Endometrial receptivity indicators in patients with adenomyosis

Aim: to improve endometrial receptivity by exogenous cytokinotherapy in patients with adenomyosis Materials and Methods: 67 patients of reproductive age divided into 2 groups were enrolled in a prospective study. A study group included 27 patients with adenomyosis, and a control one included 40 patients without it. Age, body mass index, somatic and gynecological diseases were comparable in these subjects. At the first stage, endometrial receptivity measured by pipelle biopsy performed on Day 19–24 of a menstrual cycle was evaluated. At the second stage, the study group received a cytokinotherapeutic agent, 25 units, per 1 suppository p.v. q.h.s. within 2 months (except for days of menstrual bleeding). Immediately after the end of the treatment regimen, endometrial sampling was repeated, and endometrial receptivity was assessed. An immunohistochemical testing was performed to assess a number of pinopodes (%), as well as expression of estrogen and progesterone receptors in the glandular epithelium and the stroma. Results: adenomyosis was associated with a decreased number of pinopodes (by 1.3 times), as well as an increased level of estrogen (by 2.6 and 2.3 times in the stroma and the glandular epithelium, respectively) and progesterone receptors (by 1.5 and 1.2 times in the stroma and the glandular epithelium, respectively). After the cytokinotherapy, a significant increase in a number of pinopodes (from 41.5 to 45.3%, p=0.02), as well as in expression of estrogen (from 176.4 to 192.2 [p=0.02] in the stroma; from 170.8 to 189.3 [p=0.01] in the epithelium) and progesterone receptors (from 190.1 to 236.4 [p=0.01] in the stroma; from 127.8 to 179.7 [p=0.01] in the epithelium) was reported. Conclusion: 2-month exogenous cytokinotherapy helps to improve endometrial receptivity. KEYWORDS: endometrial receptivity, adenomyosis, receptors, estrogen, progesterone, pinopodes, cytokinotherapy. FOR CITATION: Dobrokhotova Yu.E., Borovkova E.I., Belousova T.N., Safina D.S. Endometrial receptivity indicators in patients with adenomyosis. Russian Journal of Woman and Child Health. 2025;8(3):186–191 (in Russ.). DOI: 10.32364/2618-8430-2025-8-3-1