The role of stem cells in obstetrics and gynecology: A systematic review

Putri Mirani, Legiran, Cindy Kesty, Hana Andrina
In: Majalah Obstetri & Ginekologi · 2023 · vol. 31(3) , pp. 129–138 · doi:10.20473/mog.v31i32023.129-138 · W4388976700
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This systematic review found stem cells can repair endometrial damage, increase thickness, and aid fertility, but also carry risks like chromosomal abnormalities and tumor formation.

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This systematic review evaluated the role of stem cells in obstetrics and gynecology by searching PubMed, Wiley Online Library, and ScienceDirect for open-access English articles from the prior 10 years, including both original research and reviews, and analyzing results qualitatively across 15 eligible papers. The review reports that multiple articles focus on endometrium repair, where stem cell approaches may increase endometrial thickness and improve pregnancy likelihood, and it also describes potential gynecologic uses such as treatments for stress urinary incontinence and anal incontinence. It highlights a key limitation that stem cells may carry errors including chromosomal abnormalities and epigenetic/genetic defects that could theoretically contribute to tumor-initiating behavior and ectopic endometrial growth. Relevance to endometriosis: the paper notes that stem cells with potential errors could contribute to ectopic growth of endometrium (endometriosis), though its main focus is a broad systematic overview of stem cell roles across obstetrics and gynecology, including tissue repair, fertility, and other gynecologic conditions.

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Abstract

HIGHLIGHTS Stem cell technology has various roles in the field of obstetrics and gynecology, including fertility study as well as tissue damage repair. Safety profile of stem cells technology use in human still need to be assessed. ABSTRACT Objective: This study aims to review the role of stem cells in obstetrics and gynecology Materials and Methods: This review uses several databases, namely PubMed, Wiley Online Library, and ScienceDirect to search open access original and review articles in English related to stem cells, obstetrics, and gynecology) in the last 10 years. The results were then analyzed qualitatively Results: Out of 1,016 records identified through database searching, fifteen articles were eligible for review. Several articles reported the role of stem cells has a role in endometrium repair. Stem cell can also increase endometrial thickness and increase the likelihood of pregnancy. In the field of gynecology, stem cells can be use as potential treatment for stress urinary incontinence and anal incontinence. Despite of all those abilities, the stem cells might have errors, such as chromosomal abnormalities, epigenetic and genetic defect, which could potentially turn the stem cells into tumor initiating cells (TICs), thus can contribute to ectopic growth of endometrium (endometriosis), leiomyoma, leiomyosarcomas, and adenomyosis. Conclusion: Stem cell technology has various roles in the field of obstetrics and gynecology, including fertility study as well as tissue damage repair. However, in-depth research to ensure the safety profile of stem cells technology use in human is necessary.
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Abstract

Objective: This study aimed to review the role of stem cells in obstetrics and gynecology.

Materials and methods

This review used several databases, the PubMed, Wiley Online Library, and ScienceDirect to search open access original and review articles in English related to stem cells, obstetrics, and gynecology in the last 10 years. The results were analyzed qualitatively.

Results

Out of 1,016 records identified through database searching, fifteen articles were eligible for review. Several articles reported the role of stem cells in endometrium repair. Stem cell can also increase endometrial thickness and increase the likelihood of pregnancy. In the field of gynecology, stem cells can be used as potential treatment for stress urinary incontinence and anal incontinence. Despite of all those abilities, stem cells might have errors, such as chromosomal abnormalities, epigenetic and genetic defect, which could potentially turn the stem cells into tumor initiating cells (TICs), thus can contribute to ectopic growth of endometrium (endometriosis), leiomyoma, leiomyosarcomas, and adeno-myosis.

Conclusion

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The legal formal aspect of journal publication accessibility refers to Creative Commons Attribution-Non Commercial-Share alike (CC BY-NC-SA), (https://creativecommons.org/licenses/by-nc-sa/4.0/) 3. The articles published in the journal are open access and can be used for non-commercial purposes. Other than the aims mentioned above, the editorial board is not responsible for copyright violation The manuscript authentic and copyright statement submission can be downloaded ON THIS FORM.

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endometriosisadenomyosis

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