Inpatient Endometriosis Care in Germany: Hospital Caseloads and their Spatial Distribution

endometriosis, health services research, spatial distribution, German hospital quality reports Schlüsselwörter Endometriose, Gesundheitsversorgungsforschung, räumli - che Verteilung, Qualitätsbericht der Krankenhäuser received 06.03.2025 accepted after revision 12.06.2025 published online 2025

Gesundheitswesen DOI 10.1055/a-2683-9705 ISSN 0941-3790 © 2025. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/). Georg Thieme Verlag KG, Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany Correspondence Lara Brauer Philipps-Universitat Marburg, Fachbereich 20 Medizin, Institut für Gesundheitsversorgungsforschung und Klinische Epidemiologie Karl-von-Frisch-Straße 4 35032 Marburg Germany [email protected] Supplementary Material is available under https://doi.org/10.1055/a-2683-9705 AB str Act

Endometriosis is a chronic gynaecological disease with an estimated prevalence of 10–15 %. The German guide- line provides evidence-based recommendations for diagnosis and treatment, but care provided is inadequate care due to long diagnostic pathways. Recent German research focused on regional variations in outpatient care, however research on inpatient endometriosis care is still lacking. Aim of the Study The aim of the study was to examine inpa - tient endometriosis care – hospital locations and their case - loads. Spatial coverage, caseload distribution patterns and possible clusters, including certified endometriosis centres (CEC) and non-certified hospitals nationwide were analysed.

German hospital quality report data from 2021 was used as data source. The location, certification status and caseload, meaning coded ICD-10 N80 Endometriosis cases, were collected for all hospitals. Then, 20-, 40- and 60-minutes’ drive radius of CEC and non-certified hospitals were determined. Global and Local Moran’s I was calculated to assess spatial clusters in caseload.

A CEC 60-minutes’ drive radius covers 78.15 % of the area in Germany. Including all hospital locations that coded endometriosis, a maximum driving time of 40-minutes pro - vides almost nationwide coverage. High caseload clusters ap - peared in urban areas and low caseload clusters especially in eastern Germany.

The results indicate spatial clusters in providers caseload and difficulties in access to CEC for patients depending on location. Further research with patient-level data is needed to investigate the spatial distribution of patients and precise travel time for inpatient care. Zus AMMenf Assun G Hintergrund Endometriose ist eine chronische gynäkologi sche Erkrankung mit einer geschätzten Prävalenz von 10–15 %. Die deutsche Leitlinie enthält evidenzbasierte Empfehlungen für Diagnose und Behandlung, jedoch scheint es aufgrund langer Diagnosewege eine dysfunktionale oder unzureichende Ver - sorgung zu geben. Aktuelle deutsche Studien befassen sich mit den regionalen Unterschieden in der ambulanten Versorgung, Forschung zu stationärer Endometrioseversorgung fehlt bisher. Article published online: 2025-11-03 Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). Original Article Thieme

