Systematic review  of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications

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In recent decades, growing scientific interest has highlighted their potential contributions to healthcare systems, biodiversity conservation, and the preservation of cultural heritage. However, the integration of ethnomedicinal knowledge into modern medicine faces persistent challenges, particularly the lack of standardized documentation protocols and rigorous scientific validation. In this context, the present systematic review aims to assess the documentation, evaluation, and conservation of medicinal plants and their therapeutic applications across diverse cultural settings. A systematic literature review (SLR) was conducted following PRISMA guidelines, using Scopus, EBSCO, and Web of Science databases to identify peer-reviewed studies published between 2007 and 2024. Seventy studies met the inclusion criteria and were analyzed thematically to identify trends, methodological approaches, and research gaps. The findings reveal a wide diversity of medicinal plants and ethnomedicinal practices, with a strong emphasis on the documentation and conservation of traditional knowledge. Nevertheless, significant gaps persist in terms of phytochemical, pharmacological, and clinical validation, as well as in the integration of ethnomedicinal knowledge into conservation and public health policies. The thematic analysis underscores the need for standardized methodological frameworks and multidisciplinary approaches to strengthen the scientific validation, conservation, and intergenerational transmission of ethnomedicinal knowledge, ensuring its relevance for modern medicine and sustainable development." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/13-1324", "name": "Systematic review of ethnomedicinal knowledge: Documentation, evaluation,..." } } ] } Home Browse Systematic review of ethnomedicinal knowledge: Documentation, evaluation,... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Duche-Pérez A, Gutiérrez Aguilar OA, Valero Quispe JL et al. Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.12688/f1000research.157960.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Systematic Review Revised Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] Aleixandre Duche-Pérez https://orcid.org/0000-0001-9905-1489 1 , Olger Albino Gutiérrez Aguilar 1 , Javier Lucho Valero Quispe 1 , Alison Serruto Castillo 1 , Lolo Juan Mamani Daza 2 Aleixandre Duche-Pérez https://orcid.org/0000-0001-9905-1489 1 , Olger Albino Gutiérrez Aguilar 1 , [...] Javier Lucho Valero Quispe 1 , Alison Serruto Castillo 1 , Lolo Juan Mamani Daza 2 PUBLISHED 22 Dec 2025 Author details Author details 1 Universidad Catolica de Santa Maria de Arequipa, Arequipa, Arequipa, 04002, Peru 2 Universidad Nacional de San Agustin de Arequipa, Arequipa, Arequipa, 04000, Peru Aleixandre Duche-Pérez Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Olger Albino Gutiérrez Aguilar Roles: Conceptualization, Formal Analysis, Investigation, Methodology, Validation, Visualization, Writing – Original Draft Preparation Javier Lucho Valero Quispe Roles: Conceptualization, Formal Analysis, Investigation, Supervision, Visualization, Writing – Original Draft Preparation Alison Serruto Castillo Roles: Conceptualization, Formal Analysis, Investigation, Methodology, Software, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Lolo Juan Mamani Daza Roles: Conceptualization, Formal Analysis, Methodology, Project Administration, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing OPEN PEER REVIEW DETAILS REVIEWER STATUS This article is included in the Plant Science gateway. Abstract Ethnomedicine and ethnobotany constitute key fields for understanding how different cultures document, use, and transmit knowledge related to medicinal plants and their therapeutic applications. In recent decades, growing scientific interest has highlighted their potential contributions to healthcare systems, biodiversity conservation, and the preservation of cultural heritage. However, the integration of ethnomedicinal knowledge into modern medicine faces persistent challenges, particularly the lack of standardized documentation protocols and rigorous scientific validation. In this context, the present systematic review aims to assess the documentation, evaluation, and conservation of medicinal plants and their therapeutic applications across diverse cultural settings. A systematic literature review (SLR) was conducted following PRISMA guidelines, using Scopus, EBSCO, and Web of Science databases to identify peer-reviewed studies published between 2007 and 2024. Seventy studies met the inclusion criteria and were analyzed thematically to identify trends, methodological approaches, and research gaps. The findings reveal a wide diversity of medicinal plants and ethnomedicinal practices, with a strong emphasis on the documentation and conservation of traditional knowledge. Nevertheless, significant gaps persist in terms of phytochemical, pharmacological, and clinical validation, as well as in the integration of ethnomedicinal knowledge into conservation and public health policies. The thematic analysis underscores the need for standardized methodological frameworks and multidisciplinary approaches to strengthen the scientific validation, conservation, and intergenerational transmission of ethnomedicinal knowledge, ensuring its relevance for modern medicine and sustainable development. READ ALL READ LESS Keywords Ethnomedicine, Ethnobotany, Medicinal Plants, Therapeutic Applications, Conservation of Traditional Knowledge Corresponding Author(s) Aleixandre Duche-Pérez ( [email protected] ) Close Corresponding author: Aleixandre Duche-Pérez Competing interests: No competing interests were disclosed. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2025 Duche-Pérez A et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. How to cite: Duche-Pérez A, Gutiérrez Aguilar OA, Valero Quispe JL et al. Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.12688/f1000research.157960.2 ) First published: 05 Nov 2024, 13 :1324 ( https://doi.org/10.12688/f1000research.157960.1 ) Latest published: 22 Dec 2025, 13 :1324 ( https://doi.org/10.12688/f1000research.157960.2 ) Revised Amendments from Version 1 Abstract The structure was reorganized to begin with context and background, avoiding an opening focused on results. The objective was clarified and positioned after the introductory context. The methodology (SLR–PRISMA, databases, time frame) was streamlined for clarity and coherence. Key findings and critical gaps were synthesized without overreporting results. The conclusion of the abstract was strengthened with a forward-looking emphasis on standardization and multidisciplinary approaches. Conclusion The text was shortened and content resembling results or discussion was removed. The conclusion was reframed as a strategic synthesis rather than a descriptive summary. Concrete policy recommendations, integration strategies with modern pharmacology, and conservation framework models were explicitly introduced. A clearer future-oriented perspective was added, addressing globalization, migration, and climate change. Abstract The structure was reorganized to begin with context and background, avoiding an opening focused on results. The objective was clarified and positioned after the introductory context. The methodology (SLR–PRISMA, databases, time frame) was streamlined for clarity and coherence. Key findings and critical gaps were synthesized without overreporting results. The conclusion of the abstract was strengthened with a forward-looking emphasis on standardization and multidisciplinary approaches. Conclusion The text was shortened and content resembling results or discussion was removed. The conclusion was reframed as a strategic synthesis rather than a descriptive summary. Concrete policy recommendations, integration strategies with modern pharmacology, and conservation framework models were explicitly introduced. A clearer future-oriented perspective was added, addressing globalization, migration, and climate change. To read any peer review reports and author responses for this article, follow the "read" links in the Open Peer Review table. READ REVIEWER RESPONSES Introduction Ethnomedicine, as a field dedicated to the study of traditional medical practices across diverse cultural contexts, has gained increasing attention within the scientific community due to its contribution to the documentation and preservation of ancestral knowledge related to medicinal plant use. 1 , 2 These practices embody long-standing interactions between human societies and their natural environments and represent a valuable repository of empirical knowledge that has historically informed the development of therapeutic agents and continues to inspire contemporary pharmacological research. 3 , 10 In recent decades, ethnomedicinal research has expanded globally, particularly in regions characterized by high biodiversity and strong ethnobotanical traditions, where medicinal plants remain central to primary healthcare systems. 22 , 25 This growing body of literature underscores the importance of systematically documenting traditional knowledge, not only to safeguard cultural heritage but also to support biodiversity conservation and the sustainable use of plant resources. 