma: A Real-World Study

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Abstract Introduction : Intrahepatic cholangiocarcinoma (ICC) carries a rising mortality rate and poor prognosis, with current chemotherapy-based first-line standards offering limited survival benefits and high toxicity. Integrating transarterial chemoembolization (TACE) with immune checkpoint inhibitors (ICIs) and lenvatinib may enhance antitumor immunity. This multicenter study evaluated the efficacy and safety of this triple therapy (TACE-ICIs-Len) compared to standard first-line regimens. Methods : A total of 216 patients with advanced ICC were retrospectively analyzed and categorized into three groups: chemotherapy alone (Chemo, n = 74), ICIs plus chemotherapy (ICIs-Chemo, n = 82), and TACE-ICIs-Len (n = 60). Outcomes included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate, and safety. Results : The TACE-ICIs-Len group demonstrated a significant survival advantage, achieving a median OS of 20.6 months compared to 14.7 months for ICIs-Chemo and 14.0 months for Chemo (P = 0.036). Median PFS was also superior in the TACE-ICIs-Len group (11.3 vs. 6.5 vs. 5.6 months; P = 0.003). Furthermore, the triple-combination yielded a significantly higher ORR (51.7%) and a 10% conversion surgery rate. Multivariate analysis identified the TACE-ICIs-Len regimen and CEA levels as independent prognostic factors for both PFS and OS. Safety profiles were manageable across all groups. Conclusion : TACE combined with ICIs and lenvatinib is a potent and well-tolerated first-line strategy that significantly improves survival and tumor response in patients with advanced ICC.
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WITHDRAWN: Transarterial Chemoembolization, Immunotherapy and Lenvatinib for Intrahepatic Cholangiocarcinoma: A Real-World Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article WITHDRAWN: Transarterial Chemoembolization, Immunotherapy and Lenvatinib for Intrahepatic Cholangiocarcinoma: A Real-World Study Shi Feng, Huishan Sun, Weixuan Pan, An Zhang, Mingjian Piao, Chengjie Li, and 11 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8949132/v2 This work is licensed under a CC BY 4.0 License Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Editorial Note The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author. Full Text The authors have withdrawn this preprint from Research Square. Cite Share Download PDF Status: Posted Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. 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