Diagnostic accuracy of clinical tools for assessment of acute stroke: a systematic review

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Thus, a number of clinical assessment tools have been developed and this review examines their diagnostic capabilities. Methods: Diagnostic performance of currently available clinical tools for identification of acute ischaemic and haemorrhagic strokes and stroke mimicking conditions was reviewed. A systematic search of the literature published in 2015-2018 was conducted using PubMed, EMBASE, Scopus and The Cochrane Library. Prehospital and in-hospital studies with a minimum sample size of 300 patients reporting diagnostic accuracy were selected. Results: Twenty-five articles were included. Cortical signs (gaze deviation, aphasia and neglect) were shown to be significant indicators of large vessel occlusion (LVO). Sensitivity values for selecting subjects with LVO ranged from 23% to 99% whereas specificity was 24% to 97%. Clinical tools, such as FAST-ED, NIHSS, and RACE incorporating cortical signs as well as motor dysfunction demonstrated the best diagnostic accuracy. Tools for identification of stroke mimics showed sensitivity varying from 44% to 91%, and specificity of 27% to 98% with the best diagnostic performance demonstrated by FABS (90% sensitivity, 91% specificity). Hypertension and younger age predicted intracerebral haemorrhage whereas history of atrial fibrillation and diabetes were associated with ischaemia. There was a variation in approach used to establish the definitive diagnosis. Blinding of the index test assessment was not specified in about 50% of included studies. Conclusions: A wide range of clinical assessment tools for selecting subjects with acute stroke has been developed in recent years. Assessment of both cortical and motor function using RACE, FAST-ED and NIHSS showed the best diagnostic accuracy values for selecting subjects with LVO. There were limited data on clinical tools that can be used to differentiate between acute ischaemia and haemorrhage. Diagnostic accuracy appeared to be modest for distinguishing between acute stroke and stroke mimics with optimal diagnostic performance demonstrated by the FABS tool. Further prehospital research is required to improve the diagnostic utility of clinical assessments with possible application of a two-step clinical assessment or involvement of simple brain imaging, such as transcranial ultrasonography. Neurology acute cerebral ischaemia clinical prediction rules emergency care intracerebral haemorrhage large vessel occlusion recanalization stroke scoring methods thrombectomy thrombolysis. Figures Figure 1 Figure 2 Figure 3 Rationale Patients with acute stroke should have access to rapid assessment and early intervention with specialist care for optimal outcomes. Acute ischaemic stroke caused by a large vessel occlusion (LVO) is associated with high mortality rate of 80% [1] and can be optimally managed with intravenous (IV) thrombolysis followed by mechanical thrombectomy (MT). While IV thrombolysis can currently be provided in many general hospitals, MT can only be performed in specialised centres with neurointerventional facilities. Recanalization therapy must be delivered within the first hours after symptom onset to improve functional outcome [2,3]. This requires a reliable triage system for early identification of subjects eligible for reperfusion therapy. It is also crucial to exclude intracranial haemorrhage and stroke-mimicking conditions before initiating therapy to avoid giving inappropriate or potentially life-threatening IV thrombolysis. An ideal triage system could potentially be used in prehospital settings to determine both immediate care (particularly in remote areas) and transfer arrangements to appropriate hospital facilities. An increasing number of studies assessing the diagnostic performance of clinical assessment tools has been seen in recent years. A systematic review of stroke recognition instruments in suspected stroke patients was performed by Rudd et al (2016) [4], and included studies that were published before 10 August 2015. The current review follows directly on from this date, and has been designed with the aim of answering the following questions: What is the sensitivity and specificity of currently available clinical assessment tools for detecting subjects with ischaemic stroke due to LVO? What is the sensitivity and specificity of currently available clinical assessment tools for diagnosing acute haemorrhagic stroke? What is the sensitivity and specificity of currently available clinical assessment tools for differentiating between acute stroke and stroke-mimicking conditions? Methods Protocol and registration The registered protocol can be accessed on PROSPERO, the international prospective register of systematic reviews: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=112492 Eligibility criteria Inclusion and exclusion criteria are presented in Table 1. Information sources A systematic search of the literature was conducted in October 2018, using a database-specific search strategy for each of the following electronic databases: PubMed, EMBASE, Scopus and The Cochrane Library . Search strategy The search strategy included the following combination of multiple iterations of MeSH and keyword terms relating to each component of the research questions: intracranial hemorrhages, cerebral intraparenchymal hematoma, cerebrovascular apoplexy, brain infarction, acute stroke, brain ischemia, cerebrovascular occlusion, cerebral infarction, transient ischemic attack, “stroke mimic*”, prehospital emergency care, emergency care, scoring methods, neurologic signs and symptoms, differential diagnosis, neurologic examination, predictive value of tests, sensitivity and specificity, logistic models. The search was restricted to human studies, English language, adult participants, and publication years 2015-2018. This restricted publication date range was chosen to perform an updated analysis of the data available. A systematic review by Rudd et al (2016) included prospective studies and excluded retrospective studies, research within a known stroke population, tools that were exclusively used by ambulance dispatchers or with telecommunication systems [4]; however all of these were included in our systematic analysis. Study selection Titles of studies retrieved using the search strategy were screened by one of the review authors to identify studies that potentially met the inclusion criteria outlined in Table 1. The abstracts of those potentially eligible studies were independently assessed for eligibility by three review team members. Any disagreements between them over the eligibility of particular studies were resolved through discussion with a fourth reviewer. Eligible papers were tabulated and used in the qualitative synthesis. Studies which reported diagnostic accuracy values such as sensitivity, specificity, and positive and negative predictive values were included in the quantitative meta-analysis. Data collection process A dedicated data extraction form was developed and used to collect relevant information from the included studies. The inclusion of information fields in the data collection form was guided by the review questions. The following components were assessed: study identification: name of the first author and publication year; setting for the application of the studied clinical tool: prehospital or in-hospital; inclusion/exclusion criteria for participants; sample size; name of the clinical assessment tool studied (where applicable); clinical information collected; background of personnel collecting and interpreting clinical information; diagnostic approach used to establish a final diagnosis; diagnostic accuracy values: true positive, true negative, false positive, false negative values, positive and negative predictive values, and/or positive and negative likelihood ratios, sensitivity and specificity. As our analysis concerned only published data, no further data were sought from investigators. Risk of bias assessment in individual studies Two review authors qualitatively assessed included studies for a risk of bias and concerns regarding their applicability for each of three domains: patient selection, index test, and flow and timing, in accordance with the QUADAS-2 Tool quality assessment system [5]. A table summarising risk of bias and applicability concerns was constructed. Data synthesis The synthesis was performed in accordance with the Cochrane guidelines for diagnostic test accuracy reviews. The diagnostic accuracy data from each study were presented graphically by plotting sensitivities and specificities on a coupled column chart. Results Study selection The results of the study selection process are illustrated in Figure 1. Study characteristics The current review includes 25 new studies whereas adding to Rudd et al’s review (2016) [4], which included 18 primary studies out of the total number of 5622 references identified. The main characteristics of the studies included in the current review are presented in Additional file 1. In total, 25,642 cases were assessed across the included studies published between 2015-2018. Participants were recruited in the prehospital setting, or upon presentation to the hospital, or both. Of the included studies, 16/25 (64%) were retrospective. Risk of bias assessment in individual studies A summary of bias and applicability concerns is presented in Additional file 2. All included studies recruited consecutive patients. Case-control methodology was avoided in all cases. Only studies with a high sample size of more than 300 participants according to Meader et al’s (2014) classification [6] were considered for inclusion to ensure greater reliability of the study results. All included studies were analysed against the adequate blinding criterion. In 13/25 (52%) papers it was not specifically mentioned or was judged to be unclear whether the results of clinical assessment (the index test) were interpreted independently from those tests that were used to make a final diagnosis (the reference test) [7,8,17–19,9–16]. The approach for establishing the final diagnosis was described in all included studies. Hospital discharge diagnosis was referred to as the gold standard in six papers, brain or cerebral vessel imaging alone in 14 cases, and five papers used clinical assessment together with imaging to establish the definitive diagnosis. Diagnostic accuracy of clinical tools in selecting subjects with LVO More than 20 different clinical assessment tools with optimal cut-offs for selecting subjects with ischaemic stroke due to LVO were analysed in this review (Table 2). Sensitivity values ranged from 23% (NIHSS subitem LoC 1a) to 99% (NIHSS³4, NIHSS³6, a combination of reduced level of consciousness with inability to answer questions, facial weakness, arm weakness, sensation loss, and aphasia). Specificity ranged from 24% (OoH-NIHSS≥1, CPSS³1) to 97% (G-FAST=4). For simplicity, only those tools showing both sensitivity and specificity values ³80% (an arbitrarily chosen threshold) were selected to be plotted (Figure 2). It was suggested by Beume et al. (2018) [19] that cortical signs such as gaze deviation, aphasia or agnosia, and/or neglect were more accurate predictors of LVO than motor deficit alone (PPV 60%, NPV 94%). However, as demonstrated in Figure 2, FAST-ED³4 (PPV 80%, NPV 100%), NIHSS³10 (PPV 78%, NPV 99%), and RACE³5 (PPV 81%, NP 99%) had the best diagnostic accuracy for selecting subjects with LVO. All three clinical assessment tools incorporate cortical signs as well as motor dysfunction. The best sensitivity value of the combination of motor deficit and cortical signs incorporated into the Finnish Prehospital Stroke Scale (face drooping, limb weakness, speech difficulty, visual disturbance, and conjugate eye deviation) was for detection of proximal M1 occlusions (100%) and the lowest – for M2 and basilar artery – were 13% and 22%, respectively [13]. Moore et al. (2016) demonstrated that presence of all four components forming a combination of reduced consciousness level, lower limb weakness, dysarthria, and gaze deviation had sensitivity of 96% and specificity of 39% for LVO when compared with computed tomography angiography (CTA) [20]. Thus, those who do not have all four clinical features are less likely to have LVO, and therefore would not require CTA, decreasing the need for this test by about 32%. This approach might also contribute to decisions about immediate transfer to an endovascular centre for MT. Diagnostic accuracy of clinical tools in detecting acute haemorrhagic stroke The paper by Jin et al. (2016) [21] was the single eligible study for the present review that aimed to distinguish between two main subtypes of stroke – ischaemic stroke and haemorrhage. A total of 1989 cases from the Chinese population with suspected