6 , 43 Empirical studies from different geographical contexts illustrate these dynamics. Research conducted in Tanzania emphasized the urgency of documenting medicinal plant species used in traditional healthcare, especially in communities with limited access to modern medical services. 1 Similarly, ethnomedicinal surveys among the Chakma tribe in Bangladesh highlighted the central role of local healers in preserving and transmitting plant-based medical knowledge. 2 In India, studies assessing the antimicrobial activity of medicinal plants provided evidence supporting the therapeutic potential of traditionally used species, 3 while investigations in the Binalud region of Iran revealed the need for rigorous methodological frameworks to validate ethnomedicinal data and contextualize it within ecological and phytochemical analyses. 4 Additional contributions from Ethiopia, Mexico, and other regions further demonstrate the diversity and depth of ethnomedicinal knowledge worldwide. Studies documenting medicinal plant use in Ethiopian communities emphasized the vulnerability of traditional practices in contexts of rapid socio-cultural transformation, 5 while comparative analyses in Mexico highlighted how processes of acculturation influence the transmission and retention of ethnobotanical knowledge. 6 Collectively, these studies reveal both the richness of ethnomedicinal systems and the unevenness of methodological approaches employed to document and evaluate them. Despite the growing volume of research, ethnomedicinal knowledge faces increasing threats from globalization, environmental degradation, and climate change, which contribute to the erosion of both cultural traditions and biological diversity. 25 , 39 The loss of traditional knowledge, particularly among younger generations, raises critical concerns regarding the long-term continuity of ethnomedicinal practices and the conservation of medicinal plant species. These challenges underscore the need for integrative strategies that combine systematic documentation, scientific evaluation, and conservation-oriented frameworks. Against this background, this systematic review aims to provide a comprehensive synthesis of existing research on the documentation, evaluation, and conservation of medicinal plants and their therapeutic applications within ethnomedicinal contexts, offering a consolidated foundation to inform future scientific inquiry and evidence-based conservation policies. Methods To achieve the objectives set out in this research, a systematic study was conducted, rigorously following the guidelines of the PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). 73 This protocol was selected due to its wide acceptance and application in systematic reviews, ensuring a structured and thorough approach to data collection, analysis, and presentation. Additionally, to guarantee a high level of quality, transparency, and reproducibility of the study, it was complemented by a specific evaluation criteria checklist for systematic reviews. 74 These criteria were fundamental in ensuring that all aspects of the review process were conducted rigorously and methodically. Search strategy During the search process, various specialized databases were exhaustively explored, including EBSCO, Scopus, and Web of Science. These databases were chosen for their broad coverage and for hosting a significant number of internationally relevant scientific publications. The search focused on identifying articles published in high-impact scientific journals, ensuring that the included studies were contemporary and relevant to the research topic. Despite the search’s scope, no prior systematic reviews specifically addressing ethnomedicinal knowledge in terms of the documentation, evaluation, and conservation of medicinal plants and their therapeutic applications were found. This finding underscores the originality and necessity of the present review to fill this gap in the scientific literature. This study arises from a research question: What is the diversity and therapeutic value of medicinal plants documented in various cultures, and how have their ethnomedicinal applications been evaluated in the scientific literature? The search was conducted in English, using the following keywords and their associated or related concepts: ethnomedicine (ancestral medicine, cultural medicine, folk medicine, indigenous medicine, natural medicine, traditional herbal medicine, traditional medicine) and medicinal plants (curative plants, healing herbs, healing plants, herbal medicine plants, herbal remedies, medicinal botanicals, medicinal flora, medicinal herbs). In this sense, the search equation used was: (ethno OR ancestral OR cultur OR folk OR indigen* OR natura* OR tradition*) AND (medicin* OR curativ* OR remed* OR healing) AND (plant* OR herb* OR flora OR botanic*). Inclusion and exclusion criteria For the systematic review, only articles published in peer-reviewed scientific journals indexed in the Scopus, EBSCO, and Web of Science (Core Collection) databases during the period from 2007 to July 2024 were included. These studies were written in English and directly addressed topics related to the documentation, evaluation, and conservation of medicinal plants in the context of ethnomedicine. Relevant studies investigated traditional knowledge, therapeutic applications, and the cultural value of medicinal plants in various cultures worldwide. Additionally, the selected articles included in their descriptors or abstracts terms associated with “ethnomedicine” (e.g., ancestral medicine, cultural medicine, folk medicine) and “medicinal plants” (e.g., curative plants, healing herbs, etc.), ensuring their thematic relevance to the review objectives. On the other hand, studies that did not meet the previously mentioned criteria were excluded. This includes publications that were not peer-reviewed, such as literature reviews, editorials, letters to the editor, conference abstracts, and preliminary studies. Studies published outside the range of 2007 to 2024, as well as those written in languages other than English, were also excluded. Additionally, studies that did not focus on ethnomedicine or the therapeutic application of medicinal plants, especially those limited exclusively to pharmacological aspects without an ethnobotanical context, were excluded. Finally, duplicate or overlapping studies and those that did not provide sufficient detail on the evaluation, documentation, or conservation of ethnomedicinal knowledge were discarded, ensuring that only high-quality and relevant research was included in the review. Document selection procedure The researchers followed a multi-stage procedure to determine the final selection of articles. The initial database search yielded a list of 6,473 documents (N). Upon reviewing each title, 729 documents were unavailable, reducing the total to 5,744. Then, 359 duplicate titles across the databases were identified and removed. Subsequently, each document was reviewed to ensure it met the established criteria. The results were as follows: articles in languages other than English (142), non-empirical works (1,847), studies that did not focus on ethnomedicine or the therapeutic application of medicinal plants (1,932) and works that were not scientific articles (925). Ultimately, 469 documents that did not provide sufficient detail on the evaluation, documentation, or conservation of ethnomedicinal knowledge were discarded, resulting in a final sample of 70 documents that met the inclusion and exclusion criteria for this systematic review. Data analysis Given that this review demands a deeper level of detail, it was deemed essential to compile a table that gathered key information. This table includes data on the year of publication, source of the research, theoretical framework adopted, type of study conducted, instruments used, perspective addressed, study population, stated objectives, obtained conclusions, as well as the language in which the work was published. Additionally, to enrich the analysis, a comparative analysis was conducted among the selected studies, allowing for the identification of significant similarities and differences in the approaches and findings presented in the reviewed literature. This comprehensive approach not only facilitates the organization and analysis of the data but also enables a better understanding of trends and patterns in ethnomedicinal research. Results After completing the search and reviewing the results according to the established methodology, a sample of 70 documents was selected. These documents were then organized and classified based on various criteria. Table 1. Synthesis of Selected Articles (refer to extended data) provides a summary of the articles identified in this process. 71 Evolution of scientific production: Periods and areas of study The analysis of the evolution of publications reveals significant development in the depth and focus of studies over the years. Figure 1. Number of studies published during the period from 2007 to July 2024 (refer to extended data) shows the number of studies published per year. 72 The selected studies are categorized by periods as follows: (1) Beginnings Focused on Documentation and Evaluation (2007-2010): In the early years, research primarily centered on the identification and documentation of medicinal plants, as well as the collection of information about their potential applications, such as dietary supplements. 