Layer‐specific strain and dyssynchrony index alteration in new-onset systemic lupus erythematosus patients without cardiac symptom

Layer‐specific strain and dyssynchrony index alteration in new-onset systemic lupus erythematosus patients without cardiac symptom | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Layer‐specific strain and dyssynchrony index alteration in new-onset systemic lupus erythematosus patients without cardiac symptom Tingting Luo, Zhenhua Wang, Zhen Chen, Ermei Yu, Chenglong Fang This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-28237/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Layer-specific speckle-tracking echocardiography (STE) is a noninvasive approach assessing subclinical left ventricular (LV) dysfunction. We aimed to investigate: (I) layer‐specific strain and dyssynchrony index alteration; (II) disease parameters associated with layer-specific STE change; (III) effects of hydroxychloroquine (HCQ) therapy on layer-specific STE parameters in drug-naïve patients with new-onset systemic lupus erythematosus (SLE) without cardiac symptoms. Methods 35 drug-naïve patients with new-onset SLE and 25 age-and-sex-matched healthy controls were enrolled. All individuals received both conventional echocardiographic and two-dimensional STE assessment. Layer-specific global longitudinal strain (GLS), global circumferential strain (GCS) and peak systolic dispersion (PSD) were acquired in layer-specific STE. The effect of HCQ monotherapy on GLS parameters and PSD was assessed in 7 SLE patients with stable disease. Results All patients had normal left ventricular ejection fraction (LVEF). Conventional echocardiographic parameters were comparable between patients and controls. Decreased layer-specific GLS and elevated PSD were observed in SLE patients. In contrast, there’s no difference of layer-specific GCS at the basal level, papillary muscle level and apical level between patients and controls. More severely impaired GLS was observed in patients with higher disease activity, high-risk aPL profile or renal involvement. PSD increased in patients with higher disease activity or high-risk aPL profile. Correlational analysis showed that GLS at three layers and PSD correlated with high-sensitivity CRP (hsCRP) levels. PSD correlated with epicardial GLS, when treating hsCRP level, renal involvement, profile of aPL and disease activity as control variables. Multivariate regression showed hsCRP level and epicardial GLS are the predictors of layer-specific GLS impairment and elevated PSD, respectively. No change of GLS at three layers or PSD was observed in the first 6 months of HCQ treatment, compared with baseline. During the second 6 months of HCQ treatment, increase of endocardial GLS and whole layer GLS, and decrease of PSD were detected. There was no change of epicardial GLS during follow-up. Conclusion Drug-naïve patients with new-onset SLE, even having normal LVEF, are likely to have subclinical GLS impairment and LV dyssynchrony. SLE-related risk factors are associated with these dysfunctions. Continuous use of HCQ may provide beneficial effects to the silent cardiac impairment. Rheumatology Layer-specific speckle‐tracking echocardiography left ventricular dyssynchrony systemic lupus erythematosus Figures Figure 1 Figure 2 Figure 3 Figure 4 Background With advances in immunosuppressive therapies, the short-term outcome of systemic lupus erythematosus (SLE) has significantly improved. However, cardiac involvement still makes up a main part of mortalities in SLE. SLE patients have up to 10-fold increased risk of cardiovascular morbidity and mortality ( 1 ). Cardiac impairment in SLE is constantly asymptomatic and not always in parallel with disease activity ( 2 , 3 ). Transthoracic echocardiography is a routine method to screen cardiovascular system involvement in SLE. However, it often fails to detect subclinical ventricular dysfunction for multiple reasons. For example, abnormal left ventricular ejection fraction (LVEF) tends to reflect the global but not regional myocardial dysfunction. Furthermore, disadvantages including load and angle dependency and low reproducibility exist in measurement of LVEF ( 4 ). Speckle-tracking echocardiography (STE) is a practical and noninvasive facility of cardiac function assessment arising increasing attention in the past two decades. STE provides important information on subclinical LV dysfunction ( 5 ). Layer‐specific STE was recently introduced for its advantage to quantify longitudinal‐and circumferential-layer strains of the endocardium, midmyocardium, and epicardium, which makes it more sensitive and accurate ( 6 ). Moreover, peak systolic dispersion (PSD) acquired in layer-specific STE, defined as the standard deviation of the time to peak strain of the 18 segments, reflects LV mechanical dyssynchrony (LVMD). LVMD is a marker of poor prognosis in patients with cardiovascular disease (CVD), especially in those with preserved ejection fraction ( 7 )( 8 ). Hydroxychloroquine (HCQ), a cornerstone drug in SLE, has multiple potential CVD benefit to SLE patients through its pleiotropic effects ( 9 ). Nevertheless, scarce evidence of the effect of HCQ on subclinical left ventricular dysfunction in SLE patients has been reported. In the present study, to our knowledge, we evaluated subclinical cardiac dysfunction and mechanical dyssynchrony in drug-naïve patients with new-onset SLE and the effects of hydroxychloroquine monotherapy on certain STE parameters in patients with stable disease for the first time. Disease parameters associated with the layer-specific STE change were also explored. Methods Study subjects In this study, drug-naïve patients with new-onset SLE were consecutively recruited in Second affiliated hospital of Fujian Medical University from January 2019 to January 2020. These patients fulfilled 2012 American College of Rheumatology (ACR)/Systemic Lupus International Collaborating Clinics (SLICC) criteria (8). SLE patients included had no cardiac symptoms. Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K). High-risk antiphospholipid antibody (aPL) profile was defined as the presence of lupus anticoagulant or of double or triple aPL positivity, or the presence of persistently high aPL titres. Age-and-sex-matched healthy controls with negative result of antinuclear antibodies and no history of systemic disease served as healthy controls. The exclusion criteria included age <18 years, a history of treatment with cardio‐toxic drugs, acute coronary symptoms or symptomatic heart failure, previous cardiac surgery, obesity, hypertension, smoking, diabetes, bundle-branch heart block, estimated glomerular filtration rate of <30 ml/minute/1.73 m 2 and tumor. This study was approved by the ethics committee of the Second Affiliated Hospital of Fujian Medical University. Routine echocardiographic assessment 2D echocardiography examinations were performed. A GE VIVID E95 ultrasound system equipped with a 1.4~4.6 MHz transducer (M5Sc‐D probe) was applied. LVEF was determined by the following parameter: left ventricular end‐diastolic diameters (LVEDD), left ventricular end‐systolic diameters (LVESD), interventricular septal (IVS), posterior wall thickness (PWT), end‐diastolic volume and end‐systolic volumes. Diastolic parameters included E, A, e’ and E/e’. Here, the “E′” represents transmitral peak velocity of early diastole, while the “e′” and the “A” refer to the velocity of early diastole of the mitral annulus and transmitral peak velocity of late diastole, respectively. 2D Speckle‐tracking echocardiographic assessment 2D STE was performed using a GE VIVID E95 ultrasound system. Images of the apical four‐chamber, apical two‐chamber, apical LV long‐axis, and LV short‐axis views at the basal, papillary and apical levels were collected within 3~5 cardiac cycles. Software package (EchoPAC, version 201 6.3, GE Vingmed Ultrasound) was used to analyze images. The software tracked endocardium outline and divided the whole ventricular wall into 3 layers (an endocardial, a mid-myocardial and an epicardial layer). Quantitative myocardial parameters for global longitudinal strain (GLS) and global circumference strain (GCS) of each layer, as well as PSD, were obtained. Statistical analysis Differences between patients and controls and correlations were analyzed using t-test and Pearson's correlation. analysis, respectively, if data is normally distributed. If not, nonparametric Mann-Whitney rank sum test and Spearman’s correlation analysis were applied. Partial correlation analysis and multivariate linear regression were used to find out the disease parameters associated with abnormal measure value in STE. The effects of HCQ monotherapy on layer-specific STE parameters were investigated in 7 SLE patients via repeated measure ANOVA. Inter- and intra‐observer reproducibility was assessed using intra‐class correlation coefficients. Statistical significance was defined as p<0.05. All statistical analyses were performed with GraphPad Prism software 5.0 and SPSS software 21.0. Results Study population The characteristics of SLE patients and healthy controls were summarized in Table 1. In this study, a total of 35 SLE patients with new-onset disease and 25 healthy controls were enrolled. 51% had stable disease to mild disease activity (n=18), 40% had moderate disease activity (n=14), and 9% had high disease activity (n=3). No cardiac symptoms were referred in SLE patients and controls. Accordingly, all individuals had normal serum markers of cardiac injury including N-terminal pro-B-type natriuretic peptide (NT-proBNP) and Troponin I, indicating absence of clinical evidence of cardiac impairment in SLE patients. Table 1 Subjects’ characteristics of SLE patients and controls. Variables SLE(n=35) Healthy controls(n=25) p Female/Male 29/6 20/5 ＞0.05 Age(years) 33±6 32±6 0.863 Immune parameters Serum C3, gm/liter 0.62±0.18 1.13±0.08 ＜0.001 Serum C4, gm/liter 0.12±0.05 0.24±0.03 ＜0.001 ANA positive no. (%) 35(100) 0(0) NA Anti-dsDNA positive, no. (%) 25(71) 0(0) NA Antiphospholipid antibody positive, no. (%) 23(66) 0(0) NA High-risk profile aPL, no.(%) 15(42.9) 0(0) NA Disease Activity SLEDAI-2K≤4 7 NA NA 5≤SLEDAI-2K≤9 11 NA NA 10≤SLEDAI-2K≤14 14 NA NA SLEDAI-2K≥15 3 NA NA Traditional cardiac risk factors, no(%) Hypertension 0(0) 0(0) NA Diabetes 0(0) 0(0) NA Hyperlipidemia 3(9) 0(0) NA Smoking 0(0) 0(0) NA Obesity 0(0) 0(0) NA Gout 0(0) 0(0) NA Cardiac symptom, no. (%) 0(0) 0(0) NA Serum markers of cardiac injury NT-proBNP(pg/L) 116±31 114±19 0.988 Troponin I, ng/ml 0(0-0.01) 0(0-0.01) ＞0.05 Echocardiographic measurements Pulmonary hypertension, no. (%) 5(14) 0(0) NA LVEF (%) 58±3 59±3 0.132 Diastolic dysfunction, no. (%) 0(0) 0(0) NA hsCRP (mg/L) 26.11±12.92 6.97±2.12 ＜0.001 ESR (mm/H) 34±11 14±5 ＜0.001 ANA= antinuclear antibody; anti-dsDNA= anti–double-stranded DNA; SLEDAI-2K= Systemic Lupus Erythematosus Disease Activity Index-2K; aPL= antiphospholipid antibody; NT-proBNP= n-terminal pro-b-type natriuretic peptide; LVEF= left ventricular ejection fraction ; hsCRP= high sensitivity C-reactive protein; ESR= erythrocyte sedimentation rate Conventional echocardiographic parameters Conventional echocardiographic results are summarized in Table 2. All participants included had normal LVEF. No significant differences of parameters assessing systolic and diastolic function including LVEDD, LVESD, IVS, PWT, E, A, e’ and E/e’ were found between SLE patients and healthy controls(p>0.05, all). In the follow-up period of seven patients accepting HCQ monotherapy, there were no significant changes of LV diameter and LVEF. Table 2 Conventional and TDI echocardiographic parameters in SLE patients and controls Variables SLE(n=35) Healthy controls(n=25) p LVEDD (mm) 45.8±2.5 45.6±3.3 >0.05 LVESD (mm) 31.6±1.9 31.4±2,8 >0.05 IVS (mm) 9.4±0.8 9.6±0.7 >0.05 PWT (mm) 8.9±0.7 9.1±0.9 >0.05 E(cm/s) 88.0±11.3 90.2±11.6 >0.05 A(cm/s) 59.5±11.3 62.4±9.1 >0.05 e’(cm/s) 12.3±1.7 12.2±1.8 >0.05 E/e’ 7.2±0.7 7.4±0.7 >0.05 LVEDD= left ventricular end‐diastolic diameter; LVESD= left ventricular end‐systolic diameter; IVS= interventricular septum; PWT= posterior wall thickness; E= transmitral peak velocity of early diastole; A= transmitral peak velocity of late diastole; e′ = velocity of early diastole of the mitral annulus Layer-specific STE characteristics, left ventricular dyssynchrony index (PSD) and disease parameters in SLE patients Representative images of layer-specific STE of one SLE patient and one health control individual are shown in Figure 1 and 2. The results of layer-specific STE parameters are displayed in Table 3. Although no clinical evidence of cardiac involvement was detected in SLE patients through routine assessment, impaired left ventricular GLS at three layers (whole layer GLS, endocardial GLS and epicardial GLS) were observed in drug-naïve patients with new-onset SLE, compared with controls (p=0.02, 0.01, 0.04, respectively). Elevation of PSD, which reflects left ventricular dyssynchrony, was found in SLE patients (p<0.01). In contrast, there’s also no significant difference of the GCS of the three layers (midmyocardium GCS, endocardium GCS and epicardium GCS) at the basal level, papillary level and apical level between SLE patients and controls (p>0.05, all). In addition, more severe impairment of GLS was observed in SLE patients with moderate to severe active disease, high-risk aPL profile or lupus nephritis, compared with those with inactive to mild active disease, negative aPL to low-risk aPL profile or without evidence of renal involvement, respectively (Table 4). In contrast, PSD significantly increased in patients with higher disease activity or high-risk aPL, but not in those with lupus nephritis (Table 4). Correlation analysis showed that endocardial GLS, whole layer GLS, epicardial GLS and PSD correlated with high-sensitivity CRP (hsCRP) levels. PSD also correlated with the three layer-specific GLS parameters above (Figure 3). Partial correlation analysis showed that PSD correlated with epicardial GLS, but not whole layer GLS or endocardial GLS, when treating hsCRP level, renal involvement, profile of aPL and disease activity as control variable (Table 5). Multivariate regression analysis showed that hsCRP level and epicardial GLS are the predictors of layer-specific GLS impairment and PSD change, respectively (Table 6). Table 3 Lay-specific strain data and left ventricular dyssynchrony index parameters in SLE patients and controls Variables SLE Healthy controls p Whole layer GLS -17.6±3.0 -19.3±2.6 0.02 Endocardial GLS -20.0±3.2 -22.1±3.0 0.01 Epicardial GLS -15.6±2.7 -16.8±2.4 0.04 GCS at basal level Endocardium -25.6±6.3 -24.4±6.0 0.458 Mid‐myocardium -18.0±4.4 -16.9±4.5 0.376 Epicardium -12.8±4.0 -12.2±3.9 0.675 GCS at papillary muscle level Endocardium -29.0±5.5 -27.1±7.0 0.239 Mid‐myocardium -20.3±3.9 -18.3±5.3 0.124 Epicardium -14.2±4.5 -12.5±4.3 0.136 GCS at apical level Endocardium -33.8±5.7 -32.7±8.4 0.605 Mid‐myocardium -23.4±4.9 -22.5±6.3 0.686 Epicardium -16.0±5.6 -15.5±5.9 0.708 PSD 41.0±18.9 28.8±10.1 0.007 STE= speckle tracking echocardiography; GCS= global circumferential strain; GLS= global longitudinal strain; PSD= peak systolic dispersion. Table 4 Layer-specific longitudinal parameters, PSD and certain disease-related contributors of cardiovascular risk in SLE patients Whole layer GLS Endocardial GLS Epicardial GLS PSD Disease activity Inactive to mild active disease -19.3±2.3 -21.8±2.6 -17.1±2.2 34.1±16.1 Moderate to severe active disease -15.8±2.5 -18.1±2.8 -13.9±2.3 48.2±19.3 p <0.001 <0.001 <0.001 0.014 Renal involvement Without lupus nephritis -19.5±2.1 -22.0±2.4 -17.4±2.0 35.1±17.4 With lupus nephritis -16.6±2.9 -19.0±3.2 -14.6±2.6 44.0±19.3 p <0.001 0.001 0.002 0.062 aPL profile Negative and low-risk aPL profile -18.9±2.5 -21.3±2.7 -16.8±2.3 36.4±18.4 High-risk aPL profile -15.9±2.8 -18.3±3.2 -14.0±2.5 47.1±18.4 p 0.002 0.002 0.004 0.037 GCS= global circumferential strain; GLS= global longitudinal strain; PSD = peak systolic dispersion; aPL= antiphospholipid antibody Table 5 Partial correlation analysis between PSD and layer-specific GLS parameter Control Variable Variable r p HsCRP level Renal involvement Profile of aPL Disease activity PSD Whole layer GLS Endocardial GLS Epicardial GLS 0.296 0.212 0.360 0.106 0.252 0.047 PSD= peak systolic dispersion; GLS= global longitudinal strain; hsCRP= high sensitivity C-reactive protein; aPL= antiphospholipid antibody Table 6 Multivariate linear regression to analyze predictor of layer-specific GLS parameter and PSD Model Unstandardized coefficients Standardized coefficients p B Std. error Beta t Whole layer GLS Endocardial GLS Epicardial GLS PSD Constant HsCRP level Disease activity Renal involvement Profile of aPL Constant HsCRP level Disease activity Renal involvement Profile of aPL Constant HsCRP level Disease activity Renal involvement Profile of aPL Constant HsCRP level Disease activity Profile of aPL Epicardial GLS -21.725 0.121 1.728 -0.164 0.545 -24.454 0.139 2.028 -0.433 0.295 -19.294 0.104 1.385 0.055 0.730 95.394 -0.123 5.306 -0.995 3.429 0.815 0.032 1.211 1.064 0.952 0.909 0.036 1.351 1.187 1.063 0.767 0.031 1.140 1.001 0.896 32.226 0.315 8.505 7.972 1.635 0.528 0.296 -0.027 0.092 0.556 0.317 -0.064 0.046 0.492 0.258 0.010 0.134 -0.084 0.142 -0.026 0.494 -26.656 3.717 1.426 -0.154 0.572 -26.893 3.849 1.500 -0.365 0.278 -25.161 3.400 1.215 0.055 0.815 2.960 -0.390 0.624 -0.125 2.097 <0.001 0.001 0.164 0.878 0.572 <0.001 0.001 0.144 0.718 0.783 <0.001 0.002 0.234 0.957 0.422 0.006 0.699 0.537 0.901 0.045 GLS= global longitudinal strain; PSD= peak systolic dispersion; hsCRP= high sensitivity C-reactive protein; aPL= antiphospholipid antibody Effect of HCQ monotherapy on layer-specific GLS parameters and PSD in SLE patients with stable disease The effect of HCQ monotherapy for 6 months and 12 months on GLS parameters and PSD was assessed in 7 SLE patients with stable disease. The results were summarized in Table 7. Figure 4 showed change of Bull’s eye plot during HCQ monotherapy in one patient at different points in time. Cardiac enzyme, Troponin I, NT-proBNP and LVEF were within normal arrange during follow-up. Endocardial GLS and whole layer GLS showed no change after HCQ treatment for 6 months, compared with baseline. During the second 6 months of HCQ treatment, significant increase of the two strain parameters was detected. Similarly, significant decrease of PSD was observed in the second 6 months of HCQ treatment. No change of epicardial GLS was observed during follow-up. Table 7 Effect on GLS parameters and PSD by HCQ monotherapy in SLE patients with stable disease Variables Baseline 6 months 12 months p Whole layer GLS -19.0±1.8 -19.3±2.1 -21.1±2.6 ** <0.05 Endocardial GLS -21.5±2.0 -21.8±2.4 -23.8±2.8 ** 0.05 PSD 49.9±15.7 39.9±7.8 29.7±10.1 *,** <0.01 GLS= global longitudinal strain; PSD= peak systolic dispersion; HCQ= Hydroxychloroquine *p<0.05 compared with baseline. **p<0.05 compared with 6 months. Discussion In 2016, Ozawa K et al. firstly analyzed the relationship between layer-specific strain parameters and heart failure indicators in 20 systemic autoimmune disorder patients (including 7 SLE patients). They found that GCS values, but not GLS in whole, endocardial and epicardial layers correlated with serum B-type natriuretic peptide (BNP) levels ( 11 ). In addition, GCS in endocardial layer was significantly positively correlated with LVEF. To the best of our knowledge, in the present study, it is the first time to display the asymptomatic myocardial dysfunction in drug-naïve patients with new-onset SLE via speckle‐tracking‐based multilayer approach. The main findings are that decreased whole layer GLS, endocardial GLS and epicardial GLS were found in SLE patients, compared with age, sex-matched healthy individuals, suggesting that subclinical impairment of LV function can occur as early as the time SLE was new-onset and newly diagnosed. Interestingly, these SLE patients had impaired myocardial GLS but not GCS. The relationship between LS and CS was still not very clear. Emerging evidence showed that different roles was played by CS and LS in left ventricular ejection ( 12 ). Circumferential shortening was proved to contributed more to LVEF ( 11 , 13 ). In contrast, patients with impaired longitudinal shortening constantly have preserved LVEF. This result was also consistent with the study by Kraigher-Krainer et al who found that in heart failure with preserved ejection fraction (HFpEF), after adjustment for 10 baseline covariates, lower LS but not CS was associated with higher NT-proBNP, a prognostically relevant biomarker in HFpEF ( 14 ). In our study, decreased GLS was found in new-onset SLE patients with normal LVEF, suggesting GLS might be a marker for early detection of myocardial dysfunction in SLE patients. PSD had been proved to be a relatively new and useful marker for early detection of LVMD ( 15 , 16 ). Mounting evidence supports that LVMD has an independent and incremental negative impact on myocardial mechanics and remodeling. In the study by Leong et al, LV dyssynchrony is independently associated with changes in the LVEF over time in idiopathic dilated cardiomyopathy and occurrence of ventricular tachycardia after myocardial infarction ( 17 ). Fudim M et al. demonstrated that LV dyssynchrony were strongly associated with adverse outcomes among patients with coronary heart disease ( 18 ). In our study, elevation of PSD was detected in drug-naïve SLE patients for the first time, suggesting subclinical LVMD in SLE. Moreover, previous study showed that LVMD has been found to be particularly prevalent in patients with microvascular involvement ( 19 ), which is also a characteristic lesion mediated by immune complex deposition in SLE. Whether higher PSD predicts poorer prognosis of myocardial involvement in SLE needs to be clarified in further research. Mouse model and clinical evidence had shown lupus-associated risk factors play key roles in pathogenesis of CVD in SLE patients ( 20 , 21 ). Disease activity, inflammation, antiphospholipid antibody and lupus nephritis are among the most commonly studied SLE-associated cardiovascular risk factors ( 22 , 23 , 24 ). In our study, accordingly, more active disease, high-risk aPL profile, renal involvement and higher hsCRP level are linked with the tendency of more severe impaired GLS parameters and higher PSD (although not always had statistical significance). Active disease is associated with macrophage activation, enhancing the pro-inflammatory process of CVD occurrence in SLE ( 25 ). High-risk aPL profile not only mediates hypercoagulable state and endothelial dysfunction, but also exacerbate atherosclerosis inflammation in SLE with antiphospholipid syndrome ( 26 ). Gustafsson et al. reported that accelerated atherosclerosis in SLE is mainly confined to a subgroup with LN ( 27 ). The four factors above may work alone or coordinate to cause LS and PSD impairment. Interestingly, PSD correlated with the three layer-specific GLS parameters in the univariate analysis. Further partial correlation and multivariate regression analysis revealed that epicardial GLS is an independent predictor of PSD, suggesting that epicardial GLS maybe a contributor of LVMD. HCQ, has been thought to exert a broad spectrum of beneficial effects on premature CVD in SLE via targeting various SLE-related and traditional CVD risk factors ( 9 ). In the present study, we provided evidence that HCQ monotherapy for 12 months could significantly improve impaired GLS parameters including whole layer GLS and endocardial GLS but not epicardial GLS, and LVMD. We speculate that endocardial region, where has higher microvessel density, is more accessible to evoke an immune complex-mediated process, so the endocardial lesion can be easier to achieve improvement under HCQ treatment. In addition, the beneficial effects seemed to be more substantial at the time point of the second 6 months of HCQ treatment than the first 6 months, suggesting that continuous use of HCQ for more than 6 months has protective effects on asymptomatic cardiac involvement in SLE. Routine echocardiography was commonly used to assess the cardiac dysfunction in SLE patients. However, some serious limitations exist due to reasons referred above. In this study, all individuals including had normal LV systolic and diastolic function in routine echocardiography scan, suggesting longitudinal parameters measured in STE is probably more sensitive tools for myocardial function impairment at the early stage. Some limitations existed in this study. First, it is a study with a relatively short time follow-up. Thus, the predictive value of layer-specific STE parameters could not be well judged. Second, we did not enroll SLE patients having cardiac symptoms as first manifestation to assess the clinical significance more comprehensively. A large-scale study with long-term follow-up in SLE patients will be urged to evaluate the effects of these STE parameters. Conclusions In conclusion, this is the first study to demonstrate that drug-naive patients with new-onset SLE, even those with normal LVEF, are likely to have subclinical GLS impairment and LV dyssynchrony. Some SLE-related risk factors are associated with these dysfunctions. Continuous use of HCQ may provide beneficial effects to the silent cardiac impairment. Abbreviations SLE systemic lupus erythematosus LVEF left ventricular ejection fraction STE Speckle-tracking echocardiography (STE) PSD peak systolic dispersion LVMD LV mechanical dyssynchrony CVD cardiovascular disease HCQ Hydroxychloroquine ACR American College of Rheumatology SLICC Systemic Lupus International Collaborating Clinics SLEDAI-2K Systemic Lupus Erythematosus Disease Activity Index-2K aPL antiphospholipid antibody LVEDD left ventricular end-diastolic diameters LVESD left ventricular end-systolic diameters IVS interventricular septal PWT posterior wall thickness GLS global longitudinal strain GCS global circumference strain NT-proBNP n-terminal pro-b-type natriuretic peptide hsCRP high sensitivity C-reactive protein ESR erythrocyte sedimentation rate HFpEF heart failure with preserved ejection fraction Declarations Ethics approval and consent to participate The study was approved by the ethics committee of the Second Affiliated Hospital of Fujian Medical University. All patients and controls gave signed informed consent. Consent for publication All authors consented to the publication of this manuscript. Availability of data and materials The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request. Competing interests The authors declare that there are no competing interests. Funding This work was supported by Key Clinical Specialty Discipline Construction Program of Fujian, China, Natural Science Foundation of Fujian Province (grant No. 2019J01473) and Science and Technology Program of Quanzhou (grant No. 2018N014S, 2017Z009). Authors' contributions T Luo and Z Wang contribute equally to this article. Conception and design: C Fang, T Luo; Administrative support: Z Wang, Z Chen; Collection and assembly of data: Z Wang, T Luo, C Fang; Data analysis and interpretation: C Fang, E Yu, T Luo; Manuscript writing: T Luo, C Fang; Final approval of manuscript: All authors. 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Kraigher-Krainer E, Shah AM, Gupta DK, et al. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction[J]. J Am Coll Cardiol. 2014;63(5):447–56. Cianciulli TF, Saccheri MC, Rísolo MA, et al. Mechanical dispersion in Fabry disease assessed with speckle tracking echocardiography[J]. Echocardiography. 2020;37(2):293–301. Lavall D, Kuprat LK, Kandels J, et al. Left ventricular mechanical dispersion in flow-gradient patterns of severe aortic stenosis with narrow QRS complex[J]. Int J Cardiovasc Imaging. 