first-ever acute stroke were analysed. They proposed a discriminant function model based on the following clinical assessment findings: age above 65 years, past medical history of diabetes (DM), atrial fibrillation (AF), systolic blood pressure (SBP) above 180 mmHg, and vomiting at onset. It has shown a higher sensitivity but lower specificity for selecting subjects with ischaemic stroke (42-75.7% and 63.3-93.6%, respectively). Diagnostic accuracy values for haemorrhage were the opposite of the above: low sensitivity with higher specificity (58.5-93.6% and 42-79.2%, respectively). It has also been suggested that a history of AF and DM were more likely to be associated with ischaemic stroke, whereas high SBP and younger age were associated with haemorrhage. Diagnostic accuracy of clinical tools for differentiating between acute stroke and stroke-mimicking conditions There was a significant variation in diagnostic accuracy of tools designed for distinguishing between acute stroke and stroke mimics as shown in Figure 3. Sensitivity values varied from 44% (LAPSS 1998) to 91% (sNIHSS-EMS). Specificity ranged from 27% (MPDS) to 98% (LAPSS 1998) (Table 3). FABS showed the best diagnostic accuracy values with 90% sensitivity and 91% specificity [22]. The MPDS tool was developed to facilitate early identification of stroke or transient ischaemic attack by emergency medical dispatchers to enable early notification to receiving hospitals, and demonstrated satisfactory sensitivity of 86% but low specificity of 27% (PPV 20%, NPV 90%). Similarly, sNIHSS-EMS, which consisted of six NIHSS items selected as “suitable for prehospital use” [24] (level of consciousness, facial palsy, motor arm/leg, sensory, language and dysarthria), had the highest sensitivity value (91%) when compared with other clinical assessment tools but fairly low specificity (52%) (PPV 43%, NPV 93%). In contrast, LAPSS 1998 and LAPSS 2000 had the highest specificity (98% and 97%, respectively) but the lowest sensitivity (44% and 49%, respectively) values among the other tools [12,15]. The FABS tool was developed for identification of subjects with stroke-mimicking conditions and negative brain CT findings in the emergency department. The total score is calculated based on the absent risk factors for stroke (AF, hypertension, advanced age) and presence of sensory disturbance with no motor deficit. FABS showed the best overall diagnostic accuracy values of 90% sensitivity and 91% specificity (PPV 87%, NPV 93%) [22]. Discussion A reliable triage system that could allow emergency transfer of patients eligible for MT directly to a regional centre with neurointerventional facilities following early IV thrombolysis (“drip and ship”) [25] could transform stroke care. The present systematic review attempted to evaluate the diagnostic accuracy of clinical assessment tools for (1) selecting subjects with ischaemic stroke due to LVO; (2) differentiating between two main subtypes of stroke – ischaemic stroke and haemorrhage, and (3) distinguishing between acute stroke cases and stroke mimics. All reviewed studies had a minimum sample size of 300 consecutive participants [6] leading to good reliability of reported findings. There were however some limitations found in the included studies which were mainly related to unclear blinding of researchers interpreting the results of the index and reference tests, and discrepancy in the approach used to establish the gold standard. As proposed by Beume et al. (2018) [19], cortical signs such as aphasia or neglect are more accurate predictors of LVO than motor deficit alone. However, a combination of signs suggestive of cortical involvement and motor deficit, for example, as assessed by FAST-ED, RACE or NIHSS scales, led to better diagnostic accuracy when compared to the performance of cortical signs alone as evaluated by the Pomona scale (Table 2). Modest diagnostic accuracy was seen in clinical assessment tools aiming to distinguish between acute stroke and stroke mimics. The FABS tool which was designed specifically for detecting stroke mimics and included additional clinical information, such as atrial fibrillation compared to other well-established tools, for example, ROSIER, demonstrated high sensitivity and specificity rates of about 90% (PPV 87%, NPV 93%) [22]. Clinical assessment findings such as hypertension and younger age were indicative of haemorrhage, whereas a history of AF and DM were more likely to be associated with ischaemic stroke [21]. There are a few limitations of currently available tools that possibly prevent them from being widely accepted. First, their specificity rates for LVO remain quite low, which could potentially lead to inappropriate transportation of patients at high cost [27]. Second, many studies were designed in such a way that patients with haemorrhage and/or stroke-mimicking conditions were excluded, which therefore would preclude these clinical tools from being applied to prehospital settings [19]. An ideal clinical assessment tool would be a simple method that could be equally used in prehospital settings and in emergency department with high predictive values. It might be possible that a two-step approach using two different clinical assessment tools at the prehospital stage could be considered as an alternative option. The first step would be to select subjects with acute stroke who would benefit from reperfusion therapy and to exclude stroke mimicking conditions and acute intracranial haemorrhage. For this purpose, a tool with higher specificity should be considered, for example G-FAST [13]. This might allow prehospital thrombolysis to be offered to selected patients in remote areas in line with management of patients with S-T elevation myocardial infarction [29]. Thereafter, a decision on transferring subjects with suspected LVO to a specialised centre would be made on the basis of the clinical assessment score with high sensitivity value, such as NIHSS or a combination of clinical assessment findings as suggested by Moore et al. [14,20,27]. However, this approach requires further validation. It might be beneficial to use an additional diagnostic tool in combination with clinical assessment that could provide valuable information and increase the accuracy of such a triage system. Transcranial Doppler ultrasound has been shown to detect occlusions in the major cerebral arteries with 68-100% sensitivity and 78-99% specificity [30–32]. It is a relatively inexpensive and readily portable diagnostic tool that takes on average not more than 15 minutes to complete an examination of the cerebral vessels [33], and can be used in prehospital settings, potentially with remote diagnostic support [34–36]. However, further assessment and validation of this proposed system is required. Conclusion A wide range of clinical assessment tools for selecting subjects with acute stroke has been developed in recent years. Assessment of both cortical and motor function using RACE, FAST-ED or NIHSS demonstrated the best diagnostic accuracy values for selecting subjects with LVO. There were limited data on clinical tools that can be used to differentiate between acute ischaemia and haemorrhage. Diagnostic accuracy appeared to be modest for distinguishing between acute stroke and stroke mimics with optimal diagnostic performance demonstrated by the FABS tool. Further research is required to establish a novel prehospital triage system with possible application of a two-step clinical assessment or involvement of simple brain imaging, such as transcranial ultrasonography. Abbreviations AF – atrial fibrillation, DM – diabetes mellitus, IV – intravenous, LVO – large vessel occlusion, MT – mechanical thrombectomy, NPV – negative predictive value, PPV – positive predictive value, SBP – systolic blood pressure, Se – sensitivity, Sp - specificity. Declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Availability of data and materials Materials are available from the corresponding author upon request. Competing interests The authors declare no competing interests. Funding No specific funding was received for this work. Authors’ contributions All four authors were involved in the conceptualisation and development of the methodology. DA performed a complete literature search, assessment of full text of articles for eligibility and data extraction. Risk of bias assessment in individual studies was performed by DA and LE. DA performed a formal analysis of the collected data and writing of the original draft (including all tables and figures). DA finalised all drafts in consultation with LE, AM and PW. LE, AM and PW reviewed the manuscript and approved its final version. Acknowledgements This work is part of a PhD project supported by the University of Aberdeen’s Elphinstone Scholarship Programme. LE is funded by the European Space Agency SatCare grant. 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Review inclusion and exclusion criteria Domain Inclusion Exclusion Study type Comparative observational studies Case reports Prospective observational studies Selected case series Cohort studies Literature review Unselected case series Conference proceedings Full text unavailable Participants Human Non-human subjects Adults Exclusively paediatric patients Mixed paediatric and adult populations (where paediatric and adult groups are not possible to identify separately) Patients with ischaemic stroke (including patients with LVO), acute haemorrhagic stroke, and/or stroke-mimicking conditions and transient ischaemic attack Exclusively patients with non-stroke conditions, such as sickle cell disease, arteriovenous malformation, traumatic brain injury, cerebral tumour, subarachnoid haemorrhage, vertigo etc. Sample size ³ 300 participants [6] Sample size < 300 participants Setting Prehospital and in-hospital Procedure Use of a clinical assessment tool, including clinical scales, individual symptoms and signs designed for identification of patients with ischaemic stroke, including subjects with LVO, acute haemorrhagic stroke, and/or stroke-mimicking conditions Exclusively assessing the diagnostic accuracy of a brain imaging modality for identification of patients with acute stroke and/or stroke-mimicking conditions Aims/outcomes Diagnostic accuracy of clinical tools designed for identification of patients with ischaemic stroke, including subjects with LVO, acute haemorrhagic stroke, and/or stroke mimicking conditions Exclusively assessing the prognosis of functional disability caused by a stroke Diagnostic accuracy of clinical tools designed for differentiation between two main subtypes of stroke – ischaemic and haemorrhagic Exclusively evaluating factors associated with misdiagnosis of stroke Exclusively diagnosing stroke patients with no assessment of clinical factors Publication 2015 - 2018 Before January 2015 In English In languages other than English Table 2. Diagnostic accuracy values of clinical tools for selecting subjects with large vessel occlusion. Clinical assessment Se Sp PPV NPV AUC ACT-FAST [18] 0.85 0.93 0.53 0.99 0.90 aNIHSS ³ 1 [27] 0.95 0.31 0.40 0.92 - a-NIHSS item profile A ³ 3 [37] 0.64 0.69 0.76 0.55 0.66 a-NIHSS item profile B ³ 2 [37] 0.75 0.64 0.76 0.63 0.71 a-NIHSS item profile C ³ 2 [37] 0.51 0.73 0.75 0.50 0.60 a-NIHSS item profile D ³ 2 [37] 0.76 0.61 0.75 0.62 0.70 a-NIHSS item profile E ³ 2 [37] 0.71 0.65 0.76 0.60 0.68 Aphasia; Neglect/gaze deviation [19] 0.91 0.70 0.60 0.94 0.77 Arm weakness [14] 0.96 0.41 0.18 0.99 0.68 Arm weakness; Leg weakness; Dysarthria [20] 0.92 0.44 0.28 0.96 - Bernese score 1 ³ 5 [37] 0.73 0.79 0.85 0.66 0.76 Bernese score 2 ³ 2 [37] 0.71 0.80 0.84 0.64 0.74 Bernese score 3 ³ 2 [37] 0.67 0.86 0.88 0.63 0.75 Bernese score 4 ³ 1 [37] 0.67 0.83 0.86 0.63 0.74 Bernese score 5 ³ 3 [37] 0.77 0.83 0.87 0.70 0.79 CPSS ³ 1 [27] 0.96 0.24 0.38 0.93 - CPSS ³ 2 [14,26] 0.56-0.92 0.81-0.85 0.40-0.65 0.78-0.99 0.75-0.78 CPSS1 ³ 2 [37] 0.59 0.77 0.80 0.55 0.66 CPSS2 ³ 2 [37] 0.73 0.71 0.79 0.63 0.72 CPSSS ³ 1 [37,38] 0.60-0.86 0.80-0.87 0.88 0.59 0.71 CPSSS ³ 2 [9,10,24,27,38] 0.59-0.83 0.40-0.89 0.66-0.77 0.77-0.83 0.72-0.80 CPSSS ³ 3 [38] 0.51 0.93 - - - CPSSS =4 [38] 0.25 0.96 - - - C-STAT [13] 0.54 0.91 0.45 0.93 0.79 C-STAT ³ 2 [8,17,18] 0.47-0.85 0.68-0.85 0.35-0.40 0.88-0.98 0.65-0.85 DIRECT criteria [16] 0.74 0.92 0.43 0.98 0.91 EMSA ³ 3 [8] 0.75 0.50 - - 0.69 Expressive aphasia [14] 0.39 0.64 0.13 0.88 0.52 Facial weakness [14] 0.93 0.50 0.20 0.98 0.72 FAST=3 [17] 0.84 0.44 0.32 0.90 0.53 FAST-ED [13] 0.62 0.84 0.40 0.94 0.84 FAST-ED ³ 3 [26] 0.71 0.78 0.62 0.84 0.76 FAST-ED ³ 4 [8,18,24,26] 0.42-0.96 0.82-0.90 0.24-0.80 0.82-1.00 0.64-0.91 FPSS [13] 0.54 0.91 0.47 0.93 0.85 Gaze deviation [14] 0.84 0.73 0.30 0.97 0.79 G-FAST ³ 3 [13,17] 0.75-0.89 0.39-0.83 0.31-0.39 0.92-0.96 0.51-0.85 G-FAST =4 [13] 0.36 0.97 0.59 0.91 LAMS ³ 4 [9,14,18] 0.57-0.94 0.74-0.85 0.28-0.66 0.78-0.99 0.70-0.89 mNIHSS ³ 5 [37] 