Medicinal Plants and Phytochemicals used in Diabetic Nephropathy: A Comprehensive Review

Medicinal Plants and Phytochemicals used in Diabetic Nephropathy: A Comprehensive Review | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 16 March 2026 V1 Latest version Share on Medicinal Plants and Phytochemicals used in Diabetic Nephropathy: A Comprehensive Review Authors : Soubhik Bhattacharyya and Dhrubajyoti sarkar 0000-0001-5754-2167 [email protected] Authors Info & Affiliations https://doi.org/10.22541/au.177364295.55971048/v1 105 views 33 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Diabetic nephropathy (DN) is a major microvascular complication of diabetes mellitus and remains one of the leading causes of chronic kidney disease and end-stage renal disease worldwide. Although current therapeutic strategies, including glycemic control and renin–angiotensin–aldosterone system blockade, can slow disease progression, they do not adequately address the complex molecular mechanisms underlying DN pathogenesis and are often insufficient to halt progressive renal fibrosis and functional decline. Growing evidence suggests that medicinal plants and their bioactive phytochemicals exert multitarget effects by modulating oxidative stress, inflammation, fibrosis, and metabolic dysregulation. This review critically synthesises recent preclinical and clinical evidence on plant-derived interventions in DN, with particular emphasis on molecular signalling pathways, biomarker modulation, and translational relevance. Key medicinal plants, as well as reported phytochemicals, are evaluated for their nephroprotective effects. Mechanistically, these agents influence pivotal pathways, including Nrf2/Keap1-mediated antioxidant defence, NF-κB–driven inflammatory signalling, TGF-β/Smad-dependent fibrogenesis, and NLRP3 inflammasome activation. Clinical and meta-analytic data indicate that selected plant-based interventions may reduce proteinuria, improve estimated glomerular filtration rate (eGFR), and attenuate oxidative and inflammatory biomarkers, with generally favourable safety profiles when standardised formulations are used. However, significant challenges remain, including variability in herbal preparation standardisation, heterogeneity in study design, and limited high-quality randomised controlled trials. Future research should prioritise standardised botanical formulations, biomarker-guided clinical evaluation, and advanced omics-based approaches to clarify precise molecular targets and optimise therapeutic integration. Overall, medicinal plants represent promising adjunct strategies in the mechanism-oriented management of diabetic nephropathy. Supplementary Material File (manuscript of nephropathy.docx) Download 245.62 KB Information & Authors Information Version history V1 Version 1 16 March 2026 Copyright This work is licensed under a Non Exclusive No Reuse License. Authors Affiliations Soubhik Bhattacharyya Assam Down Town University View all articles by this author Dhrubajyoti sarkar 0000-0001-5754-2167 [email protected] Assam Down Town University View all articles by this author Metrics & Citations Metrics Article Usage 105 views 33 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Soubhik Bhattacharyya, Dhrubajyoti sarkar. Medicinal Plants and Phytochemicals used in Diabetic Nephropathy: A Comprehensive Review. Authorea . 16 March 2026. 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