The LINC02701/miR-193a-3p Axis Regulates ERBB4 Expression and Inhibits the Cell Cycle in Chronic Rhinosinusitis with Nasal Polyps

Background: Chronic sinusitis with nasal polyps (CRSwNP) is highly prevalent in the general population. Though CRSwNP substantially affects the quality of life of patients, there is a lack of effective treatments for this disease. Several studies have shown that long non-coding RNAs (lncRNA) and miRNAs can regulate the development of CRSwNP through ceRNA. ERBB4 is a key factor in regulating the occurrence and development of CRSwNP, but the mechanism of its expression and regulation is not clear. Objective In this study, we aimed to determine whether the LINC02701/miR-193a-3p axis could promote the development of CRSwNP by regulating the expression of ERBB4. Methods We identified differentially expressed lncRNAs, miRNAs, and mRNAs in controls and individuals with chronic sinusitis via gene set enrichment analysis. We analyzed the relationship between them by constructing a ceRNA network. We performed RNA sequencing and investigated whether the LINC02701/miR-193a-3p axis could promote the development of CRSwNP by regulating ERBB4 expression levels. Results Our findings showed that changes in LINC02701 and miR-193a-3p expression levels resulted in a change in ERBB4 expression levels. Further study found that LINC02701 regulates the expression of ERBB4 through miR-193a-3p, which in turn affects the occurrence and development of CRSwNP. Conclusion This project will provide new ideas for clinical diagnosis and treatment of CRSwNP.