0.78 0.76 0.85 0.69 0.78 mNIHSS ³ 7 [27] 0.77 0.77 0.62 0.87 - MPSS ³ 3 [27] 0.84 0.65 0.54 0.89 - Neglect [14] 0.88 0.69 0.28 0.98 0.79 Neglect/gaze deviation [14] 0.95 0.64 0.27 0.99 0.79 NIHSS ³ 4 [14,27] 0.93-0.99 0.24-0.46 0.15-0.46 0.93-0.99 0.62 NIHSS ³ 5 [27] 0.90 0.54 0.49 0.92 - NIHSS ³ 6 [8,14,26,27] 0.66-0.99 0.39-0.70 0.18-0.55 0.85-1.00 0.68-0.72 NIHSS ³ 7 [27,37] 0.81 0.72-0.77 0.59-0.84 0.72-0.89 0.79 NIHSS ³ 8 [14,24] 0.72-0.98 0.48-0.81 0.21-0.71 0.82-0.99 0.71 NIHSS ³ 9 [8,24,27] 0.53-0.81 0.72-0.85 0.59-0.75 0.81-0.89 - NIHSS ³ 10 [14,24,26,27,39] 0.64-0.98 0.56-0.88 0.23-0.78 0.80-0.99 0.75-0.84 NIHSS ³ 14 [27] 0.61 0.88 0.72 0.82 - NIHSS-8 [13] 0.63 0.89 0.44 0.94 0.84 NIHSS-8 ³ 8 [7] 0.81 0.75 0.52 0.92 0.82 NIHSS subitem – LoC (1a) [14] 0.23 0.81 0.14 0.88 0.52 NIHSS subitem – LoC (1b) [14] 0.60 0.56 0.16 0.91 0.58 NIHSS subitem – LoC (1c) [14] 0.49 0.68 0.17 0.91 0.59 NIHSS; Absence of prestroke handicap (mRS≤2); Hemineglect; AF; Female sex; Total score cut-off ³ 16 [39] 0.84 0.68-0.71 0.41-0.54 0.92-0.94 0.84 NIHSS symptom profile A or B [17] 0.76 0.65 0.40 0.90 0.68 OoH-NIHSS ≥1 [27] 0.96 0.24 0.38 0.93 - PASS [13] 0.69 0.85 0.40 0.95 0.81 PASS ³ 2 [9,14,17,18,24] 0.64-0.96 0.59-0.84 0.33-0.74 0.81-1.00 0.63-0.89 Pomona ³ 1 [14] 0.98 0.50 0.21 0.99 0.74 Pomona ³ 2 [14] 0.86 0.71 0.71 0.97 0.79 RACE ³ 3 [37] 0.74 0.80 0.85 0.67 0.77 RACE ³ 5 [8,9,16–18,24,26–28] 0.46-0.92 0.68-0.91 0.27-0.81 0.78-0.99 0.67-0.90 RACE V1 ³ 4 [28] 0.85 0.56 - - 0.81 RACE V2 ³ 4 [28] 0.85 0.62 - - 0.79 RACE V3 ³ 3 [28] 0.89 0.48 - - 0.78 RACE V4 ³ 4 [28] 0.87 0.56 - - 0.80 RACE V5 ³ 4 [28] 0.83 0.57 - - 0.79 RACE V6 ³ 4 [28] 0.83 0.63 - - 0.77 RACE V7 ³ 3 [28] 0.87 0.51 - - 0.76 Reduced level of consciousness with inability to answer questions; Leg weakness; Dysarthria; Gaze deviation [20] 0.96 0.39 0.27 0.98 - Reduced level of consciousness with inability to answer questions; Facial weakness; Arm weakness; Sensation loss; Aphasia [20] 0.99 0.28 0.99 0.25 - Reduced level of consciousness with inability to answer questions; Leg weakness; Neglect; Gaze deviation [20] 0.85 0.45 0.26 0.93 - rNIHSS (profile A, B, C, D or E vs. profile F) [27] 0.83 0.61 0.51 0.88 - ROSIER ³ 4 [27] 0.79 0.76 0.61 0.88 - sCPSSS (severe arm weakness, conjugate gaze deviation) ³ 1 [38] 0.83 0.83 sCPSSS ³ 2 [38] 0.59 0.90 sCPSSS =3 [38] 0.50 0.94 sNIHSS-1 ³ 1 [37] 0.63 0.80 0.83 0.59 0.70 sNIHSS-1 ³ 2 [27] 0.66 0.81 0.63 0.83 sNIHSS-5 ³ 2 [37] 0.76 0.77 0.84 0.68 0.76 sNIHSS-5 ³ 3 [24] 0.69 0.81 0.70 0.80 0.80 sNIHSS-5 ³ 4 [27] 0.72 0.80 0.63 0.85 - sNIHSS-8 ³ 4 [37] 0.78 0.76 0.84 0.69 0.77 sNIHSS-8 ³ 6 [24,27] 0.64-0.77 0.78-0.88 0.63-0.78 0.79-0.88 0.82 sNIHSS-EMS ³ 6 [24] 0.70 0.81 0.70 0.81 0.81 VAN [14] 0.95 0.56 0.23 0.99 0.77 Visual field defect [14] 0.88 0.75 0.33 0.98 0.82 3I-SS [9,13] 0.42-0.50 0.92-0.93 0.45-0.77 0.77-0.92 0.71-0.78 3I-SS ³ 1 [37] 0.73 0.78 0.83 0.65 0.75 3I-SS ³ 2 [17] 0.65 0.72 0.42 0.87 0.71 3I-SS ³ 4 [8,24,27] 0.19-0.40 0.94-0.95 0.74-0.85 0.71-0.74 0.65-0.80 Abbreviations: NPV – negative predictive value; PPV – positive predictive value; Se – sensitivity; Sp – specificity. Table 3. Diagnostic accuracy values of clinical tools for selecting subjects with acute stroke and stroke-mimicking conditions. Clinical tool Target condition Se Sp PPV NPV AUC CPSS [15] Acute stroke 0.83 0.69 0.50 0.91 - FABS ³ 3 [22] Stroke mimic 0.90 0.91 0.87 0.93 - FAST [12,15] Acute stroke 0.76-0.85 0.64-0.68 0.50-0.93 0.30-0.92 0.70 GZSS ³ 1.5 [12] Acute stroke 0.83 0.74 0.95 0.42 0.87 LAPSS [12] Acute stroke 0.56 0.88 0.97 0.25 - LAPSS 1998 [15] Acute stroke 0.44 0.98 0.87 0.82 - LAPSS 2000 [15] Acute stroke 0.49 0.97 0.87 0.84 - MASS [15] Acute stroke 0.63 0.94 0.79 0.87 - Med PACS [15] Acute stroke 0.71 0.92 0.76 0.90 - MPDS [23] Acute stroke 0.86 0.27 0.20 0.90 - ROSIER [12,15] Acute stroke 0.78-0.80 0.71-0.79 0.59-0.94 0.34-0.91 0.77 sNIHSS-EMS [24] Acute stroke 0.91 0.52 0.43 0.93 - TriAGe+ ³ 10 [11] Acute stroke 0.78 0.72 0.57 0.87 0.78 Abbreviations: NPV – negative predictive value; PPV – positive predictive value; Se – sensitivity; Sp – specificity. Additional material legend Additional file 1.docx Characteristics of included studies, table Additional file 2.docx Risk of bias and applicability concerns summary, table Supplementary Files Additionalfile2.pdf Additionalfile3.docx Additionalfile1.pdf PRISMAchecklistrevisedpagenumbers.pdf Cite Share Download PDF Status: Published Journal Publication published 04 Sep, 2019 Read the published version in BMC Emergency Medicine → Version 2 posted Editorial decision: Accept 15 Aug, 2019 Editor assigned by journal 14 Aug, 2019 Submission checks completed at journal 13 Aug, 2019 Editor invited by journal 13 Aug, 2019 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-2154","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":134306,"identity":"e6c1deb9-8348-4100-8c3a-14e5d148d77c","order_by":1,"name":"Daria Antipova","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAABDklEQVRIiWNgGAWjYDCCA2AEBMxg0obBgCEBIiNBSAsPREsacVrAgAdCHSashe/42YcHfjDY5dmz8x58zFNzXt6cPfcAw48ahsSZDdi1SJ5JNzjYw5BczMPMl2zMc+y24c6edwmMPccYEmfjsMXgQBrDAR4G5sQeZh4zyRlstxk33MgxYOBtYEich0vL+WcMB/8w1EO1/DtnD9LC+BeflhtpDId5GA6DtUh8bDuQCNLCDLIFl8MkbzxjOCxjcDyx5zBfssHHvuTknT1vDA7LHJMwxuV9vvNpzB/fVFQntvefPfgg4Zud7Xb2HMOHb2psZGccwGENxHkgggfBP4AnIpEBD2Elo2AUjIJRMDIBAOQLXMVgvOMhAAAAAElFTkSuQmCC","orcid":"https://orcid.org/0000-0002-0267-1903","institution":"University of Aberdeen","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Daria","middleName":"","lastName":"Antipova","suffix":""},{"id":134307,"identity":"9af4ecb9-74d3-496a-8ef5-15f7e77ac383","order_by":2,"name":"Leila Eadie","email":"","orcid":"","institution":"University of Aberdeen Institute of Applied Health Sciences","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Leila","middleName":"","lastName":"Eadie","suffix":""},{"id":134308,"identity":"8d5d3615-89b8-41ec-a469-4337d62736cf","order_by":3,"name":"Ashish Macaden","email":"","orcid":"","institution":"NHS Highland","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ashish","middleName":"","lastName":"Macaden","suffix":""},{"id":134309,"identity":"8addc896-7d69-44ff-bd59-a7b5d69403b1","order_by":4,"name":"Philip Wilson","email":"","orcid":"","institution":"University of Aberdeen Institute of Applied Health Sciences","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Philip","middleName":"","lastName":"Wilson","suffix":""}],"badges":[],"createdAt":"2019-07-08 16:02:18","currentVersionCode":2,"declarations":"","doi":"10.21203/rs.2.11249/v2","doiUrl":"https://doi.org/10.21203/rs.2.11249/v2","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12873-019-0262-1","type":"published","date":"2019-09-04T12:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":122326,"identity":"25afdfb3-6ef0-4919-8f80-590953ace528","added_by":"auto","created_at":"2019-10-12 01:09:52","extension":"jpg","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":653037,"visible":true,"origin":"","legend":"PRISMA flowchart. Outline of the study selection process using inclusion and exclusion criteria.","description":"","filename":"Figure1.jpg","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/Figure 1.jpg"},{"id":122328,"identity":"0ab6b60d-799f-467c-9797-e4303051b008","added_by":"auto","created_at":"2019-10-12 01:09:53","extension":"jpg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":490963,"visible":true,"origin":"","legend":"Bar chart. Sensitivity and specificity values across the clinical tools for selecting subjects with large vessel occlusion.","description":"","filename":"Figure2.jpg","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/Figure 2.jpg"},{"id":122331,"identity":"db14b14c-11a3-4325-ae6e-27f8f76ba2fe","added_by":"auto","created_at":"2019-10-12 01:09:53","extension":"jpg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":338820,"visible":true,"origin":"","legend":"Bar chart. Sensitivity and specificity values of clinical tools for differentiating between acute stroke and stroke-mimicking conditions.","description":"","filename":"Figure3.jpg","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/Figure 3.jpg"},{"id":13476935,"identity":"9e417dba-6c5a-4999-beeb-ab31dce9b74b","added_by":"auto","created_at":"2021-09-16 21:29:23","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":604377,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-2154/v2/180d7b74-ee71-4322-93c3-bb636006b583.pdf"},{"id":122332,"identity":"df3a4705-68e1-4110-82b5-0f40b8d94980","added_by":"auto","created_at":"2019-10-12 01:09:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":75651,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile2.pdf","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/Additional file 2.pdf"},{"id":122330,"identity":"8e0a7921-296e-4040-952b-341c25010938","added_by":"auto","created_at":"2019-10-12 01:09:53","extension":"docx","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":16316,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile3.docx","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/Additional file 3.docx"},{"id":122329,"identity":"ef516471-7d72-4650-8ab6-94f0b2534a75","added_by":"auto","created_at":"2019-10-12 01:09:53","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":147926,"visible":true,"origin":"","legend":"","description":"","filename":"Additionalfile1.pdf","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/Additional file 1.pdf"},{"id":122327,"identity":"5f434587-2c52-4aea-8936-ee49c223d784","added_by":"auto","created_at":"2019-10-12 01:09:52","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"supplement","size":96423,"visible":true,"origin":"","legend":"","description":"","filename":"PRISMAchecklistrevisedpagenumbers.pdf","url":"https://assets-eu.researchsquare.com/files/789ed0ae-86af-41f6-9457-286c3e77c902/v2/PRISMA checklist_revised page numbers.pdf"}],"financialInterests":"","formattedTitle":"Diagnostic accuracy of clinical tools for assessment of acute stroke: a systematic review","fulltext":[{"header":"Rationale","content":"\u003cp\u003ePatients with acute stroke should have access to rapid assessment and early intervention with specialist care for optimal outcomes. Acute ischaemic stroke caused by a large vessel occlusion (LVO) is associated with high mortality rate of 80% [1] and can be optimally managed with intravenous (IV) thrombolysis followed by mechanical thrombectomy (MT). While IV thrombolysis can currently be provided in many general hospitals, MT can only be performed in specialised centres with neurointerventional facilities.\u003c/p\u003e\n\u003cp\u003eRecanalization therapy must be delivered within the first hours after symptom onset to improve functional outcome [2,3]. This requires a reliable triage system for early identification of subjects eligible for reperfusion therapy. It is also crucial to exclude intracranial haemorrhage and stroke-mimicking conditions before initiating therapy to avoid giving inappropriate or potentially life-threatening IV thrombolysis. An ideal triage system could potentially be used in prehospital settings to determine both immediate care (particularly in remote areas) and transfer arrangements to appropriate hospital facilities.\u003c/p\u003e\n\u003cp\u003eAn increasing number of studies assessing the diagnostic performance of clinical assessment tools has been seen in recent years. A systematic review of stroke recognition instruments in suspected stroke patients was performed by Rudd et al (2016) [4], and included studies that were published before 10 August 2015. The current review follows directly on from this date, and has been designed with the aim of answering the following questions:\u003c/p\u003e\n\u003col\u003e\n\u003cli\u003eWhat is the sensitivity and specificity of currently available clinical assessment tools for detecting subjects with ischaemic stroke due to LVO?\u003c/li\u003e\n\u003cli\u003eWhat is the sensitivity and specificity of currently available clinical assessment tools for diagnosing acute haemorrhagic stroke?\u003c/li\u003e\n\u003cli\u003eWhat is the sensitivity and specificity of currently available clinical assessment tools for differentiating between acute stroke and stroke-mimicking conditions?\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eProtocol and registration\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe registered protocol can be accessed on PROSPERO, the international prospective register of systematic reviews:\u003c/p\u003e\n\u003cp\u003ehttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=112492\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEligibility criteria\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eInclusion and exclusion criteria are presented in Table 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eInformation sources\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA systematic search of the literature was conducted in October 2018, using a database-specific search strategy for each of the following electronic databases: \u003cem\u003ePubMed, EMBASE, Scopus\u003c/em\u003e and \u003cem\u003eThe Cochrane Library\u003c/em\u003e.