Нові підходи до проблемних питань лікування генітального ендометріозу

New approaches to the treatment of endometriosis DOI: https://doi.org/10.18370/2309-4117.2013.11.36-42Keywords: endometriosis, L-arginine, TivortinAbstract The results of the study that involving 64 women with endometriosis have shown that the use in the treatment of L-arginine (the drug Tivortin) has a direct impact on the underlying factors that play role in the development and progression of endometriosis. It makes the use of non-hormonal drug promising in treatment of endometriosis andhas an important role in the prevention of its recurrence.References - Eskenazi B, Warner MLE pidemiology of endometriosis // ObstetGynecolClin North Am. – 1997. – 24: 235–58. - Johnson N, Hummelshoj L Consensus on current management of endometriosis // Human Reproduction. – 2013. –Vol. 0. – N. 0. – Р. 1–17. - Ziegler D, Borghese B Endometriosis and infertility: pathophysiology and management Review Article // The Lancet. – 2010. – Vol. 376. Issue 9742. – Р. 730–738. - Bulun S Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis // SeminReprod Med. – 2010. – 28 (1). – Р. 36–43. - Meng-Hsing Wu Tsai Prostaglandin E2: the master of endometriosis? / Meng-Hsing Wu,Chun-Wun Lu, Pei-Chin Chuang, Shaw-Jenq // Experimental Biology and Medicine. – 2010. – 235. – Р. 668–677. - Capobianco A, Rovere-Querini P Endometriosis, a disease of the macrophage // Frontiers in Immunology and Inflammation. – 2013. – Vol. 4. – Р. 9–12. - Fernando L, Carvalho P Oxidative stress biomarkers in patients with endometriosis: systematic review // Arch Gynecol Obstet. – 2012. – Р. 286: 103. - WahI R, Chan S Identification of Cells with Colony-Forming Activity, Self-Renewal Capacity, and Multipotency in Ovarian Endometriosis // The American Journal of Pathology. – 2011. – Vol. 178. – Issue 6. – Р. 2832–2844. - Sutton CJ Prospective, randomized, double-blind, controlled trial of laser laparoscopy in the treatment of pelvic pain associated with minimal, mild, and moderate endometriosis / Sutton CJ, Ewen SP, Whitelaw N, Haines P // FertilSteril. – 1994. – Vol. 62 (4). – Р. 696–700. - Adamson GD Endometriosis classification: an update // CurrOpinObstet Gynecol. – 2011. – Vol. 23 (4). – Р. 213–20. - Janssen EB Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review / EB Janssen, K Hoppenbrouwers, C Meuleman1, TD Hooghe // Hum. Reprod. Update first published online May 31, 2013. - Laschke MW Vasculogenesis: a new piece of the endometriosis puzzle / MW Laschke, C Giebels, M Menger // Human Reproduction Update – 2011. – Vol. 17. – N. 5. – Р. 628–636 - Artini M, Ruggiero F, Papini G, Simi V Cela and AR Genazzani. – 2011. – 256 p. - Taylor R Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis / R Taylor, Jie Yu, M Torres, A Schickedanz, J Park, M Mueller, N Sidell. – Reprod Sci. – 2009. – Vol. 16 (2). – Р. 140–146. - Van A Langendonckt. Antiangiogenic and vascular-disrupting agents in endometriosis: pitfalls and promises / A Van Langendonckt, J Donnez, S Defre`re1, G Dunselman, P Groothuis // Molecular Human Reproduction. – 2008. – Vol. 14. – N. 5. – Р. 259–268. - Gupta S Role of oxidative stress in endometriosis // Reproductive BioMedicine Online. – 2006. – Vol. 13. – N 1. – Р. 126–134. - Chatterjee S Arginine metabolic pathways determine its therapeutic benefit in experimental heatstroke: Role of Th1/Th2 cytokine balance / S Chatterjee, S Premachandran, R Bagewadikar, S Bhattacharya, S Chattopadhyay, T Poduval // Nitric Oxide. – 2006. – Vol. 15. – Issue 4. – P. 408–416. - Marroni A Consistent interethnic differences in the distribution of clinically relevant endothelial nitric oxide synthase genetic polymorphisms / A Marroni, I Metzger, D Souza-Costa, S Nagassaki, V Sandrim, R Correa // Nitric Oxide. – 2005. – Vol. 12. – Issue 3. – P. 177–182. - Rogers M, D’Amato R Common Polymorphisms in Angiogenesis // Cold Spring Harbor Laboratory Press. – 2013. - Kinugasa S Increased asymmetric dimethylarginine and enhanced inflammation are associated with impaired vascular reactivity in women with endometriosis / S Kinugasa, K Shinohara, A Wakatsuki // Atherosclerosis. – 2011. – Vol. 219. – Issue 2. – P. 784–788. - Cayci T The levels of nitric oxide and asymmetric dimethylarginine in the rat endometriosis model / T Cayci, E Akgul, Y Kurt1 T Ceyhan, I Aydin, O Onguru, H Yaman, E Cakir // Journal of Obstetrics and Gynaecology Research. – 2011. – Vol. 37. – Issue 8. – P. 1041–1047. - Noris M L-arginine depletion in preeclampsia orients nitric oxide synthase toward oxidant species / Noris M, Todeschini M, Cassis P, Pasta F, Cappellini A, Bonazzola S, Macconi D, Maucci R, Porrati F, Benigni A, Picciolo C, Remuzzi G // Hypertension. – 2004. – Vol. 43 (3). – P. 614–622. - López-Jaramillo P Review: The role of the L-arginine-nitric oxide pathway in preeclampsia // TherAdvCardiovasc Dis. – 2008. – Vol. 2. – N. 4. – P. 261–275. - Khan KN Role of prostaglandin E2 in bacterial growth in women with endometriosis // Hum Reprod. – 2012. – Vol. 27 (12). – P. 3417–3424. - Stepanov YM Arginine in medical practice / Stepanov YM, Kononov IN, Zhurbina AI, Filippova AY // J. Academy of Medical Sciences of Ukraine. – 2004. – V. 10. – № 1. – P. 340–352. - Babushkina AB L-arginine from the point of view of evidence-based medicine // Ukrainian Medical Journal. – 2009. – № 6 (74). – P. 21–30. - Lisitsyna NV Medications that affect the synthesis nitric oxide and their place in the pathogenesis of preeclampsia therapy // Scientific Statement of the Belgorod State University. – 2010. – № 10. – Vol. 10. – P. 10–18. Downloads Published How to Cite Issue Section License Copyright (c) 2014 Т. Ф Татарчук, Н. Ф. Захаренко, Т. Н. Тутченко This work is licensed under a Creative Commons Attribution 4.0 International License. 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