Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies

Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Analysis Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies Jesper Gunst, Jesal Gohil, Jonathan Li, Ronald Bosch, Andrea White, and 26 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-5065764/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 21 Jan, 2025 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract Background: There is a global need to explore novel interventions conferring sustained HIV control without antiretroviral therapy (ART). The only current strategy to test efficacy is through an analytical treatment interruption (ATI). Inclusion of ‘placebo’ controls in future clinical trials poses ethical, logistical, and economic challenges and might be unnecessary if sufficient up-to-date data exists from non-intervention cohorts of people with HIV (PWH) who stop ART. To understand viral rebound dynamics and rates of post-treatment HIV control in the absence of any intervention, we undertook an individual participant data meta-analysis on time to viral rebound after ATI. Methods: We included individual-level data from clinical studies with >5 separate available plasma HIV RNA viral load (pVL) measurements within the first 84 days post-ATI in PWH receiving either placebo or no intervention. Eligible prospective studies were identified through literature search on PubMed. Early-ART was defined as ART initiation within 6 months of HIV acquisition; others were classified as late-ART or unknown. Results : In total, 24 studies published between 2000-2024 with 382 individuals were included. Median participant age was 42 years, 91% male, 75% white, 45% received early-ART. Median time to pVL >50, >400, and >10,000 copies/mL was 16 days (interquartile range [IQR]:13–25), 21 (IQR:15–28), and 32 (IQR:20–35), respectively. Post-treatment control defined as pVL <50 copies/mL at day 84 occurred in 4% (n=14) of participants (6% for early-ART and 1% for late-ART). Multivariable analysis identified at late ART initiation as an independent risk factor for earlier VL rebound (hazard ratio [HR] 1.25, P =0.005). Conclusion : Sustained control of pVL <50 copies/ml after 84 days off ART is rare in PWH who stop therapy, especially in those starting ART late. When designing future interventional HIV cure/remission trials, these findings help inform study size and design, potentially removing the need for a placebo arm thereby minimizing unnecessary risks to participants and their partners, while optimising resources. Health sciences/Diseases/Infectious diseases/HIV infections Health sciences/Diseases/Immunological disorders/Immunological deficiency syndromes/HIV infections Health sciences/Medical research/Outcomes research Figures Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 INTRODUCTION Antiretroviral therapy (ART) has dramatically improved survival and quality of life for people living with human immunodeficiency virus type 1 (HIV) (1). National and international guidelines recommend lifelong ART initiated at the time of diagnosis (1–3). Adherence to ART leads to viral suppression, prevents HIV disease progression, and eliminates the risk of onward viral transmission (1). However, ART carries risks of toxicities and side effects, requiring sustaining lifelong adherence. Access to medication burdens people with HIV (PWH) and healthcare systems, particularly in settings with limited resources and populations with high HIV prevalence (4). There is widespread interest in exploring alternative approaches to achieve long-term ART-free virological control. ART, whilst effectively blocking viral replication, is unable to eradicate HIV due to the persistence of a reservoir of latently infected cells (5), which is the source of viral recrudescence when ART is stopped. While there has been much advance in assays evaluating the HIV reservoir and HIV-specific immunity, none can accurately predict which individuals will achieve post-treatment control (PTC) after stopping ART (6). Hence, to measure clinical efficacy of any experimental approach towards eliminating the HIV reservoir or inducing immune-mediated suppression of virus replication, ART must be carefully interrupted in a controlled setting; so-called analytical treatment interruption (ATI) (7–11). A collaborative group met to develop guidelines on how to safely undertake ATI trials (12) frequently monitored plasma HIV RNA viral load (pVL) and CD4 + T cell counts throughout the period of ATI (10,11,13–15) but these recommendations are based on observations from multiple different studies, many of which were carried out using different ATI protocols and older ART regimens (10). The only known potential determinant of PTC from previous analyses is time from HIV acquisition to ART initiation (10); while generally, measures of the HIV reservoir do not accurately predict PTC (13–16). Although some individuals have demonstrated PTC after ATI (10) for the majority of PWH, viral rebound occurs rapidly, usually within weeks after stopping ART (7,8,17–19). Such ATI protocols are intense and benefit greatly from altruism and commitment from the community of PWH to reach efficacy outcomes (20,21). While inclusion of placebo or no-intervention groups to study design add great value scientifically, and maybe necessary in early phase trials, ATI carries potential risk to participants and their partners (22,23). To comprehensively map patterns of virological rebound after stopping ART under close monitoring and to inform future study designs, we undertook an individual participant data meta-analysis from studies that included an ATI among individuals that received placebo or “no intervention” prior to stopping ART. We further sought to identify pre-ATI clinical factors that influenced the timing of viral rebound. METHODS AND MATERIALS Search strategy and selection criteria We completed a literature review using the electronic database of PubMed in September 2024 using the following terms: "off therapy"[All Fields] OR "ART interruption"[All Fields] OR "treatment interruption"[All Fields] OR "Withholding Treatment"[All Fields] OR "antiretroviral interruption"[All Fields] OR "therapy interruption"[All Fields] OR "Withholding Treatment"[MeSH Terms] AND ("HIV"[Mesh]) OR ("HIV"). Several excluding terms were used to specific the search (Supplementary Table S1 ). No geographical restriction was applied. We excluded studies that were written in non-English, abstracts, letters, reviews, commentary articles, opinion articles, case reports, studies with co-infection, animal studies, in-vitro studies, mother-to-child transmission, infant/children and adolescent studies. We included prospective clinical ATI studies in adults receiving either placebo or no active intervention and where frequent pVL monitoring was conducted (defined as a minimum of 5 planned pVL measurements within the first 84 days of post-ATI with a maximum of 18 days between measurements within the first 42 days). Data extraction Covidence.org was used for literature search. Two of the authors (JDG, JG) independently screened studies for above inclusion and exclusion criteria. To access individual-level data, corresponding authors and/or principal investigators of each identified study were asked to complete a predefined data sheet. This included individual data on age at ATI, sex (female/male/other), race and ethnicity (asian, black, white, other, unknown), pre-ART pVL, nadir CD4 + T cell count, early-ART (within 6 months) or late-ART (beyond 6 months), ART regimen at ATI, CD4 + T cell count at ATI, and consecutive pVL measurements during ATI and corresponding days since start of ATI. For six individuals the clinical assay used for quantification of pVL had a limit of quantification of 65 copies/mL, thus these individuals were excluded from the analysis of time to viremia of 50 copies/mL (24). In a few cases, some participants from the identified studies did not fulfil the inclusion criteria and were excluded, which was noted for the respective studies. Definitions Early-ART versus late-ART . Early-ART initiation was defined as PWH who started ART in the presence of an HIV-positive antibody test result within up to 6 months of a previous negative antibody test, HIV + RNA or p24 in the absence of detectable antibody, or evolution of antibody testing on western blot, incident in a recency assay (25) or self-reported time of HIV acquisition less than 6 months prior to starting ART. Late-ART initiation was defined as starting ART beyond 6 months of HIV acquisition. A few individuals had unknown date of HIV acquisition and were categorized as ‘unknown’. Post-treatment control. We defined PTCs as PWH with pVL below 50 copies/mL at day 84 (12 weeks) or the closest timepoint to day 84 after stopping ART. This stringent cut-off was chosen because it mirrors the current treatment goal for HIV and excludes viremic controllers. The pVL kinetics after stopping ART were graphed and the characteristics of PTCs including pre-ATI ART regimen were tabulated. Statistical Analysis Data are presented as median (interquartile range [IQR]), median (range), or numbers (percentages) as indicated in each respective legend. The Kaplan–Meier estimator was used to assess the magnitude of the difference between the survival curves, and the log-rank test was used to compare time to viremia for the following three thresholds: 50, 400 and 10,000 copies/mL. Fisher’s exact test was used to analyze contingency tables. For correlations, Spearman’s correlation coefficient was only done for individuals with available data points. The initial viral doubling time was calculated based on the first two consecutive pVL measurements that increased, and the second measurement had to increase by 1,000 copies/mL compared to the previous measurement. The slope of this increase was calculated using a linear regression model. Univariable and multivariable Cox proportional hazards regression models were used to explore the following risk factors for time to viremia during ATI: sex, early-ART versus late-ART, and ART regimen at ATI (non-nucleoside reverse transcriptase inhibitors [NNRTI] versus non-NNRTI). Correlations between initial viral doubling time and time to viremia were estimated. Sample size estimations were calculated using either two independent study groups comparisons or one study group compared to a known value of the indicated percentages of PTC (chi-squared tests) or means of time to viremia (unpaired t tests). We estimated the size of the hypothetic study populations that would yield > 90% power to detect the indicated differences at a 5% significance level using one-sided tests. We used Stata version 17.0 and Prism version 7.0 software for statistical analyses. RESULTS In total, 942 publications were identified and screened under the search terms (Fig. 1 ). Of these studies 164 were ATI studies, and out of these 24 studies (14,17,24,26–44) were included in this individual data-based meta-analysis, and 142 ATI studies were excluded due to different reason (Fig. 1 ). Table 1 summarises the studies included in this analysis. Characteristics of included studies Of the 24 studies included in our analysis, 22 were published in peer reviewed journals between 2000–2024 (14,17,24,26–44) and 2 studies have yet to be published (AELIX-003 [NCT04364035] and BNC03 [NCT05208125]). Fourteen were RCTs (17,26,27,29,32,33,36,38,40–42,45 + AELIX-003 and BNC03) and ten were single-arm ATI studies (14,24,30,31,34,35,37,39,43,44). Thirteen studies were undertaken in Northern Europe (14,17,32–35,39–41,43,44 + AELIX-003 and BNC03) and eleven studies in North America (24,26–31,36–38,42). Most studies had only small “placebo” participant numbers with the smallest involving 4 individuals (40) and the largest being 69 individuals (30). Restart criteria for ART between the studies were based upon pVL levels and CD4 + T cell counts, but differed on the exact threshold (Supplementary Table S2). Study participant demographics The characteristics of the analysed ATI study participants are shown in Table 1. From the 382 participants of the 24 studies, 91% were male and 75% white. The median age was 42 (interquartile range [IQR] 35–49) years. The median CD4 + T cell count at ART initiation was 422 (330–558) per mm 3 and median pre-ART pVL was 48,400 (14,000–150,000) copies/mL. Forty-five and 51 percent of participants were categorized as early-ART and late-ART, respectively, while 4% were categorized as ‘unknown’. At the start of ATI, the median CD4 + T cell count was 781 (IQR 611–1,007) per mm 3 . Forty-eight percent were on an integrase-strand inhibitor regimen, while 17% were on a NNRTI-containing ART regimen at the time of ATI. NNRTI impacts time to viremia NNRTI has been shown to be associated with longer time to viral rebound likely reflecting an antiretroviral drug ‘tail’ into the ATI due to the long half-life of NNRTIs. In agreement with previous analyses, univariable analysis, non-NNRTI regimens compared to NNRTI regimens at ATI start were associated with shorter time to viremia (Supplementary Fig. S1 a + b). In multivariable analysis, NNRTI regimen at ATI start continued to be associated with longer time to pVL > 50 copies/mL (Supplementary Fig. S1 a: HR 0.50, P < 0.01). However, due to the risk of ART drug resistance, current ATI trials no longer recommend NNRTI regimens and to make our observations pertinent to current recommendations individuals entering an ATI on NNRTI regimens were omitted from the analyses of time to viral rebound, although included in the overall analyses of PTC at day 84 of ATI. Viral kinetics While viral rebound kinetics following ART interruption differed (Fig. 2 a), most individuals followed a similar pattern. Forty-four percent of the participants had a pVL below 50 copies/mL by day 14 after stopping ART but only 4% had a pVL below 50 copies/mL at day 84 (Fig. 2 b).The median time to pVL > 50 copies/mL after ART interruption was 16 days (IQR: 13–25), while time to pVL > 400 and > 10,000 copies/mL was 21 (IQR: 15–28) days and 