Universality of a surface chemical reaction network using only bi-molecular reactions

Universality of a surface chemical reaction network using only bi-molecular reactions | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Universality of a surface chemical reaction network using only bi-molecular reactions Sihai Yu, Jia Lee, Teijiro Isokawa This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3856568/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 06 May, 2024 Read the published version in Journal of Membrane Computing → Version 1 posted 7 You are reading this latest preprint version Abstract In recent years, a novel molecular computation model known as surface chemical reaction network (surface CRN) has garnered significant attention. In this approach, a chemical molecule is placed at each lattice site, and each molecule undergoes bi-molecular reactions with neighboring molecules or uni-molecular reactions autonomously. The advantages of surface CRNs have facilitated new opportunities and challenges in the field of molecular programming. In order to accomplish more intricate computational tasks, establishing a practical computational model with lower complexity on surface CRNs becomes imperative.To this end, this paper proposes a novel model of surface CRNs using only 10 species and 10 reactions, the numbers of which are less than the previous model (Clamons, 2020). In particular,this model employs merely bi-molecular reactions, by excluding all uni-molecular reactions.We show thatour new model can be used to implement a universal set of Brownian circuit elements,thereby giving rise to the universality for constructing all asynchronous circuits, like the well-known logic function, called D-latch, on the surface CRN. Surface chemical reaction network Delay-insensitive circuits Molecular computation Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Published Journal Publication published 06 May, 2024 Read the published version in Journal of Membrane Computing → Version 1 posted Editorial decision: Revision requested 10 Mar, 2024 Reviews received at journal 10 Mar, 2024 Reviewers agreed at journal 19 Jan, 2024 Reviewers invited by journal 16 Jan, 2024 Editor assigned by journal 15 Jan, 2024 Submission checks completed at journal 12 Jan, 2024 First submitted to journal 12 Jan, 2024 You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3856568","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":266714588,"identity":"926ef93c-c0fe-4cfe-8bbe-789a4a9a3085","order_by":0,"name":"Sihai Yu","email":"","orcid":"","institution":"Chongqing University, Chongqing","correspondingAuthor":false,"prefix":"","firstName":"Sihai","middleName":"","lastName":"Yu","suffix":""},{"id":266714589,"identity":"afb26912-6b8f-45bf-9c63-9531b297e573","order_by":1,"name":"Jia Lee","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAAsklEQVRIiWNgGAWjYBACPmaGhAMMFRCOBFFa2MBazpCkBUQwtpGkhZ3h4YGf8+xkNxxgPnibh8EujyiHHezdlmy84QBbsjUPQ3IxUVoO8G47kLjhAI+ZNA/DgcQGomz5Owekhf8b8VoO8zaAbWEjQYvMsWTjmYfZjC3nGCQT1sLPfyb545saO9m+480Pb7ypsCOshYGBJwFEMjYwgygDwuqBgP0ARAtRikfBKBgFo2BEAgA9sTmfxB4CmQAAAABJRU5ErkJggg==","orcid":"","institution":"Chongqing University, Chongqing","correspondingAuthor":true,"prefix":"","firstName":"Jia","middleName":"","lastName":"Lee","suffix":""},{"id":266714590,"identity":"bf0265b4-8a0e-46f8-b045-761d4d2c364d","order_by":2,"name":"Teijiro Isokawa","email":"","orcid":"","institution":"University of Hyogo","correspondingAuthor":false,"prefix":"","firstName":"Teijiro","middleName":"","lastName":"Isokawa","suffix":""}],"badges":[],"createdAt":"2024-01-12 10:29:11","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-3856568/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-3856568/v1","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1007/s41965-024-00149-w","type":"published","date":"2024-05-06T17:01:52+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":56196165,"identity":"928534be-f912-4796-a172-77e52d0784b3","added_by":"auto","created_at":"2024-05-09 18:08:12","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1933131,"visible":true,"origin":"","legend":"","description":"","filename":"Universalityofasurfacechemicalreactionnetworkusingonlybimolecularreactions24112.pdf","url":"https://assets-eu.researchsquare.com/files/rs-3856568/v1_covered_06d7dbc6-21be-44a1-9192-b98894bcd2ce.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Universality of a surface chemical reaction network using only bi-molecular reactions","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"journal-of-membrane-computing","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"jmec","sideBox":"Learn more about [Journal of Membrane Computing](https://www.springer.com/journal/41965)","snPcode":"41965","submissionUrl":"https://submission.nature.com/new-submission/41965/3","title":"Journal of Membrane Computing","twitterHandle":"","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"Springer Hybrid","inReviewEnabled":true,"inReviewRevisionsEnabled":false},"keywords":"Surface chemical reaction network, Delay-insensitive circuits, Molecular computation","lastPublishedDoi":"10.21203/rs.3.rs-3856568/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-3856568/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eIn recent years, a novel molecular computation model known as surface chemical reaction network (surface CRN) has garnered significant attention. 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