COX–2 is overesxpressed in ovarian endometriosis and might represent a therapeutic target

A. Meinel, C Leo, G. Zimmermann, H. Richard Alexander, LC Horn
In: Geburtshilfe und Frauenheilkunde · 2008 · vol. 68(S 01) · doi:10.1055/s-0028-1088624 · W2323166848
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This study investigated COX-2 expression across various anatomical sites of endometriosis to assess its potential as a therapeutic target.

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This study investigated the expression of cyclooxygenase-2 (COX-2) in endometriotic tissues collected from various anatomical sites, including ovarian, uterine, and peritoneal locations. Immunohistochemical analysis of 60 samples revealed that COX-2 was significantly overexpressed in glandular epithelial cells within ovarian lesions compared to other sites, with a high percentage of positive staining observed in most ovarian cases. The researchers noted a strong correlation between staining intensity and lesion location, highlighting that ovarian endometriosis exhibits distinct molecular characteristics relative to extraovarian forms. This paper is centrally about endometriosis — specifically focusing on the differential expression of COX-2 in ovarian versus other endometriotic implants.

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Abstract

Aims: Recent studies have suggested that cyclooxygenase–2 (COX–2) is involved in the pathogenesis of endometriosis. The aim of this study was to investigate the expression of COX–2 in different anatomical sites of endometriosis
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Methods

COX–2 expression was analysed immunohistochemically in 60 samples of endometriotic tissue from different anatomical sites (25 ovarian, 14 uterine, 21 peritoneal/Fallopian tube/omental endometriosis) using a monoclonal antibody against COX–2. Staining results were analysed semiqiantitatively for staining intensity and percent of positive cells.

Results

COX–2 immunoreaction was observed in glandular epithelial cells in 96,5% of all cases; stromal cells were completely negative. COX–2 overexpression (defined as >75% positive stained cells) was seen in 72% of the ovarian and in about 40% of uterine and peritoneal lesions (p<0.05). There was also a sognoficant correlation for staining intensity, favoring ovarian lesions (p<0.0002).

Conclusions

Increased COX–2 expression in the ovarian endometriotic lesions was observed with respect to other extraovarian localizations. Cox–2 inhibitors may be an option in the treatment of symptomatic patients with ovarian endometriosis and might play a role in prevention of ovarian carcinoma in patients who are under risk for ovarian cancer and affected by endometriosis.

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endometriosis

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