Prognostic effect of postoperative duration until adjuvant chemotherapy and cumulative S-1 dose in gastric cancer

Prognostic effect of postoperative duration until adjuvant chemotherapy and cumulative S-1 dose in gastric cancer | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Prognostic effect of postoperative duration until adjuvant chemotherapy and cumulative S-1 dose in gastric cancer Yusuke Takashima, Shuhei Komatsu, Keiji Nishibeppu, Tomohiro Arita, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.2.20067/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Adjuvant chemotherapy (AC) following curative gastrectomy for stage II/III gastric cancer (GC) is recommended in Japan. However, for various reasons, patients cannot always start AC at the appropriate time. This study was designed to investigate the effect of the postoperative duration until adjuvant chemotherapy (PDAC) and cumulative S-1 dose on prognosis. Methods Between 2008 and 2014, 76 consecutive GC patients who underwent postoperative S-1 monotherapy were enrolled in this study. Results Postoperative complications of Clavien–Dindo grade II or higher and postoperative peak C-reactive protein of 8 mg/dl or higher were significantly associated with delayed AC. The cut-off value of PDAC selected to most effectively stratify prognosis was 7 weeks. For relapse-free survival (RFS), patients with PDAC ≥ 7 weeks had an insignificantly poorer prognosis than those with PDAC < 7 weeks ( p = 0.017, 5-year RFS: PDAC ≥ 7 weeks vs. PDAC 12,000 mg [ p = 0.033; HR 0.38 (95% CI: 0.14–0.93)] were independent prognostic factors. In patients with a cumulative S-1 dose ≥ 12,000 mg, there were no prognostic differences between patients with and without PDAC ≥ 7 weeks. Conclusions 7 weeks after surgery could be an indicator starting AC. A cumulative S-1 dose of more than 12,000 mg might be a key dose for diminishing the poor prognostic effects of delaying AC. Oncology Cancer Biology adjuvant chemotherapy S-1 early initiation cumulative dose gastric cancer Figures Figure 1 Figure 2 Figure 3 Figure 4 Background Gastric cancer is the fourth most commonly diagnosed cancer and the third most common cause of cancer-related death worldwide [ 1 ]. Treatment for gastric cancer has been enhanced by improvements in surgical procedures and perioperative management [ 2 – 6 ]. Although surgical resection mainly involves macroscopic tumor resection and lymphadenectomy, the oncologic effect of surgical treatment is often limited to the local control. Therefore, perioperative therapy has been recommended to clear remaining microscopic metastasis [ 7 ]. The ACTS-GC (Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer) study and its 5-year follow-up results demonstrated that adjuvant chemotherapy (AC) with S-1 monotherapy following curative gastrectomy with lymphadenectomy significantly improved relapse-free survival and overall survival rates. Therefore, AC following curative gastrectomy has been recommended as the standard treatment in Japan for stage II/III gastric cancer since 2014 (JGCTG 2014) [ 8 , 9 ]. The ACTS-GC study proved the beneficial prognostic effect of starting S-1 treatment within 6 weeks of undergoing curative surgery. However, patients cannot always start AC at the appropriate time following surgery due to various clinical issues that can result in delayed recovery. The prognostic effect of any delay with regard to AC remains controversial [ 10 , 11 ]. Even if the prognosis may be affected by a delay in starting AC, until now there has been no definite cut-off value for the postoperative duration following curative surgery with which to stratify the prognosis [ 12 ]. Moreover, it is not clear whether a sufficient total S-1 dose during AC could affect the prognosis or diminish the poor prognostic effect resulting from a delay in starting AC. In this study, we investigated the clinical significance of the postoperative duration until adjuvant chemotherapy (PDAC) and the total cumulative S-1 dose, with particular reference to the prognosis. The results of our study suggest a crucial indicator starting AC. Our study also suggested that the cumulative S-1 dose might be key to diminishing any poor prognostic effect, even if there is a delay in starting AC. Methods Patients and surgical procedures This study was approved by the Kyoto Prefectural University of Medicine, Japan, and was therefore performed in accordance with the ethical standards laid down in the Declaration of Helsinki. Written informed consent was obtained from all patients to participate in the research. A total of 214 consecutive patients underwent curative gastrectomy with lymphadenectomy for stage II or III GC at our institute between January 2008 and December 2014. Of these 214 patients, 97 patients received S-1 monotherapy as AC. We excluded 21 patients from the study because of neoadjuvant chemotherapy (n = 2), insufficient follow-up (n = 1), recurrence during AC (n = 8), remnant GC (n = 3), and multiple carcinomas (n = 7). As a result, we retrospectively investigated 76 consecutive patients who received S-1 AC ( Fig. 1 ). Patients with clinical stage IA (clinical T1 and clinical N0 GC) underwent D1+ lymphadenectomy, while those with clinical stage IIA or higher underwent D2 or D2+ lymphadenectomy. All patients underwent macroscopic curative resection (R0); resected specimens were examined by pathologists and evaluated in accordance with the Japanese classification of GC [13]. Dissected lymph nodes were fixed in buffered formalin and embedded in paraffin prior to pathological examination. Pathologists in our institution examined embedded lymph nodes by sectioning slices in the plane of the largest node dimension to confirm the presence of metastasis. Clinicopathological findings from these patients were determined retrospectively on the basis of their hospital records. Follow-up after curative gastrectomy followed by AC Postoperative follow-up was performed in the outpatient clinic every three months following surgery. Blood chemistry was also measured every three months. Endoscopic examinations were performed annually, and computed tomography (CT) examinations were performed every three-to-six months for five years after surgery. The average follow-up period was 52.7 months. AC was begun in the outpatient clinic following discharge. The dose of S-1 was determined according to a patient’s body surface area (BSA). Specifically, patients with BSA < 1.25 m 2 received 80 mg per day; patients with 1.25 m 2 ≤ BSA < 1.5 m 2 received 100 mg per day; and patients with 1.5 m 2 ≤ BSA received 120 mg per day. The cumulative S-1 dose received by each patient during AC was calculated from their hospital records. Statistical analysis Statistical analyses were conducted using JMP version 10 (SAS Institute Inc., Cary, NC). The Mann–Whitney U test for unpaired data comprising continuous variables was used to compare clinicopathological variables. For the analysis of survival, Kaplan–Meier survival curves were constructed for groups based on univariate predictors, and differences between the groups were tested using a generalized Wilcoxon test. The Cox proportional hazards model was used for further evaluations of multivariate survival analysis. A p-value < 0.05 was considered statistically significant. Results Clinicopathological characteristics of GC patients after curative gastrectomy followed by S-1 AC Table 1 shows the clinical characteristics of GC patients who received curative gastrectomy followed by S-1 AC. The mean age of the patients was 62.9 years. Of 76 patients, 47 (61.8%) were male and 29 (38.2%) were female; 30 patients were at pStage IIA, 17 patients were at pStage IIB, 17 patients were at pStage IIIA, and 12 patients were at pStage IIIB. Total gastrectomy was performed in 30 patients (39.5%), distal gastrectomy in 44 patients (57.9%), and proximal gastrectomy was performed in two patients (2.6%) for curative resection dependent on the location of the tumor. A total of 19 patients (25.0%) underwent D1+ lymphadenectomy based on their clinical stage, while the remaining patients performed D2 or D2+ lymphadenectomy [13]. Cut-off value of PDAC to stratify the prognosis and correlation between PDAC and clinicopathological factors We performed a minimum p-value analysis for relapse-free survival (RFS) using various cut-off values for PDAC, as shown in Fig. 2 . The cut-off value of 7 weeks post-surgery was confirmed to be the upper-limit to stratify the prognosis ( p = 0.017; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC < 7 weeks; 48.5 % vs. 77.0 %). Although there were no significant differences in 5-year overall survival (OS) rates, patients in the PDAC ≥ 7 weeks group had a poorer prognosis than those in the PDAC < 7 weeks group ( p = 0.49; 5-year OS: PDAC ≥ 7 weeks vs. PDAC < 7 weeks; 74.3 % vs. 80.7 %). ( Fig. 3 ). Cut-off value of cumulative S-1 dose to stratify the prognosis and combined survival curves using PDAC and cumulative S-1 dose factors To clarify the clinical effect of cumulative S-1 dose, we performed a minimum p-value analysis for RFS using various cut-off values of cumulative S-1 dose (data not shown). A cut-off value of 12,000 mg was confirmed to stratify the prognosis most ( p = 0.006; 5-year RFS: cumulative S-1 dose ≥ 12,000 mg vs. < 12,000 mg; 84.7 % vs. 52.4 %). Next, we compared survival curves between four groups: 1) PDAC ≥ 7 weeks / total S-l dose ≥ 12,000 mg; 2) PDAC < 7 weeks / total S-l dose ≥ 12,000 mg; 3) PDAC ≥ 7 weeks / total S-l dose < 12,000 mg; and 4) PDAC < 7 weeks / total S-l dose < 