Urine metabolomic study of primary dysmenorrhea patients during menstrual period using an ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS)

Ling Fang, Na Dai, Lei Wang, Xiuxiu Zhang, Xinyu Liu, Yuming Wang, Yubo Li
In: RSC Adv. · 2014 · vol. 4(83) , pp. 44208–44213 · doi:10.1039/c4ra06860b · W2091065446
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

This study used UPLC-Q-TOF-MS-based metabolomics to identify differences in urine metabolites between primary dysmenorrhea patients and healthy controls, revealing metabolomics as an effective tool for studying PD pathogenesis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-13 · read from full text ⓘ

This urine metabolomics study used an ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS) platform to compare small-molecule metabolite profiles between primary dysmenorrhea patients and healthy controls, with all urine samples collected during the menstrual period. The authors applied multivariate statistical analyses to identify differences in metabolites and report that metabolomics is an effective approach for studying the pathogenesis of primary dysmenorrhea and for highlighting potentially important substances involved in the condition. A key limitation stated in the abstract is that the study focuses on demonstrating the metabolomic profiling approach for PD rather than providing detailed diagnostic performance or mechanistic validation. Relevance to endometriosis: the paper cites clinical data that many endometriosis patients have dysmenorrhea symptoms, though its main focus is primary dysmenorrhea metabolomic profiling.

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Abstract

Primary dysmenorrhea (PD) is a common gynecological disease that can seriously affect women's health, lives, and work. Numerous clinical data have shown that the majority of endometriosis and ovarian cancer patients have symptoms of dysmenorrhea. In this study, we established a method based on metabolomic profiling to investigate the differences in small molecule metabolites in urine samples between PD patients and healthy controls. All samples were measured by ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and analyzed by multivariate statistical methods. Findings show that metabolomics is an effective tool for studying the pathogenesis of PD which could quickly determine the important substances involved in PD, which may be beneficial for the clinical diagnosis and treatment of this disease.
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Urine metabolomic study of primary dysmenorrhea patients during menstrual period using an ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC-Q-TOF-MS)† Abstract Primary dysmenorrhea (PD) is a common gynecological disease that can seriously affect women's health, lives, and work. Numerous clinical data have shown that the majority of endometriosis and ovarian cancer patients have symptoms of dysmenorrhea. In this study, we established a method based on metabolomic profiling to investigate the differences in small molecule metabolites in urine samples between PD patients and healthy controls. All samples were measured by ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry and analyzed by multivariate statistical methods. Findings show that metabolomics is an effective tool for studying the pathogenesis of PD which could quickly determine the important substances involved in PD, which may be beneficial for the clinical diagnosis and treatment of this disease.

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endometriosisdysmenorrhea

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