Mechanisms of Endometrioma-Mediated Ovarian Damage: Myths and Facts
other
OA: green
CC0
Abstract
Ovarian endometriomas (OEMs), cystic formations within the ovaries, are a significant manifestation of endometriosis and present in 20–40% of affected women. Despite extensive research, the pathogenesis of endometriosis remains unclear, with retrograde menstruation, coelomic metaplasia, and lymphatic dissemination being proposed mechanisms. OEMs negatively impact ovarian function by reducing the ovarian reserve, disrupting folliculogenesis, and altering the ovarian microenvironment through oxidative stress, inflammation, and fibrosis. Elevated reactive oxygen species (ROS) accelerate follicular atresia, and extracellular matrix remodeling contributes to ovarian damage, while immune dysregulation and cytokine imbalances further exacerbate the condition. The presence of OEMs does not significantly affect live birth rates in in vitro fertilization (IVF) treatments, despite potential reductions in the quality and quantity of oocytes. However, their surgical excision compromises the ovarian reserve. This review highlights the complex mechanisms by which OEMs impair ovarian function and emphasizes the need for further research to develop strategies that mitigate these effects, ultimately improving reproductive outcomes for women with endometriomas.
Full text
2,631 characters
· extracted from
oa-html
· click to expand
Please use this identifier to cite or link to this item:
doi:10.22028/D291-45048
| Title: | Mechanisms of Endometrioma-Mediated Ovarian Damage: Myths and Facts |
| Author(s): | Özcan, Pınar Varlı, Bulut Sarıdoğan, Ertan Oral, Engin Mabrouk, Muhammed Usta, Taner Constantin, Alin Stefan |
| Language: | English |
| Title: | Journal of Clinical Medicine |
| Volume: | 14 |
| Issue: | 7 |
| Publisher/Platform: | MDPI |
| Year of Publication: | 2025 |
| Free key words: | endometrioma ovarian reserve in vitro fertilization infertility endometriosis |
| DDC notations: | 610 Medicine and health |
| Publikation type: | Journal Article |
| Abstract: | Ovarian endometriomas (OEMs), cystic formations within the ovaries, are a significant manifestation of endometriosis and present in 20–40% of affected women. Despite extensive research, the pathogenesis of endometriosis remains unclear, with retrograde menstruation, coelomic metaplasia, and lymphatic dissemination being proposed mechanisms. OEMs negatively impact ovarian function by reducing the ovarian reserve, disrupting folliculogenesis, and altering the ovarian microenvironment through oxidative stress, inflammation, and fibrosis. Elevated reactive oxygen species (ROS) accelerate follicular atresia, and extracellular matrix remodeling contributes to ovarian damage, while immune dysregulation and cytokine imbalances further exacerbate the condition. The presence of OEMs does not significantly affect live birth rates in in vitro fertilization (IVF) treatments, despite potential reductions in the quality and quantity of oocytes. However, their surgical excision compromises the ovarian reserve. This review highlights the complex mechanisms by which OEMs impair ovarian function and emphasizes the need for further research to develop strategies that mitigate these effects, ultimately improving reproductive outcomes for women with endometriomas. |
| DOI of the first publication: | 10.3390/jcm14072147 |
| URL of the first publication: | https://doi.org/10.3390/jcm14072147 |
| Link to this record: | urn:nbn:de:bsz:291--ds-450485 hdl:20.500.11880/39916 http://dx.doi.org/10.22028/D291-45048 |
| ISSN: | 2077-0383 |
| Date of registration: | 14-Apr-2025 |
| Faculty: | M - Medizinische Fakultät |
| Department: | M - Frauenheilkunde |
| Professorship: | M - Prof. Dr. E.-F. Solomayer |
| Collections: | SciDok - Der Wissenschaftsserver der Universität des Saarlandes |
Files for this record:
| File | Description | Size | Format | |
|---|---|---|---|---|
| jcm-14-02147.pdf | 825,64 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License
Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.
My notes (saved in your browser only)
Ask this paper
Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works
Condition tags
Citation neighborhood (no data yet)
We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2025) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.
Source provenance
- openalex
- last seen: 2026-05-10T11:08:02.341151+00:00
License: CC0
· commercial use OK