12,000 mg. With regard to patients who received a cumulative S-1 dose < 12,000 mg, there was a significant prognostic difference between the PDAC ≥ 7-weeks group and the PDAC < 7-weeks group for RFS ( p = 0.040; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC 12,000 mg there was no prognostic difference between the PDAC ≥ 7-weeks group and PDAC < 7-weeks group for RFS ( p = 0.64; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC < 7 weeks; 85.7 % vs. 84.4 %). ( Fig. 4 ) Comparison of PDAC with c linicopathological factors Next, we evaluated correlations between PDAC and clinicopathological factors using the Mann–Whitney U test. As shown in Table 2 , a high peak in the C-reactive protein (CRP) cut-off value of 8 mg/dl or above was significantly associated with a delay in starting S-1 AC. In addition, the incidence of postoperative complications (Clavien–Dindo classification ≥ II) tended to be linked to longer PDAC ( p = 0.065). There were no other significant differences between the groups with regard to other clinicopathological factors. Univariate and multivariate analysis using Cox’s proportional hazard model To elucidate the prognostic factors for recurrence-free survival, univariate and multivariate analysis using Cox’s proportional hazard model were performed. As shown in Table 2 , age, gender, BMI, histological type, a postoperative peak CRP of ≥ 8 mg/dl, complications of Clavien–Dindo grade II or higher, pT-stage, pN-stage, cumulative S-1 dose, and PDAC were selected as clinical variables. The multivariate analysis showed that PDAC ≥ 7 weeks [ p = 0.007; hazard ratio (HR) 3.99 (95% CI: 1.46–11.5)] and cumulative S-1 dose > 12,000 mg [ p = 0.033; HR 0.38 (95% CI: 0.14–0.93)] were independent prognostic factors. Discussion There have been few reports of prognostic effects with regard to PDAC and the extent of S-1 treatment in AC [11, 12, 14]. In this study, we clearly demonstrated that a PDAC ≥ 7 weeks and a cumulative S-1 dose of more than 12,000 mg were independent prognostic factors in GC patients undergoing AC following curative gastrectomy. Moreover, in patients who received a cumulative S-1 dose of more than 12,000 mg, we showed that there were no prognostic differences between patients who had a PDAC of more than or less than 7 weeks. PDAC ≥ 7 weeks. Our results strongly suggested that a cumulative S-1 dose of more than 12,000 mg is a crucial indicator and might be the key dose for diminishing the poor prognostic effects arising from a delay in AC. Concerning PDAC, we clearly demonstrated that 7 weeks was the best cut-off value to stratify the prognosis of patients with pStage II/III gastric cancer ( p = 0.017; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC < 7 weeks; 48.5 % vs. 77.0 %). From an oncological perspective, to eliminate microscopic metastasis it appears that AC should be started immediately following curative gastrectomy. PDAC has been reported to be an independent prognostic factor in other types of cancer, with various cut-off values suggested, including 12 weeks [10] and 8 weeks in colon cancer [15-17] and 13 weeks (91 days) in breast cancer [18]. With regard to gastric cancer, various cut-off values of PDAC have been reported as prognostic factors, ranging from 4 to 8 weeks [12, 16, 19-21]. Our PDAC cut-off value of 7 weeks could also be a candidate indicator. Future studies are warranted, and big data analysis might be needed to determine the best cut-off value for clinical settings. Regarding the cumulative S-1 dose, we also demonstrated that a cumulative S-1 dose of more than 12,000 mg was an independent prognostic factor for RFS [ p = 0.033; HR 0.38 (95% CI: 0.14–0.93)]. The Japanese phase 3 randomized trial (JCOG1104 [OPAS-1]) revealed that four courses of S-1 AC were inferior to eight courses of S-1 AC for achieving RFS of pStage II gastric cancer, highlighting the importance of the duration of AC [22]. Fujitani et al. also reported that S-1 AC with a duration of more than 6 months could have a prognostic impact in patients with gastric cancer [11]. There results could be a crucial indicator of the importance of S-1 AC duration. However, the S-1 dose intensity in each patient is considerably different in clinical practice, and is indeed not as high as shown in previous reports [8, 23, 24]. Therefore, we suggest that the cumulative S-1 dose is also a pivotal factor, in addition to the PDAC of S-1. The most striking finding in the present study was that there were no prognostic differences for RFS between patients with PDAC ≥ 7 weeks and those with PDAC < 7 weeks ( p = 0.64; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC < 7 weeks; 85.7 % vs. 84.4 %). Specifically, these results suggested that a cumulative S-1 dose of more than 12,000 mg might diminish the poor prognostic effect associated with a delay in AC. Similar results were also reported that S-1 AC of more than 6 months [11] and S-1 AC with a relative dose intensity of more than 64.6 % [12] have more prognostic impact than PDAC. Although which factors have the optimal impact on prognosis is unclear, we enhance on the cumulative S-1 dose. As shown by our results, patients could not always begin AC at the appropriate time because of various clinical issues, such as a high serum CRP level or postoperative complications. To avoid postoperative complications [25] and achieve low postoperative CRP levels [26], less invasive surgery is a pivotal surgical goal from a prognostic perspective, Nevertheless, if these issues are encountered and AC cannot be initiated with sufficient S-1 dose intensity, administering high cumulative S-1 dose treatment even after a long PDAC could be a valuable strategy that could potentially rescue high-risk patients with these issues. This study had some limitations: the results were obtained from a retrospective evaluation of a small number of patients at a single institute. A large-scale, multicenter cohort study is necessary to confirm the significance of PDAC and cumulative S-1 dose. Conclusions Patients with early initiation of AC had better prognosis than those with delayed initiation. 7 weeks could be a crucial indicator starting AC, and a cumulative S-1 dose of more than 12,000 mg might be a key dose for diminishing the poor prognostic effects of delaying AC. Declarations Acknowledgements Not applicable. Ethical approval and consent to participate This study was designed in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of Kyoto Prefectural University of Medicine. All patients received sufficient explanation of the study, and written informed consent was obtained. Consent for publication Not applicable. Availability of data and materials The datasets used during the current study are available from the corresponding author on reasonable request. Competing interests The authors declare that they have no competing interests. Funding There is no funding to be declared. Author Contribution: YT and SK designed this work. SK, KN, TA, TK, HK, RM, AS, YK, HI, TK, HF, KO, EO acquired clinical data and critically reviewed this manuscript. YT and SK analyzed data and wrote the paper. Abbreviations GC: gastric cancer; AC: adjuvant chemotherapy; PDAC: postoperative duration until adjuvant chemotherapy; RFS: relapse-free survival; ACTS-GC: Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer References Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A: Global cancer statistics, 2012 . CA: a cancer journal for clinicians 2015, 65 (2):87-108. Gallo A, Cha C: Updates on esophageal and gastric cancers . World J Gastroenterol 2006, 12 (20):3237-3242. Paoletti X, Oba K, Burzykowski T, Michiels S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M et al : Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis . Jama 2010, 303 (17):1729-1737. Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY et al : Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial . Lancet 2012, 379 (9813):315-321. 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Saito T, Kurokawa Y, Miyazaki Y, Makino T, Takahashi T, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y: Which is a more reliable indicator of survival after gastric cancer surgery: Postoperative complication occurrence or C-reactive protein elevation? J Surg Oncol 2015, 112 (8):894-899. Tables Table 1 Clinicopathological characteristics of patients who received S-1 monotherapy as adjuvant chemotherapy. Variable n % Total 76 Gender Male 47 62% Female 29 38% Age (years) ≥ 70 55 72% < 70 21 28% BMI a (kg/m 2 ) ≥ 18.5 69 91% < 18.5 7 9% Tumor location Upper 24 32% Middle 32 42% Lower 20 26% pT category b T1 6 8% T2 12 16% T3 39 51% T4 19 25% pN category b N0 27 36% N1 12 16% N2 21 28% N3 16 21% pStage b IIA 30 39% IIB 17 22% IIIA 17 22% IIIB 12 16% Histopathological type Differentiated 30 39% Undifferentiated 46 61% Operation Total gastrectomy 30 39% Distal gastrectomy 44 58% Proximal gastrectomy 2 3% Lymphadenectomy D1+ 19 25% D2 or D2+ 57 75% a BMI: body mass index, b Classification of Gastric Carcinoma. Table 2 Comparison of PDAC with c linicopathological factors . Variable n PDAC a (days) p -value c （ mean ± SD b ） Gender Male 47 （ 41.6 ± 12.8 ） 0.992 Female 29 （ 46.3 ± 24.5 ） Age (years) ≥ 70 21 （ 42.0 ± 11.6 ） 0.857 < 70 55 （ 43.9 ± 20.2 ） BMI d (kg/m 2 ) ≥ 18.5 69 （ 41.9 ± 12.7 ） 0.907 < 18.5 7 （ 58.4 ± 44.8 ） ASA-PS e 1 49 （ 44.1 ± 20.2 ） 0.841 ≥ 2 27 （ 42.2 ± 14.1 ） GPS f score 0 68 （ 42.8 ± 14.0 ） 0.282 ≥ 1 8 （ 48.6 ± 40.2 ） PNI g score ≥ 48 54 （ 42.6 ± 14.5 ） 0.684 < 48 22 （ 45.4 ± 25.4 ） pStage II 47 （ 42.3 ± 14.1 ） 0.945 III 29 （ 45.1 ± 23.5 ） Histological type