Factors Associated with Fertility Preservation Referral and Completion in Pediatric Patients Receiving Gonadotoxic Therapies

Factors Associated with Fertility Preservation Referral and Completion in Pediatric Patients Receiving Gonadotoxic Therapies | Authorea try { document.documentElement.classList.add('js'); } catch (e) { } var _gaq = _gaq || []; _gaq.push(['_setAccount', 'G-8VDV14Y67G']); _gaq.push(['_trackPageview']); (function() { var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true; ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js'; var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s); })(); Skip to main content Preprints Collections Wiley Open Research IET Open Research Ecological Society of Japan All Collections About About Authorea FAQs Contact Us Quick Search anywhere Search for preprint articles, keywords, etc. Search Search ADVANCED SEARCH SCROLL This is a preprint and has not been peer reviewed. Data may be preliminary. 17 June 2025 V1 Latest version Share on Factors Associated with Fertility Preservation Referral and Completion in Pediatric Patients Receiving Gonadotoxic Therapies Authors : Gabriela Betancourt 0009-0004-0487-8328 [email protected] , Sang Mee Lee , Stefania Marron Rodriguez , and Lindsay F. Schwartz Authors Info & Affiliations https://doi.org/10.22541/au.175016311.14921764/v1 153 views 81 downloads Contents Abstract Supplementary Material Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Objectives: Over 15,000 children in the United States are diagnosed with cancer annually, with many treatments impacting future fertility. Despite increased knowledge and availability of fertility preservation interventions, individual- and systems-level barriers may affect their implementation and completion. We sought to determine associations between sociodemographic factors and rates of referral for and completion of fertility preservation interventions in pediatric hematology/oncology patients at increased risk for future gonadal failure/infertility. Methods: This single center, retrospective cohort study included children aged 0-18 who were treated at the University of Chicago between 2018-2023, all at high levels of increased risk for future gonadal failure/infertility as per the Pediatric Initiative Network Risk Stratification System. Sociodemographic (sex, pubertal status, race/ethnicity, primary language) and systems-level (insurance status, “in house” versus “outside” referral) variables were collected via electronic medical records. “Social vulnerability” was calculated using the CDC/ATSDR Social Vulnerability Index. Fertility preservation referral was defined as documented discussions about fertility risks and preservation strategies, while completion included documentation of procedures. We compared rates of fertility preservation referral and completion, as well as time to referral and completion, using Chi-squared tests and t-tests. Results: 143 participants were included for analysis (62% male, 39% white, 21% Hispanic/Latine, mean age 9.1±7.1 years). 87 (61%) of participants received fertility preservation referrals, and 47 (54%) completed a procedure. No associations were observed between sociodemographic or systems-level factors and rates of referral or completion. Males had a longer time to referral from diagnosis compared to females (p=0.01). Non-white participants experienced longer times from diagnosis to referral (p=0.03) and completion (p=0.04) compared to white participants. Conclusions: Fertility preservation referral and completion rates in pediatric patients remain suboptimal. Sociodemographic and systems-level factors may be less influential than previously thought, indicating the need for further research to understand and address factors affecting fertility preservation rates. Supplementary Material File (manuscript_fpc_submission.docx) Download 91.55 KB Information & Authors Information Version history V1 Version 1 17 June 2025 Copyright This work is licensed under a Non Exclusive No Reuse License. Keywords anemia aplastic bmt for malignant conditions ie sickle cell leukemia neuroblastoma pediatric hematology/oncology stem cell transplantation Authors Affiliations Gabriela Betancourt 0009-0004-0487-8328 [email protected] The University of Chicago Comer Children's Hospital View all articles by this author Sang Mee Lee The University of Chicago Division of the Biological Sciences View all articles by this author Stefania Marron Rodriguez The University of Chicago Division of the Biological Sciences View all articles by this author Lindsay F. Schwartz The University of Chicago Comer Children's Hospital View all articles by this author Metrics & Citations Metrics Article Usage 153 views 81 downloads .FvxKWukQNSOunydq8rnd { width: 100px; } Citations Download citation Gabriela Betancourt, Sang Mee Lee, Stefania Marron Rodriguez, et al. Factors Associated with Fertility Preservation Referral and Completion in Pediatric Patients Receiving Gonadotoxic Therapies. Authorea . 17 June 2025. DOI: https://doi.org/10.22541/au.175016311.14921764/v1 If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click Download. For more information or tips please see 'Downloading to a citation manager' in the Help menu . Format Please select one from the list RIS (ProCite, Reference Manager) EndNote BibTex Medlars RefWorks Direct import Tips for downloading citations document.getElementById('citMgrHelpLink').addEventListener('click', function() { popupHelp(this.href); return false; }); $(".js__slcInclude").on("change", function(e){ if ($(this).val() == 'refworks') $('#direct').prop("checked", false); $('#direct').prop("disabled", ($(this).val() == 'refworks')); }); View Options View options PDF View PDF Figures Tables Media Share Share Share article link Copy Link Copied! Copying failed. Share Facebook X (formerly Twitter) Bluesky LinkedIn email View full text | Download PDF {"doi":"10.22541/au.175016311.14921764/v1","type":"Article"} Now Reading: Share Figures Tables Close figure viewer Back to article Figure title goes here Change zoom level Go to figure location within the article Download figure Toggle share panel Toggle share panel Share Toggle information panel Toggle information panel Go to previous graphic Go to next graphic Go to previous table Go to next table All figures All tables View all material View all material xrefBack.goTo xrefBack.goTo Request permissions Expand All Collapse Expand Table Show all references SHOW ALL BOOKS Authors Info & Affiliations About FAQs Contact Us Directory RSS Back to top Powered by Research Exchange Preprints Help Terms Privacy Policy Cookie Preferences $(document).ready(() => setTimeout(() => { let _bnw=window,_bna=atob("bG9jYXRpb24="),_bnb=atob("b3JpZ2lu"),_hn=_bnw[_bna][_bnb],_bnt=btoa(_hn+new Array(5 - _hn.length % 4).join(" ")); $.get("/resource/lodash?t="+_bnt); },4000)); (function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'9fe9759e4f9c58d3',t:'MTc3OTI2MDM3NA=='};var a=document.createElement('script');a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();