Evaluation of wound healing effect of curcumin loaded OPL carbon nanospheres embedded Chitosan membranes

Biowaste derived carbon and the biomaterial scaffolds are being used for wound healing are the focus of interest. Carbon nanospheres derived from oil palm leaves without any catalysts via pyrolysis were loaded with a traditional drug curcumin. The wound healing scaffolds were fabricated on the polypropylene non-woven fabric support using chitosan as the biopolymer matrix. Prepared carbon nanospheres and the scaffolds were characterized using ATR-IR and FESEM techniques. The wettability of scaffolds was examined to ensure the feasible moisture absorption ability, in vitro drug release profile and in vitro antibacterial activity against two bacterial. The in vivo wound healing feature of scaffolds was studied by excision wound model for MRSA infected wound. Measured % wound contraction and the bacterial count on wounds at regular time intervals proved that, the scaffold dressed with chitosan and curcumin loaded carbon nanoshperes showed an efficient reconstruction of skin through histopathological investigations.