32 (IQR: 20–35) days, respectively (Fig. 2 c-e). Time to viremia data for all individuals irrespective of ART regimen is shown in Supplementary Fig. S2. Collectively, these data demonstrate that in more than 75% of individuals (not on NNRTI regimens), pVL rebounds within 21 days and only 14 (4%) people have suppressed viremia through day 84. Post-treatment control Out of the 14 PTCs with pVL below 50 copies/mL at day 84 (Fig. 3 a), only 4 (29%) individuals had pVLs < 50 copies/mL at all prior measurements. The other 10 individuals had variable levels of viremia prior to regaining viral control to < 50 copies/mL, with 29% (n = 4) reaching a peak pVL 50–399 copies/mL, 29% (n = 4) with peak pVL between 400–10,000 copies/mL, and 14% (n = 2) reaching peak pVL above 10,000 copies/mL (Fig. 3 b + c). Examining the total study cohort of 382 individuals, categorized by levels of peak pVL 10,000 copies/mL, the percentage of PTCs at day 84 within each category were 1%, 1%, 1% and 0.5%, respectively. Among the 14 PTCs, most were male (93%) and white (71%) with an average age of 38 (IQR: 33–45) years (Fig. 3 d), similar to the demographics for the overall cohort. A significantly higher proportion ( P = 0.008) of individuals who started ART early (n = 11; 6% of 172 early-ART participants) achieved PTC compared to those who started ART late (n = 2; 1% of 195 late-ART participants). One PTC had unknown time of ART initiation relative to HIV acquisition. Among PTCs, the median CD4 + T cell count at ART interruption was 912 (IQR: 827–1219) per mm 3 . These observations highlight that PTC is very rare, in particular among people who start ART late. In addition, while 1% of ATI participants maintained ART-free suppression for 84 days, only 0.5% regained control to pVL < 50 copies/mL at 84 day when peak viremia post-ATI was higher than 10,000 copies/mL. Factors associated with time to viremia As seen in Fig. 4 a, some of the variables associated with time to viremia were highly correlated. For instance, nadir CD4 + T cell count prior to ART start correlated with the CD4 + T cell count at ATI start (Fig. 4 b; P 50 c/mL (Fig. 4 a), and these correlations became more positive with higher viremia threshold (> 400 and > 10,000 c/mL, Fig. 4 d-f). In our univariable analysis, late-ART (vs early-ART) at ATI start was associated with shorter time to viremia (Supplementary Fig. S1 a + b). In our multivariable analysis, late-ART remained a risk factor for shorter time to pVL > 50 copies/mL (Supplementary Fig. S1 a: HR 1.25, P = 0.05) and > 10,000 copies/mL (Supplementary Fig. S1 b: HR 1.61, P < 0.01). We observed a significantly longer time to viremia of 50 and 10,000 copies/mL for early-ART compared to late-ART initiation (Supplementary Fig. S1 c + d). Similar results were found when using a threshold of time to pVL > 400 copies/mL (Supplementary Fig. S3). In summary, multiple mechanistic factors may impact time to viremia after ART interruption, but in our analyses, based on clinical variables, early-ART initiation was consistently associated with both higher chance of PTC at day 84 and longer time to viremia after interrupting ART. Powering future interventional HIV cure/remission studies Using the calculated time to viremia and frequencies of PTC from this meta-analysis, we generated power calculations that may help inform the design of future ATI studies. We used our data as reference and calculated the number of participants needed in either a single arm or 2-group randomized controlled trial design with a power of 90% to detect the indicated prolonged time to viremia or proportion of PTC at a 5% significant level (Fig. 5 and Supplementary Fig. S4). If the expected outcome of an intervention is a frequency of 25% PTC among early-ART participants, 36 individuals would need to be included in a single arm design and 128 individuals in a 2-group randomized trial design (Fig. 5 a). However, due to the lower observed frequency of PTC among late-ART individuals (1%), only 12 and 64 participants would be needed in a single arm design and 2-group randomized trial design, respectively, if the expected frequency of PTC in the intervention group is 25% (Fig. 5 b). PTC is generally considered the most clinically relevant outcome in HIV cure/remission studies, but if the primary outcome is time to viremia (e.g. 50 copies/mL), 8 and 32 study participants (irrespectively of stage at ART initiation) would be needed to demonstrate a delay of at least 14 days in a single and randomized trial design, respectively (Supplementary Fig. S4a). Similarly, an expected delay in time to viremia of at least 21 days, would only require 4 and 16 individuals (irrespectively of stage at ART initiation) in a single arm and 2-group randomized trial design, respectively (Supplementary Fig. S4a). Approximately twice as many participants would be needed to demonstrate a delay of at least 14 or 21 days in time to viremia of 10,000 copies/mL (Supplementary Fig. S4b). Of note, clinical trials often include slightly more participants than needed according to the power calculations to account for drop outs, typically 10–20% more. In conclusion, adequately powering of future trials is critical for optimizing resources, risk mitigation, and advancing the HIV cure/remission agenda. Our simulated power calculations show that reducing the study population size may be possible using single arm design and our extensive dataset as reference. DISCUSSION This study was an individual participant data meta-analysis of 24 prospective clinical trials with 382 participants including frequent pVL measurements following an ATI. The definition of PTC in our analysis was rigorous, requiring sustained and stringent viral control off ART. We found that the median time to initial viremia above 50 copies/ml was just 16 days after ART interruption. Overall, the observed frequency of individuals with PTC defined as pVL < 50 copies/ml 84 days after stopping ART was 4%. This proportion was enriched for PWH who initiated early-ART (6%), while the frequency was just 1% among those who started ART more than 6 months after HIV acquisition. Thus, our study provides robust estimates on the expected time to viremia at different thresholds as well as estimates of the frequency of PTC in a large cohort of individuals that received placebo or no active intervention prior to stopping ART. Further, we identified key clinical parameters associated with time to viremia and PTC that may be used in the design and interpretation of future HIV cure/remission trials. A consistent finding in our analyses, and in agreement with others, was that starting ART less than 6 months vs more than 6 months after the time of HIV acquisition was associated with delayed time to viremia and a higher probability of PTC. Interestingly, a recent systematic review and meta-analysis estimated the overall proportion of PTC was to be as high as 8%, ranging from 3–15% (46). However, these estimates was not based on individual-level data and it also included meta-data from studies that were not prospective and did not have frequent pVL monitoring which likely led to an overestimation in the frequency of PTCs. Another published meta-analysis “The CHAMP” study compared individual-level data from 6 historic ACTG ART interruption studies but not all 6 studies used as frequent pVL monitoring as in our analysis. Using a PTC definition of 2/3 of pVL measurements had to be < 400 copies/mL during the first 6 months after stopping ART, the CHAMP investigators found that the timing of ART initiation also influenced the outcome with 13% vs 4% of those initiating ART in acute/recent infection vs chronic infection respectively, fulfilling their criteria for PTC at 6 months after stopping ART (10). In another ACTG study (ACTG5345), individuals who initiated modern ART including an integrase inhibitor regimen, in either early or chronic HIV stage underwent an ATI. Whilst there was no difference in time to viral rebound between ACTG5345 (n = 45) and historic controls on boosted protease-inhibitor regimens, a higher percentage of early-treated participants remained off ART at week 12 post ATI compared with chronic participants (9% vs 2%; P = 0.0496) (31). Thus, we conclude that in agreement with our individual data-based meta-analysis, time from HIV acquisition to ART initiation is a key determinant of subsequent ART-free virological control after ATI across different meta-analyses with varying frequency of pVL monitoring and stringency of PTC criteria. The vast majority of individuals enrolled into the 24 prospective ATI trials included in this meta-analysis were male. This reflects the population of PWH in the global north engaged in HIV cure/remission studies but leaves behind over half the population of PWH globally. More data from diverse populations and women can be anticipated as interventional ATI studies in Africa are now ongoing (47,48). Of note, amongst 82 African women undergoing ATI 22% maintained pVL < 400 copies/mL – the pVL cut-off available at the time of study, over a median of 188 weeks after stopping ART (47). A limitation of this meta-analysis is that not all studies include weekly pVL measurements. Although participants included had to have at least 5 measurements of pVL within the first 84 days after ATI with a maximum of 18 days between measures within the first 42 days there are inevitably variations in timespan between measurements. In addition, individual data-based meta-analysis may have underestimated the proportion of PTC. Depending on the protocol-defined ART restart criteria of each trial, certain individuals may have been censored prematurely before being identified as PTC. However, given our finding that PTC is rare (0.5%) when the viraemic peak was > 10,000 copies/mL, lower threshold pVL ART restart criteria were unlikely to have caused a large underestimation of the frequency of PTCs. Predictors of time to pVL rebound as well as magnitude of rebound have been explored. Historically, measures of the HIV reservoir have been shown to correlate with time to pVL rebound (14,15,47), and the size of the established HIV reservoir is also dependent on the time of ART initiation (early-ART vs late-ART) hence further supporting the observation that PTC is more likely in early-ART individuals (13,14,47). In addition, several studies have found that levels of reservoir activity (i.e., cell-associated HIV RNA or residual viremia) have predicted timing of viral rebound (13,36,49). Of the included studies in this individual data-based meta-analysis HIV reservoir measurement was assessed in 12 studies either as an inclusion criteria (n = 4) or secondary endpoint (n = 8). Since several different assays were used in these 12 studies to measure the HIV reservoir, we did not include HIV reservoir as a predictor of time to viremia. Immunological biomarkers have also been demonstrated to predict time to pVL rebound. In this meta-analysis pre-ART pVL, nadir CD4 + T-cell count and CD4 + T-cell count prior to ART interruption were collected. Nadir CD4 + prior to ART start correlated with CD4 + T-cell count pre-ATI, and has previously been shown to correlate with time from HIV acquisition to ART initiation as well as size of the HIV reservoir (13) which may explain why nadir CD4 + T cell count also correlated with time to viremia. Similarly, data from the SPARTAC trial demonstrated that immunological biomarkers of T-cell exhaustion (PD-1, Tim-3 and Lag-3) measured prior to ART start predicted subsequent time to viral rebound (16). More recently, the ACTG5345 study demonstrated that amongst 33 late-ART and 12 early-ART individuals, predictors of time and magnitude of viral rebound were high proportion of HIV-gag specific CD8 + T cells, low intact proviral HIV DNA and early-ART (13). Detailed investigation of immunological biomarkers predictive of PTC amongst 22 individuals from 8 ACTG studies who maintained pVL 24 weeks did not identify any association with HLA alleles, but these PTCs had compared to non-controllers lower levels of CD4 + and CD8 + T-cell activation, reduced markers of CD4 + T cell exhaustion, and more robust HIV-gag specific CD4 + T and NK cell responses(50). In summary, to design safe and effective ATI trials, testing novel strategies and therapies towards a HIV cure/remission, inclusion of a placebo arm whilst scientifically rigorous is now debated. This meta-analysis can be informative for future study designs to inform power, strategy, monitoring frequency and communication with potential study participants to enable anticipation of potential timing and magnitude of viral rebound. The data from this meta-analysis can also help inform the aspirational “signal” threshold of a new intervention, given the rarity of spontaneous PTC. The value of smaller, focused single arm intervention trials that can compare pertinent clinical outcomes to the findings of this individual participant data meta-analysis will enable interpretation of findings. While the inclusion of control groups maybe a requirement for regulatory registration of new agents, in certain settings there may no longer be ethical equipoise. Declarations Acknowledgements We thank all study participants who devoted time to research. The authors would also like to thank to Michael C. Sneller, Sabine Allard and Eric Florence for providing data. The authors who undertook this research were funded by awards from the following funders; the Lundbeck Foundation (JDG: R381–2021–1405 and OSS: R313-2019-790), Danish Council for Independent Research (OSS: #9060-00023B), Central Region Denmark Research Fund (OSS), Work supported by AELIX Therapeutics and partly by grants from the Spanish Research Agency and the European Reginal Development Fund (BMP: RTC-2017-6473-1), National Institute of Health (NIH) (LJM: UM1 AI164570), National Institute of Allergy and Infectious Diseases (LJM: NIH AI48398), the Philadelphia Foundation (LJM: Robert I. Jacobs Fund), The Stengel-Miller family (LJM), AIDS funds from the Commonwealth Universal Research Enhancement Program Pennsylvania, Department of Health (LJM), California University wide AIDS Research Program (LJM), the Gladstone Institute of Virology and Immunology (LJM), the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, NIH (TWC), NIH (CB: P01 AI178375 OMIT-HIV) , European Union´s Horizon Europe Research and Innovation Programme (CB: GA 101057548 ( EPIVINF ) and BMP: 681137-EAVI2020, NIH grant P01-AI131568 and by ISCIII PI20/01039), NIH/NIAID (JMP: 1 UM1 AI164561-01, USA), EU grant (RAG: FP7-HEALTH-2013-INNOVATION-1 Proposal No: 602570-2), Fondo Europeo para el Desarrollo Regional (FEDER) (RAG), the SPANISH AIDS Research Network (RAG: RD16/0025/0002– ISCIII – FEDER (RIS)), the CERCA Programme / Generalitat de Catalunya SGR 615 and SGR 653 (RG), NIAID (JLI, RB and ACTG A5345: AI068634, UM1 AI068636, UM1 AI106701) ,NIH (JL: AI150396, AI169768, AI060354), Spanish Ministry of Economy (MINECO) (LL: SAF2015-66193-R, SAF-2017-88089-R, and RTI2018-096309-B-I00), FP7-HEALTH-2013-INNOVATION-1 Proposal No: 602570-2 (LL), the Foundation for AIDS Research (JF: amfAR, grant ID 109842-65-RGRL), Bill and Melinda Gates Foundation (JG and SF: grant OPP1204692), Imperial College London (JG and SF), NIHR Biomedical Research centre at Imperial College Healthcare National Health Service Trust (JG and SF). None of the specific sources of funding had any role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript. References Trickey A, Sabin CA, Burkholder G, Crane H, d’Arminio Monforte A, Egger M, et al. Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies. Lancet HIV [Internet]. 2023 May 1;10(5):e295–307. Available from: https://doi.org/10.1016/S2352-3018(23)00028-0 Ryom L, De Miguel R, Cotter AG, Podlekareva D, Beguelin C, Waalewijn H, et al. Major revision version 11.0 of the European AIDS Clinical Society Guidelines 2021. HIV Med [Internet]. 2022 Sep 1 [cited 2024 Jan 18];23(8):849–58. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.13268 Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach [Internet] - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/34370423/ Lee MJ, Collins S, Babalis D, Johnson N, Falaschetti E, Prevost AT, et al. The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection—study protocol for a two-stage randomised phase II trial. Trials [Internet]. 2022;23(1):263. Available from: https://doi.org/10.1186/s13063-022-06151-w Ndung’u T, McCune JM, Deeks SG. Why and where an HIV cure is needed and how it might be achieved. Nature [Internet]. 2019;576(7787):397–405. Available from: https://doi.org/10.1038/s41586-019-1841-8 Zheng L, Tierney C, Bosch RJ. Analytical Treatment Interruption in HIV Trials: Statistical and Study Design Considerations. Curr HIV/AIDS Rep [Internet]. 2021 Oct 1 [cited 2024 Apr 4];18(5):475–82. Available from: https://link.springer.com/article/10.1007/s11904-021-00569-8 Rasmussen TA, Tolstrup M, Brinkmann CR, Olesen R, Erikstrup C, Solomon A, et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV. 2014;1(1):e13–21. Leth S, Schleimann MH, Nissen SK, Højen JF, Olesen R, Graversen ME, et al. Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial. Lancet HIV. 2016 Oct 1;3(10):e463–72. Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, et al. Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study. PLoS Pathog [Internet]. 2013 [cited 2024 Mar 1];9(3):e1003211. Available from: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003211 Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, et al. The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies. J Infect Dis [Internet]. 2018 Nov 5;218(12):1954–63. Available from: https://doi.org/10.1093/infdis/jiy479 Goujard C, Girault I, Rouzioux C, Lécuroux C, Deveau C, Chaix ML, et al. HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy. Antivir Ther [Internet]. 2012 [cited 2024 Mar 1];17(6):1001–9. Available from: https://pubmed.ncbi.nlm.nih.gov/22865544/ Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, et al. Recommendations for analytical antiretroviral treatment interruptions in HIV research trials—report of a consensus meeting. Lancet HIV [Internet]. 2019 Apr 1 [cited 2024 Apr 10];6(4):e259–68. Available from: http://www.thelancet.com/article/S2352301819300529/fulltext Li JZ, Melberg M, Kittilson A, Abdel-Mohsen M, Li Y, Aga E, et al. Predictors of HIV rebound differ by timing of antiretroviral therapy initiation. JCI Insight [Internet]. 2024 Feb 8 [cited 2024 Jun 11];9(3). Available from: https://doi.org/10.1172/jci. Castagna A, Muccini C, Galli L, Bigoloni A, Poli A, Spagnuolo V, et al. Analytical treatment interruption in chronic HIV-1 infection: time and magnitude of viral rebound in adults with 10 years of undetectable viral load and low HIV-DNA (APACHE study). J Antimicrob Chemother [Internet]. 2019 Jul 1 [cited 2024 Jun 11];74(7):2039–46. Available from: https://pubmed.ncbi.nlm.nih.gov/31225610/ Williams JP, Hurst J, Stöhr W, Robinson N, Brown H, Fisher M, et al. HIV-1 DNA predicts disease progression and post-treatment virological control. Elife [Internet]. 2014 [cited 2024 Jun 11];3:e03821. Available from: https://pubmed.ncbi.nlm.nih.gov/25217531/ Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun [Internet]. 2015 Oct 9 [cited 2024 Jun 11];6. Available from: https://pubmed.ncbi.nlm.nih.gov/26449164/ Gunst JD, Højen JF, Pahus MH, Rosás-Umbert M, Stiksrud B, McMahon JH, et al. Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial. Nature Medicine 2023 29:10 [Internet]. 2023 Sep 11 [cited 2024 Mar 1];29(10):2547–58. Available from: https://www.nature.com/articles/s41591-023-02547-6 Gruell H, Gunst JD, Cohen YZ, Pahus MH, Malin JJ, Platten M, et al. Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial. Lancet Microbe. 2022 Mar 1;3(3):e203–14. Kroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, et al. A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection. J Virus Erad. 2020 Sep 1;6(3):100004. Bilger A, Plenn E, Barg FK, Rendle KA, Carter WB, Lamour-Harrington A, et al. Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States. HIV Res Clin Pract [Internet]. 2023 [cited 2024 Jul 18];24(1). Available from: https://doi.org/10.1080/25787489.2023.2267825 Neergaard R, Jones NL, Roebuck C, Rendle KA, Barbati Z, Peterson B, et al. “I Know That I Was a Part of Making a Difference”: Participant Motivations for Joining a Cure-Directed HIV Trial with an Analytical Treatment Interruption. https://home.liebertpub.com/aid [Internet]. 2023 Jul 28 [cited 2024 Jul 18];39(8):414–21. Available from: https://www.liebertpub.com/doi/10.1089/aid.2022.0040 Ugarte A, Romero Y, Tricas A, Casado C, Lopez-Galindez C, Garcia F, et al. Unintended HIV-1 Infection During Analytical Therapy Interruption. J Infect Dis [Internet]. 2020 Apr 27;221(10):1740–2. Available from: https://doi.org/10.1093/infdis/jiz611 Lelièvre JD, Hocqueloux L. Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate. J Infect Dis [Internet]. 2019 Jul 2 [cited 2024 Aug 9];220(Supplement_1):S5–6. Available from: https://dx.doi.org/10.1093/infdis/jiz012 Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher C V., Beilman GJ, Chipman JG, et al. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci U S A [Internet]. 2015 Mar 10 [cited 2024 Jun 12];112(10):E1126–34. Available from: https://www.pnas.org/doi/abs/10.1073/pnas.1414926112 Yufenyuy EL, Detorio M, Dobbs T, Patel HK, Jackson K, Vedapuri S, et al. Performance evaluation of the Asante Rapid Recency Assay for verification of HIV diagnosis and detection of recent HIV-1 infections: Implications for epidemic control. PLOS Global Public Health [Internet]. 2022 May 1 [cited 2024 Jul 4];2(5):e0000316. Available from: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000316 Schooley RT, Spritzler J, Wang H, Lederman MM, Havlir D, Kuritzkes DR, et al. AIDS Clinical Trials Group 5197: A Placebo-Controlled Trial of Immunization of HIV-1-Infected Persons with a Replication-Deficient Adenovirus Type 5 Vaccine Expressing the HIV-1 Core Protein. J Infect Dis [Internet]. 2010 Sep 1 [cited 2024 Jun 12];202(5):705–16. Available from: https://dx.doi.org/10.1086/655468 Rosenberg ES, Graham BS, Chan ES, Bosch RJ, Stocker V, Maenza J, et al. Safety and Immunogenicity of Therapeutic DNA Vaccination in Individuals Treated with Antiretroviral Therapy during Acute/Early HIV-1 Infection. PLoS One [Internet]. 2010 [cited 2024 Jun 12];5(5). Available from: /pmc/articles/PMC2866663/ Jacobson JM, Bucy RP, Spritzler J, Saag MS, Eron JJ, Coombs RW, et al. Evidence That Intermittent Structured Treatment Interruption, but Not Immunization with ALVAC-HIV vCP1452, Promotes Host Control of HIV Replication: The Results of AIDS Clinical Trials Group 5068. J Infect Dis [Internet]. 2006 Sep 1 [cited 2024 Jun 12];194(5):623–32. Available from: https://dx.doi.org/10.1086/506364 Kilby JM, Bucy RP, Mildvan D, Fischl M, Santana-Bagur J, Lennox J, et al. A Randomized, Partially Blinded Phase 2 Trial of Antiretroviral Therapy, HIV-Specific Immunizations, and Interleukin‐2 Cycles to Promote Efficient Control of Viral Replication (ACTG A5024). J Infect Dis [Internet]. 2006 Dec 15 [cited 2024 Jun 12];194(12):1672–6. Available from: https://dx.doi.org/10.1086/509508 Volberding P, Demeter L, Bosch RJ, Aga E, Pettinelli C, Hirsch M, et al. Antiretroviral therapy in acute and recent HIV infection: A prospective multicenter stratified trial of intentionally interrupted treatment. AIDS [Internet]. 2009 Sep [cited 2024 Jun 12];23(15):1987–95. Available from: https://journals.lww.com/aidsonline/fulltext/2009/09240/antiretroviral_therapy_in_acute_and_recent_hiv.7.aspx Li JZ, Team ACTGAS, Aga E, Team ACTGAS, Bosch RJ, Team ACTGAS, et al. Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies. Clinical Infectious Diseases [Internet]. 2022 Mar 9 [cited 2024 Jun 12];74(5):865–70. Available from: https://dx.doi.org/10.1093/cid/ciab541 de Jong W, Leal L, Buyze J, Pannus P, Guardo A, Salgado M, et al. Therapeutic Vaccine in Chronically HIV-1-Infected Patients: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial with HTI-TriMix. Vaccines 2019, Vol 7, Page 209 [Internet]. 2019 Dec 6 [cited 2024 Jun 12];7(4):209. Available from: https://www.mdpi.com/2076-393X/7/4/209/htm Bailón L, Llano A, Cedeño S, Escribà T, Rosás-Umbert M, Parera M, et al. Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial. Nature Medicine 2022 28:12 [Internet]. 2022 Oct 27 [cited 2024 Jun 12];28(12):2611–21. Available from: https://www.nature.com/articles/s41591-022-02060-2 Calin R, Hamimi C, Lambert-Niclot S, Carcelain G, Bellet J, Assoumou L, et al. Treatment interruption in chronically HIV-infected patients with an ultralow HIV reservoir. AIDS [Internet]. 2016 Mar 13 [cited 2024 Jun 12];30(5):761–9. Available from: https://journals.lww.com/aidsonline/fulltext/2016/03130/treatment_interruption_in_chronically_hiv_infected.14.aspx Ruiz L, Martinez-Picado J, Romeu J, Paredes R, Zayat MK, Marfil S, et al. Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppression. AIDS [Internet]. 2000;14(4). Available from: https://journals.lww.com/aidsonline/fulltext/2000/03100/structured_treatment_interruption_in_chronically.13.aspx Sneller MC, Justement JS, Gittens KR, Petrone ME, Clarridge KE, Proschan MA, et al. A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection. Sci Transl Med [Internet]. 2017 Dec 6 [cited 2024 Jun 12];9(419). Available from: https://www.science.org/doi/10.1126/scitranslmed.aan8848 Sneller MC, Huiting ED, Clarridge KE, Seamon C, Blazkova J, Justement JS, et al. Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy. J Infect Dis [Internet]. 2020 Oct 13 [cited 2024 Jun 12];222(10):1655–9. Available from: https://dx.doi.org/10.1093/infdis/jiaa270 Sneller MC, Blazkova J, Justement JS, Shi V, Kennedy BD, Gittens K, et al. Combination anti-HIV antibodies provide sustained virological suppression. Nature 2022 606:7913 [Internet]. 2022 Jun 1 [cited 2024 Jun 12];606(7913):375–81. Available from: https://www.nature.com/articles/s41586-022-04797-9 De Scheerder MA, Vrancken B, Dellicour S, Schlub T, Lee E, Shao W, et al. HIV Rebound Is Predominantly Fueled by Genetically Identical Viral Expansions from Diverse Reservoirs. Cell Host Microbe [Internet]. 2019 Sep 11 [cited 2024 Jun 12];26(3):347–358.e7. Available from: http://www.cell.com/article/S1931312819303683/fulltext Gunst JD, Pahus MH, Rosás-Umbert M, Lu IN, Benfield T, Nielsen H, et al. Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial. Nature Medicine 2022 28:11 [Internet]. 2022 Oct 17 [cited 2024 Jun 12];28(11):2424–35. Available from: https://www.nature.com/articles/s41591-022-02023-7 Leal L, Couto E, Sánchez-Palomino S, Climent N, Fernández I, Miralles L, et al. Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial. Front Immunol [Internet]. 2021 Nov 11 [cited 2024 Jun 12];12:767370. Available from: www.frontiersin.org Papasavvas E, Kostman JR, Mounzer K, Grant RM, Gross R, Gallo C, et al. Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection. PLoS Med [Internet]. 2004 [cited 2024 Jun 12];1(3):218–28. Available from: /pmc/articles/PMC539050/ Pannus P, Rutsaert S, De Wit S, Allard SD, Vanham G, Cole B, et al. Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription. J Int AIDS Soc [Internet]. 2020 Feb 1;23(2):e25453. Available from: https://doi.org/10.1002/jia2.25453 Tipoe T, Ogbe A, Lee M, Brown H, Robinson N, Hall R, et al. Impact of antiretroviral therapy during primary HIV infection on T-cell immunity after treatment interruption. Eur J Immunol [Internet]. 2024 [cited 2024 Sep 6];0:2451200. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202451200 Jacobson JM, Routy JP, Welles S, DeBenedette M, Tcherepanova I, Angel JB, et al. Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: A randomized, double-blind, placebo-controlled clinical trial. J Acquir Immune Defic Syndr (1988) [Internet]. 2016 May 1 [cited 2024 Jun 12];72(1):31–8. Available from: https://journals.lww.com/jaids/fulltext/2016/05010/dendritic_cell_immunotherapy_for_hiv_1_infection.5.aspx Zhou C, Wu Y, Zhang Y, Wang Y, Wu H, Zhang T, et al. Factors associated with post-treatment control of viral load in HIV-infected patients: a systematic review and meta-analysis. Int J Infect Dis [Internet]. 