Semaglutide Alters Behaviour and Nucleus Accumbens Oscillatory Activity in Healthy Mice

SUMMARY Semaglutide, a GLP-1 receptor agonist, is widely studied in metabolic disorders, yet its effects in healthy subjects remain unclear. Here, we show that daily administration of semaglutide (0.1 mg/kg) in healthy mice alters behaviour in various tests related to stress and reward pursuit. Additionally, acute administration of semaglutide changes the oscillatory activity in the nucleus accumbens in the delta, theta and alpha bands. These findings reveal that semaglutide impacts both behaviour and neural dynamics in non-diseased brains, offering a baseline for interpreting its broader therapeutic potential.