Malignant Mixed Mullerian Tumor of Uterus in Postmenopausal Woman: a rare case report with Histopathology Review

Malignant Mixed Mullerian Tumor of Uterus in Postmenopausal Woman: a rare case report with Histopathology Review | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Malignant Mixed Mullerian Tumor of Uterus in Postmenopausal Woman: a rare case report with Histopathology Review Soumya Pamnani, Arnav Goel, Mayur Wanjari This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6685783/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Malignant Mixed Mullerian tumor are one of the most aggressive and invasive tumor with both the components of epithelial and mesenchymal commonly present in uterus and also involving other sides like ovaries, pelvic structure, bones, peritoneum or lungs. This case reports mainly focuses on the nature of the tumor and the best medical treatment available for improving the quality of lives. Malignant mixed mullerian tumour contrast enhanced computarized tomography bilateral salpingo ophrectomy abdominal hysterectomy Histopathological examination Figures Figure 1 Figure 2 Introduction Malignant Mixed Mullerian tumors (MMMT) is also known as carcinosarcoma or malignant mesodermal tumor. Only 12% of uterine cancers and 3–5% of all malignancies are malignant mixed Mullerian tumors, which are very uncommon high-grade of neoplasms. With a clinically aggressive history, they are the most prevalent type of mixed epithelial and non-epithelial endometrial cancers ( 1 ). The degree of myometrial invasion and the disease's stage are acknowledged as significant prognostic variables. The tumor grows commonly in the uterus, can develop in the ovaries, fallopian tubes, and vagina. It can also occur in the peritoneum, gastrointestinal system, biliary tract, and neck and head ( 2 ). According to histology, MMMT is a biphasic tumor made up of both mesenchymal (sarcoma) and epithelial (carcinoma) components; however, it is yet unknown that which component of the tumor is invasive. Postmenopausal women majorly experience MMMTs, which typically manifest in a severe phase with distension, unusual spotting/bleeding, and abdominal pain ( 3 ). It is thought that MMMT development is probably linked to radiation exposure, high estrogen exposure, obesity, tamoxifen medication, and nulliparity. Due to its rarity, this case report focuses on the medical outcome of the tumor and there is shortage of the data provided ( 4 ). Case A 65-year-old postmenopausal woman arrived to gynecology department with mild atypical vaginal bleeding for two weeks and moderate lower abdominal pain as her main symptoms. There were no macroscopic abnormalities seen in the cervical or vaginal regions during the clinical gynecologic examination. During physical examination, a palpable lump in the upper and left quadrant was felt. Initial testing for kidney, liver, and complete blood count were all normal. Her serum CA 125 level was 486.7 U/Ml in the laboratory reports. CECT-Abdomen displays a sizable collection in the pelvis that is filled with fluid and has a uniform wall. Following the proper counselling and taking into account the patient's age and related medical problems, the patient was set up for a laparoscopy, a histological examination, and an operational hysteroscopy. Malignant mixed Mullerian tumor with lymphovascular space invasion (LVSI) is shown by histopathological examination (HPE) as seen in Figs. 1 and 2 . The surgical procedure in the treatment of the tumor suggested by the gynecologist involved bilateral salpingo ophrectomy (BSO) and abdominal hysterectomy (TAH). In place of brachytherapy using a Cobalt machine, the patient got adjuvant radiotherapy to the pelvis by Antero-Posterior (AP)/Postero-Anterior (PA) Field Supplementary Radiotherapy 16Gy/8Fr with a smaller field size to the pelvis. On follow-up, the patient developed Omental metastases