1 , 2 Starting in 2008, studies began analyzing the microbial activity of plants, marking a more quantitative and scientific approach. 3 Between 2009 and 2010, there was an increase in research aimed at understanding the chemical and pharmacological properties of plants, 4 , 8 as well as evaluating their medicinal value in ethnoecological contexts. 9 (2) Expansion Towards Conservation and Therapeutic Applications (2011-2014): Between 2011 and 2014, a broader and more diverse approach was observed. Research began incorporating mixed methodologies, combining the collection of ethnomedicinal data with the analysis of the conservation status of medicinal plants. 12 , 13 During this period, greater emphasis was also placed on evaluating the toxicity and therapeutic activity of plants. 11 By 2014, studies focused on documenting indigenous medicinal plants, underscoring the importance of preserving traditional knowledge within local health systems. 22 (3) Consolidation and Diversification of Studies (2015-2019): From 2015 onwards, efforts to document and conserve ethnomedicinal knowledge were consolidated, but with a more specialized focus. For example, research focused on specific ethnomedicinal plants for treating gastrointestinal issues, 27 while other studies expanded the scope to include indigenous knowledge and medical practices in communities. 29 , 6 This trend continued until 2019, with research aimed at verifying the effectiveness of plants in specific treatments, such as diabetes, 38 and documenting the use of plants in specific regions. 37 (4) Towards Global Integration and Database Creation (2020-2024): In recent years, from 2020 to 2024, research has shifted towards the integration of knowledge and the creation of extensive and comprehensive databases. Some studies have worked on the systematic quantification and documentation of wild medicinal plants and their therapeutic applications. 43 , 54 Additionally, there is a growing focus on the conservation of ethnomedicinal knowledge and its promotion in global contexts. 44 , 48 Finally, by 2024, studies continue to deepen the documentation and conservation efforts, with greater consideration of cultural and ecolinguistic factors. 69 Over the years, publications have evolved from an initial focus on the basic documentation and evaluation of medicinal plants to a more integrative and multidisciplinary approach, encompassing not only the conservation of traditional knowledge but also its scientific validation and preservation in global databases. This distribution reflects a strong concentration of studies in countries with rich traditions in the use of medicinal plants and significant biological diversity, highlighting the global importance of ethnomedicine and ethnobotany. The current literature review identified: India leads with 15 studies on ethnomedicinal knowledge, documentation, evaluation, and conservation of medicinal plants, reflecting its rich biodiversity and extensive tradition in the use of these plants. Pakistan follows with 12 studies focused on the documentation and analysis of traditional knowledge, while Bangladesh, with 10 studies, stands out for its focus on the conservation of ethnomedicinal practices. Indonesia, with 8 studies, shows strong interest in documenting and exploring the use of plants in traditional medicine, and Nigeria, with 5 studies, focuses on the evaluation of medicinal properties and documentation in rural communities. Nepal and Tanzania, with 3 studies each, have contributed to the documentation and analysis of medicinal plant use in mountainous communities and the conservation of local species, respectively. Other countries, such as Mexico, Morocco, Bolivia, Venezuela, Binalud, Jordan, Papua New Guinea, China, Zimbabwe, the Philippines, Namibia, Serbia, Malaysia, and Ethiopia, have conducted one study each, demonstrating interest in the preservation and analysis of ethnomedicinal knowledge within their unique cultural and ecological contexts. Balance of objectives In the field of ethnomedicine and ethnobotany, the diversity of research conducted reflects a broad range of objectives, from the documentation and preservation of traditional knowledge to the evaluation of medicinal properties and the ecological impact of plant use. Categorizing these objectives into groups according to their general purpose provides a clearer understanding of how each study contributes to preserving and expanding knowledge about medicinal plants. Below are six main categories that group these objectives: (1) Documentation and Preservation of Ethnomedicinal Knowledge: This group of objectives focuses on the collection, preservation, and promotion of traditional ethnomedicinal knowledge, which is essential for keeping ancestral practices related to the use of medicinal plants alive: • Document medicinal plant species, practices, and traditional knowledge: Studies in this subgroup are dedicated to identifying and documenting the medicinal plants used in different communities, as well as gathering information on ethnomedicinal practices and knowledge. This includes research that identifies and documents plant species, and studies that gather information on medicinal plants used by folk practitioners. Other studies also contribute to creating detailed databases that preserve this knowledge, developing databases of medicinal plant species. 1 , 8 , 18 • Preserve ethnomedicinal knowledge and promote future studies: This subgroup includes objectives that not only document ethnomedicinal knowledge but also focus on its preservation and the promotion of additional research. For example, some studies focus on preserving ethnomedicinal knowledge to ensure that future generations can benefit from this cultural heritage. 44 , 62 (2) Evaluation of Medicinal Properties and Therapeutic Activities: This group centers on the scientific evaluation of the medicinal properties of plants and their effectiveness in treating various diseases, bridging tradition with scientific validation: • Evaluate antimicrobial, antitrypanosomal, and other therapeutic activities: Studies in this category are dedicated to analyzing the specific therapeutic properties of plants, such as their antimicrobial and antitrypanosomal activities. These studies are crucial for scientifically validating the traditional applications of plants in medicine. 3 , 10 • Evaluate plant extracts and their toxicity: This category includes studies that, in addition to evaluating the therapeutic properties of plants, examine the toxicity of their extracts to ensure their safety. Some studies focus on analyzing the safety of these extracts through in vitro and in vivo tests. 11 (3) Analysis of Bioactive Components and Pharmacological Studies: The objectives in this category aim to identify and analyze the bioactive components of medicinal plants and evaluate their potential in developing new pharmacological treatments. • Review bioactive components and pharmacological activities: Studies in this category focus on reviewing the bioactive components of plants and their pharmacological activities, contributing to the scientific understanding of the active principles underlying ethnomedicinal practices. 8 , 9 • Evaluate the effectiveness of medicinal plants and develop new treatments: Studies in this category aim not only to validate the effectiveness of traditional medicinal plants but also to explore their potential for developing new pharmacological treatments. 20 , 22 (4) Documentation and Evaluation of Indigenous Knowledge and Traditional Practices: This category focuses on the detailed study of indigenous knowledge and traditional healing practices, which are essential for understanding the diversity and richness of the use of medicinal plants in different cultures. • Study indigenous knowledge on the use of medicinal plants: Some studies are dedicated to investigating and documenting indigenous knowledge about the use of medicinal plants, providing a deep insight into how communities have utilized these resources over generations. 4 , 20 • Study healing practices in rural communities: This subtitle groups studies that focus on the specific healing practices of rural communities. Research documents and analyzes how rural communities use medicinal plants in their healing practices. 34 , 42 (5) Creation of Databases and Catalogs of Medicinal Plants: In this category, studies focus on the creation of databases and catalogs that compile and organize information on medicinal plants, facilitating future access and research on these species. • Create databases of medicinal plants used in various regions: Studies aim to compile detailed information in databases covering medicinal plants used in various regions, enabling better organization and access to this knowledge. 18 , 45 • Catalog medicinal plants used by ethnic groups: This subgroup includes studies that focus on cataloging the medicinal plants used by different ethnic groups, highlighting the cultural diversity in the use of these resources. 64 , 54 (6) Study of Ecological Impact and Conservation of Medicinal Plants: The objectives in this category are aimed at investigating the ecological impact of medicinal plant use and developing strategies for their conservation, ensuring that these practices can continue in the future: • Investigate the ecological impact and conservation of medicinal plants: Studies in this category are dedicated to understanding how the practices of harvesting and using medicinal plants impact the ecological environment, proposing measures to conserve these plants and their habitats. 