A levonorgestrel releasing intrauterine system was more cost effective than was hysterectomy for menorrhagia

(2001) Lancet 357, 273. Hurskainen R, Teperi J, Rissanen P, et al. . Quality of life and cost-effectiveness of levonorgestrel-releasing intrauterine system versus hysterectomy for treatment of menorrhagia: a randomised trial. . Jan 27; . : . –7. . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In women with menorrhagia, is the levonorgestrel releasing intrauterine system (IUS) more effective than hysterectomy for quality of life, psychological wellbeing, and cost outcomes? Randomised (allocation concealed*), unblinded,* controlled trial with 12 months follow up. 5 university hospitals in Finland. 236 women who were 35–49 years of age (mean age 43 y), had menorrhagia, and were eligible for hysterectomy. Exclusion criteria were submucous fibroids, endometrial polyps, ovarian tumors or cysts (diameter >5 cm), cervical disease, urinary and bowel symptoms or pain caused by large fibroids, lack of indication for hysterectomy, history of cancer, menopause, severe depression, metrorrhagia, previous treatment failure with levonorgestrel releasing IUS, severe acne, or uterine malformation. 228 women (97%) completed the 12 month … [1]: {openurl}?query=rft.jtitle%253DLancet%26rft.stitle%253DLancet%26rft.aulast%253DHurskainen%26rft.auinit1%253DR.%26rft.volume%253D357%26rft.issue%253D9252%26rft.spage%253D273%26rft.epage%253D277%26rft.atitle%253DQuality%2Bof%2Blife%2Band%2Bcost-effectiveness%2Bof%2Blevonorgestrel-releasing%2Bintrauterine%2Bsystem%2Bversus%2Bhysterectomy%2Bfor%2Btreatment%2Bof%2Bmenorrhagia%253A%2Ba%2Brandomised%2Btrial.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0140-6736%252800%252903615-1%26rft_id%253Dinfo%253Apmid%252F11214131%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0140-6736(00)03615-1&link_type=DOI [3]: /lookup/external-ref?access_num=11214131&link_type=MED&atom=%2Febmed%2F6%2F4%2F127.atom [4]: /lookup/external-ref?access_num=000166693400013&link_type=ISI