2023 Apr 1 [cited 2024 Jun 11];129:216–27. Available from: https://pubmed.ncbi.nlm.nih.gov/36707043/ Gossez M, Martin GE, Pace M, Ramjee G, Premraj A, Kaleebu P, et al. Virological remission after antiretroviral therapy interruption in female African HIV seroconverters. AIDS [Internet]. 2019 Feb 1 [cited 2024 Jun 11];33(2):185–97. Available from: https://pubmed.ncbi.nlm.nih.gov/30325764/ Le CN, Britto P, Brummel SS, Hoffman RM, Li JZ, Flynn PM, et al. Time to viral rebound and safety after antiretroviral treatment interruption in postpartum women compared with men. AIDS [Internet]. 2019 Nov 15 [cited 2024 Jul 18];33(14):2149–56. Available from: https://journals.lww.com/aidsonline/fulltext/2019/11150/time_to_viral_rebound_and_safety_after.4.aspx Li JZ, Etemad B, Ahmed H, Aga E, Bosch RJ, Mellors JW, et al. The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption. AIDS [Internet]. 2016 Jan 28 [cited 2024 Jul 4];30(3):343–53. Available from: https://journals.lww.com/aidsonline/fulltext/2016/01280/the_size_of_the_expressed_hiv_reservoir_predicts.2.aspx Etemad B, Sun X, Li Y, Melberg M, Moisi D, Gottlieb R, et al. HIV post-treatment controllers have distinct immunological and virological features. Proc Natl Acad Sci U S A [Internet]. 2023 Mar 10 [cited 2024 Jun 11];120(11). Available from: https://pubmed.ncbi.nlm.nih.gov/36877848/ Tables Table 1. ATI studies and individuals in the individual data-based meta-analysis. Data are median (interquartile range) unless otherwise stated. Stage at ART initiation indicates either early-ART: within 6 months of HIV acquisition or late-ART: beyond 6 months of HIV acquisition. Abbreviations: ART, antiretroviral therapy; ATI, ART interruption; PI, protease inhibitor; INSTI, integrase strand transfer inhibitor; NA, not available; NNRTI, non-nucleoside reverse transcriptase inhibitor. * Individuals excluded, whom did not fulfil the inclusion criteria of frequent measurements of plasma HIV RNA. § Individuals can only contribute to data if still off ART and the threshold is meet. Additional Declarations There is NO Competing Interest. 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Rotterdam","correspondingAuthor":false,"prefix":"","firstName":"Wesley","middleName":"","lastName":"Jong","suffix":""},{"id":353798322,"identity":"329b13b7-8a5b-4589-b646-520c6122ee54","order_by":24,"name":"Lorna Leal","email":"","orcid":"","institution":"Hospital Clínic Barcelona Barcelona","correspondingAuthor":false,"prefix":"","firstName":"Lorna","middleName":"","lastName":"Leal","suffix":""},{"id":353798323,"identity":"86228ff0-01ea-4394-b964-b2cc8c1d3c7b","order_by":25,"name":"Felipe Garcia","email":"","orcid":"","institution":"Hospital Clínic Barcelona Barcelona","correspondingAuthor":false,"prefix":"","firstName":"Felipe","middleName":"","lastName":"Garcia","suffix":""},{"id":353798324,"identity":"aee8e348-799b-4246-863d-df5930c045bd","order_by":26,"name":"Rob Gruters","email":"","orcid":"https://orcid.org/0000-0002-8486-5903","institution":"Erasmus University Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Rob","middleName":"","lastName":"Gruters","suffix":""},{"id":353798325,"identity":"1e70a67c-065b-4ecf-8d26-a96c91c4db04","order_by":27,"name":"Timothy Tipoe","email":"","orcid":"","institution":"University of Oxford","correspondingAuthor":false,"prefix":"","firstName":"Timothy","middleName":"","lastName":"Tipoe","suffix":""},{"id":353798326,"identity":"e1828946-c33e-49e1-ac04-b5d2e478c8a5","order_by":28,"name":"John Frater","email":"","orcid":"https://orcid.org/0000-0001-7163-7277","institution":"Oxford University","correspondingAuthor":false,"prefix":"","firstName":"John","middleName":"","lastName":"Frater","suffix":""},{"id":353798327,"identity":"f7f7d2ce-de59-4790-a54f-8e009e1dd9d3","order_by":29,"name":"Ole Søgaard","email":"","orcid":"https://orcid.org/0000-0001-9107-2023","institution":"Department of Infectious Diseases, Aarhus University Hospital","correspondingAuthor":false,"prefix":"","firstName":"Ole","middleName":"","lastName":"Søgaard","suffix":""},{"id":353798328,"identity":"7fa0ebc4-3876-493b-9b44-53acffc82978","order_by":30,"name":"Sarah Fidler","email":"","orcid":"https://orcid.org/0000-0003-1676-7583","institution":"Imperial College London","correspondingAuthor":false,"prefix":"","firstName":"Sarah","middleName":"","lastName":"Fidler","suffix":""}],"badges":[],"createdAt":"2024-09-10 15:44:52","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-5065764/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-5065764/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1038/s41467-025-56116-1","type":"published","date":"2025-01-21T05:00:00+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":64707590,"identity":"9aace446-85e0-4c5d-9752-171f60b50750","added_by":"auto","created_at":"2024-09-18 01:33:29","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":194470,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eFlowchart of literature review.\u003c/strong\u003e\u003c/p\u003e","description":"","filename":"image1.png","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/554001b61ccd601f0b2900c7.png"},{"id":64707586,"identity":"2c45b2e9-3114-4e50-bd99-d84cefd6de9e","added_by":"auto","created_at":"2024-09-18 01:33:29","extension":"jpeg","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":455698,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eViral kinetics, frequency of control (\u0026lt;50 copies/mL) and time to viremia of 50, 400 and 10,000 copies/mL during 84 days of ATI\u003cbr\u003e\n a,\u003c/strong\u003e Individual plasma HIV RNA levels are shown during 84 days of ATI. Bold line represents median of the entire cohort (n=382). The dotted line indicates plasma HIV RNA of 50 copies/mL. The bold line indicates median plasma HIV RNA level for the entire cohort. Of note, 86 individuals had at least one plasma HIV RNA measurement above 100,000 copies/mL and 19 individuals had at least one plasma HIV RNA measurement above 1,000,000 copies/mL. \u003cstrong\u003eb\u003c/strong\u003e, Percentage of individuals (n=376) with plasma HIV RNA \u0026lt;50 or \u0026gt;50 copies/mL during 84 days of ATI. \u003cstrong\u003ec,d,e\u003c/strong\u003e, Kaplan–Meier curves showing the percentage of individuals (not NNRTI-containing regimen) with first plasma HIV RNA measurement below the following three thresholds 50, 400 and 10,000 copies/mL during 84 days of ATI. The dotted lines indicate median times to reach the specified thresholds. Below each Kaplan-Meier curves are noted the number of individuals at risk.\u003c/p\u003e\n\u003cp\u003eART, antiretroviral therapy; ATI, ART interruption; NNRTI, non-nucleoside reverse transcriptase inhibitor.\u003c/p\u003e","description":"","filename":"image2.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/adc23783e14d0e068e051a49.jpeg"},{"id":64708707,"identity":"a774fbb1-73aa-42c3-a95c-5fb5d5f187f3","added_by":"auto","created_at":"2024-09-18 01:41:29","extension":"jpeg","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":314714,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003ePost-treatment control at day 84 of ATI\u003cbr\u003e\n a, \u003c/strong\u003ePie chart showing the percentage of individuals with plasma HIV RNA \u0026lt;50 or \u0026gt;50 copies/mL at day 84 of ATI among the entire cohort (n=376). \u003cstrong\u003eb,\u003c/strong\u003e Pie chart showing the peak plasma HIV RNA level during 84 days of ATI among the post-treatment controllers (n=14). \u003cstrong\u003ec,\u003c/strong\u003ePlasma HIV RNA levels for individuals with either sustained or regained post-treatment control at day 84 day of ATI. Bold and thin lines represent sustained (n=4) and regained (n=10) post-treatment controllers, respectively. The dotted line indicates plasma HIV RNA of 50 copies/mL. \u003cstrong\u003ed\u003c/strong\u003e, Table with characteristics of the post-treatment controllers (n=14).\u003c/p\u003e\n\u003cp\u003eART, antiretroviral therapy; ATI, ART interruption; PI, protease inhibitor; PTC, post-treatment control; INSTI, integrase strand transfer inhibitor.\u003c/p\u003e","description":"","filename":"image3.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/09012365bb10f58ef54f3e37.jpeg"},{"id":64707591,"identity":"b8cf8ce1-5bcd-4d76-a518-a92cf17ae291","added_by":"auto","created_at":"2024-09-18 01:33:29","extension":"jpeg","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":351867,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eCorrelations of immunological and virological variables for the ATI participants (not NNRTI-containing regimen)\u003cbr\u003e\n a,\u003c/strong\u003e Heat map of Spearman’s rank correlations between immunological and virological variables for the ATI participants (not NNRTI-containing regimen). *Asterisks noted at correlations with \u003cem\u003eP\u003c/em\u003evalues \u0026lt;0.05. \u003cstrong\u003eb,\u003c/strong\u003e Correlation between nadir CD4+ T cell count and CD4+ T cell count at ATI start (n=206). \u003cstrong\u003ec,\u003c/strong\u003e Correlation between nadir CD4+ T cell count and time to viremia of 50 (circles; n=208), 400 (squares; n=206) and 10,000 (triangles; n=142) copies/mL. \u003cstrong\u003ed,e,f\u003c/strong\u003e, Correlations between initial viral doubling time and time to viremia of 50 (\u003cstrong\u003ed\u003c/strong\u003e, circles; n=357), 400 (\u003cstrong\u003ee\u003c/strong\u003e, squares; n=357) and 10,000 (\u003cstrong\u003ef\u003c/strong\u003e, triangles; n=261) copies/mL, respectively. \u003cem\u003eP\u003c/em\u003e values were calculated using two-tailed Spearman’s correlation coefficient.\u003c/p\u003e\n\u003cp\u003eART, antiretroviral therapy; ATI, ART interruption; NNRTI, non-nucleoside reverse transcriptase inhibitor.\u003c/p\u003e","description":"","filename":"image4.jpeg","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/d5888d2d9be3461b2a9ab3e0.jpeg"},{"id":64707593,"identity":"badd97e0-9534-4929-a407-3e5d553597e5","added_by":"auto","created_at":"2024-09-18 01:33:29","extension":"png","order_by":5,"title":"Figure 5","display":"","copyAsset":false,"role":"figure","size":180862,"visible":true,"origin":"","legend":"\u003cp\u003e\u003cstrong\u003eNumber of participants needed in future trials to achieve 25% or 35% post-treatment control among early-ART and late-ART individuals at day 84 of ATI\u003cbr\u003e\n \u003c/strong\u003ePower calculations to be use for future study designs on how many participants would be needed for either single arm or randomized controlled trials (RCTs) with 2 groups based on the assumption that the studies would have a power of 90% to detect the indicated differences in post-treatment control (PTC) at a 5% significant level, one-sided. Early-ART (\u003cstrong\u003ea\u003c/strong\u003e) and late-ART (\u003cstrong\u003eb\u003c/strong\u003e) defined as people who started ART within or beyond 6 months of HIV acquisition.\u003c/p\u003e\n\u003cp\u003eART, antiretroviral therapy; ATI, ART interruption; PTC, post-treatment control.\u003c/p\u003e","description":"","filename":"image5.png","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/7e6640e58ca5bcae362d53a6.png"},{"id":74426185,"identity":"a40e35f2-fdd0-4b76-8dfe-e5c3ca554b50","added_by":"auto","created_at":"2025-01-22 08:07:26","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":2528718,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/f100f66f-9b65-4c1a-8138-d083cfe3119a.pdf"},{"id":64710080,"identity":"7e183ebb-ab97-4b66-a781-9c82f659f0d4","added_by":"auto","created_at":"2024-09-18 01:49:29","extension":"docx","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":1280390,"visible":true,"origin":"","legend":"","description":"","filename":"SupplementaryMaterials09sep24.docx","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/ebad47ea68c4c726e8385a4c.docx"},{"id":64708705,"identity":"b2bf6967-852b-45eb-aa57-300388adde17","added_by":"auto","created_at":"2024-09-18 01:41:29","extension":"pdf","order_by":2,"title":"","display":"","copyAsset":false,"role":"supplement","size":1436840,"visible":true,"origin":"","legend":"Reporting Summary","description":"","filename":"NMEDAN135757rs.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/9df35c69f262071935f87bf9.pdf"},{"id":64707589,"identity":"a335378d-7f45-44e8-a644-9eadbdd681f0","added_by":"auto","created_at":"2024-09-18 01:33:29","extension":"pdf","order_by":3,"title":"","display":"","copyAsset":false,"role":"supplement","size":1440843,"visible":true,"origin":"","legend":"Editorial Policy Checklist","description":"","filename":"NMEDAN135757epc.pdf","url":"https://assets-eu.researchsquare.com/files/rs-5065764/v1/c5b71b45a14cfecdc4279811.pdf"}],"financialInterests":"There is \u003cb\u003eNO\u003c/b\u003e Competing Interest.","formattedTitle":"Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies","fulltext":[{"header":"INTRODUCTION","content":"\u003cp\u003eAntiretroviral therapy (ART) has dramatically improved survival and quality of life for people living with human immunodeficiency virus type 1 (HIV) (1). National and international guidelines recommend lifelong ART initiated at the time of diagnosis (1\u0026ndash;3). Adherence to ART leads to viral suppression, prevents HIV disease progression, and eliminates the risk of onward viral transmission (1). However, ART carries risks of toxicities and side effects, requiring sustaining lifelong adherence. Access to medication burdens people with HIV (PWH) and healthcare systems, particularly in settings with limited resources and populations with high HIV prevalence (4). There is widespread interest in exploring alternative approaches to achieve long-term ART-free virological control.