Clinical significance of serum CA125 in the diagnosis of gynecological diseases

Objective:To detect the level of serum cancer antigen 125 (CA125),explore the clinical significance of serum CA125 in the diagnosis of gynecological diseases.Methods:The level of serum CA125 was detected by electrochemiluminescence immunoassay (ECLIA) in 232 women undergoing gynecological operation and 15 healthy women.Results:The percentage of the level of CA125 between 400 U/ml and 1000 U/ml was 23.3% in women with ovarian cancer,while the percentage of the level of CA125 over 1000 U/ml was 55.8%. The percentages of the level of CA125 between 35U/ml and 199 U/ml were 51.7% in women with endometriotic cysts of the ovary,54.5% in women with adenomyosis and 68.8% in women with tubo-ovarian abscess,respectivly;the positive rate of CA125 in women with ovarian cancer was 97.7%,which was significantly higher than those with the other benign and malignant tumors (P0.01); the positive rates of CA125 in women with endometriosis,adenmyosis and tubo-ovarian abscess were 62.1%,68.8% and 81.8%,respectivly,which were significantly higher than control group (P0.01),but were lower than ovarian cancer group (P0.05).Conclusion:CA125 plays an important role in the diagnosis of ovarian cancer,which is a useful diagnostic method for endometriosis,adenmyosis and tubo-ovarian abscess.