Better Health Related Quality of Life Reduced Elevated Lp(a) Levels in Man

Abstract Background: Elevated Lipoprotein(a) (Lp(a)) is an independent risk factor for premature coronary heart disease (PCHD), but drug therapy rarely changes. Recently, health related quality of life (HRQOL) has been used to measure the prognosis of PCHD, but it is unclear whether HRQOL can improve Lp(a) levels. Aim: To explore whether HRQOL score in PCHD patients is closely related to increased Lp(a) level.Methods: The retrospective study included 448 male patients, 218 male patients with PCHD (49.63±3.72 years) and 230 male healthy controls, the two groups were matched in age. According to Lp(a) levels, they were divided into normal Lp(a) group (Lp(a)<30mg/dL) and elevated Lp(a) group (Lp(a)≥30mg/dL). All participants received HRQOL scores. HRQOL scores were assessed using the health Survey of 36 items (SF-36).Results: Elevated Lp(a) subgroup had more PCHD patients 150(65.5%) than normal Lp(a) subgroup 68(31.1%), P<0.001. In elevated Lp(a) subgroup and normal Lp(a) subgroup, the Lp(a) level of PCHD patients were significantly higher than health healthy controls, and HRQOL scores were significantly lower than healthy controls(P<0.001). HRQOL scores significantly reduced the risk of PCHD (P<0.001), while Lp(a) levels significantly increased the risk of PCHD (P<0.001). HRQOL scores in the whole Lp(a) group were negatively correlated with Lp(a) levels (r=-0.131, P=0.006), but not with the elevated Lp(a) and normal Lp(a) subgroups.Conclusion: Better HRQOL may be an important indicator to reduce the risk of high Lp(a) and PCHD in man.