in spite of these measures. After so much of treatment patient could not revive and became hemodynamically unstabe. Discussion Mesenchymal and epithelial components of Müllerian origin were combined to form a malignant "mixed Müllerian tumor." Adenomyomas, adenofibromas, adenosarcomas, and carcinosarcoma are the broad classifications based on the severity of malignancy of the mesenchymal and epithelial components ( 5 ). In terms of histological characteristics, MMMTs combine mesenchymal and epithelial, and carcinomatous and sarcomatous elements, usually of high invasive grade, with a poor prognosis for patients and a very aggressive progression ( 6 ). Furthermore, this kind of tumor typically spreads quickly throughout the pelvic organs, as well as to the peritoneum, paraaortic lymphatic nodes, and even far metastaize to the liver, lungs, or bones ( 7 ). This infiltrative tumor is commonly found in the uterus, exhibiting heterogeneous aspects such as an epithelial component of high-grade serous carcinoma, and heterologous features such undifferentiated sarcoma, liposarcoma, and chondrosarcoma, together with extensive areas of bleeding and necrosis. Uterine carcinosarcoma exhibits International Federation of Gynecology and Obstetrics (FIGO) stage IC2, and pTNM stage pT1c2 are the final histological outcome seen ( 8 ). The most successful treatment for MMMT is surgical tumor removal, and we should aim to have the surgeon's unaided sight show no signs of tumor. Following surgery, systemic adjuvant chemotherapy is necessary for every patient. For MMMT, the impact of radiation therapy is debatable ( 9 ). The decision of whether or not to receive radiation therapy is unclear. After undergoing tumor excision, the patient we reported received postoperative chemotherapy consisting of four rounds of cisplatin and ifosfamide ( 10 ). Conclusion MMMTs are rare and severe tumors that mostly affect the uterus. They are termed as carcinosarcomas because of their distinct histological makeup, which includes both malignant epithelial and mesenchymal components ( 11 ). Aggressive hysteroscopy for postmenopausal bleeding and optimum surgical excision by staging laparotomy, in addition to adjuvant therapy, are critical in the treatment of uterine carcinosarcoma ( 8 ) ( 10 ) . Declarations Data availability statements: All the data that has been included in this case report is original and patient identity is not revelaed. Ethics statement: Ethical approval for this case report was obtained from Datta Meghe institute of Higher Education and Research REVIEW BOARD, Wardha. Funding: The research, or publication of this paper were all done without any financial assistance from third party. Conflict of interest: Author declared no conflict of interest. Patient consent: All the information and pictures that are uploaded in this article is all proved by the patient and proper formal consent taken from the patient and relatives. Author Contribution All the author i.e. ARNAV, SOUMYA and Mayur ,the research scientist has equally contributed to this article. The main manuscript is prepared by arnav and soumya. Mayur sir provided us an idea to complete the article. All the images and consent was taken by three of us References Sando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C. Carcinosarcoma of the corpus uteri (Malignant Müllerian Mixed Tumor): a case report in Yaoundé (Cameroon). Pan Afr Med J. 2013;16:145. Desai GS, Rathod P. Carcinosarcoma of Uterus: a Case Report. J Obstet Gynaecol India. 2022 Feb;72(1):86–8. Kuyumcuoğlu U, Kale A. Homologous Type of Malignant Mixed Mullerian Tumor of the Uterus Presenting as a Cervical Mass. Journal of the Chinese Medical Association. 