A Urine-Based Biomarker for Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Retrospective Multi-Center Study

Background: There are currently no objective diagnostic criteria for chronic prostatitis or chronic pelvic pain syndrome and no accepted therapies that cure the disease. Methods: We identified 372 patients with chronic prostatitis diagnosed from 2015 to 2018 and collect the information of age, routine urinary test, EPS and NIH-CPSI. Results: Our study demonstrated a correlation between the increase of PSEP level and NIH-CPSI scores. At meantime, the correlation was found between the PSEP level and EPS-white blood cells. Conclusions: These findings highlight the potential of PSEP as a viable indicator of symptomatic progression of CP/CPPS. Applications of PSEP assay may guide drug discovery and lead to the better treatment to improve patient’s quality of life.