The Possible Beneficial Impacts of Evodiamine on Liver Toxicity Induced by Experimental Cisplatin Administration: Effects on Oxidative Stress, Inflammation and Apoptosis

Abstract In this study, it was aimed to determine the possible beneficial effects of evodiamine on liver toxicity induced by experimental cisplatin administration in rats. For this purpose, experimental animals were divided into four groups (n=6). Groups were designed as control, evodiamine (EVO), cisplatin (CIS) and evodiamine+cisplatin (EVO+CIS) groups. All experimental process was applied according to rules of ethical. Rats were sacrificed by high dose anaesthesia. The considering the biochemical results of this study, it can be said that lipid peroxidation level increased and antioxidant enzyme activities decreased in the CIS group comparing to control and only EVO groups. But in EVO+CIS group, antioxidant activities increased and lipid peroxidation decreased. Moreover, immunohistochemically caspase 8 and TNF-α expressions were severe in CIS group, whereas, in EVO+CIS group, these expressions attenuated. According to all our findings, it can be expressed that evodiamine has beneficial effects against hepatotoxicity induced by experimental cisplatin administration