Differentiated 30 （ 41.9 ± 10.7 ） 0.663 Undifferentiated 46 （ 44.4 ± 21.8 ） Surgical approach Open 59 （ 45.0 ± 19.5 ） 0.224 Laparoscopy 17 （ 37.8 ± 11.5 ） Post-operative peak CRP h (mg/dl) ≥ 8 44 （ 46.3 ± 20.1 ） 0.046 < 8 32 （ 39.4 ± 14.6 ） Complication (C-D i ≧ II) Positive 9 （ 54.0 ± 21.2 ） 0.065 Negative 67 （ 42.0 ± 17.4 ） a PDAC: postoperative duration until adjuvant chemotherapy, b Mann-Whitney U test analysis, c SD: standard deviation, d BMI: body mass index, e ASA-PS: Physical status proposed by the American Society of Anesthesiologists (ASA), f GPS: Glasgow prognostic score, g PNI: prognostic nutritional index, h CRP: C-reactive protein, I C-D: Clavien-Dindo classification Table 3 Univariate and multivariate analysis using Cox’s proportional hazard model . Variable n Univariate a Multivariate b p value HR c 95% CI d p- value Total 76 Gender Male vs. Female 47 vs. 29 0.128 Age (years) ≥ 70 vs. < 70 21 vs. 55 0.165 BMI (kg/m 2 ) ≥ 18.5 vs. < 18.5 69 vs. 7 0.090 pT category e pT1-3 vs. pT4 57 vs. 19 0.048 4.14 1.47 - 12.14 0.008 pN category e pN0 vs. pN1-2 27 vs. 49 0.038 2.95 1.08 - 10.32 0.034 Histological type Differentiated vs. Undifferentiated 30 vs. 46 0.899 Postoperative peak-CRP (mg/dl) ≥ 8 vs. II) f Positive vs. Negative 9 vs. 67 0.637 PDAC (weeks) ≥ 7 vs. < 7 20 vs. 56 0.017 3.99 1.46 - 11.51 0.007 Cumulative S-1 dose (mg) ≥12,000 vs. < 12,000 40 vs. 36 0.006 0.38 0.14 - 0.93 0.033 a Analyzed by Log Rank (Mantel-Cox) test. b Analyzed by Cox's proportional hazard model. c HR: hazard ratio, d CI: confidence interval. e Japanese Classification of Gastric Carcinoma. f Clavien-Dindo Classification Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. 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Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Keiji","middleName":"","lastName":"Nishibeppu","suffix":""},{"id":277199,"identity":"19cf3ed3-c166-4ea8-8abc-0708a638c14f","order_by":4,"name":"Tomohiro Arita","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Tomohiro","middleName":"","lastName":"Arita","suffix":""},{"id":277200,"identity":"731555fe-7c85-4dcf-90b3-16769d906419","order_by":5,"name":"Toshiyuki Kosuga","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Toshiyuki","middleName":"","lastName":"Kosuga","suffix":""},{"id":277201,"identity":"1734f85b-0946-4bd0-ad8e-27e9ce9b2968","order_by":6,"name":"Hirotaka Konishi","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hirotaka","middleName":"","lastName":"Konishi","suffix":""},{"id":277202,"identity":"436b42d9-52c9-49cc-88e1-9a1db145832f","order_by":7,"name":"Ryo Morimura","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Ryo","middleName":"","lastName":"Morimura","suffix":""},{"id":277203,"identity":"d8bf3969-e5ac-4c22-9eea-4edc5c08431b","order_by":8,"name":"Atsushi Shiozaki","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Atsushi","middleName":"","lastName":"Shiozaki","suffix":""},{"id":277204,"identity":"32e7fd83-17d6-4102-9390-cf34f7a2b423","order_by":9,"name":"Yoshiaki Kuriu","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yoshiaki","middleName":"","lastName":"Kuriu","suffix":""},{"id":277205,"identity":"c13fadf8-0c00-4acd-bd20-c7d695720462","order_by":10,"name":"Hisashi Ikoma","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hisashi","middleName":"","lastName":"Ikoma","suffix":""},{"id":277206,"identity":"3dabc387-3b34-4d08-aaf9-99600678bcfe","order_by":11,"name":"Takeshi Kubota","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Takeshi","middleName":"","lastName":"Kubota","suffix":""},{"id":277207,"identity":"c725ef6e-c14a-4799-a451-3c64eee85f24","order_by":12,"name":"Hitoshi Fujiwara","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Hitoshi","middleName":"","lastName":"Fujiwara","suffix":""},{"id":277208,"identity":"2f77dfc4-e684-418d-b51e-b389371581f3","order_by":13,"name":"Kazuma Okamoto","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Kazuma","middleName":"","lastName":"Okamoto","suffix":""},{"id":277209,"identity":"0b12a056-8aeb-4e2b-9bb5-cc2e548d90c5","order_by":14,"name":"Eigo Otsuji","email":"","orcid":"","institution":"Kyoto Prefectural University of Medicine","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Eigo","middleName":"","lastName":"Otsuji","suffix":""}],"badges":[],"createdAt":"2020-01-01 12:18:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.2.20067/v1","doiUrl":"https://doi.org/10.21203/rs.2.20067/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":330088,"identity":"0982dd4d-1c3c-4b1b-8c4d-f917dc25de26","added_by":"auto","created_at":"2020-01-06 21:03:15","extension":"png","order_by":1,"title":"Figure 1","display":"","copyAsset":false,"role":"figure","size":175941,"visible":true,"origin":"","legend":"A total of 97 patients underwent S-1 monotherapy as adjuvant chemotherapy for stage II/III gastric cancer between 2008 and 2014. Of these, 21 patients were excluded from the study for the reasons listed in the main text. Data for the remaining 76 consecutive patients were obtained from their hospital records and retrospectively analyzed.","description":"","filename":"F1.png","url":"https://assets-eu.researchsquare.com/files/1f386ea1-b2d7-40af-9eaf-1841ce0c3062/v1/F1.png"},{"id":330089,"identity":"ce579680-5478-4fd3-abe3-a34951416c7f","added_by":"auto","created_at":"2020-01-06 21:03:17","extension":"png","order_by":2,"title":"Figure 2","display":"","copyAsset":false,"role":"figure","size":155823,"visible":true,"origin":"","legend":"Cut-off values of the postoperative duration until adjuvant chemotherapy (PDAC)\nThe cut-off value of PDAC to stratify relapse-free survival (RFS) rates the most effectively in pStage II/III gastric cancer was 7 weeks post-surgery (p = 0.017).","description":"","filename":"F2.png","url":"https://assets-eu.researchsquare.com/files/1f386ea1-b2d7-40af-9eaf-1841ce0c3062/v1/F2.png"},{"id":330090,"identity":"fe7d10b0-e74d-4e79-80c1-6dde9ca2cd4e","added_by":"auto","created_at":"2020-01-06 21:03:17","extension":"png","order_by":3,"title":"Figure 3","display":"","copyAsset":false,"role":"figure","size":203644,"visible":true,"origin":"","legend":"Comparison of 5-year relapse-free survival (RFS) rates\n(a)\tPatients with PDAC ≥ 7 weeks had a significantly poorer relapse-free survival (RFS) rate than patients with PDAC \u003c 7 weeks (5-year RFS: 48.5 % vs. 77.0 %, p = 0.017).\n(b)\tThe patients with PDAC ≥ 7 weeks had a poorer overall survival (OS) rate than patients with PDAC \u003c 7 weeks (5-year OS: 74.3 % vs. 80.7 %, p = 0.49).","description":"","filename":"F3.png","url":"https://assets-eu.researchsquare.com/files/1f386ea1-b2d7-40af-9eaf-1841ce0c3062/v1/F3.png"},{"id":330091,"identity":"9aa70042-e3f0-413b-b5aa-0eab6e28d9e6","added_by":"auto","created_at":"2020-01-06 21:03:17","extension":"png","order_by":4,"title":"Figure 4","display":"","copyAsset":false,"role":"figure","size":217466,"visible":true,"origin":"","legend":"Combined survival curves using PDAC and cumulative S-1 dose factors\nThe cohort was divided into four groups: PDAC ≥ 7 weeks and a cumulative S-1 dose ≥ 12,000 mg; PDAC \u003c 7 weeks and a cumulative S-1 dose ≥ 12,000 mg; PDAC ≥ 7 weeks and a cumulative S-1 dose \u003c 12,000 mg; and PDAC \u003c 7 weeks and a cumulative S-1 dose \u003c 12,000 mg.\n(a)\tIn patients with a cumulative S-1 dose \u003c 12,000 mg, there were significant prognostic differences between the PDAC ≥ 7-weeks group and the PDAC \u003c 7-weeks group for RFS (p = 0.040; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC \u003c 7 weeks; 25.0 % vs. 66.3 %). However, in patients with a cumulative S-1 dose \u003e 12,000 mg, there were no prognostic differences between the PDAC ≥ 7-weeks group and the PDAC \u003c 7-weeks group for RFS (p = 0.64; 5-year RFS: PDAC ≥ 7 weeks vs. PDAC \u003c 7 weeks; 85.7 % vs. 84.4 %).\n(b)\tFor patients who received a cumulative S-1 dose ≥ 12,000 mg or S-1 dose \u003c 12,000 mg, there was no difference between PDAC ≥ 7 weeks and PDAC \u003c 7 weeks (p = 0.30, PDAC ≥ 7 weeks and a cumulative S-1 dose ≥ 12,000 mg vs. PDAC \u003c 49 and a cumulative S-1 dose ≥ 12,000 mg; 100 % vs. 86.9 % / p = 0.18, PDAC ≥ 7 weeks and a cumulative S-1 dose \u003c 12,000 mg vs. PDAC \u003c 49 and a cumulative S-1 dose \u003c 12,000 mg; 57.1 % vs. 72.2 %).","description":"","filename":"F4.png","url":"https://assets-eu.researchsquare.com/files/1f386ea1-b2d7-40af-9eaf-1841ce0c3062/v1/F4.png"},{"id":13484819,"identity":"b108c6dc-7432-4ea7-91b6-903a7d86ea2d","added_by":"auto","created_at":"2021-09-16 21:59:26","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1567409,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-10679/v1/55c6f043-062a-4d1d-9b2d-33041644dedb.pdf"}],"financialInterests":"","formattedTitle":"Prognostic effect of postoperative duration until adjuvant chemotherapy and cumulative S-1 dose in gastric cancer","fulltext":[{"header":"Background","content":" \u003cp\u003eGastric cancer is the fourth most commonly diagnosed cancer and the third most common cause of cancer-related death worldwide [\u003cspan citationid=\"CR1\" class=\"CitationRef\"\u003e1\u003c/span\u003e]. Treatment for gastric cancer has been enhanced by improvements in surgical procedures and perioperative management [\u003cspan additionalcitationids=\"CR3 CR4 CR5\" citationid=\"CR2\" class=\"CitationRef\"\u003e2\u003c/span\u003e\u0026ndash;\u003cspan citationid=\"CR6\" class=\"CitationRef\"\u003e6\u003c/span\u003e]. Although surgical resection mainly involves macroscopic tumor resection and lymphadenectomy, the oncologic effect of surgical treatment is often limited to the local control. Therefore, perioperative therapy has been recommended to clear remaining microscopic metastasis [\u003cspan citationid=\"CR7\" class=\"CitationRef\"\u003e7\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe ACTS-GC (Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer) study and its 5-year follow-up results demonstrated that adjuvant chemotherapy (AC) with S-1 monotherapy following curative gastrectomy with lymphadenectomy significantly improved relapse-free survival and overall survival rates. Therefore, AC following curative gastrectomy has been recommended as the standard treatment in Japan for stage II/III gastric cancer since 2014 (JGCTG 2014) [\u003cspan citationid=\"CR8\" class=\"CitationRef\"\u003e8\u003c/span\u003e, \u003cspan citationid=\"CR9\" class=\"CitationRef\"\u003e9\u003c/span\u003e].