2020;36(4):605–14. Leong DP, Hoogslag GE, Piers SR, et al. The relationship between time from myocardial infarction, left ventricular dyssynchrony, and the risk for ventricular arrhythmia: speckle-tracking echocardiographic analysis[J]. J Am Soc Echocardiogr. 2015;28(4):470–7. Fudim M, Fathallah M, Shaw LK, et al. The Prognostic Value of Diastolic and Systolic Mechanical Left Ventricular Dyssynchrony Among Patients With Coronary Heart Disease[J]. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1215–26. Chen J, Kalogeropoulos AP, Verdes L, et al. Left-ventricular systolic and diastolic dyssynchrony as assessed by multi-harmonic phase analysis of gated SPECT myocardial perfusion imaging in patients with end-stage renal disease and normal LVEF[J]. J Nucl Cardiol. 2011;18(2):299–308. Sanghera C, Wong LM, Panahi M, et al. Cardiac phenotype in mouse models of systemic autoimmunity[J]. Dis Model Mech. 2019 Mar 8;12(3). pii: dmm036947. Bessant R, Duncan R, Ambler G, et al. Prevalence of Conventional and Lupus-Specific Risk Factors for Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: A Case–Control Study[J]. Arthritis Rheum. 2006;55(6):892–9. Roman MJ, Crow MK, Lockshin MD. Rate and determinants of progression of atherosclerosis in systemic lupus erythematosus[J]. Arthritis Rheum. 2007;56(10):3412–9. Skaggs BJ, Hahn BH, McMahon M. Accelerated atherosclerosis in patients with SLE-mechanisms and management[J]. Nat Rev Rheumatol. 2012;8(4):214–23. McHugh J. Systemic lupus erythematosus: Atherosclerosis confined to patients with nephritis[J]. Nat Rev Rheumatol. 2017;13:322. Labonte AC, Kegerreis B, Geraci NS, et al. Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus[J]. PLoS One. 2018;13(12):e0208132. Benagiano M, Borghi MO, Romagnoli J, et al. Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome[J]. Haematologica. 2019;104(12):2519–27. Gustafsson JT, Herlitz Lindberg M, Gunnarsson I, et al. Excess atherosclerosis in systemic lupus erythematosus, -A matter of renal involvement: Case control study of 281 SLE patients and 281 individually matched population controls. PLoS One. 2017;12(4):e0174572. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-28237","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":563528,"identity":"66fa5cc2-9ffb-4645-af6a-1186c09cb463","order_by":1,"name":"Tingting Luo","email":"","orcid":"","institution":"Second affiliated hospital of fujian medical university","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Tingting","middleName":"","lastName":"Luo","suffix":""},{"id":563529,"identity":"6728a636-233f-4e08-a3e1-489474fddb01","order_by":2,"name":"Zhenhua Wang","email":"","orcid":"","institution":"Second Affiliated Hospital of Fujian Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhenhua","middleName":"","lastName":"Wang","suffix":""},{"id":563530,"identity":"fddd5ced-20ab-406a-9b37-9c9db288d22b","order_by":3,"name":"Zhen Chen","email":"","orcid":"","institution":"Second Affiliated Hospital of Fujian Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Zhen","middleName":"","lastName":"Chen","suffix":""},{"id":563531,"identity":"9d3b0c54-c163-42a9-82e0-bc231d1366dc","order_by":4,"name":"Ermei Yu","email":"","orcid":"","institution":"Second Affiliated Hospital of Fujian Medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ermei","middleName":"","lastName":"Yu","suffix":""},{"id":563532,"identity":"fd1c1892-9bf6-408f-8973-e5fd55ff7b06","order_by":5,"name":"Chenglong Fang","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA70lEQVRIie3RsWrDMBCA4QsGaTnwqmBwX+GCwCTEkCEvYlFQFxECXTr6AQxd8xh+BINItuyBZAhkyZDBkMVDobXGLpbHQvUPBwJ9w0kAodAfjJdubnNkL9ZeW8pTL8HGTdJpLJie7bZajiVWTndICbZW+Qk/2ntHVtXnkmROUQHc7utBghu9qOhN1ZemuBliG0CtT0NkBSaTQEtVN0UjDeE7CMwGCcYPR6KeqDKZk1Cllwgjb0Drfv1XSIBoDHlkk8o9Mh7YrKJCMt8uGBvZdh/9V/LP57X7+k5jbg+DpI+J30fPdVfUjrgUCoVC/7kf51pIhBMlx2oAAAAASUVORK5CYII=","orcid":"","institution":"Second Affiliated Hospital of Fujian Medical University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Chenglong","middleName":"","lastName":"Fang","suffix":""}],"badges":[],"createdAt":"2020-05-11 03:54:32","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-28237/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-28237/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":1109244,"identity":"605df83c-f766-4491-9f65-ba5ccbf19209","added_by":"auto","created_at":"2020-05-15 19:31:39","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":1577351,"visible":true,"origin":"","legend":"Typical layer-specific global longitudinal strain (GLS) images of Left Ventricle (LV) from a patient with systemic lupus erythematosus(left) and one healthy individual(right). LV GLS was measured from 3 different views (apical 4 (upper level images)-, 2 (middle level images)-, and 3 (bottom level images)-chamber views). Measurement of whole layer GLS, endocardial GLS and epicardial GLS were performed.","description":"","filename":"1.png","url":"https://assets-eu.researchsquare.com/files/rs-28237/v1/1.png"},{"id":1109245,"identity":"155dfa38-53ad-446a-8a9c-3d2634ebcba5","added_by":"auto","created_at":"2020-05-15 19:31:40","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":1543413,"visible":true,"origin":"","legend":"Representative plot of layer-specific global circumferential strain (GCS) in the left ventricle (LV) of one SLE patient(left) and a healthy individual(right). LV GCS was measured from 3 different levels (apical level, papillary muscle level and basal level). Measurement of midmyocardium GCS, endocardium GCS and epicardium GCS were performed.","description":"","filename":"2.png","url":"https://assets-eu.researchsquare.com/files/rs-28237/v1/2.png"},{"id":1109246,"identity":"df5e0d70-6e2b-40d5-b89a-782de477d71d","added_by":"auto","created_at":"2020-05-15 19:31:40","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":298372,"visible":true,"origin":"","legend":"Univariate correlation between (1) global longitudinal strain (GLS) parameters and high sensitivity C reactive protein(hsCRP) levels; (2) peak systolic dispersion (PSD) and hsCRP levels; (3) PSD and GLS parameters.","description":"","filename":"3.png","url":"https://assets-eu.researchsquare.com/files/rs-28237/v1/3.png"},{"id":1109247,"identity":"3ba86c55-ca4a-4624-87a2-d768af431d57","added_by":"auto","created_at":"2020-05-15 19:31:40","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":680221,"visible":true,"origin":"","legend":"Change of layer-specific STE Bull’s eye plot during HCQ monotherapy in one patient with stable disease, which is measured at baseline, HCQ treatment for 6 months and HCQ treatment for 12 months, respectively.","description":"","filename":"4.png","url":"https://assets-eu.researchsquare.com/files/rs-28237/v1/4.png"},{"id":13503933,"identity":"b495fde6-3a1d-4b61-a39a-26564bf290d3","added_by":"auto","created_at":"2021-09-16 23:21:07","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2689513,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-28237/v1/6adc77f8-2d07-4779-86c6-8fb796e33fdb.pdf"}],"financialInterests":"","formattedTitle":"Layer‐specific strain and dyssynchrony index alteration in new-onset systemic lupus erythematosus patients without cardiac symptom","fulltext":[{"header":"Background","content":" \u003cp\u003eWith advances in immunosuppressive therapies, the short-term outcome of systemic lupus erythematosus (SLE) has significantly improved. However, cardiac involvement still makes up a main part of mortalities in SLE. SLE patients have up to 10-fold increased risk of cardiovascular morbidity and mortality (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e). Cardiac impairment in SLE is constantly asymptomatic and not always in parallel with disease activity (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e, \u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e). Transthoracic echocardiography is a routine method to screen cardiovascular system involvement in SLE. However, it often fails to detect subclinical ventricular dysfunction for multiple reasons. For example, abnormal left ventricular ejection fraction (LVEF) tends to reflect the global but not regional myocardial dysfunction. Furthermore, disadvantages including load and angle dependency and low reproducibility exist in measurement of LVEF (\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eSpeckle-tracking echocardiography (STE) is a practical and noninvasive facility of cardiac function assessment arising increasing attention in the past two decades. STE provides important information on subclinical LV dysfunction (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e). Layer‐specific STE was recently introduced for its advantage to quantify longitudinal‐and circumferential-layer strains of the endocardium, midmyocardium, and epicardium, which makes it more sensitive and accurate (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e). Moreover, peak systolic dispersion (PSD) acquired in layer-specific STE, defined as the standard deviation of the time to peak strain of the 18 segments, reflects LV mechanical dyssynchrony (LVMD). LVMD is a marker of poor prognosis in patients with cardiovascular disease (CVD), especially in those with preserved ejection fraction (\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e)(\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e).\u003c/p\u003e \u003cp\u003eHydroxychloroquine (HCQ), a cornerstone drug in SLE, has multiple potential CVD benefit to SLE patients through its pleiotropic effects (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e). Nevertheless, scarce evidence of the effect of HCQ on subclinical left ventricular dysfunction in SLE patients has been reported. In the present study, to our knowledge, we evaluated subclinical cardiac dysfunction and mechanical dyssynchrony in drug-na\u0026iuml;ve patients with new-onset SLE and the effects of hydroxychloroquine monotherapy on certain STE parameters in patients with stable disease for the first time. Disease parameters associated with the layer-specific STE change were also explored.\u003c/p\u003e "},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eStudy subjects\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eIn this study, drug-na\u0026iuml;ve patients with new-onset SLE were consecutively recruited in Second affiliated hospital of Fujian Medical University from January 2019 to January 2020. These patients fulfilled 2012 American College of Rheumatology (ACR)/Systemic Lupus International Collaborating Clinics (SLICC) criteria (8). SLE patients included had no cardiac symptoms. Disease activity was assessed by Systemic Lupus Erythematosus Disease Activity Index-2K (SLEDAI-2K). High-risk antiphospholipid antibody (aPL) profile was defined as the presence of lupus anticoagulant or of double or triple aPL positivity, or the presence of persistently high aPL titres. Age-and-sex-matched healthy controls with negative result of antinuclear antibodies and no history of systemic disease served as healthy controls. The exclusion criteria included age \u0026lt;18 years, a history of treatment with cardio‐toxic drugs, acute coronary symptoms or symptomatic heart failure, previous cardiac surgery, obesity, hypertension, smoking, diabetes, bundle-branch heart block, estimated glomerular filtration rate of \u0026lt;30 ml/minute/1.73 m\u003csup\u003e2\u003c/sup\u003e and tumor. This study was approved by the ethics committee of the Second Affiliated Hospital of Fujian Medical University.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eRoutine echocardiographic assessment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e2D echocardiography examinations were performed. A GE VIVID E95 ultrasound system equipped with a 1.4~4.6 MHz transducer (M5Sc‐D probe) was applied. LVEF was determined by the following parameter: left ventricular end‐diastolic diameters (LVEDD), left ventricular end‐systolic diameters (LVESD), interventricular septal (IVS), posterior wall thickness (PWT), end‐diastolic volume and end‐systolic volumes. Diastolic parameters included E, A, e\u0026rsquo; and E/e\u0026rsquo;. Here, the \u0026ldquo;E\u0026prime;\u0026rdquo; represents transmitral peak velocity of early diastole, while the \u0026ldquo;e\u0026prime;\u0026rdquo; and the \u0026ldquo;A\u0026rdquo; refer to the velocity of early diastole of the mitral annulus and transmitral peak velocity of late diastole, respectively.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e2D Speckle‐tracking echocardiographic assessment\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e2D STE was performed using a GE VIVID E95 ultrasound system. Images of the apical four‐chamber, apical two‐chamber, apical LV long‐axis, and LV short‐axis views at the basal, papillary and apical levels were collected within 3~5 cardiac cycles. Software package (EchoPAC, version 201 6.3, GE Vingmed Ultrasound) was used to analyze images. The software tracked endocardium outline and divided the whole ventricular wall into 3 layers (an endocardial, a mid-myocardial and an epicardial layer). Quantitative myocardial parameters for global longitudinal strain (GLS) and global circumference strain (GCS) of each layer, as well as PSD, were obtained.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eDifferences between patients and controls and correlations were analyzed using t-test and Pearson's correlation. analysis, respectively, if data is normally distributed. If not, nonparametric Mann-Whitney rank sum test and Spearman\u0026rsquo;s correlation analysis were applied. Partial correlation analysis and multivariate linear regression were used to find out the disease parameters associated with abnormal measure value in STE. The effects of HCQ monotherapy on layer-specific STE parameters were investigated in 7 SLE patients via repeated measure ANOVA. Inter- and intra‐observer reproducibility was assessed using intra‐class correlation coefficients. Statistical significance was defined as p\u0026lt;0.05. All statistical analyses were performed with GraphPad Prism software 5.0 and SPSS software 21.0.