\u003c/p\u003e \u003cp\u003eART, whilst effectively blocking viral replication, is unable to eradicate HIV due to the persistence of a reservoir of latently infected cells (5), which is the source of viral recrudescence when ART is stopped. While there has been much advance in assays evaluating the HIV reservoir and HIV-specific immunity, none can accurately predict which individuals will achieve post-treatment control (PTC) after stopping ART (6). Hence, to measure clinical efficacy of any experimental approach towards eliminating the HIV reservoir or inducing immune-mediated suppression of virus replication, ART must be carefully interrupted in a controlled setting; so-called analytical treatment interruption (ATI) (7\u0026ndash;11). A collaborative group met to develop guidelines on how to safely undertake ATI trials (12) frequently monitored plasma HIV RNA viral load (pVL) and CD4\u0026thinsp;+\u0026thinsp;T cell counts throughout the period of ATI (10,11,13\u0026ndash;15) but these recommendations are based on observations from multiple different studies, many of which were carried out using different ATI protocols and older ART regimens (10). The only known potential determinant of PTC from previous analyses is time from HIV acquisition to ART initiation (10); while generally, measures of the HIV reservoir do not accurately predict PTC (13\u0026ndash;16).\u003c/p\u003e \u003cp\u003eAlthough some individuals have demonstrated PTC after ATI (10) for the majority of PWH, viral rebound occurs rapidly, usually within weeks after stopping ART (7,8,17\u0026ndash;19). Such ATI protocols are intense and benefit greatly from altruism and commitment from the community of PWH to reach efficacy outcomes (20,21). While inclusion of placebo or no-intervention groups to study design add great value scientifically, and maybe necessary in early phase trials, ATI carries potential risk to participants and their partners (22,23).\u003c/p\u003e \u003cp\u003eTo comprehensively map patterns of virological rebound after stopping ART under close monitoring and to inform future study designs, we undertook an individual participant data meta-analysis from studies that included an ATI among individuals that received placebo or \u0026ldquo;no intervention\u0026rdquo; prior to stopping ART. We further sought to identify pre-ATI clinical factors that influenced the timing of viral rebound.\u003c/p\u003e"},{"header":"METHODS AND MATERIALS","content":"\u003cdiv id=\"Sec3\" class=\"Section2\"\u003e \u003ch2\u003eSearch strategy and selection criteria\u003c/h2\u003e \u003cp\u003eWe completed a literature review using the electronic database of PubMed in September 2024 using the following terms: \"off therapy\"[All Fields] OR \"ART interruption\"[All Fields] OR \"treatment interruption\"[All Fields] OR \"Withholding Treatment\"[All Fields] OR \"antiretroviral interruption\"[All Fields] OR \"therapy interruption\"[All Fields] OR \"Withholding Treatment\"[MeSH Terms] AND (\"HIV\"[Mesh]) OR (\"HIV\"). Several excluding terms were used to specific the search (Supplementary Table \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003e). No geographical restriction was applied. We excluded studies that were written in non-English, abstracts, letters, reviews, commentary articles, opinion articles, case reports, studies with co-infection, animal studies, in-vitro studies, mother-to-child transmission, infant/children and adolescent studies.\u003c/p\u003e \u003cp\u003eWe included prospective clinical ATI studies in adults receiving either placebo or no active intervention and where frequent pVL monitoring was conducted (defined as a minimum of 5 planned pVL measurements within the first 84 days of post-ATI with a maximum of 18 days between measurements within the first 42 days).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec4\" class=\"Section2\"\u003e \u003ch2\u003eData extraction\u003c/h2\u003e \u003cp\u003eCovidence.org was used for literature search. Two of the authors (JDG, JG) independently screened studies for above inclusion and exclusion criteria. To access individual-level data, corresponding authors and/or principal investigators of each identified study were asked to complete a predefined data sheet. This included individual data on age at ATI, sex (female/male/other), race and ethnicity (asian, black, white, other, unknown), pre-ART pVL, nadir CD4\u0026thinsp;+\u0026thinsp;T cell count, early-ART (within 6 months) or late-ART (beyond 6 months), ART regimen at ATI, CD4\u0026thinsp;+\u0026thinsp;T cell count at ATI, and consecutive pVL measurements during ATI and corresponding days since start of ATI. For six individuals the clinical assay used for quantification of pVL had a limit of quantification of 65 copies/mL, thus these individuals were excluded from the analysis of time to viremia of 50 copies/mL (24). In a few cases, some participants from the identified studies did not fulfil the inclusion criteria and were excluded, which was noted for the respective studies.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec5\" class=\"Section2\"\u003e \u003ch2\u003eDefinitions\u003c/h2\u003e \u003cp\u003e \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003eEarly-ART versus late-ART\u003c/span\u003e. Early-ART initiation was defined as PWH who started ART in the presence of an HIV-positive antibody test result within up to 6 months of a previous negative antibody test, HIV\u0026thinsp;+\u0026thinsp;RNA or p24 in the absence of detectable antibody, or evolution of antibody testing on western blot, incident in a recency assay (25) or self-reported time of HIV acquisition less than 6 months prior to starting ART. Late-ART initiation was defined as starting ART beyond 6 months of HIV acquisition. A few individuals had unknown date of HIV acquisition and were categorized as \u0026lsquo;unknown\u0026rsquo;.\u003c/p\u003e \u003cp\u003e \u003cspan type=\"Underline\" class=\"Underline\" name=\"Emphasis\"\u003ePost-treatment control.\u003c/span\u003e We defined PTCs as PWH with pVL below 50 copies/mL at day 84 (12 weeks) or the closest timepoint to day 84 after stopping ART. This stringent cut-off was chosen because it mirrors the current treatment goal for HIV and excludes viremic controllers. The pVL kinetics after stopping ART were graphed and the characteristics of PTCs including pre-ATI ART regimen were tabulated.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec6\" class=\"Section2\"\u003e \u003ch2\u003eStatistical Analysis\u003c/h2\u003e \u003cp\u003eData are presented as median (interquartile range [IQR]), median (range), or numbers (percentages) as indicated in each respective legend. The Kaplan\u0026ndash;Meier estimator was used to assess the magnitude of the difference between the survival curves, and the log-rank test was used to compare time to viremia for the following three thresholds: 50, 400 and 10,000 copies/mL. Fisher\u0026rsquo;s exact test was used to analyze contingency tables. For correlations, Spearman\u0026rsquo;s correlation coefficient was only done for individuals with available data points. The initial viral doubling time was calculated based on the first two consecutive pVL measurements that increased, and the second measurement had to increase by 1,000 copies/mL compared to the previous measurement. The slope of this increase was calculated using a linear regression model. Univariable and multivariable Cox proportional hazards regression models were used to explore the following risk factors for time to viremia during ATI: sex, early-ART versus late-ART, and ART regimen at ATI (non-nucleoside reverse transcriptase inhibitors [NNRTI] versus non-NNRTI). Correlations between initial viral doubling time and time to viremia were estimated.\u003c/p\u003e \u003cp\u003eSample size estimations were calculated using either two independent study groups comparisons or one study group compared to a known value of the indicated percentages of PTC (chi-squared tests) or means of time to viremia (unpaired t tests). We estimated the size of the hypothetic study populations that would yield\u0026thinsp;\u0026gt;\u0026thinsp;90% power to detect the indicated differences at a 5% significance level using one-sided tests. We used Stata version 17.0 and Prism version 7.0 software for statistical analyses.\u003c/p\u003e \u003c/div\u003e"},{"header":"RESULTS","content":"\u003cp\u003eIn total, 942 publications were identified and screened under the search terms (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Of these studies 164 were ATI studies, and out of these 24 studies (14,17,24,26\u0026ndash;44) were included in this individual data-based meta-analysis, and 142 ATI studies were excluded due to different reason (Fig.\u0026nbsp;\u003cspan refid=\"Fig2\" class=\"InternalRef\"\u003e1\u003c/span\u003e). Table\u0026nbsp;1 summarises the studies included in this analysis.\u003c/p\u003e \u003cdiv id=\"Sec8\" class=\"Section2\"\u003e \u003ch2\u003eCharacteristics of included studies\u003c/h2\u003e \u003cp\u003eOf the 24 studies included in our analysis, 22 were published in peer reviewed journals between 2000\u0026ndash;2024 (14,17,24,26\u0026ndash;44) and 2 studies have yet to be published (AELIX-003 [NCT04364035] and BNC03 [NCT05208125]). Fourteen were RCTs (17,26,27,29,32,33,36,38,40\u0026ndash;42,45\u0026thinsp;+\u0026thinsp;AELIX-003 and BNC03) and ten were single-arm ATI studies (14,24,30,31,34,35,37,39,43,44). Thirteen studies were undertaken in Northern Europe (14,17,32\u0026ndash;35,39\u0026ndash;41,43,44\u0026thinsp;+\u0026thinsp;AELIX-003 and BNC03) and eleven studies in North America (24,26\u0026ndash;31,36\u0026ndash;38,42). Most studies had only small \u0026ldquo;placebo\u0026rdquo; participant numbers with the smallest involving 4 individuals (40) and the largest being 69 individuals (30). Restart criteria for ART between the studies were based upon pVL levels and CD4\u0026thinsp;+\u0026thinsp;T cell counts, but differed on the exact threshold (Supplementary Table S2).\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec9\" class=\"Section2\"\u003e \u003ch2\u003eStudy participant demographics\u003c/h2\u003e \u003cp\u003eThe characteristics of the analysed ATI study participants are shown in Table\u0026nbsp;1. From the 382 participants of the 24 studies, 91% were male and 75% white. The median age was 42 (interquartile range [IQR] 35\u0026ndash;49) years. The median CD4\u0026thinsp;+\u0026thinsp;T cell count at ART initiation was 422 (330\u0026ndash;558) per mm\u003csup\u003e3\u003c/sup\u003e and median pre-ART pVL was 48,400 (14,000\u0026ndash;150,000) copies/mL. Forty-five and 51 percent of participants were categorized as early-ART and late-ART, respectively, while 4% were categorized as \u0026lsquo;unknown\u0026rsquo;. At the start of ATI, the median CD4\u0026thinsp;+\u0026thinsp;T cell count was 781 (IQR 611\u0026ndash;1,007) per mm\u003csup\u003e3\u003c/sup\u003e. Forty-eight percent were on an integrase-strand inhibitor regimen, while 17% were on a NNRTI-containing ART regimen at the time of ATI.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec10\" class=\"Section2\"\u003e \u003ch2\u003eNNRTI impacts time to viremia\u003c/h2\u003e \u003cp\u003eNNRTI has been shown to be associated with longer time to viral rebound likely reflecting an antiretroviral drug \u0026lsquo;tail\u0026rsquo; into the ATI due to the long half-life of NNRTIs. In agreement with previous analyses, univariable analysis, non-NNRTI regimens compared to NNRTI regimens at ATI start were associated with shorter time to viremia (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003ea\u0026thinsp;+\u0026thinsp;b). In multivariable analysis, NNRTI regimen at ATI start continued to be associated with longer time to pVL\u0026thinsp;\u0026gt;\u0026thinsp;50 copies/mL (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003ea: HR 0.50, \u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.01). However, due to the risk of ART drug resistance, current ATI trials no longer recommend NNRTI regimens and to make our observations pertinent to current recommendations individuals entering an ATI on NNRTI regimens were omitted from the analyses of time to viral rebound, although included in the overall analyses of PTC at day 84 of ATI.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec11\" class=\"Section2\"\u003e \u003ch2\u003eViral kinetics\u003c/h2\u003e \u003cp\u003eWhile viral rebound kinetics following ART interruption differed (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e2\u003c/span\u003ea), most individuals followed a similar pattern. Forty-four percent of the participants had a pVL below 50 copies/mL by day 14 after stopping ART but only 4% had a pVL below 50 copies/mL at day 84 (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e2\u003c/span\u003eb).The median time to pVL\u0026thinsp;\u0026gt;\u0026thinsp;50 copies/mL after ART interruption was 16 days (IQR: 13\u0026ndash;25), while time to pVL\u0026thinsp;\u0026gt;\u0026thinsp;400 and \u0026gt;\u0026thinsp;10,000 copies/mL was 21 (IQR: 15\u0026ndash;28) days and 32 (IQR: 20\u0026ndash;35) days, respectively (Fig.\u0026nbsp;\u003cspan refid=\"Fig3\" class=\"InternalRef\"\u003e2\u003c/span\u003ec-e). Time to viremia data for all individuals irrespective of ART regimen is shown in Supplementary Fig. S2.\u003c/p\u003e \u003cp\u003eCollectively, these data demonstrate that in more than 75% of individuals (not on NNRTI regimens), pVL rebounds within 21 days and only 14 (4%) people have suppressed viremia through day 84.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec12\" class=\"Section2\"\u003e \u003ch2\u003ePost-treatment control\u003c/h2\u003e \u003cp\u003eOut of the 14 PTCs with pVL below 50 copies/mL at day 84 (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e3\u003c/span\u003ea), only 4 (29%) individuals had pVLs\u0026thinsp;\u0026lt;\u0026thinsp;50 copies/mL at all prior measurements. The other 10 individuals had variable levels of viremia prior to regaining viral control to \u0026lt;\u0026thinsp;50 copies/mL, with 29% (n\u0026thinsp;=\u0026thinsp;4) reaching a peak pVL 50\u0026ndash;399 copies/mL, 29% (n\u0026thinsp;=\u0026thinsp;4) with peak pVL between 400\u0026ndash;10,000 copies/mL, and 14% (n\u0026thinsp;=\u0026thinsp;2) reaching peak pVL above 10,000 copies/mL (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e3\u003c/span\u003eb\u0026thinsp;+\u0026thinsp;c). Examining the total study cohort of 382 individuals, categorized by levels of peak pVL\u0026thinsp;\u0026lt;\u0026thinsp;50, 50\u0026ndash;399, 400\u0026thinsp;\u0026minus;\u0026thinsp;10,000, and \u0026gt;\u0026thinsp;10,000 copies/mL, the percentage of PTCs at day 84 within each category were 1%, 1%, 1% and 0.5%, respectively.