PHARMACO-EPIDEMIOLOGY OF OPPORTUNISTIC INFECTIONS AMONG THE PATIENTS ON ANTI-RETROVIRAL THERAPY

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Abstract

Background: 650,000 people died from AIDS-related illnesses worldwide in 2021. Opportunistic infections (OIs) are occurring more frequently and with progressive severity among the people infected with the Human Immunodeficiency Virus (HIV) with wide variation based on epidemiological area. Objectives: To evaluate the distribution of opportunistic infections among the patients undergoing ART and various drug use indicators, utilization patterns, interactions, adverse effects of the drugs among the patients with OIs, undergoing ART. Method: ology: Ambispective study. The present study included 424 patients diagnosed with retroviral disease and on treatment at the ART center, RRMCH. Demographic data, viral load, blood investigations, and presenting complaints at each follow-up were assessed. Results: : The Average age of our study population was 42.85 years, with male predominance. 4.7% (20/424) of the patients with OI had poor adherence. 89% are alive, 5% died during treatment. The rest had transferred out. 41.7% (48/115) presenting with tuberculosis was the commonest opportunistic infection, and thus, the anti-TB drugs were the most frequent drugs used. Conclusion: Management of opportunistic infections regularly is one of the crucial exploratory tools to determine the role of drugs and their changing trend; there has been a reduction in CD4 count even with newer ART drugs, and hence, the OIs.
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Data may be preliminary. 23 April 2025 V1 Latest version Share on PHARMACO-EPIDEMIOLOGY OF OPPORTUNISTIC INFECTIONS AMONG THE PATIENTS ON ANTI-RETROVIRAL THERAPY Authors : Manjula MJ 0000-0002-6976-8312 [email protected] , Vikas BR , and Balaji V Authors Info & Affiliations https://doi.org/10.22541/au.174539184.45398006/v1 188 views 97 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Background: 650,000 people died from AIDS-related illnesses worldwide in 2021. Opportunistic infections (OIs) are occurring more frequently and with progressive severity among the people infected with the Human Immunodeficiency Virus (HIV) with wide variation based on epidemiological area. Objectives: To evaluate the distribution of opportunistic infections among the patients undergoing ART and various drug use indicators, utilization patterns, interactions, adverse effects of the drugs among the patients with OIs, undergoing ART. Methodology: Ambispective study. The present study included 424 patients diagnosed with retroviral disease and on treatment at the ART center, RRMCH. Demographic data, viral load, blood investigations, and presenting complaints at each follow-up were assessed. Results: The Average age of our study population was 42.85 years, with male predominance. 4.7% (20/424) of the patients with OI had poor adherence. 89% are alive, 5% died during treatment. The rest had transferred out. 41.7% (48/115) presenting with tuberculosis was the commonest opportunistic infection, and thus, the anti-TB drugs were the most frequent drugs used. Conclusion: Management of opportunistic infections regularly is one of the crucial exploratory tools to determine the role of drugs and their changing trend; there has been a reduction in CD4 count even with newer ART drugs, and hence, the OIs. Supplementary Material File (ois in art.docx) Download 111.88 KB Information & Authors Information Version history V1 Version 1 23 April 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Manjula MJ 0000-0002-6976-8312 [email protected] Dr MGR Educational and Research Institute View all articles by this author Vikas BR Dr MGR Educational and Research Institute View all articles by this author Balaji V Dr MGR Educational and Research Institute View all articles by this author Metrics & Citations Metrics Article Usage 188 views 97 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Manjula MJ, Vikas BR, Balaji V. PHARMACO-EPIDEMIOLOGY OF OPPORTUNISTIC INFECTIONS AMONG THE PATIENTS ON ANTI-RETROVIRAL THERAPY. Authorea . 23 April 2025. DOI: https://doi.org/10.22541/au.174539184.45398006/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . 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