2009 Oct 1;72(10):533–5. Saenz D, Fernández JD, Cóbar JP. Challenges in diagnosis and treatment: a case report on a mixed malignant Müllerian tumor. J Surg Case Rep. 2023 Sep 16;2023(9):rjad523. Arora P, Rao S, Khurana N, Talwar D, Tanwar R. Malignant mixed Mullerian tumor of broad ligament with synchronous ovarian and endometrial carcinoma: A rare association. Journal of Cancer Research and Therapeutics. 2011 Mar;7(1):88. Cozlea AL, Gheorghe M, Kiss SL, Fandi A, Stanca M, Mocan S, et al. Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review. Exp Ther Med. 2022 Feb;23(2):177. Rajshekar SK, Guruprasad B, Shakunthala P, Rathod P, Devi U, Bafna U. Malignant mixed Mullerian tumour of the uterus. Ecancermedicalscience. 2013 Apr 4;7:302. Chen H, Hu P, Wu F. Primary malignant mixed mullerian tumor of the peritoneum: a case report. Transl Cancer Res. 2019 Jun;8(3):992–5. Zhang L, Shimizu D, Killeen JL, Honda SA, Lu D, Stanoyevitch A, et al. Serous Carcinoma component championed by Heparin Binding-EGF Like Growth Factor (HB-EGF) Predisposing to Metastasis and Recurrence in Stage I Uterine Malignant Mixed Mullerian Tumor. Hum Pathol. 2016 Jul;53:159–67. Lee TY, Lee C, Choi WJ, Lee JY, Kim HY. Synchronous occurrence of primary malignant mixed müllerian tumor in ovary and uterus. Obstet Gynecol Sci. 2013 Jul;56(4):269–72. Kanthan R, Senger JLB, Diudea D. Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins. World J Surg Oncol. 2010 Jul 19;8:60. Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6685783","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":493757293,"identity":"7621b8f7-95ef-44d9-91c6-fbfa30d4264b","order_by":0,"name":"Soumya Pamnani","email":"","orcid":"","institution":"Jawaharlal Nehru Medical College, Wardha, Maharashtra, India","correspondingAuthor":false,"prefix":"","firstName":"Soumya","middleName":"","lastName":"Pamnani","suffix":""},{"id":493757294,"identity":"ba844837-b66a-4334-a1c8-c9f2beadfa8b","order_by":1,"name":"Arnav Goel","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA8ElEQVRIiWNgGAWjYBACNhiDT/798x8fQCLsBLTwI/TmMEjOADGYCWiRbEDSIs0DYhHSYnD77MHPPL9s5NgYzh4wtvm1TZ6PmYHxw8ccPFrO5SVL8/alGbMx9iUk5/bdNmxjZmCWnLkNj5YzPAaSM3sOJwJVGhzO7bnNCGSwMfPi0WJ/hsf4J1BLfRsbg2GzZc9te4JagLaYSXz4cTiBjYfHmJnhx+1EorRYfGxIM2yTYEtj7G24ndzGzNhMyC/GNxL+2MjzSzAfY/jx57bt/Pbmgx8+4tECBoxtKAzGBgLqQeAPBmMUjIJRMApGAQIAABeKTS/jFb7ZAAAAAElFTkSuQmCC","orcid":"","institution":"Jawaharlal Nehru Medical College, Wardha, Maharashtra, India","correspondingAuthor":true,"prefix":"","firstName":"Arnav","middleName":"","lastName":"Goel","suffix":""},{"id":493757295,"identity":"ff352c23-c9ff-4382-8fbb-9c750e5d1376","order_by":2,"name":"Mayur Wanjari","email":"","orcid":"","institution":"Jawaharlal Nehru Medical College, Wardha, Maharashtra, India","correspondingAuthor":false,"prefix":"","firstName":"Mayur","middleName":"","lastName":"Wanjari","suffix":""}],"badges":[],"createdAt":"2025-05-17 08:53:23","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6685783/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6685783/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":88408520,"identity":"1cc4bd12-142a-43ca-9f4c-795940ebc744","added_by":"auto","created_at":"2025-08-06 08:13:00","extension":"jpeg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":123561,"visible":true,"origin":"","legend":"\u003cp\u003esarcomatous component\u003c/p\u003e","description":"","filename":"floatimage1.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-6685783/v1/843db8b21003812b6f1b849e.jpeg"},{"id":88408517,"identity":"5159f7e9-fdf6-4785-8371-4fafeb3659df","added_by":"auto","created_at":"2025-08-06 08:13:00","extension":"jpeg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":137484,"visible":true,"origin":"","legend":"\u003cp\u003ecarcinoma component\u003c/p\u003e","description":"","filename":"floatimage2.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-6685783/v1/638544c0e08d1060ba5b46c0.jpeg"},{"id":91145981,"identity":"4f01ad9e-f929-47b8-9d4f-f51b1d8db854","added_by":"auto","created_at":"2025-09-12 06:11:30","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":499269,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6685783/v1/90610122-7fdf-4907-b0d4-b350419fef57.