\u003c/p\u003e \u003cp\u003eAmong the 14 PTCs, most were male (93%) and white (71%) with an average age of 38 (IQR: 33\u0026ndash;45) years (Fig.\u0026nbsp;\u003cspan refid=\"Fig4\" class=\"InternalRef\"\u003e3\u003c/span\u003ed), similar to the demographics for the overall cohort. A significantly higher proportion (\u003cem\u003eP\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.008) of individuals who started ART early (n\u0026thinsp;=\u0026thinsp;11; 6% of 172 early-ART participants) achieved PTC compared to those who started ART late (n\u0026thinsp;=\u0026thinsp;2; 1% of 195 late-ART participants). One PTC had unknown time of ART initiation relative to HIV acquisition. Among PTCs, the median CD4\u0026thinsp;+\u0026thinsp;T cell count at ART interruption was 912 (IQR: 827\u0026ndash;1219) per mm\u003csup\u003e3\u003c/sup\u003e. These observations highlight that PTC is very rare, in particular among people who start ART late. In addition, while 1% of ATI participants maintained ART-free suppression for 84 days, only 0.5% regained control to pVL\u0026thinsp;\u0026lt;\u0026thinsp;50 copies/mL at 84 day when peak viremia post-ATI was higher than 10,000 copies/mL.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec13\" class=\"Section2\"\u003e \u003ch2\u003eFactors associated with time to viremia\u003c/h2\u003e \u003cp\u003eAs seen in Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e4\u003c/span\u003ea, some of the variables associated with time to viremia were highly correlated. For instance, nadir CD4\u0026thinsp;+\u0026thinsp;T cell count prior to ART start correlated with the CD4\u0026thinsp;+\u0026thinsp;T cell count at ATI start (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e4\u003c/span\u003eb; \u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.0001) but also with time to viremia (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e4\u003c/span\u003ec). There were significant positive correlations between initial viral doubling time and time to pVL\u0026thinsp;\u0026gt;\u0026thinsp;50 c/mL (Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e4\u003c/span\u003ea), and these correlations became more positive with higher viremia threshold (\u0026gt;\u0026thinsp;400 and \u0026gt;\u0026thinsp;10,000 c/mL, Fig.\u0026nbsp;\u003cspan refid=\"Fig5\" class=\"InternalRef\"\u003e4\u003c/span\u003ed-f).\u003c/p\u003e \u003cp\u003eIn our univariable analysis, late-ART (vs early-ART) at ATI start was associated with shorter time to viremia (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003ea\u0026thinsp;+\u0026thinsp;b). In our multivariable analysis, late-ART remained a risk factor for shorter time to pVL\u0026thinsp;\u0026gt;\u0026thinsp;50 copies/mL (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003ea: HR 1.25, \u003cem\u003eP\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.05) and \u0026gt;\u0026thinsp;10,000 copies/mL (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003eb: HR 1.61, \u003cem\u003eP\u003c/em\u003e\u0026thinsp;\u0026lt;\u0026thinsp;0.01). We observed a significantly longer time to viremia of 50 and 10,000 copies/mL for early-ART compared to late-ART initiation (Supplementary Fig. \u003cspan refid=\"MOESM1\" class=\"InternalRef\"\u003eS1\u003c/span\u003ec\u0026thinsp;+\u0026thinsp;d). Similar results were found when using a threshold of time to pVL\u0026thinsp;\u0026gt;\u0026thinsp;400 copies/mL (Supplementary Fig. S3). In summary, multiple mechanistic factors may impact time to viremia after ART interruption, but in our analyses, based on clinical variables, early-ART initiation was consistently associated with both higher chance of PTC at day 84 and longer time to viremia after interrupting ART.\u003c/p\u003e \u003c/div\u003e \u003cdiv id=\"Sec14\" class=\"Section2\"\u003e \u003ch2\u003ePowering future interventional HIV cure/remission studies\u003c/h2\u003e \u003cp\u003eUsing the calculated time to viremia and frequencies of PTC from this meta-analysis, we generated power calculations that may help inform the design of future ATI studies. We used our data as reference and calculated the number of participants needed in either a single arm or 2-group randomized controlled trial design with a power of 90% to detect the indicated prolonged time to viremia or proportion of PTC at a 5% significant level (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e5\u003c/span\u003e and Supplementary Fig. S4). If the expected outcome of an intervention is a frequency of 25% PTC among early-ART participants, 36 individuals would need to be included in a single arm design and 128 individuals in a 2-group randomized trial design (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e5\u003c/span\u003ea). However, due to the lower observed frequency of PTC among late-ART individuals (1%), only 12 and 64 participants would be needed in a single arm design and 2-group randomized trial design, respectively, if the expected frequency of PTC in the intervention group is 25% (Fig.\u0026nbsp;\u003cspan refid=\"Fig6\" class=\"InternalRef\"\u003e5\u003c/span\u003eb).\u003c/p\u003e \u003cp\u003ePTC is generally considered the most clinically relevant outcome in HIV cure/remission studies, but if the primary outcome is time to viremia (e.g. 50 copies/mL), 8 and 32 study participants (irrespectively of stage at ART initiation) would be needed to demonstrate a delay of at least 14 days in a single and randomized trial design, respectively (Supplementary Fig. S4a). Similarly, an expected delay in time to viremia of at least 21 days, would only require 4 and 16 individuals (irrespectively of stage at ART initiation) in a single arm and 2-group randomized trial design, respectively (Supplementary Fig. S4a). Approximately twice as many participants would be needed to demonstrate a delay of at least 14 or 21 days in time to viremia of 10,000 copies/mL (Supplementary Fig. S4b). Of note, clinical trials often include slightly more participants than needed according to the power calculations to account for drop outs, typically 10\u0026ndash;20% more. In conclusion, adequately powering of future trials is critical for optimizing resources, risk mitigation, and advancing the HIV cure/remission agenda. Our simulated power calculations show that reducing the study population size may be possible using single arm design and our extensive dataset as reference.\u003c/p\u003e \u003c/div\u003e"},{"header":"DISCUSSION","content":"\u003cp\u003e This study was an individual participant data meta-analysis of 24 prospective clinical trials with 382 participants including frequent pVL measurements following an ATI. The definition of PTC in our analysis was rigorous, requiring sustained and stringent viral control off ART. We found that the median time to initial viremia above 50 copies/ml was just 16 days after ART interruption. Overall, the observed frequency of individuals with PTC defined as pVL\u0026thinsp;\u0026lt;\u0026thinsp;50 copies/ml 84 days after stopping ART was 4%. This proportion was enriched for PWH who initiated early-ART (6%), while the frequency was just 1% among those who started ART more than 6 months after HIV acquisition. Thus, our study provides robust estimates on the expected time to viremia at different thresholds as well as estimates of the frequency of PTC in a large cohort of individuals that received placebo or no active intervention prior to stopping ART. Further, we identified key clinical parameters associated with time to viremia and PTC that may be used in the design and interpretation of future HIV cure/remission trials.\u003c/p\u003e \u003cp\u003eA consistent finding in our analyses, and in agreement with others, was that starting ART less than 6 months vs more than 6 months after the time of HIV acquisition was associated with delayed time to viremia and a higher probability of PTC. Interestingly, a recent systematic review and meta-analysis estimated the overall proportion of PTC was to be as high as 8%, ranging from 3\u0026ndash;15% (46). However, these estimates was not based on individual-level data and it also included meta-data from studies that were not prospective and did not have frequent pVL monitoring which likely led to an overestimation in the frequency of PTCs. Another published meta-analysis \u0026ldquo;The CHAMP\u0026rdquo; study compared individual-level data from 6 historic ACTG ART interruption studies but not all 6 studies used as frequent pVL monitoring as in our analysis. Using a PTC definition of 2/3 of pVL measurements had to be \u0026lt;\u0026thinsp;400 copies/mL during the first 6 months after stopping ART, the CHAMP investigators found that the timing of ART initiation also influenced the outcome with 13% vs 4% of those initiating ART in acute/recent infection vs chronic infection respectively, fulfilling their criteria for PTC at 6 months after stopping ART (10). In another ACTG study (ACTG5345), individuals who initiated modern ART including an integrase inhibitor regimen, in either early or chronic HIV stage underwent an ATI. Whilst there was no difference in time to viral rebound between ACTG5345 (n\u0026thinsp;=\u0026thinsp;45) and historic controls on boosted protease-inhibitor regimens, a higher percentage of early-treated participants remained off ART at week 12 post ATI compared with chronic participants (9% vs 2%; \u003cem\u003eP\u003c/em\u003e\u0026thinsp;=\u0026thinsp;0.0496) (31). Thus, we conclude that in agreement with our individual data-based meta-analysis, time from HIV acquisition to ART initiation is a key determinant of subsequent ART-free virological control after ATI across different meta-analyses with varying frequency of pVL monitoring and stringency of PTC criteria.\u003c/p\u003e \u003cp\u003eThe vast majority of individuals enrolled into the 24 prospective ATI trials included in this meta-analysis were male. This reflects the population of PWH in the global north engaged in HIV cure/remission studies but leaves behind over half the population of PWH globally. More data from diverse populations and women can be anticipated as interventional ATI studies in Africa are now ongoing (47,48). Of note, amongst 82 African women undergoing ATI 22% maintained pVL\u0026thinsp;\u0026lt;\u0026thinsp;400 copies/mL \u0026ndash; the pVL cut-off available at the time of study, over a median of 188 weeks after stopping ART (47).\u003c/p\u003e \u003cp\u003eA limitation of this meta-analysis is that not all studies include weekly pVL measurements. Although participants included had to have at least 5 measurements of pVL within the first 84 days after ATI with a maximum of 18 days between measures within the first 42 days there are inevitably variations in timespan between measurements. In addition, individual data-based meta-analysis may have underestimated the proportion of PTC. Depending on the protocol-defined ART restart criteria of each trial, certain individuals may have been censored prematurely before being identified as PTC. However, given our finding that PTC is rare (0.5%) when the viraemic peak was \u0026gt;\u0026thinsp;10,000 copies/mL, lower threshold pVL ART restart criteria were unlikely to have caused a large underestimation of the frequency of PTCs.\u003c/p\u003e \u003cp\u003ePredictors of time to pVL rebound as well as magnitude of rebound have been explored. Historically, measures of the HIV reservoir have been shown to correlate with time to pVL rebound (14,15,47), and the size of the established HIV reservoir is also dependent on the time of ART initiation (early-ART vs late-ART) hence further supporting the observation that PTC is more likely in early-ART individuals (13,14,47). In addition, several studies have found that levels of reservoir activity (i.e., cell-associated HIV RNA or residual viremia) have predicted timing of viral rebound (13,36,49). Of the included studies in this individual data-based meta-analysis HIV reservoir measurement was assessed in 12 studies either as an inclusion criteria (n\u0026thinsp;=\u0026thinsp;4) or secondary endpoint (n\u0026thinsp;=\u0026thinsp;8). Since several different assays were used in these 12 studies to measure the HIV reservoir, we did not include HIV reservoir as a predictor of time to viremia.\u003c/p\u003e \u003cp\u003eImmunological biomarkers have also been demonstrated to predict time to pVL rebound. In this meta-analysis pre-ART pVL, nadir CD4\u0026thinsp;+\u0026thinsp;T-cell count and CD4\u0026thinsp;+\u0026thinsp;T-cell count prior to ART interruption were collected. Nadir CD4\u0026thinsp;+\u0026thinsp;prior to ART start correlated with CD4\u0026thinsp;+\u0026thinsp;T-cell count pre-ATI, and has previously been shown to correlate with time from HIV acquisition to ART initiation as well as size of the HIV reservoir (13) which may explain why nadir CD4\u0026thinsp;+\u0026thinsp;T cell count also correlated with time to viremia. Similarly, data from the SPARTAC trial demonstrated that immunological biomarkers of T-cell exhaustion (PD-1, Tim-3 and Lag-3) measured prior to ART start predicted subsequent time to viral rebound (16). More recently, the ACTG5345 study demonstrated that amongst 33 late-ART and 12 early-ART individuals, predictors of time and magnitude of viral rebound were high proportion of HIV-gag specific CD8\u0026thinsp;+\u0026thinsp;T cells, low intact proviral HIV DNA and early-ART (13). Detailed investigation of immunological biomarkers predictive of PTC amongst 22 individuals from 8 ACTG studies who maintained pVL\u0026thinsp;\u0026lt;\u0026thinsp;400 copies/mL for \u0026gt;\u0026thinsp;24 weeks did not identify any association with HLA alleles, but these PTCs had compared to non-controllers lower levels of CD4\u0026thinsp;+\u0026thinsp;and CD8\u0026thinsp;+\u0026thinsp;T-cell activation, reduced markers of CD4\u0026thinsp;+\u0026thinsp;T cell exhaustion, and more robust HIV-gag specific CD4\u0026thinsp;+\u0026thinsp;T and NK cell responses(50).