4 , 25 Methodological overview In the reviewed studies on ethnomedicinal knowledge, the methodological approaches are primarily divided into three categories: quantitative, qualitative, and mixed methods. The quantitative approach is predominant, utilized in 32 of the 70 reviewed studies. These studies focus on the collection and analysis of numerical data through surveys, structured questionnaires, and laboratory experiments. For example, a quantitative approach was employed to collect and analyze medicinal herbs using semi-structured questionnaires and laboratory tests, while other studies documented traditional knowledge through semi-structured questionnaires. 9 , 61 Qualitative studies make up a significant portion of the total, with 26 investigations. This approach is mainly used to explore and understand traditional knowledge, often through interviews, direct observations, and ethnographic techniques. For instance, some research employed semi-structured interviews and the collection of plant samples, while other studies used the rapport technique during ethnographic interviews. 63 , 69 The mixed-methods approach, which combines quantitative and qualitative methods, was used in 12 studies. These studies integrate the collection of quantitative data with the depth of qualitative research to provide a more comprehensive analysis. For example, interviews and semi-structured questionnaires were used, combining numerical data with detailed observations. 8 Moreover, the reviewed studies employ a wide variety of techniques and instruments for data collection, each adapted to the specific objectives of the research. The most common techniques are presented below: • Semi-structured interviews and questionnaires: These are the most used instruments, present in 48 of the 70 studies. Semi-structured interviews allow researchers to collect detailed and flexible data, while questionnaires provide a structure to quantify responses. These methods were employed, for example, to explore ethnomedicinal knowledge. 23 , 34 • Direct and participant observation: This is a key technique in qualitative and mixed-method studies, used in 19 studies. This technique allows researchers to directly witness and record ethnomedicinal practices in their natural context. In some studies, direct observation was combined with questionnaires to examine the use and cultivation of medicinal plants. 32 • Field surveys: Used in 14 studies, these are a common technique in quantitative and mixed-method studies. Field surveys allow researchers to collect extensive data on the use of medicinal plants in different communities. For instance, field surveys were used along with interviews to gather detailed information on the use of plants to treat diabetes. 38 • Although less common, some studies (5 out of 70) incorporate experimental and laboratory techniques, especially in research aimed at scientifically validating the medicinal properties of plants. For example, antibacterial assays, antioxidant tests, and phytochemical analyses were conducted in laboratories to evaluate the properties of medicinal plants. 69 • The technique of guided walks and plant collection was used in 9 studies, particularly those focused on documenting plant species in their natural environment. Guided walks allow researchers to collect plants and obtain direct information from local practitioners. In terms of approach, the reviewed studies show a significant preference for the quantitative approach, though a large portion also relies on qualitative and mixed methods to address the complexity of ethnomedicinal knowledge. The combination of semi-structured interviews with direct observation and field data collection techniques stands out as the most robust methodology for documenting and analyzing the use of medicinal plants. Studies that integrate experimental techniques offer added value by validating the therapeutic applications of the documented plants, allowing for a deeper understanding and conservation of this ancestral knowledge. The employed methodology reflects a balance between extensive data collection and in-depth exploration of specific cultural contexts, which together strengthen the credibility and applicability of the findings in the field of ethnomedicine. Documentation, evaluation, and conservation of medicinal plants The documentation of medicinal plants is a fundamental activity for the preservation of ethnobotanical and ethnomedicinal knowledge, which has been passed down through generations in many cultures. This process not only involves recording the species of plants used but also capturing details about their identification, distribution, collection methods, plant parts used, remedy preparation, and therapeutic uses. It is emphasized that the systematic documentation of medicinal plants is essential to ensure that this knowledge is not lost, especially in communities where the oral transmission of knowledge is declining due to modernization and the influence of Western medicine. 1 , 17 Work in Bangladesh highlights the importance of documenting not only plant species but also the knowledge and practices of traditional healers. 2 , 8 This type of documentation is vital for maintaining the cultural and biological richness of local communities and provides a solid foundation for future research in pharmacology and conservation. On the other hand, it is illustrated how the detailed documentation of species in specific regions, such as the Wuliang Mountains in China or the Chinglai Valley in Pakistan, can help in understanding local biodiversity and the communities’ dependence on medicinal plants. 35 , 37 However, documentation faces several challenges. Acculturation, migration, and modernization have led to the loss of knowledge in many regions. It is warned that the loss of this knowledge is particularly acute among younger generations, who show a growing disinterest in traditional practices. 24 , 44 This phenomenon not only threatens the extinction of valuable knowledge but also the disappearance of plant species that could have significant undiscovered medicinal uses. To mitigate these risks, documentation must be a continuous and collaborative effort involving researchers, local communities, and conservation organizations. The integration of modern methods, such as electronic databases and digital identification tools, with traditional data collection practices can help preserve this knowledge more efficiently. Additionally, it is crucial that the documentation is accessible and available to future generations to ensure that this cultural and biological heritage is not lost. Furthermore, the scientific evaluation of medicinal plants is a crucial step in transforming traditional knowledge into validated and safe therapeutic applications. Studies are presented that demonstrate the efficacy of certain plants in antimicrobial activity, a finding that has significant implications for the development of new antibiotics in a world where antimicrobial resistance is a growing concern. 3 , 10 These studies underline the need to systematically evaluate the pharmacological properties of plants to identify bioactive compounds that can be used in modern medicine. The evaluation is not limited to antimicrobial activity alone. It has been shown how certain plant extracts can enhance the efficacy of traditional antibiotics, suggesting that combinations of plants and medications could offer new therapeutic solutions. 8 , 11 This synergistic approach between traditional and modern medicine opens a promising field for pharmacological research. However, the evaluation faces significant challenges. It is highlighted that many plants have not yet been fully studied in terms of their chemical components and biological effects. 29 , 30 The lack of detailed phytochemical studies and clinical trials is a barrier to incorporating these plants into conventional medicine. Additionally, the variability in the concentrations of active compounds, influenced by factors such as climate, soil, and collection techniques, makes the evaluation even more complex. To overcome these challenges, a multidisciplinary approach that combines ethnobotany, chemistry, molecular biology, and pharmacology is essential. This approach can help identify, isolate, and synthesize bioactive compounds from medicinal plants and evaluate their safety and efficacy through controlled clinical trials. Additionally, collaboration with local communities, who possess deep knowledge of these plants, is fundamental to directing research toward the most promising species and practices. Finally, the conservation of medicinal plants is a critical concern, as many of these species are threatened by overexploitation, habitat destruction, and climate change. It is emphasized how the commercial exploitation of medicinal plants has led to the reduction of wild populations, putting both biodiversity and the availability of essential medicinal resources for local communities at risk. 36 , 38 Conservation is not only an ecological issue but also a cultural and economic one. It is noted that medicinal plants are an integral part of the lives of many communities, not only for their therapeutic value but also as a source of income and as part of cultural identity. 