Endometriosis is a benign, chronic gynaecological disease associ - ated with painful menstruation, heavy bleeding or infertility [1, 2]. The disease has a significant impact on women’s lives and they often experience a lack of understanding from the healthcare sys- tem, stigmatisation of their pain and delayed diagnoses [2, 3]. However, the precise healthcare situation of endometriosis pa- tients or even reliable rates of endometriosis prevalence are not avail- able in Germany due to a lack of data [4]. It is estimated that 10–15 % of all women of reproductive age are affected and 40,000 women develop endometriosis each year [4]. Recent research showed that annual prevalence continued to increase from 2012 to 2022, but re- mained below epidemiological prevalence estimates [5]. The guideline Diagnosis and Therapy of Endometriosis [6] provides evidence-based recommendations for diagnosis and treatment. Still, on average, it takes 2.3 years from symptom onset to the first contact with providers, and 7.7 years elapse from first contact to diagnosis [7]. This suggests that dysfunctional or inadequate care still seems to exist, particularly due to long diagnostic pathways. A certification programme and treatment standards have been initiated in several European countries to improve the quality of care for endometriosis patients [6]. The German guideline states that pa- tients should be treated by an interdisciplinary team in a certified structure (e. g. centre) that integrates all necessary specialities across sectors. Therefore, the consensus-based care algorithm includes cer- tified endometriosis centres (CEC) for diagnosis, operative/interdis- ciplinary laparoscopy, follow-up and conservative therapy [6]. How- ever, the QS ENDO quality assurance programme for German-speak- ing countries (DACH region) estimates that around 60 % of endometriosis patients are not treated in hospitals with a CEC [8]. There is little research on the differences on the quality of pa - tient care in a CEC and a non-certified hospital. In general, in certi- fied centres, e. g. for cancer care, guideline-conforming care is high- er in percentage than in non-certified facilities [9]. Specifically for CEC, improved quality of life and lower complication rates were as- sociated with certification status [10]. Although the ESHRE Endometriosis Guideline [11] no longer re- commends laparoscopy as the diagnostic gold standard, laparos - copy is still the standard procedure to surgical therapy [6]. Often, laparoscopy is used for diagnostic examination and, if necessary, treatment of endometriosis during the same procedure [6], mean- ing inpatient care has its irreplaceable importance. However, little is known about the structure of inpatient endometriosis care, in particular about the distribution of hospitals providing such care in Germany. The need for a regional monitoring to evaluate health- care provision as a first step to healthcare improvement and equi- ty is well known [12, 13], meaning that investigations on the distri- bution of inpatient care and the certified care structure for endo - metriosis are needed. Therefore, the aim of this study was to examine the spatial dis- tribution and accessibility of CEC and non-certified hospitals and to evaluate their caseload in order to show regions with low access to specialised care.

