The Establishment of Endometriosis models and Histological Observation in experimental Rats

Objective To research the endometriosis and get some ideal animal models. Methods Endometriosis was surgically induced in 60 rats. The growth of the transplant and rats'estrus cycle was observed by the means of optical microscope, electronmicroscpoe and the hisochemistry method in different time after the implantation operation. Results There was 60% transplant to develop. The inner wall of the cyst had endometrum epithelial cell,and it altered cycle with the normal endometrum. The cysts enlarged graduall at first and had contracted tendency after that, and the cysts on the utero ligment were bigger than the ones in the abdominal wall and the crossing site of the uterus in the same time. But there is no difference in the abdominal wall and the crossing site of the uterus.Conclusion The model of endometriosis in a rat established by implanting the self-endometrum to the utero ligament or the abdominal wall or the crossing site of the uterus is the convenient method to study the endometriosis. This ectopic endometrium can change corresponding the reproductive cycle, and has physiological function like the normal endometrum.