39 , 43 The loss of these plants would not only affect people’s health but also their cultural heritage and economic livelihood. One of the biggest challenges for conservation is the lack of awareness and the absence of effective policies. Although local communities have vast knowledge about the use of medicinal plants, this knowledge is fading due to the lack of interest among younger generations and the pressure of modernization. 43 The intensification of mining, agricultural expansion, and deforestation, as observed in the Aravalli Hills, exacerbates this situation by destroying the natural habitats of these plants. 39 To address these issues, concerted efforts are needed on several fronts. The creation of protected areas and the implementation of sustainable cultivation practices can help preserve endangered species. Additionally, seed collection and the establishment of germplasm banks are important strategies to ensure that these plants can be restored in the future. Education and awareness among local communities, especially among the youth, are crucial for the long-term conservation of ethnobotanical knowledge and resources. Therapeutic applications The therapeutic applications of medicinal plants are varied and cover a wide range of diseases and conditions. Since ancient times, communities have used plants to treat both common and complex ailments, from bacterial infections to chronic diseases like diabetes and cancer. It has been documented how medicinal plants have been effective in treating diseases that are difficult to manage with modern medicine, highlighting their continued relevance in healthcare. 12 , 27 Studies show that although some plants have well-documented therapeutic applications, many others remain underutilized and poorly understood, representing a vast field of opportunities for research and the development of new medicines. 37 , 64 The scientific validation of these uses is essential for integrating traditional medicine into the modern healthcare system, providing treatments that are often more accessible and culturally acceptable for rural communities. The challenge in the therapeutic application of medicinal plants lies in the variability of active compounds and the lack of standardization in preparation and administration methods. Moreover, it is crucial to evaluate the toxicity and potential side effects of these remedies before their widespread adoption. 39 , 40 This requires not only rigorous clinical trials but also a careful approach to prevent the overexploitation of plants that may become scarce or endangered. Finally, the integration of the therapeutic applications of medicinal plants into modern medicine should not be seen as a replacement but as a complement. Interdisciplinary research and collaboration between traditional healers, scientists, and healthcare professionals are key to developing more effective and accessible therapies. These collaborations can also promote the more sustainable use of natural resources, ensuring that medicinal plants remain a valuable source of health and well-being in the future. Discussion This systematic review has revealed a series of significant findings across various regions and cultures. This discussion not only analyzes the key results but also identifies the gaps and voids in the literature that limit our complete understanding of this field. One of the most prominent aspects of the review is the rich diversity of medicinal plants documented in different communities, as shown by studies that have identified and classified numerous plant species used in traditional medicine, emphasizing the importance of documenting this knowledge before it is lost due to modernization. 1 , 12 However, a significant gap in the literature is the lack of standardization in documentation methods. While some studies employ mixed techniques, such as surveys and structured interviews, 2 others rely heavily on qualitative observations without a clear systematic framework. This inconsistency hinders the comparison between studies and the consolidation of a coherent body of knowledge. Additionally, although many plants with therapeutic potential have been documented, there is a void in the rigorous scientific evaluation of these plants. 3 , 11 The literature reveals that many of these plants have not yet undergone clinical trials or detailed phytochemical studies, limiting their integration into modern medicine. This lack of scientific validation is a critical gap that needs to be addressed to fully harness the potential of medicinal plants. The link between ethnomedicinal knowledge and biodiversity conservation is another central theme in the literature. Studies underscore how traditional practices of using medicinal plants contribute to the conservation of plant species. 22 , 25 However, the literature also highlights a gap in research on the long-term impacts of domestication and cultivation of medicinal plants. Although these practices have been proposed as conservation strategies, evidence on their effectiveness and long-term sustainability is lacking. 8 , 38 Moreover, the absence of longitudinal studies tracking the evolution of these practices in response to climatic and economic changes represents a significant gap in the literature. Another important gap is the lack of integration between ethnomedicinal knowledge and conservation policies. Although some studies have pointed out the need for greater community participation in natural resource management, 30 the literature lacks an in-depth analysis of how policies can be designed to genuinely incorporate and value local knowledge. This is essential to ensure effective biodiversity conservation and the maintenance of traditional practices. A recurring challenge in the literature is the scientific validation of ethnomedicinal knowledge. While some studies have demonstrated the therapeutic potential of certain plants, the lack of exhaustive clinical and phytochemical research remains a major barrier. 10 , 69 Significant gaps exist in the literature regarding the identification of active compounds responsible for the documented medicinal properties. Most of the reviewed studies stop at the observation of traditional uses without advancing towards the synthesis and testing of bioactive compounds in controlled environments. Furthermore, while scientific validation offers opportunities for the development of new medications, the literature lacks a multidisciplinary approach that combines ethnobotany, chemistry, pharmacology, and biotechnology. 11 , 20 This lack of an integrated approach is a significant void that limits the potential of medicinal plants to be utilized in modern medicine. The preservation of ethnomedicinal knowledge is a recurring theme in most of the reviewed studies. Oral transmission is at risk due to modernization and the lack of interest among younger generations. 24 , 34 However, an important gap in the literature is the lack of studies on effective methods to revitalize and preserve this knowledge. Although strategies such as written documentation and education have been proposed, the literature lacks research on the long-term effectiveness of these strategies. 54 Another significant gap is the lack of studies on the intergenerational transmission of ethnomedicinal knowledge in contexts of migration and globalization. Most of the reviewed studies focus on rural and relatively isolated communities, but there is little literature on how these practices adapt and persist in communities that have experienced significant migrations or are exposed to global cultural influences. This systematic review has revealed a rich variety of ethnomedicinal knowledge, highlighting the importance of documenting, evaluating, and conserving medicinal plants and their therapeutic applications. However, it has also identified several gaps and voids in the literature that need to be addressed to fully leverage this knowledge. The lack of standardization in documentation, insufficient scientific validation, limited integration between conservation and policies, and the need for effective strategies for intergenerational knowledge preservation are challenges that require attention. Addressing these gaps will not only strengthen our understanding of ethnomedicinal knowledge but also facilitate its integration into modern medicine and biodiversity conservation, ensuring that these valuable insights are preserved and benefit future generations. Conclusion This systematic review confirms that ethnomedicinal knowledge constitutes a critical biocultural resource for healthcare, biodiversity conservation, and scientific innovation. While the reviewed studies document a remarkable diversity of medicinal plants and traditional practices across cultures, they also reveal persistent structural gaps that limit the effective translation of this knowledge into modern health and conservation systems. To address these gaps, three priority actions emerge. First, policy frameworks should formally recognize ethnomedicinal knowledge as part of national health and biodiversity strategies. This includes the adoption of standardized documentation protocols, the legal protection of traditional knowledge, and the inclusion of local communities in decision-making