\u003c/p\u003e \u003cp\u003eThe ACTS-GC study proved the beneficial prognostic effect of starting S-1 treatment within 6 weeks of undergoing curative surgery. However, patients cannot always start AC at the appropriate time following surgery due to various clinical issues that can result in delayed recovery. The prognostic effect of any delay with regard to AC remains controversial [\u003cspan citationid=\"CR10\" class=\"CitationRef\"\u003e10\u003c/span\u003e, \u003cspan citationid=\"CR11\" class=\"CitationRef\"\u003e11\u003c/span\u003e]. Even if the prognosis may be affected by a delay in starting AC, until now there has been no definite cut-off value for the postoperative duration following curative surgery with which to stratify the prognosis [\u003cspan citationid=\"CR12\" class=\"CitationRef\"\u003e12\u003c/span\u003e]. Moreover, it is not clear whether a sufficient total S-1 dose during AC could affect the prognosis or diminish the poor prognostic effect resulting from a delay in starting AC.\u003c/p\u003e \u003cp\u003eIn this study, we investigated the clinical significance of the postoperative duration until adjuvant chemotherapy (PDAC) and the total cumulative S-1 dose, with particular reference to the prognosis. The results of our study suggest a crucial indicator starting AC. Our study also suggested that the cumulative S-1 dose might be key to diminishing any poor prognostic effect, even if there is a delay in starting AC.\u003c/p\u003e "},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003ePatients and surgical procedures\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was approved by the Kyoto Prefectural University of Medicine, Japan, and was therefore performed in accordance with the ethical standards laid down in the Declaration of Helsinki. Written informed consent was obtained from all patients to participate in the research. A total of 214 consecutive patients underwent curative gastrectomy with lymphadenectomy for stage II or III GC at our institute between January 2008 and December 2014. Of these 214 patients, 97 patients received S-1 monotherapy as AC. We excluded 21 patients from the study because of neoadjuvant chemotherapy (n = 2), insufficient follow-up (n = 1), recurrence during AC (n = 8), remnant GC (n = 3), and multiple carcinomas (n = 7). As a result, we retrospectively investigated 76 consecutive patients who received S-1 AC (\u003cstrong\u003eFig. 1\u003c/strong\u003e).\u003c/p\u003e\n\u003cp\u003ePatients with clinical stage IA (clinical T1 and clinical N0 GC) underwent D1+ lymphadenectomy, while those with clinical stage IIA or higher underwent D2 or D2+ lymphadenectomy. All patients underwent macroscopic curative resection (R0); resected specimens were examined by pathologists and evaluated in accordance with the Japanese classification of GC [13]. Dissected lymph nodes were fixed in buffered formalin and embedded in paraffin prior to pathological examination. Pathologists in our institution examined embedded lymph nodes by sectioning slices in the plane of the largest node dimension to confirm the presence of metastasis. Clinicopathological findings from these patients were determined retrospectively on the basis of their hospital records.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eFollow-up after curative gastrectomy followed by AC \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003ePostoperative follow-up was performed in the outpatient clinic every three months following surgery. Blood chemistry was also measured every three months. Endoscopic examinations were performed annually, and computed tomography (CT) examinations were performed every three-to-six months for five years after surgery. The average follow-up period was 52.7 months.\u003c/p\u003e\n\u003cp\u003eAC was begun in the outpatient clinic following discharge. The dose of S-1 was determined according to a patient\u0026rsquo;s body surface area (BSA). Specifically, patients with BSA \u0026lt; 1.25 m\u003csup\u003e2\u003c/sup\u003e received 80 mg per day; patients with 1.25 m\u003csup\u003e2\u003c/sup\u003e \u0026le; BSA \u0026lt; 1.5 m\u003csup\u003e2\u003c/sup\u003e received 100 mg per day; and patients with 1.5 m\u003csup\u003e2\u003c/sup\u003e \u0026le; BSA received 120 mg per day. The cumulative S-1 dose received by each patient during AC was calculated from their hospital records.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eStatistical analysis\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStatistical analyses were conducted using JMP version 10 (SAS Institute Inc., Cary, NC). The Mann\u0026ndash;Whitney U test for unpaired data comprising continuous variables was used to compare clinicopathological variables. For the analysis of survival, Kaplan\u0026ndash;Meier survival curves were constructed for groups based on univariate predictors, and differences between the groups were tested using a generalized Wilcoxon test. The Cox proportional hazards model was used for further evaluations of multivariate survival analysis. A p-value \u0026lt; 0.05 was considered statistically significant.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003e\u003cem\u003eClinicopathological characteristics of GC patients after curative gastrectomy followed by S-1 AC \u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eTable 1\u003c/strong\u003e shows the clinical characteristics of GC patients who received curative gastrectomy followed by S-1 AC. The mean age of the patients was 62.9 years. Of 76 patients, 47 (61.8%) were male and 29 (38.2%) were female; 30 patients were at pStage IIA, 17 patients were at pStage IIB, 17 patients were at pStage IIIA, and 12 patients were at pStage IIIB. Total gastrectomy was performed in 30 patients (39.5%), distal gastrectomy in 44 patients (57.9%), and proximal gastrectomy was performed in two patients (2.6%) for curative resection dependent on the location of the tumor. A total of 19 patients (25.0%) underwent D1+ lymphadenectomy based on their clinical stage, while the remaining patients performed D2 or D2+ lymphadenectomy [13].\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eCut-off value of PDAC to stratify the prognosis and correlation between PDAC and clinicopathological factors\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe performed a minimum p-value analysis for relapse-free survival (RFS) using various cut-off values for PDAC, as shown in \u003cstrong\u003eFig. 2\u003c/strong\u003e. The cut-off value of 7 weeks post-surgery was confirmed to be the upper-limit to stratify the prognosis (\u003cem\u003ep\u003c/em\u003e = 0.017; 5-year RFS: PDAC \u0026ge; 7 weeks vs. PDAC \u0026lt; 7 weeks; 48.5 % vs. 77.0 %). Although there were no significant differences in 5-year overall survival (OS) rates, patients in the PDAC \u0026ge; 7 weeks group had a poorer prognosis than those in the PDAC \u0026lt; 7 weeks group (\u003cem\u003ep\u003c/em\u003e = 0.49; 5-year OS: PDAC \u0026ge; 7 weeks vs. PDAC \u0026lt; 7 weeks; 74.3 % vs. 80.7 %). (\u003cstrong\u003eFig. 3\u003c/strong\u003e).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eCut-off value of cumulative S-1 dose to stratify the prognosis and combined survival curves using PDAC and cumulative S-1 dose factors\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo clarify the clinical effect of cumulative S-1 dose, we performed a minimum p-value analysis for RFS using various cut-off values of cumulative S-1 dose (data not shown). A cut-off value of 12,000 mg was confirmed to stratify the prognosis most (\u003cem\u003ep\u003c/em\u003e = 0.006; 5-year RFS: cumulative S-1 dose \u0026ge; 12,000 mg vs. \u0026lt; 12,000 mg; 84.7 % vs. 52.4 %).\u003c/p\u003e\n\u003cp\u003eNext, we compared survival curves between four groups: 1) PDAC \u0026ge; 7 weeks / total S-l dose \u0026ge; 12,000 mg; 2) PDAC \u0026lt; 7 weeks / total S-l dose \u0026ge; 12,000 mg; 3) PDAC \u0026ge; 7 weeks / total S-l dose \u0026lt; 12,000 mg; and 4) PDAC \u0026lt; 7 weeks / total S-l dose \u0026lt; 12,000 mg. With regard to patients who received a cumulative S-1 dose \u0026lt; 12,000 mg, there was a significant prognostic difference between the PDAC \u0026ge; 7-weeks group and the PDAC \u0026lt; 7-weeks group for RFS (\u003cem\u003ep\u003c/em\u003e = 0.040; 5-year RFS: PDAC \u0026ge; 7 weeks vs. PDAC \u0026lt; 7 weeks; 25.0 % vs. 66.3 %). However, in patients who received a cumulative S-1 dose \u0026gt; 12,000 mg there was no prognostic difference between the PDAC \u0026ge; 7-weeks group and PDAC \u0026lt; 7-weeks group for RFS (\u003cem\u003ep\u003c/em\u003e = 0.64; 5-year RFS: PDAC \u0026ge; 7 weeks vs. PDAC \u0026lt; 7 weeks; 85.7 % vs. 84.4 %). (\u003cstrong\u003eFig. 4\u003c/strong\u003e)\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eComparison of PDAC with c\u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cem\u003elinicopathological factors\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNext, we evaluated correlations between PDAC and clinicopathological factors using the Mann\u0026ndash;Whitney U test. As shown in \u003cstrong\u003eTable 2\u003c/strong\u003e, a high peak in the C-reactive protein (CRP) cut-off value of 8 mg/dl or above was significantly associated with a delay in starting S-1 AC. In addition, the incidence of postoperative complications (Clavien\u0026ndash;Dindo classification \u0026ge; II) tended to be linked to longer PDAC (\u003cem\u003ep\u003c/em\u003e = 0.065). There were no other significant differences between the groups with regard to other clinicopathological factors.