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eStudy population\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe characteristics of SLE patients and healthy controls were summarized in Table 1. In this study, a total of 35 SLE patients with new-onset disease and 25 healthy controls were enrolled. 51% had stable disease to mild disease activity (n=18), 40% had moderate disease activity (n=14), and 9% had high disease activity (n=3). No cardiac symptoms were referred in SLE patients and controls. Accordingly, all individuals had normal serum markers of cardiac injury including N-terminal pro-B-type natriuretic peptide (NT-proBNP) and Troponin I, indicating absence of clinical evidence of cardiac impairment in SLE patients.\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; line-height: 26.666664123535156px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003eTable 1\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eSubjects\u0026rsquo; characteristics of SLE patients and controls.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eVariables\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSLE(n=35)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHealthy controls(n=25)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eFemale/Male\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e29/6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e20/5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e＞0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eAge(years)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e33\u0026plusmn;6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e32\u0026plusmn;6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.863\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eImmune parameters\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Serum C3, gm/liter\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.62\u0026plusmn;0.18\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.13\u0026plusmn;0.08\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e＜0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSerum C4, gm/liter\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.12\u0026plusmn;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.24\u0026plusmn;0.03\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e＜0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eANA positive no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e35(100)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eAnti-dsDNA positive, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e25(71)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eAntiphospholipid antibody positive, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e23(66)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHigh-risk profile aPL, no.(%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e15(42.9)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease Activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSLEDAI-2K\u0026le;4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e5\u0026le;SLEDAI-2K\u0026le;9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e10\u0026le;SLEDAI-2K\u0026le;14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e14\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; SLEDAI-2K\u0026ge;15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eTraditional cardiac risk factors, no(%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 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border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 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border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 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border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 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border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Obesity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Gout\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eCardiac symptom, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSerum markers of cardiac injury\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.75pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; NT-proBNP(pg/L)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.75pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e116\u0026plusmn;31\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.75pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e114\u0026plusmn;19\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.75pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.988\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Troponin I, ng/ml\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0-0.01)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0-0.01)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e＞0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEchocardiographic measurements\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Pulmonary hypertension, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e5(14)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eLVEF (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e58\u0026plusmn;3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e59\u0026plusmn;3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.132\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 7.5pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDiastolic dysfunction, no. (%)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0(0)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eNA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ehsCRP (mg/L)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e26.11\u0026plusmn;12.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e6.97\u0026plusmn;2.12\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e＜0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eESR (mm/H)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e34\u0026plusmn;11\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e14\u0026plusmn;5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e＜0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eANA= antinuclear antibody; anti-dsDNA= anti\u0026ndash;double-stranded DNA; SLEDAI-2K= Systemic Lupus Erythematosus Disease Activity Index-2K; aPL= antiphospholipid antibody; NT-proBNP= n-terminal pro-b-type natriuretic peptide; LVEF=\u0026nbsp;\u003c/span\u003e\u003ca href=\"http://www.baidu.com/link?url=UhA31QoJgGNOLjtdyX-CVGmPOn0dpfFSD2zAbUhB6Oj2KjU_6loaKEBQ9vaKYnv8U5Qn7MDrvEBVnVWIzvBf-A54HnV9uCvZxRS1wb5g0ZwSBKhPRwk8vq3cLyMyj0ckDK0FW1iR1HmuLNKt0ZVcQ_\" target=\"_blank\"\u003e\u003cspan style=\"line-height: 20px; text-decoration: none;\"\u003eleft ventricular ejection fraction\u003c/span\u003e\u003c/a\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 10px; line-height: 20px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003e; hsCRP= high sensitivity C-reactive protein; ESR= erythrocyte sedimentation rate\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConventional echocardiographic parameters\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eConventional echocardiographic results are summarized in Table 2. All participants included had normal LVEF. No significant differences of parameters assessing systolic and diastolic function including LVEDD, LVESD, IVS, PWT, E, A, e\u0026rsquo; and E/e\u0026rsquo; were found between SLE patients and healthy controls(p\u0026gt;0.05, all). In the follow-up period of seven patients accepting HCQ monotherapy, there were no significant changes of LV diameter and LVEF.\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; line-height: 26.666664123535156px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003eTable 2\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eConventional and TDI echocardiographic parameters in SLE patients and controls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eVariables\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSLE(n=35)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHealthy controls(n=25)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eLVEDD (mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e45.8\u0026plusmn;2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e45.6\u0026plusmn;3.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eLVESD (mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e31.6\u0026plusmn;1.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e31.4\u0026plusmn;2,8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eIVS (mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e9.4\u0026plusmn;0.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e9.6\u0026plusmn;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePWT (mm)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e8.9\u0026plusmn;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e9.1\u0026plusmn;0.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eE(cm/s)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e88.0\u0026plusmn;11.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e90.2\u0026plusmn;11.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eA(cm/s)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e59.5\u0026plusmn;11.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e62.4\u0026plusmn;9.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ee\u0026rsquo;(cm/s)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e12.3\u0026plusmn;1.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e12.2\u0026plusmn;1.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eE/e\u0026rsquo;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e7.2\u0026plusmn;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e7.4\u0026plusmn;0.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eLVEDD= left ventricular end‐diastolic diameter; LVESD= left ventricular end‐systolic diameter; IVS= interventricular septum; PWT= posterior wall thickness; E= transmitral peak velocity of early diastole; A= transmitral peak velocity of late diastole; e\u0026prime;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003cspan style=\"font-size: 10px; line-height: 20px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003e\u0026nbsp;= velocity of early diastole of the mitral annulus\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eLayer-specific STE characteristics, left ventricular dyssynchrony index (PSD) and disease parameters in SLE patients\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eRepresentative images of layer-specific STE of one SLE patient and one health control individual are shown in Figure 1 and 2. The results of layer-specific STE parameters are displayed in Table 3. Although no clinical evidence of cardiac involvement was detected in SLE patients through routine assessment, impaired left ventricular GLS at three layers (whole layer GLS, endocardial GLS and epicardial GLS) were observed in drug-na\u0026iuml;ve patients with new-onset SLE, compared with controls (p=0.02, 0.01, 0.04, respectively). Elevation of PSD, which reflects left ventricular dyssynchrony, was found in SLE patients (p\u0026lt;0.01). In contrast, there\u0026rsquo;s also no significant difference of the GCS of the three layers (midmyocardium GCS, endocardium GCS and epicardium GCS) at the basal level, papillary level and apical level between SLE patients and controls (p\u0026gt;0.05, all).\u003c/p\u003e\n\u003cp\u003eIn addition, more severe impairment of GLS was observed in SLE patients with moderate to severe active disease, high-risk aPL profile or lupus nephritis, compared with those with inactive to mild active disease, negative aPL to low-risk aPL profile or without evidence of renal involvement, respectively (Table 4). In contrast, PSD significantly increased in patients with higher disease activity or high-risk aPL, but not in those with lupus nephritis (Table 4).\u003c/p\u003e\n\u003cp\u003eCorrelation analysis showed that endocardial GLS, whole layer GLS, epicardial GLS and PSD correlated with high-sensitivity CRP (hsCRP) levels. PSD also correlated with the three layer-specific GLS parameters above (Figure 3). Partial correlation analysis showed that PSD correlated with epicardial GLS, but not whole layer GLS or endocardial GLS, when treating hsCRP level, renal involvement, profile of aPL and disease activity as control variable (Table 5). Multivariate regression analysis showed that hsCRP level and epicardial GLS are the predictors of layer-specific GLS impairment and PSD change, respectively (Table 6).\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; line-height: 26.666664123535156px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003eTable 3\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eLay-specific strain data and left ventricular dyssynchrony index parameters in SLE patients and controls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eVariables\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSLE\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHealthy controls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eWhole layer GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-17.6\u0026plusmn;3.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.3\u0026plusmn;2.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.02\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEndocardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-20.0\u0026plusmn;3.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-22.1\u0026plusmn;3.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEpicardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-15.6\u0026plusmn;2.