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eSearch strategy\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe search strategy included the following combination of multiple iterations of MeSH and keyword terms relating to each component of the research questions: intracranial hemorrhages, cerebral intraparenchymal hematoma, cerebrovascular apoplexy, brain infarction, acute stroke, brain ischemia, cerebrovascular occlusion, cerebral infarction, transient ischemic attack, \u0026ldquo;stroke mimic*\u0026rdquo;, prehospital emergency care, emergency care, scoring methods, neurologic signs and symptoms, differential diagnosis, neurologic examination, predictive value of tests, sensitivity and specificity, logistic models.\u003c/p\u003e\n\u003cp\u003eThe search was restricted to human studies, English language, adult participants, and publication years 2015-2018. This restricted publication date range was chosen to perform an updated analysis of the data available. A systematic review by Rudd et al (2016) included prospective studies and excluded retrospective studies, research within a known stroke population, tools that were exclusively used by ambulance dispatchers or with telecommunication systems [4]; however all of these were included in our systematic analysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStudy selection \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTitles of studies retrieved using the search strategy were screened by one of the review authors to identify studies that potentially met the inclusion criteria outlined in Table 1. The abstracts of those potentially eligible studies were independently assessed for eligibility by three review team members. Any disagreements between them over the eligibility of particular studies were resolved through discussion with a fourth reviewer.\u003c/p\u003e\n\u003cp\u003eEligible papers were tabulated and used in the qualitative synthesis. Studies which reported diagnostic accuracy values such as sensitivity, specificity, and positive and negative predictive values were included in the quantitative meta-analysis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eData collection process\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA dedicated data extraction form was developed and used to collect relevant information from the included studies. The inclusion of information fields in the data collection form was guided by the review questions. The following components were assessed:\u003c/p\u003e\n\u003cul\u003e\n\u003cli\u003estudy identification: name of the first author and publication year;\u003c/li\u003e\n\u003cli\u003esetting for the application of the studied clinical tool: prehospital or in-hospital;\u003c/li\u003e\n\u003cli\u003einclusion/exclusion criteria for participants;\u003c/li\u003e\n\u003cli\u003esample size;\u003c/li\u003e\n\u003cli\u003ename of the clinical assessment tool studied (where applicable);\u003c/li\u003e\n\u003cli\u003eclinical information collected;\u003c/li\u003e\n\u003cli\u003ebackground of personnel collecting and interpreting clinical information;\u003c/li\u003e\n\u003cli\u003ediagnostic approach used to establish a final diagnosis;\u003c/li\u003e\n\u003cli\u003ediagnostic accuracy values: true positive, true negative, false positive, false negative values, positive and negative predictive values, and/or positive and negative likelihood ratios, sensitivity and specificity.\u003c/li\u003e\n\u003c/ul\u003e\n\u003cp\u003eAs our analysis concerned only published data, no further data were sought from investigators.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eRisk of bias assessment in individual studies \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTwo review authors qualitatively assessed included studies for a risk of bias and concerns regarding their applicability for each of three domains: patient selection, index test, and flow and timing, in accordance with the QUADAS-2 Tool quality assessment system [5]. A table summarising risk of bias and applicability concerns was constructed.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eData synthesis\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe synthesis was performed in accordance with the Cochrane guidelines for diagnostic test accuracy reviews. The diagnostic accuracy data from each study were presented graphically by plotting sensitivities and specificities on a coupled column chart.\u003c/p\u003e"},{"header":"Results ","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStudy selection\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe results of the study selection process are illustrated in Figure 1.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStudy characteristics\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe current review includes 25 new studies whereas adding to Rudd et al\u0026rsquo;s review (2016) [4], which included 18 primary studies out of the total number of 5622 references identified. \u0026nbsp;The main characteristics of the studies included in the current review are presented in Additional file 1.\u003c/p\u003e\n\u003cp\u003eIn total, 25,642 cases were assessed across the included studies published between 2015-2018. Participants were recruited in the prehospital setting, or upon presentation to the hospital, or both. Of the included studies, 16/25 (64%) were retrospective.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eRisk of bias assessment in individual studies\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eA summary of bias and applicability concerns is presented in Additional file 2.\u003c/p\u003e\n\u003cp\u003eAll included studies recruited consecutive patients. Case-control methodology was avoided in all cases. Only studies with a high sample size of more than 300 participants according to Meader et al\u0026rsquo;s (2014) classification [6] were considered for inclusion to ensure greater reliability of the study results. All included studies were analysed against the adequate blinding criterion.\u003c/p\u003e\n\u003cp\u003eIn 13/25 (52%) papers it was not specifically mentioned or was judged to be unclear whether the results of clinical assessment (the index test) were interpreted independently from those tests that were used to make a final diagnosis (the reference test) [7,8,17\u0026ndash;19,9\u0026ndash;16].\u003c/p\u003e\n\u003cp\u003eThe approach for establishing the final diagnosis was described in all included studies. Hospital discharge diagnosis was referred to as the gold standard in six papers, brain or cerebral vessel imaging alone in 14 cases, and five papers used clinical assessment together with imaging to establish the definitive diagnosis.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDiagnostic accuracy of clinical tools in selecting subjects with LVO\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMore than 20 different clinical assessment tools with optimal cut-offs for selecting subjects with ischaemic stroke due to LVO were analysed in this review (Table 2).\u003c/p\u003e\n\u003cp\u003eSensitivity values ranged from 23% (NIHSS subitem LoC 1a) to 99% (NIHSS\u0026sup3;4, NIHSS\u0026sup3;6, a combination of reduced level of consciousness with inability to answer questions, facial weakness, arm weakness, sensation loss, and aphasia). Specificity ranged from 24% (OoH-NIHSS\u0026ge;1, CPSS\u0026sup3;1) to 97% (G-FAST=4).\u0026nbsp; For simplicity, only those tools showing both sensitivity and specificity values \u0026sup3;80% (an arbitrarily chosen threshold) were selected to be plotted (Figure 2).\u003c/p\u003e\n\u003cp\u003eIt was suggested by Beume et al. (2018) [19] that cortical signs such as gaze deviation, aphasia or agnosia, and/or neglect were more accurate predictors of LVO than motor deficit alone (PPV 60%, NPV 94%). However, as demonstrated in Figure 2, FAST-ED\u0026sup3;4 (PPV 80%, NPV 100%), NIHSS\u0026sup3;10 (PPV 78%, NPV 99%), and RACE\u0026sup3;5 (PPV 81%, NP 99%) had the best diagnostic accuracy for selecting subjects with LVO. All three clinical assessment tools incorporate cortical signs as well as motor dysfunction.\u003c/p\u003e\n\u003cp\u003eThe best sensitivity value of the combination of motor deficit and cortical signs incorporated into the Finnish Prehospital Stroke Scale (face drooping, limb weakness, speech difficulty, visual disturbance, and conjugate eye deviation) was for detection of proximal M1 occlusions (100%) and the lowest \u0026ndash; for M2 and basilar artery \u0026ndash; were 13% and 22%, respectively [13].\u003c/p\u003e\n\u003cp\u003eMoore et al. (2016) demonstrated that presence of all four components forming a combination of reduced consciousness level, lower limb weakness, dysarthria, and gaze deviation had sensitivity of 96% and specificity of 39% for LVO when compared with computed tomography angiography (CTA) [20]. Thus, those who do not have all four clinical features are less likely to have LVO, and therefore would not require CTA, decreasing the need for this test by about 32%. This approach might also contribute to decisions about immediate transfer to an endovascular centre for MT.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDiagnostic accuracy of clinical tools in detecting acute haemorrhagic stroke\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe paper by Jin et al. (2016) [21] was the single eligible study for the present review that aimed to distinguish between two main subtypes of stroke \u0026ndash; ischaemic stroke and haemorrhage. A total of 1989 cases from the Chinese population with suspected first-ever acute stroke were analysed. They proposed a discriminant function model based on the following clinical assessment findings: age above 65 years, past medical history of diabetes (DM), atrial fibrillation (AF), systolic blood pressure (SBP) above 180 mmHg, and vomiting at onset. It has shown a higher sensitivity but lower specificity for selecting subjects with ischaemic stroke (42-75.7% and 63.3-93.6%, respectively). Diagnostic accuracy values for haemorrhage were the opposite of the above: low sensitivity with higher specificity (58.5-93.6% and 42-79.2%, respectively). It has also been suggested that a history of AF and DM were more likely to be associated with ischaemic stroke, whereas high SBP and younger age were associated with haemorrhage.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eDiagnostic accuracy of clinical tools for differentiating between acute stroke and stroke-mimicking conditions \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere was a significant variation in diagnostic accuracy of tools designed for distinguishing between acute stroke and stroke mimics as shown in Figure 3.\u003c/p\u003e\n\u003cp\u003eSensitivity values varied from 44% (LAPSS 1998) to 91% (sNIHSS-EMS). Specificity ranged from 27% (MPDS) to 98% (LAPSS 1998) (Table 3). FABS showed the best diagnostic accuracy values with 90% sensitivity and 91% specificity [22].\u003c/p\u003e\n\u003cp\u003eThe MPDS tool was developed to facilitate early identification of stroke or transient ischaemic attack by emergency medical dispatchers to enable early notification to receiving hospitals, and demonstrated satisfactory sensitivity of 86% but low specificity of 27% (PPV 20%, NPV 90%). Similarly, sNIHSS-EMS, which consisted of six NIHSS items selected as \u0026ldquo;suitable for prehospital use\u0026rdquo; [24] (level of consciousness, facial palsy, motor arm/leg, sensory, language and dysarthria), had the highest sensitivity value (91%) \u0026nbsp;when compared with other clinical assessment tools but fairly low specificity (52%) (PPV 43%, NPV 93%). In contrast, LAPSS 1998 and LAPSS 2000 had the highest specificity (98% and 97%, respectively) but the lowest sensitivity (44% and 49%, respectively) values among the other tools [12,15].\u003c/p\u003e\n\u003cp\u003eThe FABS tool was developed for identification of subjects with stroke-mimicking conditions and negative brain CT findings in the emergency department. The total score is calculated based on the absent risk factors for stroke (AF, hypertension, advanced age) and presence of sensory disturbance with no motor deficit. FABS showed the best overall diagnostic accuracy values of 90% sensitivity and 91% specificity (PPV 87%, NPV 93%) [22].\u003c/p\u003e"},{"header":"Discussion ","content":"\u003cp\u003eA reliable triage system that could allow emergency transfer of patients eligible for MT directly to a regional centre with neurointerventional facilities following early IV thrombolysis (\u0026ldquo;drip and ship\u0026rdquo;) [25] could transform stroke care. The present systematic review attempted to evaluate the diagnostic accuracy of clinical assessment tools for (1) selecting subjects with ischaemic stroke due to LVO; (2) differentiating between two main subtypes of stroke \u0026ndash; ischaemic stroke and haemorrhage, and (3) distinguishing between acute stroke cases and stroke mimics.