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Malignant Mixed Mullerian Tumor of Uterus in Postmenopausal Woman: a rare case report with Histopathology Review","fulltext":[{"header":"Introduction","content":"\u003cp\u003eMalignant Mixed Mullerian tumors (MMMT) is also known as carcinosarcoma or malignant mesodermal tumor. Only 12% of uterine cancers and 3–5% of all malignancies are malignant mixed Mullerian tumors, which are very uncommon high-grade of neoplasms. With a clinically aggressive history, they are the most prevalent type of mixed epithelial and non-epithelial endometrial cancers (\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e). The degree of myometrial invasion and the disease's stage are acknowledged as significant prognostic variables. The tumor grows commonly in the uterus, can develop in the ovaries, fallopian tubes, and vagina. It can also occur in the peritoneum, gastrointestinal system, biliary tract, and neck and head (\u003cspan citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e). According to histology, MMMT is a biphasic tumor made up of both mesenchymal (sarcoma) and epithelial (carcinoma) components; however, it is yet unknown that which component of the tumor is invasive. Postmenopausal women majorly experience MMMTs, which typically manifest in a severe phase with distension, unusual spotting/bleeding, and abdominal pain (\u003cspan citationid=\"CR3\" class=\"CitationRef\"\u003e3\u003c/span\u003e). It is thought that MMMT development is probably linked to radiation exposure, high estrogen exposure, obesity, tamoxifen medication, and nulliparity. Due to its rarity, this case report focuses on the medical outcome of the tumor and there is shortage of the data provided (\u003cspan citationid=\"CR4\" class=\"CitationRef\"\u003e4\u003c/span\u003e).\u003c/p\u003e"},{"header":"Case","content":"\u003cp\u003eA 65-year-old postmenopausal woman arrived to gynecology department with mild atypical vaginal bleeding for two weeks and moderate lower abdominal pain as her main symptoms. There were no macroscopic abnormalities seen in the cervical or vaginal regions during the clinical gynecologic examination. During physical examination, a palpable lump in the upper and left quadrant was felt. Initial testing for kidney, liver, and complete blood count were all normal. Her serum CA 125 level was 486.7 U/Ml in the laboratory reports. CECT-Abdomen displays a sizable collection in the pelvis that is filled with fluid and has a uniform wall. Following the proper counselling and taking into account the patient's age and related medical problems, the patient was set up for a laparoscopy, a histological examination, and an operational hysteroscopy. Malignant mixed Mullerian tumor with lymphovascular space invasion (LVSI) is shown by histopathological examination (HPE) as seen in Figs.\u0026nbsp;1 and \u003cspan refid=\"Fig1\" class=\"InternalRef\"\u003e2\u003c/span\u003e. The surgical procedure in the treatment of the tumor suggested by the gynecologist involved bilateral salpingo ophrectomy (BSO) and abdominal hysterectomy (TAH). In place of brachytherapy using a Cobalt machine, the patient got adjuvant radiotherapy to the pelvis by Antero-Posterior (AP)/Postero-Anterior (PA) Field Supplementary Radiotherapy 16Gy/8Fr with a smaller field size to the pelvis. On follow-up, the patient developed Omental metastases in spite of these measures. After so much of treatment patient could not revive and became hemodynamically unstabe. \u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eMesenchymal and epithelial components of M\u0026uuml;llerian origin were combined to form a malignant \"mixed M\u0026uuml;llerian tumor.