The study uses German hospital quality reports (HQR) 2021 as data source, Isochrones process in OpenRouteService as well as Spatial Autocorrelation (Global Moran’s I) and Cluster and Outlier Analysis (Anselin Local Moran’s I) processes in ArcGIS Pro 2024 for the spa- tial analysis of coded inpatient caseloads Data sources German Hospital Quality Reports The HQR are made publicly available by the Federal Joint Commit- tee (G-BA), which specified that hospitals must report on inpatient care for each location every year [14]. The coded endometriosis caseload, defined as a discharge diag- nosis of ICD-10 N80 Endometriosis and all subgroups, of each hos - pital location in the 2021 HQR was used as the basic population. Also, endometriosis-related inpatient procedures were identified using the operation and procedure code (OPS). According to the en- dometriosis guideline, specific OPS exist only in part and mainly for the destruction of endometriosis lesions [6]. Therefore, OPS 5- 651.b, 5-702.2 and 5-702.4 were included. Other OPS were exclud- ed as it is not possible to filter out whether they were specifically coded for endometriosis. Each included ICD-10 and OPS Codes are presented in the online-Appendix (t able s1). The exact case number is not reported in the HQR for privacy reasons, if the caseloads were fewer than four cases [15].Then, the Ziel der Studie Die Studie untersuchte die räumliche Ver - teilung der stationären Endometrioseversorgung, genauer gesagt die Krankenhausstandorte und ihre Fallzahlen. Räumli- che Abdeckung, Verteilungsmuster der Fallzahlen und mögli - che Cluster wurden bei zertifizierten Endometriosezenten (CEC) und nicht-zertifizierten Standorten bundesweit evaluiert. Methode Datenquelle waren die deutschen Krankenhaus-Qua- litätsberichte aus dem Jahr 2021. Krankenhausstandorte, Zerti - fizierungsstatus und Fallzahlen (kodierte ICD-10 N80 Endome- triosefälle) wurden erfasst. Danach wurde der 20-, 40- und 60-Minuten Fahrzeitradius zu den CEC und den nicht-zertifi - zierten Krankenhäusern ermittelt. Global und Local Moran’s I wurde berechnet um räumliche Cluster der Fälle zu bestimmen. Ergebnisse Ein 60-Minuten Fahrzeitradius zu CEC deckt 78,15 % der Fläche in Deutschland ab. Unter Einbeziehung aller Krankenhausstandorte, die Endometriose kodiert haben, er gibt sich bei einer maximalen Fahrtzeit von 40 Minuten eine fast landesweite Abdeckung. Hohe Fallzahlen-Cluster traten in städtischen Gebieten und niedrige Fallzahlen-Cluster vor allem in Ostdeutschland auf. Schlussfolgerung Die Ergebnisse deuten auf räumliche Cluster der Fallzahlen und auf Schwierigkeiten beim Zugang zu den CEC für Patientinnen je nach Standort hin. Weitere Untersu - chungen mit Daten auf Patientinnen-Ebene sind erforderlich, um die räumliche Verteilung der Personen und die genaue Fahrtzeit für die stationäre Versorgung zu untersuchen. Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). odd value of 1.5 cases was assumed, as already applied for HQR data analysis before [16]. The possible error in the calculation of the caseloads was squared using DESTATIS data. According to DESTATIS, 32,304 discharged patients were coded as endometrio- sis cases in 2021 [17]. Furthermore, name, hospital location ID and address of the hos- pital was extracted. List of certified endometriosis centres The Endometriosis-Association Germany (Endometriose-Vereinigung Deutschland e.V.) has listed all hospitals certified by the Endome- triosis Research Foundation (SEF) on its website [18]. We therefore defined all hospitals listed on this website as CEC. At the time of data collection (15 July 2024), 72 providers were listed as certified, of which 68 were identified in the 2021 HQR. The remaining 4 were either outpatient providers and probably accidentally listed with the inpatient CEC, or they did not provide their HQR for 2021. Therefore, n = 68 hospitals were included in our CEC sample. Data Analysis Descriptive analysis Inpatient endometriosis caseloads were analysed descriptively. Case numbers were calculated for each ICD-10 code and, in the case of data protection, estimated using the procedure described. Then, total cases were calculated by summing all N80.x codes to an overall endometriosis caseload for each hospital location. Fre - quencies, means and standard deviations of total cases were cal - culated for all hospital locations, separately for CEC and non-certi- fied hospital locations with at least one coded endometriosis case. These steps were repeated for OPS codes 5-651b and 5-702.2 / 5-702.4 summed up. Data was processed with Excel 2019 and SPSS 29. Spatial analysis We analysed spatial coverage to provide an initial general estimate for the care situation in Germany (a.). Then, we carried out spatial statistics within a defined radius to identify regions with particu - larly high or low clusters, and therefore gaps in care (b.). Based on the addresses in the HQR, the geographical positions of the hospi- tal location ID were determined using OpenStreetMap. a. The spatial coverage (drive radius) was calculated separately for CEC and for all hospitals with at least one case. A recent study on pain medicine discussed that a 30 to 45 minutes (min) drive is reasonable for specialised pain care in Germany, with up to 60 min being acceptable in individual cases [19]. Applying this to endometriosis care, a maximum driving time (DT) of 60 min was set. Thus, regions with DT less than or equal to 20-, 40- and 60-min to CEC and other hospitals was determined and present- ed with Isochrones function/module of OpenRouteService. b. To identify regional spatial clusters in coded cases, Moran’s I analyses were performed [20]. All hospital locations coding en- dometriosis in 2021 were included. The number of cases at each hospital location was compared with cases at hospitals within a 45 km radius. A distance of 45 km was set for patients based on an assumed driving time of 45 min at an average car speed of 60 km/h. Global Moran’s I analysis [20] was performed to inves- tigate whether caseloads were clustered. If Global Moran's I shows a significant spatial correlation, Local Moran’s I [20] can be used to test for local clusters. Global and Local Moran’s I analysis was performed using ArcGIS Pro 2024. QGIS Version 3.36.1 was used for visualisation.