processes related to medicinal plant management. Second, integration with modern pharmacology requires the establishment of interdisciplinary research pathways that link ethnobotanical documentation with phytochemical screening, preclinical validation, and ethically designed clinical studies. Such integration would enable the identification of promising bioactive compounds while respecting cultural ownership and ensuring benefit-sharing mechanisms. Third, conservation strategies should move beyond isolated preservation efforts and adopt integrated models that combine in situ conservation, community-based cultivation, and germplasm banking. These models should be supported by education programs aimed at strengthening intergenerational knowledge transmission and by digital ethnobotanical databases that ensure long-term accessibility and continuity. Finally, future research should prioritize longitudinal and comparative studies to assess how globalization, migration, and climate change reshape ethnomedicinal practices. Addressing these dynamics through adaptive policy and research frameworks will be essential to safeguard ethnomedicinal knowledge as a living, evolving system, ensuring its relevance for sustainable healthcare and biodiversity conservation in the twenty-first century. Ethics and consent No Ethics and consent required. Data availability statement Underlying data No data associated with this article. Extended data Figshare: 1) Table 1. Synthesis of Selected Articles, https://doi.org/10.6084/m9.figshare.27284889 . 71 2) Figure 1. Number of studies published during the period from 2007 to July 2024, https://doi.org/10.6084/m9.figshare.27284934 . 72 This project contains the following extended data: • Table 1. Synthesis of Selected Articles.docx • Figure 1. Number of studies published during the period from 2007 to July 2024 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). Reporting guidelines Figshare: Checklist Prisma 2020 for “Systematic Review of Ethnomedicinal Knowledge: Documentation, Evaluation, and Conservation of Medicinal Plants and Their Therapeutic Applications”, https://doi.org/10.6084/m9.figshare.27285135 . Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0). References 1. Moshi MJ, Otieno DF, Mbabazi PK: Ethnomedicine of the Kagera Region, north western Tanzania. Part 2: The medicinal plants used in Katoro Ward, Bukoba District. J. Ethnobiol. Ethnomed. 2007; 6 (1): 19. PubMed Abstract | Publisher Full Text | Free Full Text 2. Rahmatullah M, Hanif A, Jahan R, et al. : An ethnomedicinal survey of medicinal plants used as food supplements by the Chakma tribe of Bandarban district, Bangladesh. J. Pharmacogn. Phytochem. 2007; 14 : 7–16. 3. 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Reference Source Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 05 Nov 2024 ADD YOUR COMMENT Comment Author details Author details 1 Universidad Catolica de Santa Maria de Arequipa, Arequipa, Arequipa, 04002, Peru 2 Universidad Nacional de San Agustin de Arequipa, Arequipa, Arequipa, 04000, Peru Aleixandre Duche-Pérez Roles: Conceptualization, Data Curation, Formal Analysis, Funding Acquisition, Investigation, Methodology, Project Administration, Resources, Software, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Olger Albino Gutiérrez Aguilar Roles: Conceptualization, Formal Analysis, Investigation, Methodology, Validation, Visualization, Writing – Original Draft Preparation Javier Lucho Valero Quispe Roles: Conceptualization, Formal Analysis, Investigation, Supervision, Visualization, Writing – Original Draft Preparation Alison Serruto Castillo Roles: Conceptualization, Formal Analysis, Investigation, Methodology, Software, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing Lolo Juan Mamani Daza Roles: Conceptualization, Formal Analysis, Methodology, Project Administration, Supervision, Writing – Original Draft Preparation, Writing – Review & Editing Competing interests No competing interests were disclosed. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 22 Dec 2025, 13:1324 https://doi.org/10.12688/f1000research.157960.2 version 1 Published: 05 Nov 2024, 13:1324 https://doi.org/10.12688/f1000research.157960.1 Copyright © 2025 Duche-Pérez A et al . This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Duche-Pérez A, Gutiérrez Aguilar OA, Valero Quispe JL et al. Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.12688/f1000research.157960.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 22 Dec 2025 Revised Views 0 Cite How to cite this report: Sharma IP. Reviewer Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.193875.r444057 ) The direct URL for this report is: https://f1000research.com/articles/13-1324/v2#referee-response-444057 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 08 Jan 2026 Ishwar Prakash Sharma , Patanjali Research Foundation, Haridwar, Uttarakhand, India Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.193875.r444057 The manuscript presents a potentially valuable synthesis of global ethnomedicinal knowledge, and the methodology section is generally well structured. However, the number of studies included in the review is limited. Considering the substantial volume of ethnomedicinal research published annually across ... Continue reading READ ALL The manuscript presents a potentially valuable synthesis of global ethnomedicinal knowledge, and the methodology section is generally well structured. However, the number of studies included in the review is limited. Considering the substantial volume of ethnomedicinal research published annually across different countries, the inclusion of only 70 articles appears insufficient to support a comprehensive global assessment. A major limitation of the study is the absence of statistical analyses, which are essential for robust scientific evaluation in review-based research. Quantitative approaches (e.g., frequency analysis, bibliometric indicators, or comparative statistics) would substantially strengthen the credibility and interpretability of the findings. Furthermore, the Results and Discussion sections are not presented in a rigorous scientific format and do not adequately reflect a systematic analytical study. Similarly, the Conclusion lacks scientific framing and reads more like a general narrative rather than a synthesis of evidence-based outcomes derived from the analysis. In its current form, the manuscript is not suitable for indexing. Substantial revision is required, including the incorporation of a larger and more representative dataset, application of appropriate statistical and analytical tools, and restructuring of the Results, Discussion, and Conclusion sections to align with standard scientific conventions. Additionally, Table 1 lacks clarity and analytical depth, as it merely outlines article themes without highlighting the significance, key findings, or scientific outputs of the included studies. Enhancing the table to reflect study objectives, methodologies, and major outcomes would improve its utility and contribution to the manuscript. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Yes Is the statistical analysis and its interpretation appropriate? Partly Are the conclusions drawn adequately supported by the results presented in the review? Partly If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) No Competing Interests: No competing interests were disclosed. Reviewer Expertise: Medicinal Plants, Ethnomedicine, Phytodiversity I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Sharma IP. Reviewer Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.193875.r444057 ) The direct URL for this report is: https://f1000research.com/articles/13-1324/v2#referee-response-444057 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 05 Nov 2024 Views 0 Cite How to cite this report: Qureshi R. Reviewer Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.173488.r346952 ) The direct URL for this report is: https://f1000research.com/articles/13-1324/v1#referee-response-346952 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 14 Aug 2025 Rahmatullah Qureshi , Department of Botany, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan Not Approved VIEWS 0 https://doi.org/10.5256/f1000research.173488.r346952 The article titled “Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications” provides a valuable synthesis of global ethnomedicinal knowledge. However, a critical evaluation reveals several shortcomings and methodological flaws that, if ... Continue reading READ ALL The article titled “Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications” provides a valuable synthesis of global ethnomedicinal knowledge. However, a critical evaluation reveals several shortcomings and methodological flaws that, if addressed, could greatly improve its rigor, reliability, and impact. Below is a detailed assessment: Critical Shortcomings and Flaws 1. Lack of Quantitative Analysis Issue: While the study follows a systematic review methodology, it fails to incorporate statistical meta-analysis or any quantitative synthesis. Impact: The absence of effect size comparisons, frequency analysis of plant uses, or diversity indices weakens the analytical depth. Recommendation: Employ meta-analytic tools or at least frequency distribution tables, Jaccard’s similarity index, or ethnobotanical indices (e.g., Use Value, Fidelity Level). 