\u003c/p\u003e \u003cp\u003eIn summary, to design safe and effective ATI trials, testing novel strategies and therapies towards a HIV cure/remission, inclusion of a placebo arm whilst scientifically rigorous is now debated. This meta-analysis can be informative for future study designs to inform power, strategy, monitoring frequency and communication with potential study participants to enable anticipation of potential timing and magnitude of viral rebound. The data from this meta-analysis can also help inform the aspirational \u0026ldquo;signal\u0026rdquo; threshold of a new intervention, given the rarity of spontaneous PTC. The value of smaller, focused single arm intervention trials that can compare pertinent clinical outcomes to the findings of this individual participant data meta-analysis will enable interpretation of findings. While the inclusion of control groups maybe a requirement for regulatory registration of new agents, in certain settings there may no longer be ethical equipoise.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe thank all study participants who devoted time to research. The authors would also like to thank\u0026nbsp;to Michael C. Sneller, Sabine Allard and Eric Florence for providing data.\u0026nbsp;The authors who undertook this research were funded by awards from the following funders;\u0026nbsp;the Lundbeck Foundation (JDG: R381\u0026ndash;2021\u0026ndash;1405 and OSS: R313-2019-790),\u0026nbsp;Danish Council for Independent Research (OSS: #9060-00023B), Central Region Denmark Research Fund (OSS),\u0026nbsp;Work supported by AELIX Therapeutics and partly by grants from the Spanish Research Agency and the European Reginal Development Fund (BMP: RTC-2017-6473-1), National Institute of Health (NIH) (LJM: UM1 AI164570),\u0026nbsp;National Institute of Allergy and Infectious Diseases (LJM: NIH AI48398), the Philadelphia Foundation (LJM: Robert I. Jacobs Fund), The Stengel-Miller family (LJM), AIDS funds from the Commonwealth Universal Research\u0026nbsp;Enhancement Program Pennsylvania, Department of Health (LJM),\u0026nbsp;California University wide AIDS Research Program (LJM), the Gladstone Institute of Virology and Immunology\u0026nbsp;(LJM),\u0026nbsp;the Division of Intramural Research of the National Institute of Allergy and Infectious Diseases, NIH (TWC),\u0026nbsp;NIH (CB:\u0026nbsp;P01 AI178375\u0026nbsp;\u003cem\u003eOMIT-HIV)\u003c/em\u003e,\u0026nbsp;European Union\u0026acute;s Horizon Europe Research and Innovation Programme (CB: GA 101057548 (\u003cem\u003eEPIVINF\u003c/em\u003e) and BMP: 681137-EAVI2020, NIH grant P01-AI131568 and by ISCIII PI20/01039), NIH/NIAID (JMP: 1 UM1 AI164561-01, USA),\u0026nbsp;EU grant (RAG: FP7-HEALTH-2013-INNOVATION-1 Proposal No: 602570-2), Fondo Europeo para el Desarrollo Regional (FEDER) (RAG), the SPANISH AIDS Research Network (RAG: RD16/0025/0002\u0026ndash; ISCIII \u0026ndash; FEDER (RIS)), the CERCA Programme / Generalitat de Catalunya SGR 615 and SGR 653 (RG), \u0026nbsp;NIAID (JLI, RB and ACTG A5345: AI068634, UM1 AI068636, UM1 AI106701) ,NIH (JL: AI150396, AI169768, AI060354), Spanish Ministry of Economy (MINECO) (LL: SAF2015-66193-R, SAF-2017-88089-R, and RTI2018-096309-B-I00),\u0026nbsp;FP7-HEALTH-2013-INNOVATION-1 Proposal No: 602570-2 (LL), the\u0026nbsp;Foundation for AIDS Research (JF: amfAR, grant ID\u0026nbsp;109842-65-RGRL), Bill and Melinda Gates Foundation (JG and SF: grant OPP1204692), Imperial College London (JG and SF), NIHR Biomedical Research centre at Imperial College Healthcare National Health Service Trust (JG and SF).\u0026nbsp;None of the specific sources of funding had any role in the conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript.\u003cstrong\u003e\u003cbr\u003e\u0026nbsp;\u003c/strong\u003e\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\u003cli\u003e\u003cspan\u003e Trickey A, Sabin CA, Burkholder G, Crane H, d\u0026rsquo;Arminio Monforte A, Egger M, et al. Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies. Lancet HIV [Internet]. 2023 May 1;10(5):e295\u0026ndash;307. Available from: https://doi.org/10.1016/S2352-3018(23)00028-0\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Ryom L, De Miguel R, Cotter AG, Podlekareva D, Beguelin C, Waalewijn H, et al. Major revision version 11.0 of the European AIDS Clinical Society Guidelines 2021. HIV Med [Internet]. 2022 Sep 1 [cited 2024 Jan 18];23(8):849\u0026ndash;58. Available from: https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.13268\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Consolidated Guidelines on HIV Prevention, Testing, Treatment, Service Delivery and Monitoring: Recommendations for a Public Health Approach [Internet] - PubMed [Internet]. [cited 2024 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/34370423/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Lee MJ, Collins S, Babalis D, Johnson N, Falaschetti E, Prevost AT, et al. The RIO trial: rationale, design, and the role of community involvement in a randomised placebo-controlled trial of antiretroviral therapy plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) in participants diagnosed with recent HIV infection\u0026mdash;study protocol for a two-stage randomised phase II trial. Trials [Internet]. 2022;23(1):263. Available from: https://doi.org/10.1186/s13063-022-06151-w\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Ndung\u0026rsquo;u T, McCune JM, Deeks SG. Why and where an HIV cure is needed and how it might be achieved. Nature [Internet]. 2019;576(7787):397\u0026ndash;405. Available from: https://doi.org/10.1038/s41586-019-1841-8\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Zheng L, Tierney C, Bosch RJ. Analytical Treatment Interruption in HIV Trials: Statistical and Study Design Considerations. Curr HIV/AIDS Rep [Internet]. 2021 Oct 1 [cited 2024 Apr 4];18(5):475\u0026ndash;82. Available from: https://link.springer.com/article/10.1007/s11904-021-00569-8\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Rasmussen TA, Tolstrup M, Brinkmann CR, Olesen R, Erikstrup C, Solomon A, et al. Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial. Lancet HIV. 2014;1(1):e13\u0026ndash;21.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Leth S, Schleimann MH, Nissen SK, H\u0026oslash;jen JF, Olesen R, Graversen ME, et al. Combined effect of Vacc-4x, recombinant human granulocyte macrophage colony-stimulating factor vaccination, and romidepsin on the HIV-1 reservoir (REDUC): a single-arm, phase 1B/2A trial. Lancet HIV. 2016 Oct 1;3(10):e463\u0026ndash;72.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e S\u0026aacute;ez-Ciri\u0026oacute;n A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, et al. Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study. PLoS Pathog [Internet]. 2013 [cited 2024 Mar 1];9(3):e1003211. Available from: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003211\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, et al. The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies. J Infect Dis [Internet]. 2018 Nov 5;218(12):1954\u0026ndash;63. Available from: https://doi.org/10.1093/infdis/jiy479\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Goujard C, Girault I, Rouzioux C, L\u0026eacute;curoux C, Deveau C, Chaix ML, et al. HIV-1 control after transient antiretroviral treatment initiated in primary infection: role of patient characteristics and effect of therapy. Antivir Ther [Internet]. 2012 [cited 2024 Mar 1];17(6):1001\u0026ndash;9. Available from: https://pubmed.ncbi.nlm.nih.gov/22865544/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Julg B, Dee L, Ananworanich J, Barouch DH, Bar K, Caskey M, et al. Recommendations for analytical antiretroviral treatment interruptions in HIV research trials\u0026mdash;report of a consensus meeting. Lancet HIV [Internet]. 2019 Apr 1 [cited 2024 Apr 10];6(4):e259\u0026ndash;68. Available from: http://www.thelancet.com/article/S2352301819300529/fulltext\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Li JZ, Melberg M, Kittilson A, Abdel-Mohsen M, Li Y, Aga E, et al. Predictors of HIV rebound differ by timing of antiretroviral therapy initiation. JCI Insight [Internet]. 2024 Feb 8 [cited 2024 Jun 11];9(3). Available from: https://doi.org/10.1172/jci.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Castagna A, Muccini C, Galli L, Bigoloni A, Poli A, Spagnuolo V, et al. Analytical treatment interruption in chronic HIV-1 infection: time and magnitude of viral rebound in adults with 10 years of undetectable viral load and low HIV-DNA (APACHE study). J Antimicrob Chemother [Internet]. 2019 Jul 1 [cited 2024 Jun 11];74(7):2039\u0026ndash;46. Available from: https://pubmed.ncbi.nlm.nih.gov/31225610/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Williams JP, Hurst J, St\u0026ouml;hr W, Robinson N, Brown H, Fisher M, et al. HIV-1 DNA predicts disease progression and post-treatment virological control. Elife [Internet]. 2014 [cited 2024 Jun 11];3:e03821. Available from: https://pubmed.ncbi.nlm.nih.gov/25217531/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Hurst J, Hoffmann M, Pace M, Williams JP, Thornhill J, Hamlyn E, et al. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption. Nat Commun [Internet]. 2015 Oct 9 [cited 2024 Jun 11];6. Available from: https://pubmed.ncbi.nlm.nih.gov/26449164/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Gunst JD, H\u0026oslash;jen JF, Pahus MH, Ros\u0026aacute;s-Umbert M, Stiksrud B, McMahon JH, et al. Impact of a TLR9 agonist and broadly neutralizing antibodies on HIV-1 persistence: the randomized phase 2a TITAN trial. Nature Medicine 2023 29:10 [Internet]. 2023 Sep 11 [cited 2024 Mar 1];29(10):2547\u0026ndash;58. Available from: https://www.nature.com/articles/s41591-023-02547-6\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Gruell H, Gunst JD, Cohen YZ, Pahus MH, Malin JJ, Platten M, et al. Effect of 3BNC117 and romidepsin on the HIV-1 reservoir in people taking suppressive antiretroviral therapy (ROADMAP): a randomised, open-label, phase 2A trial. Lancet Microbe. 2022 Mar 1;3(3):e203\u0026ndash;14.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Kroon EDMB, Ananworanich J, Pagliuzza A, Rhodes A, Phanuphak N, Trautmann L, et al. A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection. J Virus Erad. 2020 Sep 1;6(3):100004.\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Bilger A, Plenn E, Barg FK, Rendle KA, Carter WB, Lamour-Harrington A, et al. Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States. HIV Res Clin Pract [Internet]. 2023 [cited 2024 Jul 18];24(1). Available from: https://doi.org/10.1080/25787489.2023.2267825\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Neergaard R, Jones NL, Roebuck C, Rendle KA, Barbati Z, Peterson B, et al. \u0026ldquo;I Know That I Was a Part of Making a Difference\u0026rdquo;: Participant Motivations for Joining a Cure-Directed HIV Trial with an Analytical Treatment Interruption. https://home.liebertpub.com/aid [Internet]. 2023 Jul 28 [cited 2024 Jul 18];39(8):414\u0026ndash;21. Available from: https://www.liebertpub.com/doi/10.1089/aid.2022.0040\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Ugarte A, Romero Y, Tricas A, Casado C, Lopez-Galindez C, Garcia F, et al. Unintended HIV-1 Infection During Analytical Therapy Interruption. J Infect Dis [Internet]. 2020 Apr 27;221(10):1740\u0026ndash;2. Available from: https://doi.org/10.1093/infdis/jiz611\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Leli\u0026egrave;vre JD, Hocqueloux L. Unintended HIV-1 Transmission to a Sex Partner in a Study of a Therapeutic Vaccine Candidate. J Infect Dis [Internet]. 2019 Jul 2 [cited 2024 Aug 9];220(Supplement_1):S5\u0026ndash;6. Available from: https://dx.doi.org/10.1093/infdis/jiz012\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher C V., Beilman GJ, Chipman JG, et al. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption. Proc Natl Acad Sci U S A [Internet]. 2015 Mar 10 [cited 2024 Jun 12];112(10):E1126\u0026ndash;34. Available from: https://www.pnas.org/doi/abs/10.1073/pnas.1414926112\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Yufenyuy EL, Detorio M, Dobbs T, Patel HK, Jackson K, Vedapuri S, et al. Performance evaluation of the Asante Rapid Recency Assay for verification of HIV diagnosis and detection of recent HIV-1 infections: Implications for epidemic control. PLOS Global Public Health [Internet]. 2022 May 1 [cited 2024 Jul 4];2(5):e0000316. Available from: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000316\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Schooley RT, Spritzler J, Wang H, Lederman MM, Havlir D, Kuritzkes DR, et al. AIDS Clinical Trials Group 5197: A Placebo-Controlled Trial of Immunization of HIV-1-Infected Persons with a Replication-Deficient Adenovirus Type 5 Vaccine Expressing the HIV-1 Core Protein. J Infect Dis [Internet]. 2010 Sep 1 [cited 2024 Jun 12];202(5):705\u0026ndash;16. Available from: https://dx.doi.org/10.1086/655468\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Rosenberg ES, Graham BS, Chan ES, Bosch RJ, Stocker V, Maenza J, et al. Safety and Immunogenicity of Therapeutic DNA Vaccination in Individuals Treated with Antiretroviral Therapy during Acute/Early HIV-1 Infection. PLoS One [Internet]. 2010 [cited 2024 Jun 12];5(5). Available from: /pmc/articles/PMC2866663/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Jacobson JM, Bucy RP, Spritzler J, Saag MS, Eron JJ, Coombs RW, et al. Evidence That Intermittent Structured Treatment Interruption, but Not Immunization with ALVAC-HIV vCP1452, Promotes Host Control of HIV Replication: The Results of AIDS Clinical Trials Group 5068. J Infect Dis [Internet]. 2006 Sep 1 [cited 2024 Jun 12];194(5):623\u0026ndash;32. Available from: https://dx.doi.org/10.1086/506364\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Kilby JM, Bucy RP, Mildvan D, Fischl M, Santana-Bagur J, Lennox J, et al. A Randomized, Partially Blinded Phase 2 Trial of Antiretroviral Therapy, HIV-Specific Immunizations, and Interleukin‐2 Cycles to Promote Efficient Control of Viral Replication (ACTG A5024). J Infect Dis [Internet]. 