Caseload Overall, 32,440.5 endometriosis cases were coded in 2021. In CEC (n = 68), a total of 13,709.5 cases (42.26 %) were observed. In hos- pital locations without CEC and at least one endometriosis case (n = 807), 18,731 cases (57.74 %) were coded. ▶table 1 shows the caseload (including privacy calculations) for CEC and non-CEC, ▶table 2 the caseload for each included ICD-10 and OPS code. The included OPS codes are not solely specified for endometri- osis cases. This suggests that other OPS codes were probably used for endometriosis cases, or that the included OPS were also used for other diseases. Consequently, the determined caseload of en - dometriosis and selected OPS codes do not correspond. Spatial distribution Driving time Caseloads and DT were analysed and cartographically presented. ▶f ig. 1 shows cases and DT for CEC, with most cases coded in Co- logne and Berlin. In Munich, medium caseload was coded in two lo- cations. Less than 500 cases were coded in each remaining CEC (n = 64). The distribution of CEC varies from state to state, ranging from zero CEC in Bremen, Mecklenburg-Western Pomerania (M-WP) and Saxony-Anhalt (S-A) to 21 in North Rhine-Westphalia (NRW). With a maximum DT of 60 min, the CEC alone do not cover the entire country, but 78.15 % of the total area and 91.32 % of the fe- ▶table 1 Total caseload. n ( %) total cases ( %) M sD Md [Min–Max] All hospitals with at least 1 coded endometriosis case 875 (100 %) 32,440.5 (100 %) 37.07 79.93 17.5 [1.5–1135] Non-certified hospital locations & at least 1 coded endometriosis case 807 (92.23 %) 18,731 (57.74 %) 23.21 30.67 15 [1.5–388.5] Hospitals with certified centre 68 (7.77 %) 13,709.5 (42.26 %) 201.61 205.53 149.52 [15.5–1135] total cases, number of coded ICD-10-GM N80 endometriosis cases including all subcategories and data protection calculation; M, Mean; SD, standard deprivation; Md, Median; Min, minimum; Max, maximum. Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). Original Article Thieme male population. Only the west of M-WP is covered within 60 min, as are the south and eastern parts of S-A. In Brandenburg, the 60 min radius around Berlin is covered, the outskirts mainly not. North and south Thuringia are also not covered, with one CEC in the east. Gaps also exist in the north, east and south of Saxony, as well as in south- ern Baden-Württemberg (B-W), eastern Bavaria, northern Schleswig- Holstein and western Rhineland-Palatinate (R-P). Major cities in NRW, e. g. Cologne, Duisburg and Münster, can be reached within 20 min DT, with most of the state being accessible within 40 min. ▶f ig. 2 shows all non-certified hospitals with at least one en - dometriosis case. Most cases were coded in the cities of Neuss, Frankfurt (n = 2), Munich and Wuppertal. Caseload > 37.5 − 158 were coded in 138 hospital locations, while caseloads ≤ 37.5 were coded in the remaining 664 hospital locations. Considering all hospitals that coded endometriosis, almost the entire country is covered within a 40 min DT, expect for a few areas where it takes 60 min to reach a hospital (e. g. Ortenau district, the Brandenburg border or in frontier regions). NRW, Berlin, Hamburg and Bremen are mainly covered with a DT of 20 min and medium or large case numbers. Spatial cluster Global Moran’s I test revealed a slightly positive, significant spatial correlation (I = 0.028, z = 1.722; p = 0.085) of coded cases, mean - ing the distribution of caseloads is clustered. Local Moran’s I was performed to assess clusters of high and low case numbers in hospitals. The cartographic visualisation is shown in ▶f ig. 3. Low-Low clusters can be identified in Saxony, M-WP, S-A, Lower Saxony, Thuringia, Brandenburg, Bavaria, Flensburg city, the Hoch- sauerland district and R-P. Those clusters are mainly located in east- ern Germany, with the most clusters in Saxony. High-High clusters can be found in the city of Munich and its en- virons, Berlin, Brandenburg, the districts of Cologne and Düssel - dorf, in B-W in the city of Freiburg and the district of Stuttgart, and in Frankfurt.