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003eAll reviewed studies had a minimum sample size of 300 consecutive participants [6] leading to good reliability of reported findings. There were however some limitations found in the included studies which were mainly related to unclear blinding of researchers interpreting the results of the index and reference tests, and discrepancy in the approach used to establish the gold standard.\u003c/p\u003e\n\u003cp\u003eAs proposed by Beume et al. (2018) [19], cortical signs such as aphasia or neglect are more accurate predictors of LVO than motor deficit alone. However, a combination of signs suggestive of cortical involvement and motor deficit, for example, as assessed by FAST-ED, RACE or NIHSS scales, led to better diagnostic accuracy when compared to the performance of cortical signs alone as evaluated by the Pomona scale (Table 2). \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eModest diagnostic accuracy was seen in clinical assessment tools aiming to distinguish between acute stroke and stroke mimics. The FABS tool which was designed specifically for detecting stroke mimics and included additional clinical information, such as atrial fibrillation compared to other well-established tools, for example, ROSIER, demonstrated high sensitivity and specificity rates of about 90% (PPV 87%, NPV 93%) [22]. Clinical assessment findings such as hypertension and younger age were indicative of haemorrhage, whereas a history of AF and DM were more likely to be associated with ischaemic stroke [21].\u0026nbsp; \u0026nbsp;\u003c/p\u003e\n\u003cp\u003eThere are a few limitations of currently available tools that possibly prevent them from being widely accepted. First, their specificity rates for LVO remain quite low, which could potentially lead to inappropriate transportation of patients at high cost [27]. Second, many studies were designed in such a way that patients with haemorrhage and/or stroke-mimicking conditions were excluded, which therefore would preclude these clinical tools from being applied to prehospital settings [19].\u003c/p\u003e\n\u003cp\u003eAn ideal clinical assessment tool would be a simple method that could be equally used in prehospital settings and in emergency department with high predictive values. It might be possible that a two-step approach using two different clinical assessment tools at the prehospital stage could be considered as an alternative option. The first step would be to select subjects with acute stroke who would benefit from reperfusion therapy and to exclude stroke mimicking conditions and acute intracranial haemorrhage. For this purpose, a tool with higher specificity should be considered, for example G-FAST [13]. This might allow prehospital thrombolysis to be offered to selected patients in remote areas in line with management of patients with S-T elevation myocardial infarction [29]. Thereafter, a decision on transferring subjects with suspected LVO to a specialised centre would be made on the basis of the clinical assessment score with high sensitivity value, such as NIHSS or a combination of clinical assessment findings as suggested by Moore et al. [14,20,27]. However, this approach requires further validation.\u003c/p\u003e\n\u003cp\u003eIt might be beneficial to use an additional diagnostic tool in combination with clinical assessment that could provide valuable information and increase the accuracy of such a triage system. Transcranial Doppler ultrasound has been shown to detect occlusions in the major cerebral arteries with 68-100% sensitivity and 78-99% specificity [30\u0026ndash;32]. It is a relatively inexpensive and readily portable diagnostic tool that takes on average not more than 15 minutes to complete an examination of the cerebral vessels [33], and can be used in prehospital settings, potentially with remote diagnostic support [34\u0026ndash;36]. However, further assessment and validation of this proposed system is required.\u003c/p\u003e"},{"header":"Conclusion","content":"\u003cp\u003eA wide range of clinical assessment tools for selecting subjects with acute stroke has been developed in recent years. Assessment of both cortical and motor function using RACE, FAST-ED or NIHSS demonstrated the best diagnostic accuracy values for selecting subjects with LVO. There were limited data on clinical tools that can be used to differentiate between acute ischaemia and haemorrhage. Diagnostic accuracy appeared to be modest for distinguishing between acute stroke and stroke mimics with optimal diagnostic performance demonstrated by the FABS tool. Further research is required to establish a novel prehospital triage system with possible application of a two-step clinical assessment or involvement of simple brain imaging, such as transcranial ultrasonography.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eAF – atrial fibrillation, DM – diabetes mellitus, IV – intravenous, LVO – large vessel occlusion, MT – mechanical thrombectomy, NPV – negative predictive value, PPV – positive predictive value, SBP – systolic blood pressure, Se – sensitivity, Sp - specificity.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eEthics approval and consent to participate\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eConsent for publication\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAvailability of data and materials\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eMaterials are available from the corresponding author upon request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eCompeting interests\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eFunding\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNo specific funding was received for this work.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAuthors\u0026rsquo; contributions \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAll four authors were involved in the conceptualisation and development of the methodology. DA performed a complete literature search, assessment of full text of articles for eligibility and data extraction. Risk of bias assessment in individual studies was performed by DA and LE. DA performed a formal analysis of the collected data and writing of the original draft (including all tables and figures). DA finalised all drafts in consultation with LE, AM and PW. LE, AM and PW reviewed the manuscript and approved its final version.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eAcknowledgements\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work is part of a PhD project supported by the University of Aberdeen\u0026rsquo;s Elphinstone Scholarship Programme. LE is funded by the European Space Agency SatCare grant.\u003c/p\u003e\n\u003cp\u003eThe authors would like to thank Hannah Thomas and Emma Foster for the help with assessing full text of articles for eligibility for the current review.\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eHacke W, Schwab S, Horn M, Spranger M, De Georgia M, von Kummer R. \u0026ldquo;Malignant\u0026rdquo; middle cerebral artery territory infarction: clinical course and prognostic signs. Arch Neurol. 1996;53:309\u0026ndash;15.\u003c/li\u003e\n\u003cli\u003eGoyal M, Menon BK, van Zwam WH, Dippel DWJ, Mitchell PJ, Demchuk AM, et al. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet (London, England). 2016;387:1723\u0026ndash;31.\u003c/li\u003e\n\u003cli\u003eSaver JL, Fonarow GC, Smith EE, Reeves MJ, Grau-Sepulveda M V, Pan W, et al. Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA. 2013;309:2480\u0026ndash;8.\u003c/li\u003e\n\u003cli\u003eRudd M, Buck D, Ford GA, Price CI. A systematic review of stroke recognition instruments in hospital and prehospital settings. Emerg Med J. 2016;33:818\u0026ndash;22.\u003c/li\u003e\n\u003cli\u003eWhiting PF, Rutjes AWS, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med. 2011;155:529\u0026ndash;36.\u003c/li\u003e\n\u003cli\u003eMeader N, King K, Llewellyn A, Norman G, Brown J, Rodgers M, et al. A checklist designed to aid consistency and reproducibility of GRADE assessments: development and pilot validation. Vol. 3, Systematic Reviews. 2014. p. 82.\u003c/li\u003e\n\u003cli\u003eDemeestere J, Garcia-Esperon C, Lin L, Bivard A, Ang T, Smoll NR, et al. Validation of the National Institutes of Health Stroke Scale-8 to Detect Large Vessel Occlusion in Ischemic Stroke. J Stroke Cerebrovasc Dis. 2017;26:1419\u0026ndash;26.\u003c/li\u003e\n\u003cli\u003eGropen TI, Boehme A, Martin-Schild S, Albright K, Samai A, Pishanidar S, et al. Derivation and Validation of the Emergency Medical Stroke Assessment and Comparison of Large Vessel Occlusion Scales. J Stroke Cerebrovasc Dis. 2018;27:806\u0026ndash;15.\u003c/li\u003e\n\u003cli\u003eHastrup S, Damgaard D, Johnsen SP, Andersen G. Prehospital acute stroke severity scale to predict large artery occlusion: Design and comparison with other scales. Stroke. 2016;47:1772\u0026ndash;6.\u003c/li\u003e\n\u003cli\u003eKatz BS, McMullan JT, Sucharew H, Adeoye O, Broderick JP. Design and Validation of a Prehospital Scale to Predict Stroke Severity: Cincinnati Prehospital Stroke Severity Scale. Stroke. 2015;46:1508\u0026ndash;12. 7\u003c/li\u003e\n\u003cli\u003eKuroda R, Nakada T, Ojima T, Serizawa M, Imai N, Yagi N, et al. The TriAGe+ Score for Vertigo or Dizziness: A Diagnostic Model for Stroke in the Emergency Department. J Stroke Cerebrovasc Dis. 2017;26:1144\u0026ndash;53.\u003c/li\u003e\n\u003cli\u003eMao H, Lin P, Mo J, Li Y, Chen X, Rainer TH, et al. Development of a new stroke scale in an emergency setting. BMC Neurol. 2016;16:168.\u003c/li\u003e\n\u003cli\u003eOllikainen JP, Janhunen H V, Tynkkynen JA, Mattila KM, Halinen MM, Oksala NK, et al. The Finnish Prehospital Stroke Scale Detects Thrombectomy and Thrombolysis Candidates-A Propensity Score-Matched Study. J Stroke Cerebrovasc Dis. 2018;27:771\u0026ndash;7.\u003c/li\u003e\n\u003cli\u003ePanichpisal K, Nugent K, Singh M, Rovin R, Babygirija R, Moradiya Y, et al. Pomona Large Vessel Occlusion Screening Tool for Prehospital and Emergency Room Settings. Interv Neurol. 2018;7:196\u0026ndash;203.\u003c/li\u003e\n\u003cli\u003ePurrucker JC, Hametner C, Engelbrecht A, Bruckner T, Popp E, Poli S. Comparison of stroke recognition and stroke severity scores for stroke detection in a single cohort. J Neurol Neurosurg Psychiatry. 2015;86:1021\u0026ndash;8.\u003c/li\u003e\n\u003cli\u003eRodr\u0026iacute;guez-Pardo J, Fuentes B, Alonso de Leci\u0026ntilde;ana M, Xim\u0026eacute;nez-Carrillo \u0026Aacute;, Zapata-Wainberg G, \u0026Aacute;lvarez-Fraga J, et al. The Direct Referral to Endovascular Center criteria: a proposal for pre-hospital evaluation of acute stroke in the Madrid Stroke Network. Eur J Neurol. 2017;24:509\u0026ndash;15.\u003c/li\u003e\n\u003cli\u003eScheitz JF, Abdul-Rahim AH, Macisaac RL, Cooray C, Sucharew H, Kleindorfer D, et al. Clinical Selection Strategies to Identify Ischemic Stroke Patients with Large Anterior Vessel Occlusion: Results from SITS-ISTR (Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Registry). Stroke. 2017;48:290\u0026ndash;7.\u003c/li\u003e\n\u003cli\u003eZhao H, Pesavento L, Coote S, Rodrigues E, Salvaris P, Smith K, et al. Ambulance clinical triage for acute stroke treatment paramedic triage algorithm for large vessel occlusion. Stroke. 2018;49.\u003c/li\u003e\n\u003cli\u003eBeume L-A, Hieber M, Kaller CP, Nitschke K, Bardutzky J, Urbach H, et al. Large Vessel Occlusion in Acute Stroke. Stroke. 2018;49:2323\u0026ndash;9.\u003c/li\u003e\n\u003cli\u003eMoore RD, Jackson JC, Venkatesh SL, Quarfordt SD, Baxter BW. Revisiting the NIH Stroke Scale as a screening tool for proximal vessel occlusion: Can advanced imaging be targeted in acute stroke? J Neurointerv Surg. 2016;8:1208\u0026ndash;10.\u003c/li\u003e\n\u003cli\u003eJin HQ, Wang JC, Sun YA, Lyu P, Cui W, Liu YY, et al. Prehospital identification of stroke subtypes in Chinese rural areas. Chin Med J (Engl). 2016;129:1041\u0026ndash;6.\u003c/li\u003e\n\u003cli\u003eGoyal N, Tsivgoulis G, Male S, Metter EJ, Iftikhar S, Kerro A, et al. FABS: An Intuitive Tool for Screening of Stroke Mimics in the Emergency Department. Stroke. 2016;47:2216\u0026ndash;20.\u003c/li\u003e\n\u003cli\u003eClawson JJ, Scott G, Gardett I, Youngquist S, Taillac P, Fivaz C, et al. Predictive Ability of an Emergency Medical Dispatch Stroke Diagnostic Tool in Identifying Hospital-Confirmed Strokes. J Stroke Cerebrovasc Dis. 2016;25:2031\u0026ndash;42.\u003c/li\u003e\n\u003cli\u003ePurrucker JC, H\u0026auml;rtig F, Richter H, Engelbrecht A, Hartmann J, Auer J, et al. Design and validation of a clinical scale for prehospital stroke recognition, severity grading and prediction of large vessel occlusion: The shortened NIH Stroke Scale for emergency medical services. BMJ Open. 2017;7.