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eUnivariate and multivariate analysis using Cox\u0026rsquo;s proportional hazard model\u003c/em\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo elucidate the prognostic factors for recurrence-free survival, univariate and multivariate analysis using Cox\u0026rsquo;s proportional hazard model were performed. As shown in \u003cstrong\u003eTable 2\u003c/strong\u003e, age, gender, BMI, histological type, a postoperative peak CRP of \u0026ge; 8 mg/dl, complications of Clavien\u0026ndash;Dindo grade II or higher, pT-stage, pN-stage, cumulative S-1 dose, and PDAC were selected as clinical variables. The multivariate analysis showed that PDAC \u0026ge; 7 weeks [\u003cem\u003ep\u003c/em\u003e = 0.007; hazard ratio (HR) 3.99 (95% CI: 1.46\u0026ndash;11.5)] and cumulative S-1 dose \u0026gt; 12,000 mg [\u003cem\u003ep\u003c/em\u003e = 0.033; HR 0.38 (95% CI: 0.14\u0026ndash;0.93)] were independent prognostic factors.\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eThere have been few reports of prognostic effects with regard to PDAC and the extent of S-1 treatment in AC [11, 12, 14]. In this study, we clearly demonstrated that a PDAC \u0026ge; 7 weeks and a cumulative S-1 dose of more than 12,000 mg were independent prognostic factors in GC patients undergoing AC following curative gastrectomy. Moreover, in patients who received a cumulative S-1 dose of more than 12,000 mg, we showed that there were no prognostic differences between patients who had a PDAC of more than or less than 7 weeks. PDAC \u0026ge; 7 weeks. Our results strongly suggested that a cumulative S-1 dose of more than 12,000 mg is a crucial indicator and might be the key dose for diminishing the poor prognostic effects arising from a delay in AC.\u003c/p\u003e\n\u003cp\u003eConcerning PDAC, we clearly demonstrated that 7 weeks was the best cut-off value to stratify the prognosis of patients with pStage II/III gastric cancer (\u003cem\u003ep\u003c/em\u003e = 0.017; 5-year RFS: PDAC \u0026ge; 7 weeks vs. PDAC \u0026lt; 7 weeks; 48.5 % vs. 77.0 %). From an oncological perspective, to eliminate microscopic metastasis it appears that AC should be started immediately following curative gastrectomy. PDAC has been reported to be an independent prognostic factor in other types of cancer, with various cut-off values suggested, including 12 weeks [10] and 8 weeks in colon cancer [15-17] and 13 weeks (91 days) in breast cancer [18]. With regard to gastric cancer, various cut-off values of PDAC have been reported as prognostic factors, ranging from 4 to 8 weeks [12, 16, 19-21]. Our PDAC cut-off value of 7 weeks could also be a candidate indicator. Future studies are warranted, and big data analysis might be needed to determine the best cut-off value for clinical settings.\u0026nbsp;\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp; Regarding the cumulative S-1 dose, we also demonstrated that a cumulative S-1 dose of more than 12,000 mg was an independent prognostic factor for RFS [\u003cem\u003ep\u003c/em\u003e = 0.033; HR 0.38 (95% CI: 0.14\u0026ndash;0.93)]. The Japanese phase 3 randomized trial (JCOG1104 [OPAS-1]) revealed that four courses of S-1 AC were inferior to eight courses of S-1 AC for achieving RFS of pStage II gastric cancer, highlighting the importance of the duration of AC [22]. Fujitani et al. also reported that S-1 AC with a duration of more than 6 months could have a prognostic impact in patients with gastric cancer [11]. There results could be a crucial indicator of the importance of S-1 AC duration. However, the S-1 dose intensity in each patient is considerably different in clinical practice, and is indeed not as high as shown in previous reports [8, 23, 24]. Therefore, we suggest that the cumulative S-1 dose is also a pivotal factor, in addition to the PDAC of S-1.\u003c/p\u003e\n\u003cp\u003e\u0026nbsp;\u0026nbsp; The most striking finding in the present study was that there were no prognostic differences for RFS between patients with PDAC \u0026ge; 7 weeks and those with PDAC \u0026lt; 7 weeks (\u003cem\u003ep\u003c/em\u003e = 0.64; 5-year RFS: PDAC \u0026ge; 7 weeks vs. PDAC \u0026lt; 7 weeks; 85.7 % vs. 84.4 %). Specifically, these results suggested that a cumulative S-1 dose of more than 12,000 mg might diminish the poor prognostic effect associated with a delay in AC. Similar results were also reported that S-1 AC of more than 6 months [11] and S-1 AC with a relative dose intensity of more than 64.6 % [12] have more prognostic impact than PDAC. Although which factors have the optimal impact on prognosis is unclear, we enhance on the cumulative S-1 dose. As shown by our results, patients could not always begin AC at the appropriate time because of various clinical issues, such as a high serum CRP level or postoperative complications. To avoid postoperative complications [25] and achieve low postoperative CRP levels [26], less invasive surgery is a pivotal surgical goal from a prognostic perspective, Nevertheless, if these issues are encountered and AC cannot be initiated with sufficient S-1 dose intensity, administering high cumulative S-1 dose treatment even after a long PDAC could be a valuable strategy that could potentially rescue high-risk patients with these issues.\u003c/p\u003e\n\u003cp\u003eThis study had some limitations: the results were obtained from a retrospective evaluation of a small number of patients at a single institute. A large-scale, multicenter cohort study is necessary to confirm the significance of PDAC and cumulative S-1 dose.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003ePatients with early initiation of AC had better prognosis than those with delayed initiation. 7 weeks could be a crucial indicator starting AC, and a cumulative S-1 dose of more than 12,000 mg might be a key dose for diminishing the poor prognostic effects of delaying AC.\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eAcknowledgements\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eEthical approval and consent to participate \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was designed in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of Kyoto Prefectural University of Medicine. All patients received sufficient explanation of the study, and written informed consent was obtained.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe datasets used during the current study are available from the corresponding author on reasonable request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThere is no funding to be declared.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor Contribution: \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eYT and SK designed this work. SK, KN, TA, TK, HK, RM, AS, YK, HI, TK, HF, KO, EO acquired clinical data and critically reviewed this manuscript. YT and SK analyzed data and wrote the paper.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eGC: gastric cancer; AC: adjuvant chemotherapy; PDAC: postoperative duration until adjuvant chemotherapy; RFS: relapse-free survival; ACTS-GC: Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eTorre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A: \u003cstrong\u003eGlobal cancer statistics, 2012\u003c/strong\u003e. \u003cem\u003eCA: a cancer journal for clinicians \u003c/em\u003e2015, \u003cstrong\u003e65\u003c/strong\u003e(2):87-108.\u003c/li\u003e\n\u003cli\u003eGallo A, Cha C: \u003cstrong\u003eUpdates on esophageal and gastric cancers\u003c/strong\u003e. \u003cem\u003eWorld J Gastroenterol \u003c/em\u003e2006, \u003cstrong\u003e12\u003c/strong\u003e(20):3237-3242.\u003c/li\u003e\n\u003cli\u003ePaoletti X, Oba K, Burzykowski T, Michiels S, Ohashi Y, Pignon JP, Rougier P, Sakamoto J, Sargent D, Sasako M\u003cem\u003e et al\u003c/em\u003e: \u003cstrong\u003eBenefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis\u003c/strong\u003e. \u003cem\u003eJama \u003c/em\u003e2010, \u003cstrong\u003e303\u003c/strong\u003e(17):1729-1737.\u003c/li\u003e\n\u003cli\u003eBang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH, Lee KW, Kim YH, Noh SI, Cho JY\u003cem\u003e et al\u003c/em\u003e: \u003cstrong\u003eAdjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial\u003c/strong\u003e. \u003cem\u003eLancet \u003c/em\u003e2012, \u003cstrong\u003e379\u003c/strong\u003e(9813):315-321.\u003c/li\u003e\n\u003cli\u003eFuse N, Bando H, Chin K, Ito S, Yoshikawa T, Tsuburaya A, Terashima M, Kawashima Y, Fukunaga T, Gotoh M\u003cem\u003e et al\u003c/em\u003e: \u003cstrong\u003eAdjuvant capecitabine plus oxaliplatin after D2 gastrectomy in Japanese patients with gastric cancer: a phase II study\u003c/strong\u003e. \u003cem\u003eGastric Cancer \u003c/em\u003e2017, \u003cstrong\u003e20\u003c/strong\u003e(2):332-340.