Inpatient endometriosis care in Germany shows regional variation. A tendency towards clusters with more coded cases in urban areas and fewer coded cases in eastern Germany was observed. Particu- larly areas in the eastern German states, which largely correspond to the territory of the former GDR, were not covered with a driving time (DT) of 60 min to certified endometriosis centres (CEC). The evalua- tion of all hospital locations that coded at least one endometriosis case in the HQR 2021 showed an almost nationwide DT of 40 min. To our knowledge, there is little research on spatial clusters of inpatient endometriosis care in Germany. So far, prevalence or in- cidence studies [21, 22] or regional trends in outpatient care [5, 23] have mainly been analysed. Data on outpatient care provide evidence of regional variations in prevalence [5] and healthcare structures [23], suggesting that endometriosis is more frequently diagnosed in regions with a CEC. Each additional centre is associated with 0.28 more cases per 1,000 women with statutory health insurance [23]. Greater diagnostic expertise at CEC may explain some differences, but certified hos - pitals alone do not fully account for regional variation. Clusters with high incidence were identified in NRW and southern Germany, where most of the CEC are located [23]. Regional clusters with high prevalence of diagnosed endometriosis were also found in south - ern Germany and Lower Saxony [5]. There was no clustering in re- gions with many CEC, but a cluster in Saxony with low diagnosis prevalence and districts close to CEC had a higher prevalence [5]. This is consistent with our findings, as we identified high clusters of inpatient cases in southern Germany, NRW and Berlin and low clusters of caseloads in eastern Germany. With regard to CEC, the QS ENDO quality assurance programme was developed for the DACH region to provide further insights, which showed that about 60 % of endometriosis patients are not treated in CEC [8]. Based on our results, it is possible that accessi - bility of centres may play a role. We were able to show that CEC alone are not accessible to all patients within 60 min DT, so we as- sume that patients either accept a longer DT or seek care in non- certified hospitals and may receive less specialised care. However, specialised care is guideline-conform as the care al - gorithm includes a CEC for diagnosis, laparoscopy, and follow-up or conservative therapy [6]. CEC were also associated with im - proved quality of life and low major complication rates [10]. There- fore, access to CEC should be available to all patients. A possible solution would be a better spatial distribution or more CEC. How - ever, we assume that staff shortages, financial barriers (e. g. the ▶table 2 Caseload for each ICD-10 and OPS code (see appendix for code explanations). c aseload calculations (including data protection) in hospitals with certified centre (n = 68) in hospitals without certified centre (n = 807) total ( %) Ic D-10-GM n80.x total 13,709.5 (42.26 %) 18,731 (57.74 %) 32,440.5 (100 %) → N80.- 0 7 7 (0.02 %) → N80.0 2,724.5 4,954 7,678.5 (23.67 %) → N80.1 2,638.5 6,322.5 8,961 (27.62 %) → N80.2 54.5 187 241.5 (0.74 %) → N80.3 6,545.5 4,477 11,022.5 (33.98 %) → N80.4 355.5 255 610.5 (1.88 %) → N80.5 383 285.5 668.5 (2.06 %) → N80.6 199.5 604 723.5 (2.23 %) → N80.8 729 1,268.5 1,997.5 (6.16 %) → N80.9 159.5 370.5 530 (1.63 %) OPs 5-651.b 1,342.5 (30.19 %) 3,104 (69.81 %) 4,446.5 (100 %) OPs 5-702.2 + 5-702.4 13,686.5 (51.86 %) 12,704 (48.14 %) 26,390.5 (100 %) Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). cost of the certification process) and/or structural factors (e. g. a lack of regional cooperation) may influence hospitals in regions without a CEC to decide not to pursue or achieve certification. Tele- medicine networks may hereby be a possible tool for providing medical infrastructure and improving quality, presumably also for endometriosis care, particularly in regions without a CEC [24]. Research on certified centres for other gynaecological condi - tions underlines their importance. In oncology care, centres can improve cost-effectiveness while optimising quality [25], which ad- vocates treatment in certified centres to meet quality indicators [9] and in terms of health economics [25]. These factors may also apply to CEC. International research also found heterogeneous incidence pat- tern in hospitalisation, suggesting changing practices, awareness, inequalities and environmental factors [26]. Similarly in Italy, en - dometriosis incidence showed a spatial gradient, with a cluster of high-risk municipalities [27]. 