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-16.8\u0026plusmn;2.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.04\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eGCS at basal level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Endocardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-25.6\u0026plusmn;6.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-24.4\u0026plusmn;6.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.458\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Mid‐myocardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-18.0\u0026plusmn;4.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-16.9\u0026plusmn;4.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.376\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Epicardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-12.8\u0026plusmn;4.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-12.2\u0026plusmn;3.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.675\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eGCS at papillary muscle level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Endocardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-29.0\u0026plusmn;5.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-27.1\u0026plusmn;7.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.239\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Mid‐myocardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-20.3\u0026plusmn;3.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-18.3\u0026plusmn;5.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.124\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Epicardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-14.2\u0026plusmn;4.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-12.5\u0026plusmn;4.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.136\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eGCS at apical level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Endocardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-33.8\u0026plusmn;5.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-32.7\u0026plusmn;8.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.605\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Mid‐myocardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-23.4\u0026plusmn;4.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-22.5\u0026plusmn;6.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.686\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Epicardium\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-16.0\u0026plusmn;5.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-15.5\u0026plusmn;5.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.708\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 163.05pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"40.33457249070632%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePSD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"19.33085501858736%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e41.0\u0026plusmn;18.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 120.5pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 21.25pt;\" width=\"29.925650557620816%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e28.8\u0026plusmn;10.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 41.75pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; background-position: initial initial; background-repeat: initial initial;\" width=\"10.408921933085502%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.007\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eSTE= speckle tracking echocardiography; GCS= global circumferential strain; GLS= global longitudinal strain; PSD= peak systolic dispersion.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 32px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eTable 4\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eLayer-specific longitudinal parameters, PSD and certain disease-related contributors of cardiovascular risk in SLE patients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" width=\"593\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eWhole layer GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEndocardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEpicardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePSD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Inactive to mild active disease\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.3\u0026plusmn;2.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-21.8\u0026plusmn;2.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-17.1\u0026plusmn;2.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e34.1\u0026plusmn;16.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Moderate to severe active disease\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-15.8\u0026plusmn;2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-18.1\u0026plusmn;2.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-13.9\u0026plusmn;2.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e48.2\u0026plusmn;19.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; \u003cem\u003ep\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.014\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eRenal involvement\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Without lupus nephritis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.5\u0026plusmn;2.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-22.0\u0026plusmn;2.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-17.4\u0026plusmn;2.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e35.1\u0026plusmn;17.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; With lupus nephritis\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-16.6\u0026plusmn;2.9\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.0\u0026plusmn;3.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-14.6\u0026plusmn;2.6\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e44.0\u0026plusmn;19.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; \u003cem\u003ep\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.002\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.062\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eaPL profile\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: -.5in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt .5in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Negative and low-risk aPL profile\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-18.9\u0026plusmn;2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-21.3\u0026plusmn;2.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-16.8\u0026plusmn;2.3\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e36.4\u0026plusmn;18.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; High-risk aPL profile\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-15.9\u0026plusmn;2.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-18.3\u0026plusmn;3.2\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-14.0\u0026plusmn;2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e47.1\u0026plusmn;18.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 134.7pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"30.354131534569984%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; text-indent: 7.5pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"15.85160202360877%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.002\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"19.05564924114671%\"\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.002\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.537942664418214%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.004\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.45pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"17.200674536256322%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.037\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eGCS= global circumferential strain; GLS= global longitudinal strain; PSD = peak systolic dispersion; aPL= antiphospholipid antibody\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eTable 5\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003e\u0026nbsp;Partial correlation analysis between PSD and layer-specific GLS parameter\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 164.05pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"39.53068592057762%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eControl Variable\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"23.646209386281587%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eVariable\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 72.15pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"17.32851985559567%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003er\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.65pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; vertical-align: top;\" valign=\"top\" width=\"19.494584837545126%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 106.1pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"25.49728752260398%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHsCRP level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eRenal involvement\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eProfile of aPL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"13.924050632911392%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePSD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 97.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"23.688969258589513%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eWhole layer GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEndocardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEpicardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 72.15pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"17.359855334538878%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.296\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.212\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.360\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 80.65pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"19.529837251356238%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.106\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.252\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.047\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"25.49728752260398%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"13.924050632911392%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"23.688969258589513%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"17.359855334538878%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"19.529837251356238%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePSD= peak systolic dispersion; GLS= global longitudinal strain; hsCRP= high sensitivity C-reactive protein; aPL= antiphospholipid antibody\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 32px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eTable 6\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eMultivariate linear regression to analyze predictor of layer-specific GLS parameter and PSD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 46.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.2pt; vertical-align: top;\" rowspan=\"2\" valign=\"top\" width=\"11.371841155234657%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 87.75pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.2pt; vertical-align: top;\" colspan=\"2\" rowspan=\"2\" valign=\"top\" width=\"21.119133574007222%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eModel\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 106.3pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.2pt; vertical-align: top;\" colspan=\"4\" valign=\"top\" width=\"25.63176895306859%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eUnstandardized coefficients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 127.55pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.2pt; vertical-align: top;\" colspan=\"5\" valign=\"top\" width=\"30.685920577617328%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eStandardized coefficients\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 46.25pt; border-top-width: 1pt; border-style: solid none; border-top-color: #7f7f7f; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.2pt; vertical-align: top;\" rowspan=\"2\" valign=\"top\" width=\"11.191335740072201%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; text-indent: 3.75pt; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 49.6pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.15pt; vertical-align: top;\" valign=\"top\" width=\"21.221864951768488%\"\u003e\n\u003cp style=\"margin: 0in -3.55pt 0.0001pt 0in; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;B\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 46.05pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.15pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"19.614147909967844%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;Std. error\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 72.65pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.15pt; vertical-align: top;\" colspan=\"4\" valign=\"top\" width=\"31.189710610932476%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; Beta\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 65.55pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 5.15pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"27.974276527331188%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 18.