Synthesis And Characterization Of Fe0@Chitosan/Cellulose Green Nanocomposite As Advanced Carrier For Ibuprofen Drug; Loading And Release Properties

Abstract Green nanocomposite of Fe0@chitosan/cellulose (Fe0@CH/CS) was synthesized utilizing the green extract of khaya senegalensis leaves and sugarcane bagasse as cellulose precursor. The composite was evaluated as an effective carrier for ibuprofen drug (IBF) considering its release and loading properties. The Fe0@CH/CS is of significant IBF loading capacity (553 mg/g) and the loading behavior can be directed by the values of the experimental variables. The loading of IBF into Fe0@CH/CS is in agreement with the classic Langmuir isotherm (R2> 0.95) and Pseudo-first order kinetic (R2> 0.97). This displays homogenous, physisorption, and a monolayer loading of IBF into Fe0@CH/CS. Based on the findings of the Monolayer model with one energy as advanced isotherm model, the Fe0@CH/CS structure is of 252.6 mg/g active receptors density and each rector was occupied by two or three IBF ions (n=2.18) by multi-molecular mechanism. The determined IBF loading energy (4.81 kJ/mol) demonstrates the physical loading of the drug by Van-der Waals forces and/or hydrogen bonding. The Fe0@CH/CS structure is of significant release profiles as carrier for IBF which continued up to 260 h (gastric buffer) and 180 h (intestinal buffer). The studied release kinetics and the obtained diffusion exponent (0.58 (pH 1.2) and 0.48 (pH 7.4)) reflect the release of IBF from Fe0@CH/CS by complex diffusion and erosion mechanisms. The cytotoxicity tests declared the safe and biocompatible value of both Fe0@CH/CS and IBF loaded Fe0@CH/CS on the human bronchial epithelial cells.