Current status of relationship between helper T cell 17/regulatory T cell imbalance and endometriosis

中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (01) : 2 -7. doi: 10.3877/cma.j.issn.1673-5250.2019.01.001 述评 辅助性T细胞17及调节性T细胞比例失衡与子宫内膜异位症研究现状 - 1. 四川大学华西第二医院妇产科、出生缺陷与相关妇儿疾病教育部重点实验室，成都 610041 - 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China 子宫内膜异位症(EMs)是目前严重困扰育龄期女性的常见疾病，因其发病机制复杂，病因尚未阐明，以及其易种植、复发等类似肿瘤的特性，迄今尚无确切诊治手段。最新研究发现，EMs属于一种自身免疫性疾病，与T细胞免疫密切相关。CD4＋T细胞的2个重要亚型，辅助性T细胞(Th)17与调节性T细胞(Treg)比例(Th17/Treg)失衡及其所致的腹腔内环境稳态失衡，均与EMs发生、病变程度及其导致不孕等临床特征有关。笔者拟就Th17/Treg与免疫内环境失衡在EMs中的最新研究现状进行阐述。 Endometriosis (EMs) is a common disease that seriously perplex the women of childbearing age at present. Because of its complicated pathogenesis, unknown etiology and characteristics of easy implantation and recurrence similar to tumor, there is still no definite diagnosis and treatment strategies for EMs. Recent studies have found that EMs is an autoimmune disease and closely related to T cell immunity. The helper T cell (Th) 17 and regulatory T cell (Treg) are two important subtypes of CD4+ T cells. The imbalance of Th17/Treg and imntraperitoneal environment affected by the imbalance of two cells proportion are related to the occurrence and degree of EMs, and also related to infertility of EMs. In this article, we focus on the latest research status of Th17/Treg and immune-internal environment imbalance in EMs. | [1] | Nisenblat V, Bossuyt PM, Shaikh R, et al. Blood biomarkers for the non-invasive diagnosis of endometriosis [J]. Cochrane Database Syst Rev, 2016, 5: CD012179. | | [2] | Kocbek V, Vouk K, Bersinger NA, et al. 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