\u003c/li\u003e\n\u003cli\u003eKomatsu S, Otsuji E: \u003cstrong\u003eEssential updates 2017/2018: Recent topics in the treatment and research of gastric cancer in Japan\u003c/strong\u003e. \u003cem\u003eAnn Gastroenterol Surg \u003c/em\u003e\u003c/li\u003e\n\u003cli\u003eGunderson LL: \u003cstrong\u003eGastric cancer--patterns of relapse after surgical resection\u003c/strong\u003e. \u003cem\u003eSemin Radiat Oncol \u003c/em\u003e2002, \u003cstrong\u003e12\u003c/strong\u003e(2):150-161.\u003c/li\u003e\n\u003cli\u003eSakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, Furukawa H, Nakajima T, Ohashi Y, Imamura H\u003cem\u003e et al\u003c/em\u003e: \u003cstrong\u003eAdjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine\u003c/strong\u003e. \u003cem\u003eThe New England journal of medicine \u003c/em\u003e2007, \u003cstrong\u003e357\u003c/strong\u003e(18):1810-1820.\u003c/li\u003e\n\u003cli\u003e\u003cstrong\u003eJapanese gastric cancer treatment guidelines 2014 (ver. 4)\u003c/strong\u003e. \u003cem\u003eGastric Cancer \u003c/em\u003e2017, \u003cstrong\u003e20\u003c/strong\u003e(1):1-19.\u003c/li\u003e\n\u003cli\u003eHershman D, Hall MJ, Wang X, Jacobson JS, McBride R, Grann VR, Neugut AI: \u003cstrong\u003eTiming of adjuvant chemotherapy initiation after surgery for stage III colon cancer\u003c/strong\u003e. \u003cem\u003eCancer \u003c/em\u003e2006, \u003cstrong\u003e107\u003c/strong\u003e(11):2581-2588.\u003c/li\u003e\n\u003cli\u003eFujitani K, Kurokawa Y, Takeno A, Endoh S, Ohmori T, Fujita J, Yamasaki M, Takiguchi S, Mori M, Doki Y: \u003cstrong\u003eTime to initiation or duration of S-1 adjuvant chemotherapy; 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1\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eClinicopathological characteristics of patients who received S-1 monotherapy as adjuvant chemotherapy.\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:278.15pt;margin-left:4.95pt;border-collapse:collapse;\" width=\"371\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eVariable\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd 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style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTotal\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eGender\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e47\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e62%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eFemale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e38%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAge (years)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e72%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026lt; 70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e21\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e28%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eBMI \u003csup\u003ea\u003c/sup\u003e (kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;18.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e91%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026lt; 18.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e9%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTumor location\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp 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style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e32%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New 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width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e28%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eN3\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e16\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e21%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n 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style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e39%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eIIB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e22%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New 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4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e22%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eIIIB\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e12\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e16%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHistopathological type\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eDifferentiated\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e39%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eUndifferentiated\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e61%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eOperation\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTotal gastrectomy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e39%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eDistal gastrectomy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e58%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eProximal gastrectomy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e3%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eLymphadenectomy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eD1+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e25%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:110.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"39.516129032258064%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:109.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"38.97849462365591%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eD2 or D2+\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e57\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e75%\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:219.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"78.49462365591398%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ea\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eBMI: body mass index,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"2\" style=\"width:219.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"78.49462365591398%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eb\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eClassification of Gastric Carcinoma.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:19.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.258064516129032%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:11.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"4.032258064516129%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:28.25pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"10.21505376344086%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\n \u003cbr\u003e\u0026nbsp;\n \u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTable 2\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;color:black;\"\u003eComparison of PDAC with c\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;color:black;\"\u003elinicopathological factors\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;color:black;\"\u003e.\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:460.7pt;margin-left:4.95pt;border-collapse:collapse;\" width=\"614\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eVariable\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003en\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:118.15pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"25.649350649350648%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePDAC \u003csup\u003ea\u003c/sup\u003e (days)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:28.95pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cem\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size:13px;font-family: \u0026quot;Times New Roman\u0026quot;,serif;\"\u003e-value \u003csup\u003ec\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003emean\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eSD \u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eGender\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e47\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e41.6\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e12.8\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.992\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eFemale\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e46.3\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e24.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAge (years)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;70\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e21\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e42.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e11.6\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.857\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026lt; 70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e43.9\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e20.2\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eBMI \u003csup\u003ed\u003c/sup\u003e (kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;18.