2006 Dec 15 [cited 2024 Jun 12];194(12):1672\u0026ndash;6. Available from: https://dx.doi.org/10.1086/509508\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Volberding P, Demeter L, Bosch RJ, Aga E, Pettinelli C, Hirsch M, et al. Antiretroviral therapy in acute and recent HIV infection: A prospective multicenter stratified trial of intentionally interrupted treatment. AIDS [Internet]. 2009 Sep [cited 2024 Jun 12];23(15):1987\u0026ndash;95. Available from: https://journals.lww.com/aidsonline/fulltext/2009/09240/antiretroviral_therapy_in_acute_and_recent_hiv.7.aspx\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Li JZ, Team ACTGAS, Aga E, Team ACTGAS, Bosch RJ, Team ACTGAS, et al. Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies. Clinical Infectious Diseases [Internet]. 2022 Mar 9 [cited 2024 Jun 12];74(5):865\u0026ndash;70. Available from: https://dx.doi.org/10.1093/cid/ciab541\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e de Jong W, Leal L, Buyze J, Pannus P, Guardo A, Salgado M, et al. Therapeutic Vaccine in Chronically HIV-1-Infected Patients: A Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial with HTI-TriMix. Vaccines 2019, Vol 7, Page 209 [Internet]. 2019 Dec 6 [cited 2024 Jun 12];7(4):209. Available from: https://www.mdpi.com/2076-393X/7/4/209/htm\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Bail\u0026oacute;n L, Llano A, Cede\u0026ntilde;o S, Escrib\u0026agrave; T, Ros\u0026aacute;s-Umbert M, Parera M, et al. Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial. Nature Medicine 2022 28:12 [Internet]. 2022 Oct 27 [cited 2024 Jun 12];28(12):2611\u0026ndash;21. Available from: https://www.nature.com/articles/s41591-022-02060-2\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Calin R, Hamimi C, Lambert-Niclot S, Carcelain G, Bellet J, Assoumou L, et al. Treatment interruption in chronically HIV-infected patients with an ultralow HIV reservoir. AIDS [Internet]. 2016 Mar 13 [cited 2024 Jun 12];30(5):761\u0026ndash;9. Available from: https://journals.lww.com/aidsonline/fulltext/2016/03130/treatment_interruption_in_chronically_hiv_infected.14.aspx\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Ruiz L, Martinez-Picado J, Romeu J, Paredes R, Zayat MK, Marfil S, et al. Structured treatment interruption in chronically HIV-1 infected patients after long-term viral suppression. AIDS [Internet]. 2000;14(4). Available from: https://journals.lww.com/aidsonline/fulltext/2000/03100/structured_treatment_interruption_in_chronically.13.aspx\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Sneller MC, Justement JS, Gittens KR, Petrone ME, Clarridge KE, Proschan MA, et al. A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection. Sci Transl Med [Internet]. 2017 Dec 6 [cited 2024 Jun 12];9(419). Available from: https://www.science.org/doi/10.1126/scitranslmed.aan8848\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Sneller MC, Huiting ED, Clarridge KE, Seamon C, Blazkova J, Justement JS, et al. Kinetics of Plasma HIV Rebound in the Era of Modern Antiretroviral Therapy. J Infect Dis [Internet]. 2020 Oct 13 [cited 2024 Jun 12];222(10):1655\u0026ndash;9. Available from: https://dx.doi.org/10.1093/infdis/jiaa270\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Sneller MC, Blazkova J, Justement JS, Shi V, Kennedy BD, Gittens K, et al. Combination anti-HIV antibodies provide sustained virological suppression. Nature 2022 606:7913 [Internet]. 2022 Jun 1 [cited 2024 Jun 12];606(7913):375\u0026ndash;81. Available from: https://www.nature.com/articles/s41586-022-04797-9\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e De Scheerder MA, Vrancken B, Dellicour S, Schlub T, Lee E, Shao W, et al. HIV Rebound Is Predominantly Fueled by Genetically Identical Viral Expansions from Diverse Reservoirs. Cell Host Microbe [Internet]. 2019 Sep 11 [cited 2024 Jun 12];26(3):347\u0026ndash;358.e7. Available from: http://www.cell.com/article/S1931312819303683/fulltext\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Gunst JD, Pahus MH, Ros\u0026aacute;s-Umbert M, Lu IN, Benfield T, Nielsen H, et al. Early intervention with 3BNC117 and romidepsin at antiretroviral treatment initiation in people with HIV-1: a phase 1b/2a, randomized trial. Nature Medicine 2022 28:11 [Internet]. 2022 Oct 17 [cited 2024 Jun 12];28(11):2424\u0026ndash;35. Available from: https://www.nature.com/articles/s41591-022-02023-7\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Leal L, Couto E, S\u0026aacute;nchez-Palomino S, Climent N, Fern\u0026aacute;ndez I, Miralles L, et al. Effect of Intranodally Administered Dendritic Cell-Based HIV Vaccine in Combination With Pegylated Interferon α-2a on Viral Control Following ART Discontinuation: A Phase 2A Randomized Clinical Trial. Front Immunol [Internet]. 2021 Nov 11 [cited 2024 Jun 12];12:767370. Available from: www.frontiersin.org\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Papasavvas E, Kostman JR, Mounzer K, Grant RM, Gross R, Gallo C, et al. Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection. PLoS Med [Internet]. 2004 [cited 2024 Jun 12];1(3):218\u0026ndash;28. Available from: /pmc/articles/PMC539050/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Pannus P, Rutsaert S, De Wit S, Allard SD, Vanham G, Cole B, et al. Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription. J Int AIDS Soc [Internet]. 2020 Feb 1;23(2):e25453. Available from: https://doi.org/10.1002/jia2.25453\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Tipoe T, Ogbe A, Lee M, Brown H, Robinson N, Hall R, et al. Impact of antiretroviral therapy during primary HIV infection on T-cell immunity after treatment interruption. Eur J Immunol [Internet]. 2024 [cited 2024 Sep 6];0:2451200. Available from: https://onlinelibrary.wiley.com/doi/full/10.1002/eji.202451200\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Jacobson JM, Routy JP, Welles S, DeBenedette M, Tcherepanova I, Angel JB, et al. Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: A randomized, double-blind, placebo-controlled clinical trial. J Acquir Immune Defic Syndr (1988) [Internet]. 2016 May 1 [cited 2024 Jun 12];72(1):31\u0026ndash;8. Available from: https://journals.lww.com/jaids/fulltext/2016/05010/dendritic_cell_immunotherapy_for_hiv_1_infection.5.aspx\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Zhou C, Wu Y, Zhang Y, Wang Y, Wu H, Zhang T, et al. Factors associated with post-treatment control of viral load in HIV-infected patients: a systematic review and meta-analysis. Int J Infect Dis [Internet]. 2023 Apr 1 [cited 2024 Jun 11];129:216\u0026ndash;27. Available from: https://pubmed.ncbi.nlm.nih.gov/36707043/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Gossez M, Martin GE, Pace M, Ramjee G, Premraj A, Kaleebu P, et al. Virological remission after antiretroviral therapy interruption in female African HIV seroconverters. AIDS [Internet]. 2019 Feb 1 [cited 2024 Jun 11];33(2):185\u0026ndash;97. Available from: https://pubmed.ncbi.nlm.nih.gov/30325764/\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Le CN, Britto P, Brummel SS, Hoffman RM, Li JZ, Flynn PM, et al. Time to viral rebound and safety after antiretroviral treatment interruption in postpartum women compared with men. AIDS [Internet]. 2019 Nov 15 [cited 2024 Jul 18];33(14):2149\u0026ndash;56. Available from: https://journals.lww.com/aidsonline/fulltext/2019/11150/time_to_viral_rebound_and_safety_after.4.aspx\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Li JZ, Etemad B, Ahmed H, Aga E, Bosch RJ, Mellors JW, et al. The size of the expressed HIV reservoir predicts timing of viral rebound after treatment interruption. AIDS [Internet]. 2016 Jan 28 [cited 2024 Jul 4];30(3):343\u0026ndash;53. Available from: https://journals.lww.com/aidsonline/fulltext/2016/01280/the_size_of_the_expressed_hiv_reservoir_predicts.2.aspx\u003c/span\u003e\u003c/li\u003e \u003cli\u003e\u003cspan\u003e Etemad B, Sun X, Li Y, Melberg M, Moisi D, Gottlieb R, et al. HIV post-treatment controllers have distinct immunological and virological features. Proc Natl Acad Sci U S A [Internet]. 2023 Mar 10 [cited 2024 Jun 11];120(11). Available from: https://pubmed.ncbi.nlm.nih.gov/36877848/\u003c/span\u003e\u003c/li\u003e\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp\u003e\u003cstrong\u003eTable 1. ATI studies and individuals in the\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003eindividual data-based meta-analysis.\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cimg 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\"\u003e\u003c/strong\u003e\u003cbr\u003e\u003c/p\u003e\n\u003cp\u003eData are median (interquartile range) unless otherwise stated. Stage at ART initiation indicates either early-ART: within 6 months of HIV acquisition or late-ART: beyond 6 months of HIV acquisition.\u003c/p\u003e\n\u003cp\u003eAbbreviations: ART, antiretroviral therapy; ATI, ART interruption; PI, protease inhibitor; INSTI, integrase strand transfer inhibitor; NA, not available; NNRTI, non-nucleoside reverse transcriptase inhibitor.\u003c/p\u003e\n\u003cp\u003e* Individuals excluded, whom did not fulfil the inclusion criteria of frequent measurements of plasma HIV RNA.\u003c/p\u003e\n\u003cp\u003e\u0026sect; Individuals can only contribute to data if still off ART and the threshold is meet.\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":true,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"nature-portfolio","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"","title":"Nature Portfolio","twitterHandle":"","acdcEnabled":false,"dfaEnabled":false,"editorialSystem":"ejp","reportingPortfolio":"","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-5065764/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-5065764/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e There is a global need to explore novel interventions conferring sustained HIV control without antiretroviral therapy (ART). The only current strategy to test efficacy is through an analytical treatment interruption (ATI). Inclusion of ‘placebo’ controls in future clinical trials poses ethical, logistical, and economic challenges and might be unnecessary if sufficient up-to-date data exists from non-intervention cohorts of people with HIV (PWH) who stop ART. To understand viral rebound dynamics and rates of post-treatment HIV control in the absence of any intervention, we undertook an individual participant data meta-analysis on time to viral rebound after ATI.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods: \u003c/strong\u003eWe included individual-level data from clinical studies with \u0026gt;5 separate available plasma HIV RNA viral load (pVL) measurements within the first 84 days post-ATI in PWH receiving either placebo or no intervention. Eligible prospective studies were identified through literature search on PubMed. Early-ART was defined as ART initiation within 6 months of HIV acquisition; others were classified as late-ART or unknown.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e: In total, 24 studies published between 2000-2024 with 382 individuals were included. Median participant age was 42 years, 91% male, 75% white, 45% received early-ART. Median time to pVL \u0026gt;50, \u0026gt;400, and \u0026gt;10,000 copies/mL was 16 days (interquartile range [IQR]:13–25), 21 (IQR:15–28), and 32 (IQR:20–35), respectively. Post-treatment control defined as pVL \u0026lt;50 copies/mL at day 84 occurred in 4% (n=14) of participants (6% for early-ART and 1% for late-ART). Multivariable analysis identified at late ART initiation as an independent risk factor for earlier VL rebound (hazard ratio [HR] 1.25, \u003cem\u003eP\u003c/em\u003e=0.005).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e: Sustained control of pVL \u0026lt;50 copies/ml after 84 days off ART is rare in PWH who stop therapy, especially in those starting ART late. When designing future interventional HIV cure/remission trials, these findings help inform study size and design, potentially removing the need for a placebo arm thereby minimizing unnecessary risks to participants and their partners, while optimising resources.\u003c/p\u003e","manuscriptTitle":"Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2024-09-18 01:33:24","doi":"10.21203/rs.3.rs-5065764/v1","editorialEvents":[],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"nature-communications","isNatureJournal":true,"hasQc":false,"allowDirectSubmit":false,"externalIdentity":"NCOMMS","sideBox":"Learn more about [Nature Communications](http://www.nature.com/ncomms/)","snPcode":"","submissionUrl":"https://mts-ncomms.nature.com/","title":"Nature Communications","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"ejp","reportingPortfolio":"Nature Communications","inReviewEnabled":true,"inReviewRevisionsEnabled":false}}],"origin":"","ownerIdentity":"799aed44-5767-47b7-b3d8-075de1da2c41","owner":[],"postedDate":"September 18th, 2024","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":37602530,"name":"Health sciences/Diseases/Infectious diseases/HIV infections"},{"id":37602531,"name":"Health sciences/Diseases/Immunological disorders/Immunological deficiency syndromes/HIV infections"},{"id":37602532,"name":"Health sciences/Medical research/Outcomes research"}],"tags":[],"updatedAt":"2025-01-22T08:07:21+00:00","versionOfRecord":{"articleIdentity":"rs-5065764","link":"https://doi.org/10.1038/s41467-025-56116-1","journal":{"identity":"nature-communications","isVorOnly":false,"title":"Nature Communications"},"publishedOn":"2025-01-21 05:00:00","publishedOnDateReadable":"January 21st, 2025"},"versionCreatedAt":"2024-09-18 01:33:24","video":"","vorDoi":"10.1038/s41467-025-56116-1","vorDoiUrl":"https://doi.org/10.1038/s41467-025-56116-1","workflowStages":[]},"version":"v1","identity":"rs-5065764","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-5065764","identity":"rs-5065764","version":["v1"]},"buildId":"qtupq5eGEP_6zYnWcrvyt","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}