Combo effect of hypomagnesemia and hypokalaemia inducing nephrogenic diabetes insipidus in a patient with type 1 diabetes mellitus
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A patient with type 1 diabetes mellitus developed nephrogenic diabetes insipidus due to the combined effects of hypomagnesemia and hypokalaemia, highlighting a potential direct role for low magnesium in this condition.
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Abstract
NDI is rarely considered versus diabetes mellitus in the situation of polyuria. It is well known that hypokalaemia and hypercalcemia induce NDI through decreased activity of arginine vasopressin and downregulation of Aquaporin-2 water channels in the collecting ducts. However, not much is known whether hypomagnesemia can directly induce NDI.
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