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003et\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 63.8pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"15.315315315315315%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eWhole layer GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEndocardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEpicardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePSD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"17.117117117117118%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eConstant\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHsCRP level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eRenal involvement\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eProfile of aPL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eConstant\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHsCRP level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eRenal involvement\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eProfile of aPL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eConstant\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHsCRP level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eRenal involvement\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eProfile of aPL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eConstant\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eHsCRP level\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eDisease activity\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eProfile of aPL\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; font-size: 14px; font-family: DengXian; line-height: 28px; text-align: left;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEpicardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 50.3pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"12.072072072072071%\"\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 12.8pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-21.725\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.121\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.728\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.164\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.545\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt 3pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-24.454\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.139\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e2.028\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.433\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0.1pt; text-align: center; font-size: 14px; font-family: DengXian; text-indent: -0.4pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; \u0026nbsp; \u0026nbsp;0.295\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in -0.4pt 0.0001pt 3pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 9.45pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.294\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.104\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.385\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.055\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 18.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.730\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt 3pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; \u0026nbsp;95.394\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.123\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e5.306\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.995\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 18.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e3.429\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.45pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" colspan=\"3\" valign=\"top\" width=\"13.873873873873874%\"\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 3.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.815\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 3.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.032\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 3.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.211\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 3.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.064\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 3.75pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.952\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0.25in 0.0001pt 3pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.909\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 0.25in 0.0001pt 3pt; 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text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15.6pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.140\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 7.5pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 7.5pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.896\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 17.4pt 0.0001pt 3pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e32.226\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 21.75pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.315\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 21.75pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e8.505\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 21.75pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e7.972\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 7.5pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.635\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.45pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" valign=\"top\" width=\"13.873873873873874%\"\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 0.528\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 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text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.134\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.084\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.142\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.026\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.494\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.45pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"13.873873873873874%\"\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-26.656\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e3.717\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.426\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.154\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.572\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 10.2pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-26.893\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e3.849\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.500\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 7.5pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.365\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.278\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 7.5pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-25.161\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e3.400\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt -0.3pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 13.9pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e1.215\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.055\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.815\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 4.6pt 0.0001pt 3pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; \u0026nbsp;2.960\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.390\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.624\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-0.125\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e2.097\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 57.45pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: #7f7f7f; padding: 0in 5.4pt; height: 62.95pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"13.873873873873874%\"\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;0.164\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;0.878\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 0.572\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 11.25pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;0.144\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp;0.718\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026nbsp; 0.783\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.001\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.002\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.234\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt; text-align: center; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.957\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.422\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.006\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.699\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.537\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 14.25pt 0.0001pt 3pt; text-align: right; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.901\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in 3pt 0.0001pt 0in; text-align: justify; font-size: 14px; font-family: DengXian; text-indent: 15pt; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e0.045\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"11.39240506329114%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"3.9783001808318263%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"17.179023508137433%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"11.934900542495479%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"0.18083182640144665%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"10.849909584086799%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"2.5316455696202533%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"0.3616636528028933%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"13.924050632911392%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"0.7233273056057866%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"13.019891500904158%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"2.7124773960216997%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"11.211573236889693%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 0in 0.0001pt; text-align: justify; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-size: 10px; line-height: 20px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003eGLS= global longitudinal strain; PSD= peak systolic dispersion; hsCRP= high sensitivity C-reactive protein; aPL= antiphospholipid antibody\u003c/span\u003e\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEffect of HCQ monotherapy on layer-specific GLS parameters and PSD in SLE patients with stable disease\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe effect of HCQ monotherapy for 6 months and 12 months on GLS parameters and PSD was assessed in 7 SLE patients with stable disease. The results were summarized in Table 7. Figure 4 showed change of Bull\u0026rsquo;s eye plot during HCQ monotherapy in one patient at different points in time. Cardiac enzyme, Troponin I, NT-proBNP and LVEF were within normal arrange during follow-up.\u003c/p\u003e\n\u003cp\u003eEndocardial GLS and whole layer GLS showed no change after HCQ treatment for 6 months, compared with baseline. During the second 6 months of HCQ treatment, significant increase of the two strain parameters was detected. Similarly, significant decrease of PSD was observed in the second 6 months of HCQ treatment. No change of epicardial GLS was observed during follow-up.\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 10px; line-height: 26.666664123535156px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003eTable 7\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 26.666664123535156px;\"\u003eEffect on GLS parameters and PSD by HCQ monotherapy in SLE patients with stable disease\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\" border=\"1\" cellspacing=\"0\" cellpadding=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 78pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20.392156862745097%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eVariables\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20.392156862745097%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eBaseline\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"22.15686274509804%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e6 months\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"18.431372549019606%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e12 months\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-top-width: 1pt; border-style: solid none; border-top-color: black; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 0.2in; vertical-align: top;\" valign=\"top\" width=\"18.627450980392158%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cem\u003e\u003cspan style=\"line-height: 20px;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 78pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20.392156862745097%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eWhole layer GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20.392156862745097%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.0\u0026plusmn;1.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"22.15686274509804%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 1.65pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-19.3\u0026plusmn;2.1\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"18.431372549019606%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 1.7pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-21.1\u0026plusmn;2.6\u003csup\u003e**\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"18.627450980392158%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEndocardial GLS\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 3.0pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-21.5\u0026plusmn;2.