\u003c/li\u003e\n\u003cli\u003eHolodinsky JK, Williamson TS, Demchuk AM, Zhao H, Zhu L, Francis MJ, et al. Modeling Stroke Patient Transport for All Patients With Suspected Large-Vessel Occlusion. JAMA Neurol. 2018;75:1477\u0026ndash;86.\u003c/li\u003e\n\u003cli\u003eLima FO, Silva GS, Furie KL, Frankel MR, Lev MH, Camargo ECS, et al. Field Assessment Stroke Triage for Emergency Destination: A Simple and Accurate Prehospital Scale to Detect Large Vessel Occlusion Strokes. Stroke. 2016;47:1997\u0026ndash;2002.\u003c/li\u003e\n\u003cli\u003eTurc G, Maier B, Naggara O, Seners P, Isabel C, Tisserand M, et al. Clinical Scales Do Not Reliably Identify Acute Ischemic Stroke Patients With Large-Artery Occlusion. Stroke. 2016;47:1466\u0026ndash;72.\u003c/li\u003e\n\u003cli\u003eCarrera D, Campbell BC V, Cortes J, Gorchs M, Querol M, Jimenez X, et al. Predictive Value of Modifications of the Prehospital Rapid Arterial Occlusion Evaluation Scale for Large Vessel Occlusion in Patients with Acute Stroke. J Stroke Cerebrovasc Dis. 2017;26:74\u0026ndash;7.\u003c/li\u003e\n\u003cli\u003ePedley DK, Beedie S, Ferguson J. Mobile telemetry for pre-hospital thrombolysis: problems and solutions. J Telemed Telecare. 2005;11 Suppl 1:78\u0026ndash;80.\u003c/li\u003e\n\u003cli\u003eTsivgoulis G, Sharma VK, Lao AY, Malkoff MD, Alexandrov A V. Validation of transcranial Doppler with computed tomography angiography in acute cerebral ischemia. Stroke. 2007;38:1245\u0026ndash;9.\u003c/li\u003e\n\u003cli\u003eWada K, Kimura K, Minematsu K, Yasaka M, Uchino M, Yamaguchi T. Combined carotid and transcranial color-coded sonography in acute ischemic stroke. Eur J Ultrasound. 2002;15:101\u0026ndash;8.\u003c/li\u003e\n\u003cli\u003eTsivgoulis G, Sharma VK, Hoover SL, Lao AY, Ardelt AA, Malkoff MD, et al. Applications and advantages of power motion-mode Doppler in acute posterior circulation cerebral ischemia. Stroke. 2008;39:1197\u0026ndash;204.\u003c/li\u003e\n\u003cli\u003eGerriets T, Goertler M, Stolz E, Postert T, Sliwka U, Schlachetzki F, et al. Feasibility and validity of transcranial duplex sonography in patients with acute stroke. J Neurol Neurosurg Psychiatry. 2002;73:17\u0026ndash;20.\u003c/li\u003e\n\u003cli\u003eEadie L, Regan L, Mort A, Shannon H, Walker J, MacAden A, et al. Telestroke assessment on the move: prehospital streamlining of patient pathways. Stroke. 2015;46:e38-40.\u003c/li\u003e\n\u003cli\u003eEadie L, Mulhern J, Regan L, Mort A, Shannon H, Macaden A, et al. Remotely supported prehospital ultrasound: A feasibility study of real-time image transmission and expert guidance to aid diagnosis in remote and rural communities. J Telemed Telecare. 2018;24:616-22.\u003c/li\u003e\n\u003cli\u003eMort A, Eadie L, Regan L, Macaden A, Heaney D, Bouamrane M-M, et al. Combining transcranial ultrasound with intelligent communication methods to enhance the remote assessment and management of stroke patients: Framework for a technology demonstrator. Health Informatics J. 2016;22:691\u0026ndash;701.\u003c/li\u003e\n\u003cli\u003eHeldner MR, Hsieh K, Broeg-Morvay A, Mordasini P, B\u0026uuml;hlmann M, Jung S, et al. Clinical prediction of large vessel occlusion in anterior circulation stroke: mission impossible? J Neurol. 2016;263:1633\u0026ndash;40.\u003c/li\u003e\n\u003cli\u003eKummer BR, Gialdini G, Sevush JL, Kamel H, Patsalides A, Navi BB. External Validation of the Cincinnati Prehospital Stroke Severity Scale. J Stroke Cerebrovasc Dis. 2016;25:1270\u0026ndash;4.\u003c/li\u003e\n\u003cli\u003eVanacker P, Heldner MR, Amiguet M, Faouzi M, Cras P, Ntaios G, et al. Prediction of Large Vessel Occlusions in Acute Stroke: National Institute of Health Stroke Scale Is Hard to Beat. Crit Care Med. 2016;44:e336-43.\u003c/li\u003e\n\u003cli\u003eChen K, Schneider ALC, Llinas RH, Marsh EB. Keep it simple: vascular risk factors and focal exam findings correctly identify posterior circulation ischemia in \u0026ldquo;dizzy\u0026rdquo; patients. BMC Emerg Med. 2016;16:37.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u0026nbsp;\u003cspan style=\"font-family: 'Arial',sans-serif;\"\u003eTable 1. Review inclusion and exclusion criteria\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"margin-left: 5.4pt; background: #D0DDEF; border-collapse: collapse; border: none;\" width=\"601\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 10.2pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 10.2pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eDomain\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 178.05pt; border: solid windowtext 1.0pt; border-left: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 10.2pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eInclusion\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border: solid windowtext 1.0pt; border-left: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 10.2pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp style=\"text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusion\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.9pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; border-top: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 1.9pt;\" rowspan=\"5\" width=\"124\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eStudy type\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 1.9pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eComparative observational studies\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 1.9pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eCase reports\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 20.0pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 20.0pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eProspective observational studies\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 20.0pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSelected case series\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 12.85pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 12.85pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eCohort studies\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 12.85pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eLiterature review\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 4.85pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 4.85pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eUnselected case series\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 4.85pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eConference proceedings\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 3.95pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 3.95pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 3.95pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFull text unavailable\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 8.75pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; border-top: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 8.75pt;\" rowspan=\"4\" width=\"124\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eParticipants\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 8.75pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eHuman\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 8.75pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNon-human subjects\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 38.6pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 38.6pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAdults\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 38.6pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusively paediatric patients\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eMixed paediatric and adult populations (where paediatric and adult groups are not possible to identify separately)\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 37.3pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 37.3pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ePatients with ischaemic stroke (including patients with LVO), acute haemorrhagic stroke, and/or stroke-mimicking conditions and transient ischaemic attack\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 37.3pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusively patients with non-stroke conditions, such as sickle cell disease, arteriovenous malformation, traumatic brain injury, cerebral tumour, subarachnoid haemorrhage, vertigo etc.\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 15.55pt;\"\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 15.55pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSample size \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e 300 participants\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[6]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 15.55pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSample size \u0026lt; 300 participants\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 10.35pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; border-top: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 10.35pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSetting\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 178.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 10.35pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ePrehospital and in-hospital\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 10.35pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 58.15pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; border-top: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 58.15pt;\" width=\"124\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eProcedure\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.0pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 58.15pt;\" colspan=\"2\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eUse of a clinical assessment tool, including clinical scales, individual symptoms and signs designed for identification of patients with ischaemic stroke, including subjects with LVO, acute haemorrhagic stroke, and/or stroke-mimicking conditions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 179.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 0in 5.4pt 0in 5.4pt; height: 58.15pt;\" width=\"239\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusively assessing the diagnostic accuracy of a brain imaging modality for identification of patients with acute stroke and/or stroke-mimicking conditions\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 54.25pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; border-top: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 54.25pt;\" rowspan=\"3\" width=\"124\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAims/outcomes\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 178.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 54.25pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eDiagnostic accuracy of clinical tools designed for identification of patients with ischaemic stroke, including subjects with LVO, acute haemorrhagic stroke, and/or stroke mimicking conditions \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 54.25pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusively assessing the prognosis of functional disability caused by a stroke \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 28.45pt;\"\u003e\n\u003ctd style=\"width: 178.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 28.45pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eDiagnostic accuracy of clinical tools designed for differentiation between two main subtypes of stroke \u0026ndash; ischaemic and haemorrhagic \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 28.45pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusively evaluating factors associated with misdiagnosis of stroke\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 178.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 1.0pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 1.0pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExclusively diagnosing stroke patients with no assessment of clinical factors \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 2.55pt;\"\u003e\n\u003ctd style=\"width: 92.75pt; border: solid windowtext 1.0pt; border-top: none; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 2.55pt;\" rowspan=\"2\" width=\"124\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ePublication \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 178.