Cannabidiol Reduces D1 and D2 Medium Spiny Neuron Excitability in the Nucleus Accumbens Core

Cannabidiol (CBD) is a non-psychotomimetic phytocannabinoid constituent of the cannabis plant that shows promise for the treatment of a variety of neuropsychiatric disorders such as anxiety disorders, post-traumatic stress disorder, and substance use disorders. The nucleus accumbens (NAc) is a key brain region in the etiologies of these disorders and is actively modulated by CBD. Prior research has established that CBD alters the molecular composition of the NAc, but none have assessed how CBD affects NAc neuronal function. In this study, we demonstrate that CBD significantly decreases D1 and D2 medium spiny neuron membrane excitability, broadens action potentials, and has no effect on spontaneous excitatory synaptic transmission in the NAc core. These data enhance our understanding of CBD’s physiological effects and provide mechanistic insight into its therapeutic potential.