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 4.35pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-21.8\u0026plusmn;2.4\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 13.05pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-23.8\u0026plusmn;2.8\u003csup\u003e**\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: .1in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eEpicardial GLS\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 3.0pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-16.8\u0026plusmn;1.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 4.35pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-17.1\u0026plusmn;2.0\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 13.05pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e-18.7\u0026plusmn;2.5\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 76.55pt; border: none; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: .1in; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026gt;0.05\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 78pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20.392156862745097%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 0in; font-size: 14px; font-family: SimSun; line-height: 28px; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003ePSD\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 77.95pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"20.392156862745097%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 1.65pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e49.9\u0026plusmn;15.7\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 85.05pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"22.15686274509804%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 1.65pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e39.9\u0026plusmn;7.8\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.85pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" colspan=\"2\" valign=\"top\" width=\"18.431372549019606%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 1.7pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e29.7\u0026plusmn;10.1\u003csup\u003e*,**\u003c/sup\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 70.9pt; border-style: none none solid; border-bottom-width: 1pt; border-bottom-color: black; background-color: white; padding: 0in 5.4pt; height: 21.25pt; vertical-align: top;\" valign=\"top\" width=\"18.627450980392158%\"\u003e\n\u003cp style=\"text-align: justify; text-indent: 1.55pt; font-size: 14px; font-family: SimSun; line-height: 200%; margin: 0in 0in .0001pt 0in;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e\u0026lt;0.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"border: none;\" width=\"19.96086105675147%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"0.3913894324853229%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"19.569471624266146%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"0.7827788649706457%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"19.17808219178082%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"2.935420743639922%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"17.025440313111545%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"1.5655577299412915%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003ctd style=\"border: none;\" width=\"18.59099804305284%\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003eGLS= global longitudinal strain; PSD= peak systolic dispersion; HCQ= Hydroxychloroquine\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 10px;\"\u003e\u003cspan style=\"color: #000000;\"\u003e\u003cspan style=\"line-height: 20px;\"\u003e*p\u0026lt;0.05 compared with baseline.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u003cspan style=\"font-size: 10px; line-height: 20px; font-family: Verdana, Geneva, sans-serif; color: #000000;\"\u003e**p\u0026lt;0.05 compared with 6 months.\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in; margin-bottom: .0001pt; text-align: left; font-size: 14px; font-family: DengXian; line-height: 28px;\"\u003e\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":" \u003cp\u003eIn 2016, Ozawa K et al. firstly analyzed the relationship between layer-specific strain parameters and heart failure indicators in 20 systemic autoimmune disorder patients (including 7 SLE patients). They found that GCS values, but not GLS in whole, endocardial and epicardial layers correlated with serum B-type natriuretic peptide (BNP) levels (\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e). In addition, GCS in endocardial layer was significantly positively correlated with LVEF. To the best of our knowledge, in the present study, it is the first time to display the asymptomatic myocardial dysfunction in drug-na\u0026iuml;ve patients with new-onset SLE via speckle‐tracking‐based multilayer approach. The main findings are that decreased whole layer GLS, endocardial GLS and epicardial GLS were found in SLE patients, compared with age, sex-matched healthy individuals, suggesting that subclinical impairment of LV function can occur as early as the time SLE was new-onset and newly diagnosed.\u003c/p\u003e \u003cp\u003eInterestingly, these SLE patients had impaired myocardial GLS but not GCS. The relationship between LS and CS was still not very clear. Emerging evidence showed that different roles was played by CS and LS in left ventricular ejection (\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e). Circumferential shortening was proved to contributed more to LVEF (\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e, \u003cspan citationid=\"CR13\" class=\"CitationRef\"\u003e13\u003c/span\u003e). In contrast, patients with impaired longitudinal shortening constantly have preserved LVEF. This result was also consistent with the study by Kraigher-Krainer et al who found that in heart failure with preserved ejection fraction (HFpEF), after adjustment for 10 baseline covariates, lower LS but not CS was associated with higher NT-proBNP, a prognostically relevant biomarker in HFpEF (\u003cspan citationid=\"CR14\" class=\"CitationRef\"\u003e14\u003c/span\u003e). In our study, decreased GLS was found in new-onset SLE patients with normal LVEF, suggesting GLS might be a marker for early detection of myocardial dysfunction in SLE patients.\u003c/p\u003e \u003cp\u003ePSD had been proved to be a relatively new and useful marker for early detection of LVMD (\u003cspan citationid=\"CR15\" class=\"CitationRef\"\u003e15\u003c/span\u003e, \u003cspan citationid=\"CR16\" class=\"CitationRef\"\u003e16\u003c/span\u003e). Mounting evidence supports that LVMD has an independent and incremental negative impact on myocardial mechanics and remodeling. In the study by Leong et al, LV dyssynchrony is independently associated with changes in the LVEF over time in idiopathic dilated cardiomyopathy and occurrence of ventricular tachycardia after myocardial infarction (\u003cspan citationid=\"CR17\" class=\"CitationRef\"\u003e17\u003c/span\u003e). Fudim M et al. demonstrated that LV dyssynchrony were strongly associated with adverse outcomes among patients with coronary heart disease (\u003cspan citationid=\"CR18\" class=\"CitationRef\"\u003e18\u003c/span\u003e). In our study, elevation of PSD was detected in drug-na\u0026iuml;ve SLE patients for the first time, suggesting subclinical LVMD in SLE. Moreover, previous study showed that LVMD has been found to be particularly prevalent in patients with microvascular involvement (\u003cspan citationid=\"CR19\" class=\"CitationRef\"\u003e19\u003c/span\u003e), which is also a characteristic lesion mediated by immune complex deposition in SLE. Whether higher PSD predicts poorer prognosis of myocardial involvement in SLE needs to be clarified in further research.\u003c/p\u003e \u003cp\u003eMouse model and clinical evidence had shown lupus-associated risk factors play key roles in pathogenesis of CVD in SLE patients (\u003cspan citationid=\"CR20\" class=\"CitationRef\"\u003e20\u003c/span\u003e, \u003cspan citationid=\"CR21\" class=\"CitationRef\"\u003e21\u003c/span\u003e). Disease activity, inflammation, antiphospholipid antibody and lupus nephritis are among the most commonly studied SLE-associated cardiovascular risk factors (\u003cspan citationid=\"CR22\" class=\"CitationRef\"\u003e22\u003c/span\u003e, \u003cspan citationid=\"CR23\" class=\"CitationRef\"\u003e23\u003c/span\u003e, \u003cspan citationid=\"CR24\" class=\"CitationRef\"\u003e24\u003c/span\u003e). In our study, accordingly, more active disease, high-risk aPL profile, renal involvement and higher hsCRP level are linked with the tendency of more severe impaired GLS parameters and higher PSD (although not always had statistical significance). Active disease is associated with macrophage activation, enhancing the pro-inflammatory process of CVD occurrence in SLE (\u003cspan citationid=\"CR25\" class=\"CitationRef\"\u003e25\u003c/span\u003e). High-risk aPL profile not only mediates hypercoagulable state and endothelial dysfunction, but also exacerbate atherosclerosis inflammation in SLE with antiphospholipid syndrome (\u003cspan citationid=\"CR26\" class=\"CitationRef\"\u003e26\u003c/span\u003e). Gustafsson et al. reported that accelerated atherosclerosis in SLE is mainly confined to a subgroup with LN (\u003cspan citationid=\"CR27\" class=\"CitationRef\"\u003e27\u003c/span\u003e). The four factors above may work alone or coordinate to cause LS and PSD impairment. Interestingly, PSD correlated with the three layer-specific GLS parameters in the univariate analysis. Further partial correlation and multivariate regression analysis revealed that epicardial GLS is an independent predictor of PSD, suggesting that epicardial GLS maybe a contributor of LVMD.\u003c/p\u003e \u003cp\u003eHCQ, has been thought to exert a broad spectrum of beneficial effects on premature CVD in SLE via targeting various SLE-related and traditional CVD risk factors (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e). In the present study, we provided evidence that HCQ monotherapy for 12 months could significantly improve impaired GLS parameters including whole layer GLS and endocardial GLS but not epicardial GLS, and LVMD. We speculate that endocardial region, where has higher microvessel density, is more accessible to evoke an immune complex-mediated process, so the endocardial lesion can be easier to achieve improvement under HCQ treatment. In addition, the beneficial effects seemed to be more substantial at the time point of the second 6 months of HCQ treatment than the first 6 months, suggesting that continuous use of HCQ for more than 6 months has protective effects on asymptomatic cardiac involvement in SLE.\u003c/p\u003e \u003cp\u003eRoutine echocardiography was commonly used to assess the cardiac dysfunction in SLE patients. However, some serious limitations exist due to reasons referred above. In this study, all individuals including had normal LV systolic and diastolic function in routine echocardiography scan, suggesting longitudinal parameters measured in STE is probably more sensitive tools for myocardial function impairment at the early stage.\u003c/p\u003e \u003cp\u003eSome limitations existed in this study. First, it is a study with a relatively short time follow-up. Thus, the predictive value of layer-specific STE parameters could not be well judged. Second, we did not enroll SLE patients having cardiac symptoms as first manifestation to assess the clinical significance more comprehensively. A large-scale study with long-term follow-up in SLE patients will be urged to evaluate the effects of these STE parameters.\u003c/p\u003e "},{"header":"Conclusions","content":" \u003cp\u003eIn conclusion, this is the first study to demonstrate that drug-naive patients with new-onset SLE, even those with normal LVEF, are likely to have subclinical GLS impairment and LV dyssynchrony. Some SLE-related risk factors are associated with these dysfunctions. Continuous use of HCQ may provide beneficial effects to the silent cardiac impairment.