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 2.55pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2015 - 2018\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 2.55pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eBefore January 2015\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr style=\"height: 1.0pt;\"\u003e\n\u003ctd style=\"width: 178.05pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 1.0pt;\" width=\"237\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eIn English\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 2.5in; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; background: transparent; padding: 4.0pt 4.0pt 4.0pt 4.0pt; height: 1.0pt;\" colspan=\"2\" width=\"240\"\u003e\n\u003cp style=\"text-align: justify;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eIn languages other than English\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\u003c/br\u003e\u003c/br\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif;\"\u003eTable 2. Diagnostic accuracy values of clinical tools for selecting subjects with large vessel occlusion. \u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eClinical assessment\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSe\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSp\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ePPV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNPV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAUC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eACT-FAST \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[18]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eaNIHSS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[27]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.31\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ea-NIHSS item profile A \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.55\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.66\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ea-NIHSS item profile B \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ea-NIHSS item profile C \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ea-NIHSS item profile D \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ea-NIHSS item profile E \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.65\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAphasia; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNeglect/gaze deviation \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[19]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eArm weakness \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.41\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.18\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eArm weakness;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eLeg weakness;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eDysarthria \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[20]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eBernese score 1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e5 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.73\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.66\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eBernese score 2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eBernese score 3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.67\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eBernese score 4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.67\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.86\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eBernese score 5 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eCPSS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[27]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eC-STAT \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[13]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.68-0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.35-0.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88-0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.65-0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eDIRECT criteria \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[16]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eExpressive aphasia \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.13\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFacial weakness \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.20\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFAST=3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[17]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.32\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.53\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFAST-ED \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[13]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFAST-ED \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[26]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFAST-ED \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[8,18,24,26]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.42-0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.82-0.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.24-0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.82-1.00\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64-0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.47\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e8 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14,24]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.72-0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.48-0.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.21-0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.59-0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.81-0.89\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64-0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.56-0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; 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border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e14 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[27]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS-8 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[13]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.89\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.44\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS-8 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e8 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[7]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.82\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS subitem \u0026ndash; LoC (1a) \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.23\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.14\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS subitem \u0026ndash; LoC (1b) \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.60\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.16\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.58\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS subitem \u0026ndash; LoC (1c) \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[14]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.49\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.17\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.59\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS; \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAbsence of prestroke handicap (mRS\u0026le;2);\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eHemineglect;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAF;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFemale sex;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eTotal score cut-off \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e16 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[39]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.68-0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.41-0.54\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.92-0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNIHSS symptom profile A or B \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.24\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.38\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ePASS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[9,14,17,18,24]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64-0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.59-0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.33-0.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.21\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.67-0.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eRACE V1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[28]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.81\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eRACE V2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[28]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.62\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eRACE V4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[28]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.56\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eRACE V5 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[28]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eRACE V6 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[28]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eRACE V7 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[28]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eReduced level of consciousness with inability to answer questions;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eLeg weakness;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eDysarthria;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eGaze deviation \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[20]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.96\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.39\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.27\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.98\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eReduced level of consciousness with inability to answer questions;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFacial weakness;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eArm weakness;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSensation loss;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAphasia \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[20]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.28\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.99\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.25\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eReduced level of consciousness with inability to answer questions;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eLeg weakness;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNeglect;\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eGaze deviation \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[20]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.45\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.26\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003erNIHSS (profile A, B, C, D or E vs. profile F) \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[27]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.51\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eROSIER \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[27]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.79\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.61\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.88\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esCPSSS (severe arm weakness, conjugate gaze deviation) \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[38]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esCPSSS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[38]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.59\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esCPSSS =3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[38]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esNIHSS-1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e1 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.63\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esNIHSS-5 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esNIHSS-5 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; 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border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; 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border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esNIHSS-8 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[37]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.84\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; 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line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.75\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3I-SS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e2 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[17]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.65\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.42\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.71\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 162.8pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"217\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3I-SS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e4 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[8,24,27]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 63.75pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"85\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.19-0.40\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.94-0.95\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.74-0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.71-0.74\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 54.