\" Adenomyomas, adenofibromas, adenosarcomas, and carcinosarcoma are the broad classifications based on the severity of malignancy of the mesenchymal and epithelial components (\u003cspan citationid=\"CR5\" class=\"CitationRef\"\u003e5\u003c/span\u003e). In terms of histological characteristics, MMMTs combine mesenchymal and epithelial, and carcinomatous and sarcomatous elements, usually of high invasive grade, with a poor prognosis for patients and a very aggressive progression (\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e). Furthermore, this kind of tumor typically spreads quickly throughout the pelvic organs, as well as to the peritoneum, paraaortic lymphatic nodes, and even far metastaize to the liver, lungs, or bones (\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e). This infiltrative tumor is commonly found in the uterus, exhibiting heterogeneous aspects such as an epithelial component of high-grade serous carcinoma, and heterologous features such undifferentiated sarcoma, liposarcoma, and chondrosarcoma, together with extensive areas of bleeding and necrosis. Uterine carcinosarcoma exhibits International Federation of Gynecology and Obstetrics (FIGO) stage IC2, and pTNM stage pT1c2 are the final histological outcome seen (\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e).\u003c/p\u003e\u003cp\u003eThe most successful treatment for MMMT is surgical tumor removal, and we should aim to have the surgeon's unaided sight show no signs of tumor. Following surgery, systemic adjuvant chemotherapy is necessary for every patient. For MMMT, the impact of radiation therapy is debatable (\u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e). The decision of whether or not to receive radiation therapy is unclear. After undergoing tumor excision, the patient we reported received postoperative chemotherapy consisting of four rounds of cisplatin and ifosfamide (\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e).\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eMMMTs are rare and severe tumors that mostly affect the uterus. They are termed as carcinosarcomas because of their distinct histological makeup, which includes both malignant epithelial and mesenchymal components (\u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e). Aggressive hysteroscopy for postmenopausal bleeding and optimum surgical excision by staging laparotomy, in addition to adjuvant therapy, are critical in the treatment of uterine carcinosarcoma (\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e) (\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e) .\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003eData availability statements:\u003c/p\u003e\n\u003cp\u003eAll the data that has been included in this case report is original and patient identity is not revelaed.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eEthics statement:\u003c/p\u003e\n\u003cp\u003eEthical approval for this case report was obtained from Datta Meghe institute of Higher Education and Research REVIEW BOARD, Wardha.\u003c/p\u003e\n\u003cp\u003eFunding:\u003c/p\u003e\n\u003cp\u003eThe research, or publication of this paper were all done without any financial assistance from third party.\u003c/p\u003e\n\u003cp\u003eConflict of interest:\u003c/p\u003e\n\u003cp\u003eAuthor declared no conflict of interest.\u003c/p\u003e\n\u003cp\u003ePatient consent:\u003c/p\u003e\n\u003cp\u003eAll the information and pictures that are uploaded in this article is all proved by the patient and proper formal consent taken from the patient and relatives.\u0026nbsp;\u003c/p\u003e\u003ch2\u003eAuthor Contribution\u003c/h2\u003e\u003cp\u003eAll the author i.e. ARNAV, SOUMYA and Mayur ,the research scientist has equally contributed to this article. The main manuscript is prepared by arnav and soumya. Mayur sir provided us an idea to complete the article. All the images and consent was taken by three of us\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eSando Z, Fouelifack FY, Fouogue JT, Fouedjio JH, Anoudem CE, Nangue C. Carcinosarcoma of the corpus uteri (Malignant M\u0026uuml;llerian Mixed Tumor): a case report in Yaound\u0026eacute; (Cameroon). Pan Afr Med J. 2013;16:145. \u003c/li\u003e\n\u003cli\u003eDesai GS, Rathod P. Carcinosarcoma of Uterus: a Case Report. J Obstet Gynaecol India. 