Activity in occipito-temporal cortex is involved in tool-use planning and contributes to tool-related semantic neural representations

Activity in occipito-temporal cortex is involved in tool-use planning and contributes to tool-related semantic neural representations | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Activity in occipito-temporal cortex is involved in tool-use planning and contributes to tool-related semantic neural representations Simon Thibault, Eric Koun, Romeo Salemme, Alice Catherine Roy, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-1436075/v2 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 30 Sep, 2024 Read the published version in Neurobiology of Language → Version 2 posted You are reading this latest preprint version Show more versions Abstract Tool use and language are highly refined human abilities which may show neural commonalitiesdue to their potential reciprocal interaction during evolution . Recent work provided evidence for shared neural resources between tool use and syntax. However, whether activity within the tool-use network also contributes to semantic neural representations of tool nouns remains untested. Tothis aim, we identified the tool-use planning network with fMRI while participants used pliers.The very same participants underwent a semantic priming task including two categories, tool nouns and animal nouns, to highlight the respective underlying networks. With multivariateanalyses of the activation neural patterns, we tested whether activity in tool-use brain clusters takespart to the neural representation of tool nouns compared to animal nouns. The results revealed thatword semantic categories were decoded within the left OTC activated by preparing to use a tool, with similar patterns of brain activity for words within the same category. In addition, in the samearea, neural activations for tool nouns were found to be higher than those for animal nouns. Thesefindings suggest that activity in tool-use related brain areas encodes semantic informationseparately for tool nouns and animal nouns, thus supporting the embodiment of tool-noun processing in the tool-use sensorimotor network. Tool use Semantics Language fMRI Embodied Cognition Full Text Additional Declarations The authors declare no competing interests. Supplementary Files SIrevised.pdf Cite Share Download PDF Status: Published Journal Publication published 30 Sep, 2024 Read the published version in Neurobiology of Language → Version 2 posted You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-1436075","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":362306867,"identity":"41914d0c-839e-444c-92d8-7af8879b2988","order_by":0,"name":"Simon 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PDF\u003c/a\u003e."}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Tool use, Semantics, Language, fMRI, Embodied Cognition","lastPublishedDoi":"10.21203/rs.3.rs-1436075/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-1436075/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eTool use and language are highly refined \u003cem\u003ehuman\u003c/em\u003e abilities which may show neural commonalitiesdue to their potential reciprocal interaction during \u003cem\u003eevolution\u003c/em\u003e. Recent work provided evidence for shared neural resources between tool use and syntax. However, whether activity within the tool-use network also contributes to semantic neural representations of tool nouns remains untested. Tothis \u0026nbsp;aim, \u0026nbsp;we \u0026nbsp;identified \u0026nbsp;the \u0026nbsp;tool-use \u0026nbsp;planning \u0026nbsp;network with \u0026nbsp;fMRI \u0026nbsp;while \u0026nbsp;participants \u0026nbsp;used \u0026nbsp;pliers.The very \u0026nbsp;same \u0026nbsp;participants \u0026nbsp;underwent \u0026nbsp;a semantic \u0026nbsp;priming \u0026nbsp;task \u0026nbsp;including two \u0026nbsp;categories, \u0026nbsp;tool nouns and \u003cem\u003eanimal\u003c/em\u003e \u0026nbsp;nouns, to \u0026nbsp;highlight \u0026nbsp;the respective \u0026nbsp;underlying \u0026nbsp;networks. With \u0026nbsp;multivariateanalyses of the activation neural patterns, we tested whether activity in tool-use \u003cem\u003ebrain\u003c/em\u003e clusters takespart to the neural representation of tool nouns compared to \u003cem\u003eanimal\u003c/em\u003e nouns. The results revealed thatword semantic categories were decoded within the left OTC activated by preparing to use a tool, with similar patterns of \u003cem\u003ebrain\u003c/em\u003e activity for words within the same category. In addition, in the samearea, neural activations for tool nouns were found to be higher than those for \u003cem\u003eanimal\u003c/em\u003e nouns. Thesefindings \u0026nbsp;suggest that \u0026nbsp;activity \u0026nbsp;in \u0026nbsp;tool-use \u0026nbsp;related \u003cem\u003ebrain\u003c/em\u003e \u0026nbsp;areas \u0026nbsp;encodes \u0026nbsp;semantic \u0026nbsp;informationseparately \u0026nbsp;for \u0026nbsp;tool \u0026nbsp;nouns and \u003cem\u003eanimal\u003c/em\u003e \u0026nbsp;nouns, thus \u0026nbsp;supporting \u0026nbsp;the \u0026nbsp;embodiment of \u0026nbsp;tool-noun processing in the tool-use sensorimotor network.\u003c/p\u003e","manuscriptTitle":"Activity in occipito-temporal cortex is involved in tool-use planning and contributes to tool-related semantic neural representations","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2024-10-04 17:30:43","doi":"10.21203/rs.3.rs-1436075/v2","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2022-03-28 20:44:29","doi":"10.21203/rs.3.rs-1436075/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"5db022da-32da-4463-9e48-715e44b80302","owner":[],"postedDate":"October 4th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[],"tags":[],"updatedAt":"2024-10-16T13:28:28+00:00","versionOfRecord":{"articleIdentity":"rs-1436075","link":"https://doi.org/10.1162/nol_a_00159","journal":{"identity":"neurobiology-of-language","isVorOnly":true,"title":"Neurobiology of Language"},"publishedOn":"2024-10-01 00:00:00","publishedOnDateReadable":"October 1st, 2024"},"versionCreatedAt":"2024-10-04 17:30:43","video":"","vorDoi":"10.1162/nol_a_00159","vorDoiUrl":"https://doi.org/10.1162/nol_a_00159","workflowStages":[]},"version":"v2","identity":"rs-1436075","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-1436075","identity":"rs-1436075","version":["v2"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}