\u003c/p\u003e "},{"header":"Abbreviations","content":" \u003cdiv class=\"DefinitionList\"\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eSLE\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003esystemic lupus erythematosus\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLVEF\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eleft ventricular ejection fraction\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eSTE\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eSpeckle-tracking echocardiography (STE)\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePSD\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003epeak systolic dispersion\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLVMD\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eLV mechanical dyssynchrony\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eCVD\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ecardiovascular disease\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eHCQ\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eHydroxychloroquine\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eACR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eAmerican College of Rheumatology\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eSLICC\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eSystemic Lupus International Collaborating Clinics\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eSLEDAI-2K\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eSystemic Lupus Erythematosus Disease Activity Index-2K\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eaPL\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eantiphospholipid antibody\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLVEDD\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eleft ventricular end-diastolic diameters\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eLVESD\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eleft ventricular end-systolic diameters\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eIVS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003einterventricular septal\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ePWT\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eposterior wall thickness\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eGLS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eglobal longitudinal strain\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eGCS\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eglobal circumference strain\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eNT-proBNP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003en-terminal pro-b-type natriuretic peptide\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003ehsCRP\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003ehigh sensitivity C-reactive protein\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eESR\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eerythrocyte sedimentation rate\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003cdiv class=\"DefinitionListEntry\"\u003e \u003cdiv class=\"Term\"\u003eHFpEF\u003c/div\u003e \u003cdiv class=\"Description\"\u003e \u003cp\u003eheart failure with preserved ejection fraction\u003c/p\u003e \u003c/div\u003e \u003c/div\u003e \u003c/div\u003e "},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe study was approved by the ethics committee of the Second Affiliated Hospital of Fujian Medical University. All patients and controls gave signed informed consent.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll authors consented to the publication of this manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that there are no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by Key Clinical Specialty Discipline Construction Program of Fujian, China, Natural Science Foundation of Fujian Province (grant No. 2019J01473) and Science and Technology Program of Quanzhou (grant No. 2018N014S, 2017Z009).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors' contributions\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eT Luo and Z Wang contribute equally to this article. Conception and design: C Fang, T Luo; Administrative support: Z Wang, Z Chen; Collection and assembly of data: Z Wang, T Luo, C Fang; Data analysis and interpretation: C Fang, E Yu, T Luo; Manuscript writing: T Luo, C Fang; Final approval of manuscript: All authors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCorresponding author\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eCorrespondence to Chenglong Fang.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors thank Peng Guo for the excellent technical assistance.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e \u003cspan\u003eThomas G, Mancini J, Jourde-Chiche, et al. Mortality associated with systemic lupus erythematosus in France assessed by multiple-cause-of-death analysis [J]. Arthritis Rheumatol. 2014;66(9):2503\u0026ndash;11.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eBernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus [J]. Arthr Rhuem. 2006;54(8):2550\u0026ndash;7.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eGuo Q, Wu LM, Wang Z, et al. Early Detection of Silent Myocardial Impairment in Drug-Naive Patients With New-Onset Systemic Lupus Erythematosus: A Three-Center Prospective Study[J]. Arthritis Rheumatol. 2018, (12):2014\u0026ndash;2024.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eMor-Avi V, Lang RM, Badano LP, et al. Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. Eur J Echocardiogr. 2011;12(3):167\u0026ndash;205.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eVoigt JU, Pedrizzetti G, Lysyansky P, et al. Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI/ASE/Industry Task Force to standardize deformation imaging[J]. J Am Soc Echocardiogr. 2015;28(2):183\u0026ndash;93.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eSarvari SI, Haugaa KH, Zahid W, et al. Layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant CAD in patients with non-ST-segment elevation acute coronary syndrome[J]. JACC Cardiovasc Imaging. 2013;6(5):535\u0026ndash;44.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eBiering-S\u0026oslash;rensen T, Shah SJ, Anand I, et al. Prognostic importance of left ventricular mechanical dyssynchrony in heart failure with preserved ejection fraction[J]. Eur J Heart Fail. 2017;19(8):1043\u0026ndash;52.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eHaugaa KH, Grenne BL, Eek CH, et al. Strain echocardiography improves risk prediction of ventricular arrhythmias after myocardial infarction[J]. JACC Cardiovasc Imaging. 2013;6(8):841\u0026ndash;50.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eFloris A, Piga M, Mangoni AA, et al. Protective Effects of Hydroxychloroquine against Accelerated Atherosclerosis in Systemic Lupus Erythematosus[J]. Mediators Inflamm. 2018 Feb 18;2018:3424136.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003ePetri M, Orbai AM, Alarc\u0026oacute;n GS, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics Classification Criteria for systemic lupus erythematosus[J]. Arthritis Rheum. 2012;64(8):2677\u0026ndash;86.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eOzawa K, Funabashi N, Sugiura A, et al. Layer specific strain measurement and its relationship to heart failure indicators in systemic autoimmune disorder patients: A multi-layer transthoracic echocardiography study[J]. Int J Cardiol. 2016 Oct;1:220:693\u0026ndash;9.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eCarlsson M, Heiberg E, Ostenfeld E, et al. Functional Contribution of?Circumferential Versus Longitudinal Strain[J]. J Am Coll Cardiol. 2018;71(2):254\u0026ndash;5.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eStokke TM, Hasselberg NE, Smedsrud MK, et al. Geometry as a Confounder When Assessing Ventricular Systolic Function: Comparison Between Ejection Fraction and Strain[J]. J Am Coll Cardiol. 2017;70(8):942\u0026ndash;54.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eKraigher-Krainer E, Shah AM, Gupta DK, et al. Impaired systolic function by strain imaging in heart failure with preserved ejection fraction[J]. J Am Coll Cardiol. 2014;63(5):447\u0026ndash;56.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eCianciulli TF, Saccheri MC, R\u0026iacute;solo MA, et al. Mechanical dispersion in Fabry disease assessed with speckle tracking echocardiography[J]. Echocardiography. 2020;37(2):293\u0026ndash;301.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eLavall D, Kuprat LK, Kandels J, et al. Left ventricular mechanical dispersion in flow-gradient patterns of severe aortic stenosis with narrow QRS complex[J]. Int J Cardiovasc Imaging. 2020;36(4):605\u0026ndash;14.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eLeong DP, Hoogslag GE, Piers SR, et al. The relationship between time from myocardial infarction, left ventricular dyssynchrony, and the risk for ventricular arrhythmia: speckle-tracking echocardiographic analysis[J]. J Am Soc Echocardiogr. 2015;28(4):470\u0026ndash;7.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eFudim M, Fathallah M, Shaw LK, et al. The Prognostic Value of Diastolic and Systolic Mechanical Left Ventricular Dyssynchrony Among Patients With Coronary Heart Disease[J]. JACC Cardiovasc Imaging. 2019 Jul;12(7 Pt 1):1215\u0026ndash;26.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eChen J, Kalogeropoulos AP, Verdes L, et al. Left-ventricular systolic and diastolic dyssynchrony as assessed by multi-harmonic phase analysis of gated SPECT myocardial perfusion imaging in patients with end-stage renal disease and normal LVEF[J]. J Nucl Cardiol. 2011;18(2):299\u0026ndash;308.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eSanghera C, Wong LM, Panahi M, et al. Cardiac phenotype in mouse models of systemic autoimmunity[J]. Dis Model Mech. 2019 Mar 8;12(3). pii: dmm036947.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eBessant R, Duncan R, Ambler G, et al. Prevalence of Conventional and Lupus-Specific Risk Factors for Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: A Case\u0026ndash;Control Study[J]. Arthritis Rheum. 2006;55(6):892\u0026ndash;9.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eRoman MJ, Crow MK, Lockshin MD. Rate and determinants of progression of atherosclerosis in systemic lupus erythematosus[J]. Arthritis Rheum. 2007;56(10):3412\u0026ndash;9.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eSkaggs BJ, Hahn BH, McMahon M. Accelerated atherosclerosis in patients with SLE-mechanisms and management[J]. Nat Rev Rheumatol. 2012;8(4):214\u0026ndash;23.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eMcHugh J. Systemic lupus erythematosus: Atherosclerosis confined to patients with nephritis[J]. Nat Rev Rheumatol. 2017;13:322.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eLabonte AC, Kegerreis B, Geraci NS, et al. Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus[J]. PLoS One. 2018;13(12):e0208132.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eBenagiano M, Borghi MO, Romagnoli J, et al. Interleukin-17/Interleukin-21 and Interferon-γ producing T cells specific for β2 Glycoprotein I in atherosclerosis inflammation of systemic lupus erythematosus patients with antiphospholipid syndrome[J]. Haematologica. 2019;104(12):2519\u0026ndash;27.\u003c/span\u003e \u003c/li\u003e \u003cli\u003e \u003cspan\u003eGustafsson JT, Herlitz Lindberg M, Gunnarsson I, et al. Excess atherosclerosis in systemic lupus erythematosus, -A matter of renal involvement: Case control study of 281 SLE patients and 281 individually matched population controls. PLoS One. 2017;12(4):e0174572.\u003c/span\u003e \u003c/li\u003e\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Layer-specific speckle‐tracking echocardiography; left ventricular dyssynchrony; systemic lupus erythematosus","lastPublishedDoi":"10.21203/rs.3.rs-28237/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-28237/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003ch2\u003eBackground\u003c/h2\u003e \u003cp\u003eLayer-specific speckle-tracking echocardiography (STE) is a noninvasive approach assessing subclinical left ventricular (LV) dysfunction. We aimed to investigate: (I) layer‐specific strain and dyssynchrony index alteration; (II) disease parameters associated with layer-specific STE change; (III) effects of hydroxychloroquine (HCQ) therapy on layer-specific STE parameters in drug-na\u0026iuml;ve patients with new-onset systemic lupus erythematosus (SLE) without cardiac symptoms.\u003c/p\u003e\u003ch2\u003eMethods\u003c/h2\u003e \u003cp\u003e35 drug-na\u0026iuml;ve patients with new-onset SLE and 25 age-and-sex-matched healthy controls were enrolled. All individuals received both conventional echocardiographic and two-dimensional STE assessment. Layer-specific global longitudinal strain (GLS), global circumferential strain (GCS) and peak systolic dispersion (PSD) were acquired in layer-specific STE. The effect of HCQ monotherapy on GLS parameters and PSD was assessed in 7 SLE patients with stable disease.\u003c/p\u003e\u003ch2\u003eResults\u003c/h2\u003e \u003cp\u003eAll patients had normal left ventricular ejection fraction (LVEF). Conventional echocardiographic parameters were comparable between patients and controls. Decreased layer-specific GLS and elevated PSD were observed in SLE patients. In contrast, there\u0026rsquo;s no difference of layer-specific GCS at the basal level, papillary muscle level and apical level between patients and controls. More severely impaired GLS was observed in patients with higher disease activity, high-risk aPL profile or renal involvement. PSD increased in patients with higher disease activity or high-risk aPL profile. Correlational analysis showed that GLS at three layers and PSD correlated with high-sensitivity CRP (hsCRP) levels. PSD correlated with epicardial GLS, when treating hsCRP level, renal involvement, profile of aPL and disease activity as control variables. Multivariate regression showed hsCRP level and epicardial GLS are the predictors of layer-specific GLS impairment and elevated PSD, respectively. No change of GLS at three layers or PSD was observed in the first 6 months of HCQ treatment, compared with baseline. During the second 6 months of HCQ treatment, increase of endocardial GLS and whole layer GLS, and decrease of PSD were detected. There was no change of epicardial GLS during follow-up.\u003c/p\u003e\u003ch2\u003eConclusion\u003c/h2\u003e \u003cp\u003eDrug-na\u0026iuml;ve patients with new-onset SLE, even having normal LVEF, are likely to have subclinical GLS impairment and LV dyssynchrony. SLE-related risk factors are associated with these dysfunctions. Continuous use of HCQ may provide beneficial effects to the silent cardiac impairment.\u003c/p\u003e","manuscriptTitle":"Layer‐specific strain and dyssynchrony index alteration in new-onset systemic lupus erythematosus patients without cardiac symptom","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-05-15 19:31:39","doi":"10.21203/rs.3.rs-28237/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"dd446709-803a-40f0-93b5-dc2264d0589f","owner":[],"postedDate":"May 15th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":101429,"name":"Rheumatology"}],"tags":[],"updatedAt":"2020-06-05T17:05:37+00:00","versionOfRecord":[],"versionCreatedAt":"2020-05-15 19:31:39","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-28237","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-28237","identity":"rs-28237","version":["v1"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}