2022 Feb;72(1):86\u0026ndash;8. \u003c/li\u003e\n\u003cli\u003eKuyumcuoğlu U, Kale A. Homologous Type of Malignant Mixed Mullerian Tumor of the Uterus Presenting as a Cervical Mass. Journal of the Chinese Medical Association. 2009 Oct 1;72(10):533\u0026ndash;5. \u003c/li\u003e\n\u003cli\u003eSaenz D, Fern\u0026aacute;ndez JD, C\u0026oacute;bar JP. Challenges in diagnosis and treatment: a case report on a mixed malignant M\u0026uuml;llerian tumor. J Surg Case Rep. 2023 Sep 16;2023(9):rjad523. \u003c/li\u003e\n\u003cli\u003eArora P, Rao S, Khurana N, Talwar D, Tanwar R. Malignant mixed Mullerian tumor of broad ligament with synchronous ovarian and endometrial carcinoma: A rare association. Journal of Cancer Research and Therapeutics. 2011 Mar;7(1):88. \u003c/li\u003e\n\u003cli\u003eCozlea AL, Gheorghe M, Kiss SL, Fandi A, Stanca M, Mocan S, et al. Malignant mixed M\u0026uuml;llerian tumor of the fallopian tube: Case report and literature review. Exp Ther Med. 2022 Feb;23(2):177. \u003c/li\u003e\n\u003cli\u003eRajshekar SK, Guruprasad B, Shakunthala P, Rathod P, Devi U, Bafna U. Malignant mixed Mullerian tumour of the uterus. Ecancermedicalscience. 2013 Apr 4;7:302. \u003c/li\u003e\n\u003cli\u003eChen H, Hu P, Wu F. Primary malignant mixed mullerian tumor of the peritoneum: a case report. Transl Cancer Res. 2019 Jun;8(3):992\u0026ndash;5. \u003c/li\u003e\n\u003cli\u003eZhang L, Shimizu D, Killeen JL, Honda SA, Lu D, Stanoyevitch A, et al. Serous Carcinoma component championed by Heparin Binding-EGF Like Growth Factor (HB-EGF) Predisposing to Metastasis and Recurrence in Stage I Uterine Malignant Mixed Mullerian Tumor. Hum Pathol. 2016 Jul;53:159\u0026ndash;67. \u003c/li\u003e\n\u003cli\u003eLee TY, Lee C, Choi WJ, Lee JY, Kim HY. Synchronous occurrence of primary malignant mixed m\u0026uuml;llerian tumor in ovary and uterus. Obstet Gynecol Sci. 2013 Jul;56(4):269\u0026ndash;72. \u003c/li\u003e\n\u003cli\u003eKanthan R, Senger JLB, Diudea D. Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins. World J Surg Oncol. 2010 Jul 19;8:60. \u003c/li\u003e\n\u003c/ol\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Malignant mixed mullerian tumour, contrast enhanced computarized tomography, bilateral salpingo ophrectomy, abdominal hysterectomy, Histopathological examination","lastPublishedDoi":"10.21203/rs.3.rs-6685783/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6685783/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eMalignant Mixed Mullerian tumor are one of the most aggressive and invasive tumor with both the components of epithelial and mesenchymal commonly present in uterus and also involving other sides like ovaries, pelvic structure, bones, peritoneum or lungs. This case reports mainly focuses on the nature of the tumor and the best medical treatment available for improving the quality of lives.\u003c/p\u003e","manuscriptTitle":"Malignant Mixed Mullerian Tumor of Uterus in Postmenopausal Woman: a rare case report with Histopathology Review","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-08-06 08:12:55","doi":"10.21203/rs.3.rs-6685783/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2cb08199-d9f1-4495-91e1-8c5650ff6d74","owner":[],"postedDate":"August 6th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2025-09-12T05:39:21+00:00","versionOfRecord":[],"versionCreatedAt":"2025-08-06 08:12:55","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-6685783","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-6685783","identity":"rs-6685783","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}