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"72\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.65-0.80\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif;\"\u003eAbbreviations: NPV \u0026ndash; negative predictive value; PPV \u0026ndash; positive predictive value; Se \u0026ndash; sensitivity; Sp \u0026ndash; specificity.\u003c/span\u003e\u003c/p\u003e\u003c/br\u003e\u003c/br\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif;\"\u003eTable 3. Diagnostic accuracy values of clinical tools for selecting subjects with acute stroke and stroke-mimicking conditions.\u003c/span\u003e\u003c/p\u003e\n\u003ctable style=\"border-collapse: collapse; border: none;\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eClinical tool\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eTarget condition\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSe\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eSp\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003ePPV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eNPV\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border: solid windowtext 1.0pt; border-left: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAUC\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eCPSS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[15]\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e\u0026nbsp; \u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAcute stroke\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.83\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.69\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.50\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFABS\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e3 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[22]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eStroke mimic\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.90\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eFAST \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[12,15]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAcute stroke\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.76-0.85\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.64-0.68\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.50-0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.30-0.92\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.70\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; 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text-align: center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eROSIER \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[12,15]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; 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border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.59-0.94\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.34-0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.77\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003esNIHSS-EMS \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[24]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAcute stroke\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.91\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.52\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.43\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.93\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 99.0pt; border: solid windowtext 1.0pt; border-top: none; padding: 0in 5.4pt 0in 5.4pt;\" width=\"132\"\u003e\n\u003cp style=\"margin-bottom: .0001pt;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eTriAGe+\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: Symbol;\"\u003e\u0026sup3;\u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e10 \u003c/span\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e[11]\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 92.15pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"123\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003eAcute stroke\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.72\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.57\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 56.7pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"76\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.87\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003ctd style=\"width: 32.85pt; border-top: none; border-left: none; border-bottom: solid windowtext 1.0pt; border-right: solid windowtext 1.0pt; padding: 0in 5.4pt 0in 5.4pt;\" width=\"44\"\u003e\n\u003cp style=\"margin-bottom: .0001pt; text-align: center;\"\u003e\u003cspan style=\"font-size: 9.0pt; line-height: 200%; font-family: 'Arial',sans-serif;\"\u003e0.78\u003c/span\u003e\u003c/p\u003e\n\u003c/td\u003e\n\u003c/tr\u003e\n\u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-family: 'Arial',sans-serif; color: white;\"\u003e\u003cspan style=\"color: #000000;\"\u003eAbbreviations: NPV \u0026ndash; negative predictive\u003c/span\u003e \u003c/span\u003e\u003cspan style=\"font-family: 'Arial',sans-serif;\"\u003evalue; PPV \u0026ndash; positive \u003c/span\u003e\u003cspan style=\"line-height: 200%; font-family: 'Arial',sans-serif;\"\u003epredictive value; Se \u0026ndash; sensitivity; Sp \u0026ndash; specificity. \u003c/span\u003e\u003c/p\u003e"},{"header":"Additional material legend","content":"\u003cp\u003eAdditional file 1.docx Characteristics of included studies, table\u003c/p\u003e\n\u003cp\u003eAdditional file 2.docx Risk of bias and applicability concerns summary, table\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"emmd","sideBox":"Learn more about [BMC Emergency Medicine](http://bmcemergmed.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/emmd","title":"BMC Emergency Medicine","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"acute cerebral ischaemia; clinical prediction rules; emergency care; intracerebral haemorrhage; large vessel occlusion; recanalization; stroke; scoring methods; thrombectomy; thrombolysis. ","lastPublishedDoi":"10.21203/rs.2.11249/v2","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.11249/v2","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"Introduction: Recanalisation therapy in acute ischaemic stroke is highly time-sensitive, and requires early identification of eligible patients to ensure better outcomes. Thus, a number of clinical assessment tools have been developed and this review examines their diagnostic capabilities.\nMethods: Diagnostic performance of currently available clinical tools for identification of acute ischaemic and haemorrhagic strokes and stroke mimicking conditions was reviewed. A systematic search of the literature published in 2015-2018 was conducted using PubMed, EMBASE, Scopus and The Cochrane Library. Prehospital and in-hospital studies with a minimum sample size of 300 patients reporting diagnostic accuracy were selected.\nResults: Twenty-five articles were included. Cortical signs (gaze deviation, aphasia and neglect) were shown to be significant indicators of large vessel occlusion (LVO). Sensitivity values for selecting subjects with LVO ranged from 23% to 99% whereas specificity was 24% to 97%. Clinical tools, such as FAST-ED, NIHSS, and RACE incorporating cortical signs as well as motor dysfunction demonstrated the best diagnostic accuracy. Tools for identification of stroke mimics showed sensitivity varying from 44% to 91%, and specificity of 27% to 98% with the best diagnostic performance demonstrated by FABS (90% sensitivity, 91% specificity). Hypertension and younger age predicted intracerebral haemorrhage whereas history of atrial fibrillation and diabetes were associated with ischaemia. There was a variation in approach used to establish the definitive diagnosis. Blinding of the index test assessment was not specified in about 50% of included studies.\nConclusions: A wide range of clinical assessment tools for selecting subjects with acute stroke has been developed in recent years. Assessment of both cortical and motor function using RACE, FAST-ED and NIHSS showed the best diagnostic accuracy values for selecting subjects with LVO. There were limited data on clinical tools that can be used to differentiate between acute ischaemia and haemorrhage. Diagnostic accuracy appeared to be modest for distinguishing between acute stroke and stroke mimics with optimal diagnostic performance demonstrated by the FABS tool. Further prehospital research is required to improve the diagnostic utility of clinical assessments with possible application of a two-step clinical assessment or involvement of simple brain imaging, such as transcranial ultrasonography.","manuscriptTitle":"Diagnostic accuracy of clinical tools for assessment of acute stroke: a systematic review","msid":"","msnumber":"","nonDraftVersions":[{"code":2,"date":"2019-10-12 01:09:51","doi":"10.21203/rs.2.11249/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Accept","date":"2019-08-15T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2019-08-14T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2019-08-13T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-08-13T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"emmd","sideBox":"Learn more about [BMC Emergency Medicine](http://bmcemergmed.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/emmd","title":"BMC Emergency Medicine","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2019-07-12 02:28:03","doi":"10.21203/rs.2.11249/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"editorInvitedReview","content":"","date":"2019-08-01T12:00:00+00:00","index":1,"fulltext":"Form responses:\n---\n* Does the work include the necessary controls?\nIf not, please specify which controls are required in your comments to the authors.\tYes: **Are the conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the authors.\tYes**\n"},{"type":"decision","content":"Minor revision","date":"2019-08-01T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2019-07-30T12:00:00+00:00","index":2,"fulltext":"Form responses:\n---\n* Does the work include the necessary controls?\nIf not, please specify which controls are required in your comments to the authors.\tNo: **Are the conclusions drawn adequately supported by the data shown?\nIf not, please explain in your comments to the authors.\tYes**\n"},{"type":"reviewerAgreed","content":"","date":"2019-07-14T12:00:00+00:00","index":2,"fulltext":""},{"type":"reviewerAgreed","content":"","date":"2019-07-12T12:00:00+00:00","index":1,"fulltext":""},{"type":"editorAssigned","content":"","date":"2019-07-09T12:00:00+00:00","index":"","fulltext":""},{"type":"reviewersInvited","content":"","date":"2019-07-09T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2019-07-08T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2019-07-08T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-emergency-medicine","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"emmd","sideBox":"Learn more about [BMC Emergency Medicine](http://bmcemergmed.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/emmd","title":"BMC Emergency Medicine","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"560f11b9-7e7a-43f3-b51b-5d10172fddb7","owner":[],"postedDate":"October 12th, 2019","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":16467,"name":"Neurology"}],"tags":[],"updatedAt":"","versionOfRecord":{"articleIdentity":"rs-2154","link":"https://doi.org/10.1186/s12873-019-0262-1","journal":{"identity":"bmc-emergency-medicine","isVorOnly":false,"title":"BMC Emergency Medicine"},"publishedOn":"2019-09-04 12:00:00","publishedOnDateReadable":"September 4th, 2019"},"versionCreatedAt":"2019-10-12 01:09:51","video":"","vorDoi":"10.1186/s12873-019-0262-1","vorDoiUrl":"https://doi.org/10.1186/s12873-019-0262-1","workflowStages":[]},"version":"v2","identity":"rs-2154","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-2154","version":["v2"]},"buildId":"7rjqhiLT3MXkJMwkYKINL","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}