15.5 – 500 500 – 1000 1000 – 1135 Caseload ICD-10 N80 certified centres (n=68) 20 minutes driving time 40 minutes driving time 60 minutes driving time Driving times to certified centres ▶f ig. 1 Driving time and caseload of certified centres. Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). Original Article Thieme In our study, environmental factors and socio-economic struc- tures are likely to explain some of the spatial patterns. However, HQR data cannot be used to identify individual patients, so we do not have information on, e. g., socioeconomic status (SES). Yet SES may have an impact on patients’ choice of hospital, as patients with higher SES may have less difficulty in choosing or travelling to specialised care, while those with lower SES may lack access or information [28]. This shows case numbers from the HQR have limitations. First, they can only be used to determine general coding frequencies, not person-specific codes, and coding practices may influence case- load. It is not possible to estimate diagnoses prevalence using the HQR. The 2021 data may also be biased by reduced use of health services during the pandemic [29]. We did not consider population or female density for spatial case clusters. Besides, this investiga - 1.5 – 37.5 37.5 – 158 158 – 388.5 Caseload ICD-10 N80 non-certified hospitals n=807 20 minutes driving time 40 minutes driving time 60 minutes driving time Driving times to all hospital locations ▶f ig. 2 Driving time to all hospitals and caseload of non-certified hospitals. Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). High-High cluster: hospital with high caseload surrounded by hospitals with high caseload within 45 km Local Moran's I (radius=45km) Included hospital locations: n=875 Low-Low cluster : hospital with low caseload surrounded by hospitals with low caseload within 45 km Hoch-Niedrig Cluster: hospital with high caseload surrounded by hospitals with low caseload within 45 km Niedrig-Hoch Cluster: hospital with low caseload surrounded by hospitals with high caseload within 45 km Non-significant hospital Location of certifie d endometriosis centre ▶f ig. 3 Local Moran’s I (radius = 45 km) for all hospital locations. tion does not allow conclusions about waiting times for treatment, which seems likely in regions with high clusters. Our case calculations resulted in a slightly higher total than re - ported by DESTATIS [17] for 2021 (32,440.5 estimated cases vs. 32,304 reported cases), which may have led to an overestimate in some hospitals. However, it also shows that our calculations are within a good range, meaning our study provides a robust overview of caseloads and spatial patterns. Another strength is the analysis of DT to CEC, which has not been investigated before.

The spatial distribution of coded endometriosis cases from the HQR varied, with higher clusters in urban areas and lower clusters in east- ern Germany. Assuming a driving time of 60 min to a certified en- dometriosis centre, there is no nationwide coverage, mainly for the eastern German states. Including the non-certified hospitals, a driv- ing time of 40 min was found almost nationwide. The results show the importance of either more certified centres or a better distri - bution to cover all areas. Further research with person-related data Brauer L et al. Inpatient endometriosis care in … Gesundheitswesen | © 2025. The Author(s). Original Article Thieme linked to population is needed for precise statements about the spatial distribution of inpatient cases, diagnoses and endometrio - sis-related surgery. These investigations could ensure barrier-free access to inpatient endometriosis care, regardless of the person or location, in line with the principle of equity in health care. Data Availability The dataset generated in this study is available from the correspond - ing author on reasonable request. German Hospital Quality Report data is publicly available. Contributions LB, LJ and MG developed the study concept and design. Analyses were carried out by LB and LJ. The results were interpreted by LB. LB wrote the first draft of the manuscript; LJ and MG revised and approved it. Conflict of Interest The authors declare that they have no conflict of interest.

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