Values of OAS Gene Family in the Expression Signature, Immune Cell Infiltration and Prognosis of Human Bladder Cancer

Background: BLCA is one of the most common genitourinary malignancies in the world, but its pathogenic genes have not been fully identified and the treatment outcomes are still unsatisfactory. Although the members of 2', 5'-oligoadenylate synthetase (OAS) gene family are known involved in some tumorous biological processes, the roles of the OAS gene family in BLCA are still undetermined. Methods: : By combining the vast bioinformatic datasets analyses of BLCA and the experimental verification on clinical BLCA specimen, we identified the expressions and biological functions of OAS gene family members in BLCA with comparison to normal bladder tissues. Results: : We showed that the expression levels of OAS gene family members were higher in BLCA than in normal bladder tissues. The expression levels of most OAS genes had correlations with prognosis, genomic mutation, methylation and infiltration levels of CD4+T cells, CD8+T cells, neutrophils, and dendritic cells in the microenvironment of BLCA. In addition, high expression levels of OAS1, OAS2, OAS3, and OASL predicted better overall survival in BLCA patients. Conclusions: : We conclude that the expression levels of OAS genes may be considered as a signature of BLCA and can reflect immune cell infiltration in BLCA microenvironment and predict the overall survival of BLCA. The study may provide new insights into the diagnosis, treatment, and prognosis of BLCA.