The Immunology of Endometriosis and the Therapeutic Potential of Bispecific Antibodies: A Hypothesis

Mahdi Mohseni, Morvarid Mohseni, Manouchehr Nasrollahzadeh Saravi, Mehrdad Saravi, Iman Menbari Oskouie, Masoumeh Majidi Zolbin
In: Academic Journal of Surgery · 2025 · doi:10.18502/ajs.v7i4.17468 · W4406053422
Other OA: closed CC0
Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-08-25 ⓘ

This hypothesis proposes that bispecific antibodies targeting specific markers on endometrial and immune cells could offer a novel therapeutic strategy for endometriosis by addressing the disease's inflammatory nature.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-25 · read from full text ⓘ

This hypothesis paper explores the immunological mechanisms underlying endometriosis, focusing on how chronic inflammation and immune evasion contribute to lesion establishment and progression. The authors propose that bispecific antibodies, which can simultaneously target two distinct antigens, offer a promising therapeutic strategy by modulating specific immune pathways involved in disease pathology. They outline potential molecular targets within the tumor microenvironment of endometriotic implants that could be addressed through this novel immunotherapeutic approach. This paper is centrally about endometriosis — specifically proposing bispecific antibodies as a future treatment modality based on current understanding of its immunology.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Endometriosis is a chronic inflammatory disease characterized by the presence of endometrial lesions outside the uterus. Current treatment methods primarily focus on hormone-based therapy or invasive procedures. However, given the crucial role of the immune system in disease initiation and progression, there is an opportunity to explore new treatment approaches. Bispecific antibodies, which bind two different cells using their bivalent arms, have shown promise in treating cancers and autoimmune diseases. This study postulates that, due to the similarities in pathogenesis between endometriosis and the aforementioned diseases, a novel therapeutic method based on this new target could be introduced. This approach could potentially lead to a reduction in the limitations to patients' quality of life. In addition, it is important to highlight that future studies should prioritize the identification of specific binding markers on endometrial cells. This could contribute to the development of new diagnostic tools for the disease. Furthermore, the production of bispecific antibodies that selectively bind to these receptors on immune cells may prove effective in improving the immune response.
Full text 1,662 characters · extracted from oa-doi-fallback · click to expand
Publication Academic Journal of Surgery Record type Journal article Published 3 January 2025 Authors Mahdi Mohseni | Manouchehr Nasrollahzadeh Saravi | Iman Menbari Oskouie | Masoumeh Majidi Zolbin The publisher of this work supports multiple resolution. The work is available from the following locations: {'doi': '10.18502/ajs.v7i4.17468', 'member_id': '7770', 'member': 'Knowledge E DMCC', 'container-title': 'Academic Journal of Surgery', 'primary-resource': 'https://publish.kne-publishing.com/index.php/AJS/article/view/17468', 'tld': 'kne-publishing.com', 'clearbit-logo': '/static/no_logo.svg', 'coaccess': [], 'multiple-resolution': [{'url': 'https://ajs.tums.ac.ir/index.php/ajs/article/view/280', 'tld': 'tums.ac.ir', 'clearbit-logo': '/static/no_logo.svg'}], 'type': 'JOURNAL ARTICLE', 'published_date': '3 January 2025', 'publication': 'Academic Journal of Surgery', 'title': 'The Immunology of Endometriosis and the Therapeutic Potential of Bispecific Antibodies: A Hypothesis', 'name': None, 'id': None, 'location': None, 'display_doi': 'https://doi.org/10.18502/ajs.v7i4.17468', 'grant_info': None, 'grant_info_funders': None, 'grant_info_funder_ids': '', 'grant_info_type': None, 'multiple_lead_investigators': [], 'multiple_co_lead_investigators': [], 'multiple_investigators': [], 'finances': [], 'project_description': None, 'award_amount': None, 'award_start': None, 'funding_scheme': None, 'internal_award_number': None, 'editors': None, 'authors': 'Mahdi Mohseni | Manouchehr Nasrollahzadeh Saravi | Iman Menbari Oskouie | Masoumeh Majidi Zolbin', 'chairs': None, 'supplementary_ids': None} https://doi.org/10.18502/ajs.v7i4.17468 JSON XML

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-doi-fallback ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Condition tags

endometriosis

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
unpaywall
last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0 · commercial use OK