2. Superficial Methodological Rigor Issue: Although the PRISMA framework is cited, the methodological execution is descriptive rather than analytical. No details of quality assessment tools (e.g., Cochrane, GRADE, AMSTAR) are presented. Impact: This reduces transparency and reproducibility. Recommendation: Include detailed methodological quality scoring or bias risk assessment of the included studies. 3. Limited Regional Balance and Inclusion Issue: The review focuses primarily on studies from Latin America, Africa, and parts of Asia, but omits several ethnobotanically rich areas (e.g., Pakistan, Central Asia, Caucasus, and Andean-Amazonian overlap). Impact: This gives an incomplete global perspective, undermining the claim of a “systematic global review.” Recommendation: Incorporate regional studies from neglected areas (e.g., recent work from Pakistan, Central Asia, SE Europe). 4. Absence of Standardization Framework Issue: The review mentions a “lack of standardization” in documentation and evaluation but does not propose or apply any taxonomy or framework to address this gap. Impact: This results in a descriptive narrative rather than a normative or prescriptive review. Recommendation: Suggest or test a standardized framework like WHO guidelines, the ISE Code of Ethics, or an ethnopharmacological validation pipeline. 5. Unclear Thematic Coding or Software Use Issue: It states that “thematic analysis” was performed, but no mention is made of using qualitative data analysis software (e.g., NVivo , MAXQDA , ATLAS.ti ) or coding frameworks. Impact: Reduces transparency, makes reproducibility difficult. Recommendation: Clearly describe thematic coding process and software use. 6. Overgeneralized Conclusions Issue: The conclusions are broad, stating the “need for standardized protocols and multidisciplinary approaches,” but lack specificity or actionable insight. Impact: Limits its utility for policy, practice, or future research design. Recommendation: Propose concrete policy suggestions, integration strategies with modern pharmacology, or model conservation frameworks. 7. Exclusion of Non-English Literature Issue: The review excludes all non-English studies, which is a major limitation in ethnomedicine, where local-language publications are rich sources. Impact: Omits valuable indigenous knowledge from China, Russia, Iran, Turkey, Pakistan, etc. Recommendation: Include at least translated abstracts or use multilingual co-reviewers to widen inclusion. 8. No Mention of Ethical Protocols Issue: There's no discussion of ethical considerations (e.g., PIC, informed consent, Nagoya Protocol, indigenous IP rights). Impact: Ethnobotanical studies are closely tied to bioethics and sovereignty. Recommendation: Address ethics in knowledge acquisition, data sharing, and benefit distribution. 9. Insufficient Integration with Pharmacological Validation Issue: The article calls for validation but does not compare traditional uses with phytochemical/pharmacological studies. Impact: Fails to bridge the gap between ethnomedicine and biomedicine. Recommendation: Cross-link ethnomedicinal claims with known bioactive compounds or existing pharmacological trials. 10. Vague Presentation of the 70 Selected Studies Issue: The data table is not presented (as per the summary), and there is no taxonomy of plant families, disease categories, or traditional uses. Impact: Limits synthesis and comparative utility. Recommendation: Provide taxonomic and pharmacological classification of documented plants, possibly in a supplementary table. Suggested Additional Considerations Concern Area Observed Flaw Suggested Improvement Review Depth Mostly narrative/descriptive Include statistical summaries and thematic maps Global Coverage Lacks South & Central Asian input Include recent work from Pakistan, India, Kazakhstan, etc. Tools Used Not specified Use software like NVivo/ATLAS.ti for coding and mapping Data Comparability No standard terminology used Harmonize terms using WHO or IUCN terminology Therapeutic Relevance Not assessed per disease group Map plants to WHO ICD classification or ailment categories Authorship Experience No subject-area authority disclosed Collaborate with expert ethnobotanists and pharmacologists Conclusion While the article is commendable in its intent and theme, it falls short of being a robust, globally representative, and methodologically rigorous systematic review. To make it impactful: Improve methodological transparency Widen regional scope Strengthen quantitative synthesis Integrate pharmacological correlations Address ethical and standardization frameworks Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? No Is the statistical analysis and its interpretation appropriate? No Are the conclusions drawn adequately supported by the results presented in the review? No If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) No Competing Interests: No competing interests were disclosed. Reviewer Expertise: Ethnobotany & Medicinal Plants I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Qureshi R. Reviewer Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.173488.r346952 ) The direct URL for this report is: https://f1000research.com/articles/13-1324/v1#referee-response-346952 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Ahmed HM. Reviewer Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.173488.r364583 ) The direct URL for this report is: https://f1000research.com/articles/13-1324/v1#referee-response-364583 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 11 Mar 2025 Hiwa M. Ahmed , Bakrajo Technical Institute, Sulaimani Polytechnic University, Sulaymaniyah, Kurdistan Region, Iraq Approved VIEWS 0 https://doi.org/10.5256/f1000research.173488.r364583 -The abstract should be reshaped, as you have started with results other than the introduction. -The first two sections of the introduction need reference. -You mentioned several times the aim, while the aim should be at the end ... Continue reading READ ALL -The abstract should be reshaped, as you have started with results other than the introduction. -The first two sections of the introduction need reference. -You mentioned several times the aim, while the aim should be at the end of the introduction. -Conclusion Please reshape your conclusion, it is too much, and it looks like results and discussions. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Yes Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Partly If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Yes Competing Interests: No competing interests were disclosed. Reviewer Expertise: Bioactive Natural Products, Ethnomedicine, Medicinal Plants, Human Nutrition. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Ahmed HM. Reviewer Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.173488.r364583 ) The direct URL for this report is: https://f1000research.com/articles/13-1324/v1#referee-response-364583 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 05 Nov 2024 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 22 Dec 25 read Version 1 05 Nov 24 read read Hiwa M. Ahmed , Sulaimani Polytechnic University, Sulaymaniyah, Iraq Rahmatullah Qureshi , Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan Ishwar Prakash Sharma , Patanjali Research Foundation, Haridwar, India Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2026 Sharma I. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 08 Jan 2026 | for Version 2 Ishwar Prakash Sharma , Patanjali Research Foundation, Haridwar, Uttarakhand, India 0 Views copyright © 2026 Sharma I. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The manuscript presents a potentially valuable synthesis of global ethnomedicinal knowledge, and the methodology section is generally well structured. However, the number of studies included in the review is limited. Considering the substantial volume of ethnomedicinal research published annually across different countries, the inclusion of only 70 articles appears insufficient to support a comprehensive global assessment. A major limitation of the study is the absence of statistical analyses, which are essential for robust scientific evaluation in review-based research. Quantitative approaches (e.g., frequency analysis, bibliometric indicators, or comparative statistics) would substantially strengthen the credibility and interpretability of the findings. Furthermore, the Results and Discussion sections are not presented in a rigorous scientific format and do not adequately reflect a systematic analytical study. Similarly, the Conclusion lacks scientific framing and reads more like a general narrative rather than a synthesis of evidence-based outcomes derived from the analysis. In its current form, the manuscript is not suitable for indexing. Substantial revision is required, including the incorporation of a larger and more representative dataset, application of appropriate statistical and analytical tools, and restructuring of the Results, Discussion, and Conclusion sections to align with standard scientific conventions. Additionally, Table 1 lacks clarity and analytical depth, as it merely outlines article themes without highlighting the significance, key findings, or scientific outputs of the included studies. Enhancing the table to reflect study objectives, methodologies, and major outcomes would improve its utility and contribution to the manuscript. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Yes Is the statistical analysis and its interpretation appropriate? Partly Are the conclusions drawn adequately supported by the results presented in the review? Partly If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) No Competing Interests No competing interests were disclosed. Reviewer Expertise Medicinal Plants, Ethnomedicine, Phytodiversity I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) Sharma IP. Peer Review Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.193875.r444057) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1324/v2#referee-response-444057 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Qureshi R. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 14 Aug 2025 | for Version 1 Rahmatullah Qureshi , Department of Botany, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan 0 Views copyright © 2025 Qureshi R. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Not Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The article titled “Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications” provides a valuable synthesis of global ethnomedicinal knowledge. However, a critical evaluation reveals several shortcomings and methodological flaws that, if addressed, could greatly improve its rigor, reliability, and impact. Below is a detailed assessment: Critical Shortcomings and Flaws 1. Lack of Quantitative Analysis Issue: While the study follows a systematic review methodology, it fails to incorporate statistical meta-analysis or any quantitative synthesis. Impact: The absence of effect size comparisons, frequency analysis of plant uses, or diversity indices weakens the analytical depth. Recommendation: Employ meta-analytic tools or at least frequency distribution tables, Jaccard’s similarity index, or ethnobotanical indices (e.g., Use Value, Fidelity Level). 2. Superficial Methodological Rigor Issue: Although the PRISMA framework is cited, the methodological execution is descriptive rather than analytical. No details of quality assessment tools (e.g., Cochrane, GRADE, AMSTAR) are presented. Impact: This reduces transparency and reproducibility. Recommendation: Include detailed methodological quality scoring or bias risk assessment of the included studies. 3. Limited Regional Balance and Inclusion Issue: The review focuses primarily on studies from Latin America, Africa, and parts of Asia, but omits several ethnobotanically rich areas (e.g., Pakistan, Central Asia, Caucasus, and Andean-Amazonian overlap). Impact: This gives an incomplete global perspective, undermining the claim of a “systematic global review.” Recommendation: Incorporate regional studies from neglected areas (e.g., recent work from Pakistan, Central Asia, SE Europe). 4. Absence of Standardization Framework Issue: The review mentions a “lack of standardization” in documentation and evaluation but does not propose or apply any taxonomy or framework to address this gap. Impact: This results in a descriptive narrative rather than a normative or prescriptive review. Recommendation: Suggest or test a standardized framework like WHO guidelines, the ISE Code of Ethics, or an ethnopharmacological validation pipeline. 5. Unclear Thematic Coding or Software Use Issue: It states that “thematic analysis” was performed, but no mention is made of using qualitative data analysis software (e.g., NVivo , MAXQDA , ATLAS.ti ) or coding frameworks. Impact: Reduces transparency, makes reproducibility difficult. Recommendation: Clearly describe thematic coding process and software use. 6. Overgeneralized Conclusions Issue: The conclusions are broad, stating the “need for standardized protocols and multidisciplinary approaches,” but lack specificity or actionable insight. Impact: Limits its utility for policy, practice, or future research design. Recommendation: Propose concrete policy suggestions, integration strategies with modern pharmacology, or model conservation frameworks. 7. Exclusion of Non-English Literature Issue: The review excludes all non-English studies, which is a major limitation in ethnomedicine, where local-language publications are rich sources. Impact: Omits valuable indigenous knowledge from China, Russia, Iran, Turkey, Pakistan, etc. Recommendation: Include at least translated abstracts or use multilingual co-reviewers to widen inclusion. 8. No Mention of Ethical Protocols Issue: There's no discussion of ethical considerations (e.g., PIC, informed consent, Nagoya Protocol, indigenous IP rights). Impact: Ethnobotanical studies are closely tied to bioethics and sovereignty. Recommendation: Address ethics in knowledge acquisition, data sharing, and benefit distribution. 9. Insufficient Integration with Pharmacological Validation Issue: The article calls for validation but does not compare traditional uses with phytochemical/pharmacological studies. Impact: Fails to bridge the gap between ethnomedicine and biomedicine. Recommendation: Cross-link ethnomedicinal claims with known bioactive compounds or existing pharmacological trials. 10. Vague Presentation of the 70 Selected Studies Issue: The data table is not presented (as per the summary), and there is no taxonomy of plant families, disease categories, or traditional uses. Impact: Limits synthesis and comparative utility. Recommendation: Provide taxonomic and pharmacological classification of documented plants, possibly in a supplementary table. Suggested Additional Considerations Concern Area Observed Flaw Suggested Improvement Review Depth Mostly narrative/descriptive Include statistical summaries and thematic maps Global Coverage Lacks South & Central Asian input Include recent work from Pakistan, India, Kazakhstan, etc. Tools Used Not specified Use software like NVivo/ATLAS.ti for coding and mapping Data Comparability No standard terminology used Harmonize terms using WHO or IUCN terminology Therapeutic Relevance Not assessed per disease group Map plants to WHO ICD classification or ailment categories Authorship Experience No subject-area authority disclosed Collaborate with expert ethnobotanists and pharmacologists Conclusion While the article is commendable in its intent and theme, it falls short of being a robust, globally representative, and methodologically rigorous systematic review. To make it impactful: Improve methodological transparency Widen regional scope Strengthen quantitative synthesis Integrate pharmacological correlations Address ethical and standardization frameworks Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? No Is the statistical analysis and its interpretation appropriate? No Are the conclusions drawn adequately supported by the results presented in the review? No If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) No Competing Interests No competing interests were disclosed. Reviewer Expertise Ethnobotany & Medicinal Plants I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above. reply Respond to this report Responses (0) Qureshi R. Peer Review Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.173488.r346952) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1324/v1#referee-response-346952 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2025 Ahmed H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 11 Mar 2025 | for Version 1 Hiwa M. Ahmed , Bakrajo Technical Institute, Sulaimani Polytechnic University, Sulaymaniyah, Kurdistan Region, Iraq 0 Views copyright © 2025 Ahmed H. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions -The abstract should be reshaped, as you have started with results other than the introduction. -The first two sections of the introduction need reference. -You mentioned several times the aim, while the aim should be at the end of the introduction. -Conclusion Please reshape your conclusion, it is too much, and it looks like results and discussions. Are the rationale for, and objectives of, the Systematic Review clearly stated? Yes Are sufficient details of the methods and analysis provided to allow replication by others? Yes Is the statistical analysis and its interpretation appropriate? Yes Are the conclusions drawn adequately supported by the results presented in the review? Partly If this is a Living Systematic Review, is the ‘living’ method appropriate and is the search schedule clearly defined and justified? (‘Living Systematic Review’ or a variation of this term should be included in the title.) Yes Competing Interests No competing interests were disclosed. Reviewer Expertise Bioactive Natural Products, Ethnomedicine, Medicinal Plants, Human Nutrition. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Ahmed HM. Peer Review Report For: Systematic review of ethnomedicinal knowledge: Documentation, evaluation, and conservation of medicinal plants and their therapeutic applications [version 2; peer review: 1 approved, 2 not approved] . F1000Research 2025, 13 :1324 ( https://doi.org/10.5256/f1000research.173488.r364583) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/13-1324/v1#referee-response-364583 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved - fundamental flaws in the paper seriously undermine the findings and conclusions Adjust parameters to alter display View on desktop for interactive features Includes Interactive Elements View on desktop for interactive features Competing Interests Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. 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