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e69\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e41.9\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e12.7\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.907\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026lt; 18.5\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e58.4\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e44.8\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eASA-PS \u003csup\u003ee\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e44.1\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e20.2\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.841\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e27\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e42.2\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e14.1\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eGPS \u003csup\u003ef\u003c/sup\u003e score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e68\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e42.8\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e14.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.282\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;1\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e48.6\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e40.2\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePNI \u003csup\u003eg\u003c/sup\u003e score\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;48\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e54\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e42.6\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e14.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.684\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026lt; 48\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e22\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e45.4\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e25.4\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003epStage\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eII\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e47\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e42.3\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e14.1\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.945\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eIII\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e45.1\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e23.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHistological type\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eDifferentiated\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e30\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e41.9\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e10.7\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.663\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eUndifferentiated\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e44.4\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e21.8\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eSurgical approach\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eOpen\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e59\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e45.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e19.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.224\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eLaparoscopy\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e17\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e37.8\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e11.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePost-operative peak CRP \u003csup\u003eh\u003c/sup\u003e (mg/dl)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e44\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e46.3\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e20.1\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.046\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026lt; 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e32\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e39.4\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e14.6\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eComplication (C-D\u003csup\u003e\u0026nbsp;i\u0026nbsp;\u003c/sup\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS Mincho\u0026quot;;\"\u003e≧\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;II)\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePositive\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e9\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e54.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e21.2\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.065\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:161.0pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"34.9025974025974%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:82.6pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"17.857142857142858%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eNegative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:23.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"5.194805194805195%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:right;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e（\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:38.35pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"8.279220779220779%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e42.0\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.95pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e±\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:33.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"7.142857142857143%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e17.4\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:15.4pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"3.409090909090909%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e）\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"2.272727272727273%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:54.65pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"11.85064935064935%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"11\" style=\"width:460.7pt;border:none;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ea\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePDAC: postoperative duration until adjuvant chemotherapy, \u003csup\u003eb\u003c/sup\u003e Mann-Whitney U test analysis,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"11\" style=\"width:460.7pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ec\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eSD: standard deviation, \u003csup\u003ed\u0026nbsp;\u003c/sup\u003eBMI: body mass index,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"11\" style=\"width:460.7pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ee\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eASA-PS: Physical status proposed by the American Society of Anesthesiologists (ASA),\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"11\" style=\"width:460.7pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ef\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eGPS: Glasgow prognostic score, \u003csup\u003eg\u0026nbsp;\u003c/sup\u003ePNI: prognostic nutritional index,\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"11\" style=\"width:460.7pt;padding:0in 4.95pt 0in 4.95pt;height:15.0pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eh\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCRP: C-reactive protein, \u003csup\u003eI\u0026nbsp;\u003c/sup\u003eC-D: Clavien-Dindo classification\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:27.0pt;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTable 3\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eUnivariate and multivariate analysis using Cox’s proportional hazard model\u003cstrong\u003e.\u003c/strong\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"width:472.95pt;margin-left:4.95pt;border-collapse:collapse;\" width=\"631\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.40095087163233%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eVariable\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.361331220285262%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003en\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.312202852614897%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eUnivariate \u003csup\u003ea\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border:none;border-top:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.218700475435816%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"5\" style=\"width:164.25pt;border-top:solid windowtext 1.0pt;border-left:none;border-bottom:solid windowtext 1.0pt;border-right:none;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"34.7068145800317%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMultivariate \u003csup\u003eb\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ep\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;value\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHR\u003csup\u003e\u0026nbsp;c\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd colspan=\"3\" style=\"width:82.2pt;border:none;border-bottom: solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"17.40506329113924%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e95% CI \u003csup\u003ed\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cem\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ep-\u003c/span\u003e\u003c/em\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003evalue\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eTotal\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e76\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eGender\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eMale vs. Female\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e47 vs. 29\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.128\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAge (years)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PMincho\u0026quot;,serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;70 vs. \u0026lt; 70\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e21 vs. 55\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.165\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eBMI (kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥ 18.5 vs. \u0026lt; 18.5\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e69 vs. 7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.090\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003epT category \u003csup\u003ee\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003epT1-3 vs. pT4\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e57 vs. 19\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.048\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e4.14\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.47\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e12.14\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.008\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003epN category \u003csup\u003ee\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003epN0 vs. pN1-2\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e27 vs. 49\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.038\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e2.95\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.08\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e10.32\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.034\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHistological type\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eDifferentiated vs. Undifferentiated\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e30 vs. 46\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.899\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePostoperative peak-CRP (mg/dl)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥ 8 vs. \u0026lt; 8\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e44 vs. 32\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.933\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eComplication (C-D\u0026gt;II) \u003csup\u003ef\u003c/sup\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePositive vs. Negative\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e9 vs. 67\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.637\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ePDAC (weeks)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥ 7 vs. \u0026lt; 7\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e20 vs. 56\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.017\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e3.99\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e1.46\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e11.51\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.007\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eCumulative S-1 dose (mg)\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width:177.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"37.34177215189873%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e≥12,000 vs. \u0026lt; 12,000\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:58.25pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"12.341772151898734%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e40 vs. 36\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:63.05pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"13.291139240506329%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.006\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:10.2pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.2151898734177213%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;MS PGothic\u0026quot;,sans-serif;\"\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.38\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:30.5pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"6.487341772151899%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.14\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:13.8pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"2.848101265822785%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e-\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:37.9pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"8.069620253164556%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.93\u0026nbsp;\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width:51.55pt;border:none;border-bottom:solid windowtext 1.0pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"10.917721518987342%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;text-align:center;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003e0.033\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"9\" style=\"width:472.95pt;border:none;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ea\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAnalyzed by Log Rank (Mantel-Cox) test.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"9\" style=\"width:472.95pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eb\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eAnalyzed by Cox's proportional hazard model.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"9\" style=\"width:472.95pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ec\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eHR: hazard ratio, \u003csup\u003ed\u003c/sup\u003e CI: confidence interval.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"9\" style=\"width:472.95pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ee\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eJapanese Classification of Gastric Carcinoma.\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"9\" style=\"width:472.95pt;padding:0in 4.95pt 0in 4.95pt;height:16.5pt;\" width=\"100%\"\u003e\n \u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:normal;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003csup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003ef\u0026nbsp;\u003c/span\u003e\u003c/sup\u003e\u003cspan style=\"font-size:13px;font-family:\u0026quot;Times New Roman\u0026quot;,serif;\"\u003eClavien-Dindo Classification\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:27.0pt;font-size:13px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-family:\u0026quot;Times New Roman\u0026quot;,serif;color:black;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003c/p\u003e\n\u003cp style=\"margin:0in;margin-bottom:.0001pt;line-height:200%;font-size:14px;font-family:\u0026quot;Century\u0026quot;,serif;\"\u003e\u0026nbsp;\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"adjuvant chemotherapy, S-1, early initiation, cumulative dose, gastric cancer ","lastPublishedDoi":"10.21203/rs.2.20067/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.2.20067/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eAdjuvant chemotherapy (AC) following curative gastrectomy for stage II/III gastric cancer (GC) is recommended in Japan. However, for various reasons, patients cannot always start AC at the appropriate time. This study was designed to investigate the effect of the postoperative duration until adjuvant chemotherapy (PDAC) and cumulative S-1 dose on prognosis.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\u003cp\u003eBetween 2008 and 2014, 76 consecutive GC patients who underwent postoperative S-1 monotherapy were enrolled in this study.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\u003cp\u003ePostoperative complications of Clavien–Dindo grade II or higher and postoperative peak C-reactive protein of 8 mg/dl or higher were significantly associated with delayed AC. The cut-off value of PDAC selected to most effectively stratify prognosis was 7 weeks. For relapse-free survival (RFS), patients with PDAC ≥ 7 weeks had an insignificantly poorer prognosis than those with PDAC \u0026lt; 7 weeks (\u003cem\u003ep\u003c/em\u003e = 0.017, 5-year RFS: PDAC ≥ 7 weeks vs. PDAC \u0026lt; 7 weeks, 48.5% vs. 77.0%). A multivariate analysis showed that PDAC ≥ 7 weeks [\u003cem\u003ep\u003c/em\u003e = 0.007; hazard ratio (HR) 3.99 (95% CI: 1.46–11.5)] and cumulative S-1 dose \u0026gt; 12,000 mg [\u003cem\u003ep\u003c/em\u003e = 0.033; HR 0.38 (95% CI: 0.14–0.93)] were independent prognostic factors. In patients with a cumulative S-1 dose ≥ 12,000 mg, there were no prognostic differences between patients with and without PDAC ≥ 7 weeks.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions\u003c/strong\u003e\u003c/p\u003e\u003cp\u003e7 weeks after surgery could be an indicator starting AC. A cumulative S-1 dose of more than 12,000 mg might be a key dose for diminishing the poor prognostic effects of delaying AC.\u003c/p\u003e","manuscriptTitle":"Prognostic effect of postoperative duration until adjuvant chemotherapy and cumulative S-1 dose in gastric cancer","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2020-01-06 21:03:14","doi":"10.21203/rs.2.20067/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"2f24ff30-3258-46f7-9fd1-43cc145fcd1c","owner":[],"postedDate":"January 6th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[{"id":47018,"name":"Oncology"},{"id":47019,"name":"Cancer Biology"}],"tags":[],"updatedAt":"","versionOfRecord":[],"versionCreatedAt":"2020-01-06 21:03:14","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-10679","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"identity":"rs-10679","version":["v1"]},"buildId":"FbvkV6FR0MCFSLy54lSbu","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}